Details for: DNAI1

Gene ID: 27019

Symbol: DNAI1

Ensembl ID: ENSG00000122735

Description: dynein axonemal intermediate chain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.4740
    Cell Significance Index: -10.0000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.8972
    Cell Significance Index: 8.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8424
    Cell Significance Index: 37.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8116
    Cell Significance Index: 19.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7109
    Cell Significance Index: 26