Details for: FETUB

Gene ID: 26998

Symbol: FETUB

Ensembl ID: ENSG00000090512

Description: fetuin B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 10.3143
    Cell Significance Index: 173.4800
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.7626
    Cell Significance Index: 0.9900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.7618
    Cell Significance Index: 7.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.2875
    Cell Significance Index: 7.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2300
    Cell Significance Index: 45.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1564
    Cell Significance Index: 2.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1544
    Cell Significance Index: 2.2500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.1295
    Cell Significance Index: 1.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.1019
    Cell Significance Index: 3.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0985
    Cell Significance Index: 1.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0962
    Cell Significance Index: 1.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0294
    Cell Significance Index: 0.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0247
    Cell Significance Index: 1.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0140
    Cell Significance Index: 9.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0027
    Cell Significance Index: 0.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0002
    Cell Significance Index: 0.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0013
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0016
    Cell Significance Index: -0.8800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.9000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0035
    Cell Significance Index: -0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0039
    Cell Significance Index: -1.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0055
    Cell Significance Index: -2.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0059
    Cell Significance Index: -0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0073
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0089
    Cell Significance Index: -1.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0101
    Cell Significance Index: -1.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0110
    Cell Significance Index: -1.8800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0119
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0125
    Cell Significance Index: -2.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0150
    Cell Significance Index: -1.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0153
    Cell Significance Index: -2.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0164
    Cell Significance Index: -2.3900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0175
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0194
    Cell Significance Index: -2.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0237
    Cell Significance Index: -1.2300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0242
    Cell Significance Index: -0.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0259
    Cell Significance Index: -1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0268
    Cell Significance Index: -2.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0277
    Cell Significance Index: -0.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0306
    Cell Significance Index: -2.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0354
    Cell Significance Index: -2.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0367
    Cell Significance Index: -1.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0375
    Cell Significance Index: -2.5200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0405
    Cell Significance Index: -0.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0418
    Cell Significance Index: -1.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0435
    Cell Significance Index: -1.0900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0437
    Cell Significance Index: -0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0440
    Cell Significance Index: -2.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0447
    Cell Significance Index: -2.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0453
    Cell Significance Index: -2.5400
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.0459
    Cell Significance Index: -0.4200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0461
    Cell Significance Index: -0.4800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0499
    Cell Significance Index: -0.5400
  • Cell Name: deuterosomal cell (CL4033044)
    Fold Change: -0.0530
    Cell Significance Index: -0.4200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0544
    Cell Significance Index: -0.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0544
    Cell Significance Index: -1.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0545
    Cell Significance Index: -1.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0547
    Cell Significance Index: -2.4200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0551
    Cell Significance Index: -0.5800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0555
    Cell Significance Index: -0.5500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0565
    Cell Significance Index: -0.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0575
    Cell Significance Index: -1.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0650
    Cell Significance Index: -2.4600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0682
    Cell Significance Index: -0.4900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0697
    Cell Significance Index: -0.4500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0726
    Cell Significance Index: -0.5400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0745
    Cell Significance Index: -0.9600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0763
    Cell Significance Index: -0.8900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0765
    Cell Significance Index: -0.8800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0769
    Cell Significance Index: -0.5100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0774
    Cell Significance Index: -0.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0806
    Cell Significance Index: -1.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0856
    Cell Significance Index: -2.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0858
    Cell Significance Index: -2.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0859
    Cell Significance Index: -2.4500
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0862
    Cell Significance Index: -0.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0870
    Cell Significance Index: -2.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0872
    Cell Significance Index: -1.9100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0873
    Cell Significance Index: -1.7400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0873
    Cell Significance Index: -0.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0878
    Cell Significance Index: -1.2500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0883
    Cell Significance Index: -0.9100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0892
    Cell Significance Index: -1.1700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0903
    Cell Significance Index: -1.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0905
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0914
    Cell Significance Index: -1.0000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0948
    Cell Significance Index: -1.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0992
    Cell Significance Index: -2.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1014
    Cell Significance Index: -1.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1026
    Cell Significance Index: -2.4600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1029
    Cell Significance Index: -0.8700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1061
    Cell Significance Index: -1.2700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1069
    Cell Significance Index: -2.5900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1073
    Cell Significance Index: -1.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1083
    Cell Significance Index: -2.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Fetuin B exhibits several unique characteristics that distinguish it from other fetuin family members. Its expression is primarily restricted to specific cell types, including progenitor cells, endothelial cells, and stem cells. Fetuin B shows high affinity binding to metalloendopeptidases, which are enzymes involved in the regulation of peptide hormone degradation. Additionally, Fetuin B has been shown to inhibit the binding of sperm to the zona pellucida, a critical step in fertilization. These characteristics highlight the complex regulatory mechanisms controlled by the Fetuin B gene. **Pathways and Functions:** The Fetuin B gene is involved in several key pathways, including: 1. **Negative regulation of endopeptidase activity**: Fetuin B inhibits the activity of endopeptidases, which are enzymes responsible for the degradation of peptide hormones. 2. **Metalloendopeptidase inhibition**: Fetuin B binds to metalloendopeptidases, regulating their activity and preventing excessive degradation of peptide hormones. 3. **Binding of sperm to zona pellucida**: Fetuin B inhibits the binding of sperm to the zona pellucida, a critical step in fertilization. 4. **Extracellular exosome and extracellular region**: Fetuin B is secreted into the extracellular environment, where it regulates cellular interactions and signaling. **Clinical Significance:** The dysregulation of the Fetuin B gene has been implicated in various human diseases, including: 1. **Cancer**: Overexpression of Fetuin B has been linked to tumor progression and metastasis in several types of cancer. 2. **Neurological disorders**: Fetuin B has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Reproductive disorders**: Dysregulation of Fetuin B has been linked to impaired fertilization and reproductive dysfunction. 4. **Gastrointestinal disorders**: Fetuin B has been implicated in the pathogenesis of gastrointestinal disorders, such as inflammatory bowel disease. In conclusion, the Fetuin B gene is a multifunctional protein that plays a critical role in regulating cellular processes, including endopeptidase activity, metalloendopeptidase inhibition, and sperm binding to the zona pellucida. Its dysregulation has significant implications for human health, with potential applications in the diagnosis and treatment of various diseases. Further research is necessary to fully elucidate the complex mechanisms controlled by the Fetuin B gene and its role in human disease.

Genular Protein ID: 4056288039

Symbol: FETUB_HUMAN

Name: Fetuin-B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10947975

Title: Fetuin-B, a second member of the fetuin family in mammals.

PubMed ID: 10947975

DOI: 10.1042/bj3500589

PubMed ID: 15499407

Title: Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity.

PubMed ID: 15499407

DOI: 10.1139/g04-043

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 23562279

Title: Fetuin-B, a liver-derived plasma protein is essential for fertilization.

PubMed ID: 23562279

DOI: 10.1016/j.devcel.2013.03.001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 382
  • Mass: 42055
  • Checksum: C73977793A30AF8A
  • Sequence:
  • MGLLLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR DINKDRKDGY 
    VLRLNRVNDA QEYRRGGLGS LFYLTLDVLE TDCHVLRKKA WQDCGMRIFF ESVYGQCKAI 
    FYMNNPSRVL YLAAYNCTLR PVSKKKIYMT CPDCPSSIPT DSSNHQVLEA ATESLAKYNN 
    ENTSKQYSLF KVTRASSQWV VGPSYFVEYL IKESPCTKSQ ASSCSLQSSD SVPVGLCKGS 
    LTRTHWEKFV SVTCDFFESQ APATGSENSA VNQKPTNLPK VEESQQKNTP PTDSPSKAGP 
    RGSVQYLPDL DDKNSQEKGP QEAFPVHLDL TTNPQGETLD ISFLFLEPME EKLVVLPFPK 
    EKARTAECPG PAQNASPLVL PP

Genular Protein ID: 468316359

Symbol: Q5J875_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15499407

Title: Identification of fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity.

PubMed ID: 15499407

DOI: 10.1139/g04-043

Sequence Information:

  • Length: 317
  • Mass: 34590
  • Checksum: 38F9F3B75D3EA48F
  • Sequence:
  • MGLFLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR DINKDRKDGY 
    VLRLNRVNDA QEYRRAISKK KIYMTCPDCP SSIPTDSSNH QVLEAATESL AKYNNENTSK 
    QYSLFKVTRA SSQWVVGPSY FVEYLIKESP CTKSQASSCS LQSSDSVPVG LCKGSLTRTH 
    WEKFVSVTCD FFESQAPATG SENSAVNQKP TNLPKVEESQ QKNTPPTDSP SKAGPRGSVQ 
    YLPDLDDKNS QEKGPQEAFP VHLDLTTNPQ GETLDISFLF LEPMEEKLVV LPFPKEKART 
    AECPGPAQNA SPLVLPP

Genular Protein ID: 1156899520

Symbol: E9PG08_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 317
  • Mass: 34556
  • Checksum: 3EBF11155F9AE26F
  • Sequence:
  • MGLLLPLALC ILVLCCGAMS PPQLALNPSA LLSRGCNDSD VLAVAGFALR DINKDRKDGY 
    VLRLNRVNDA QEYRRAISKK KIYMTCPDCP SSIPTDSSNH QVLEAATESL AKYNNENTSK 
    QYSLFKVTRA SSQWVVGPSY FVEYLIKESP CTKSQASSCS LQSSDSVPVG LCKGSLTRTH 
    WEKFVSVTCD FFESQAPATG SENSAVNQKP TNLPKVEESQ QKNTPPTDSP SKAGPRGSVQ 
    YLPDLDDKNS QEKGPQEAFP VHLDLTTNPQ GETLDISFLF LEPMEEKLVV LPFPKEKART 
    AECPGPAQNA SPLVLPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.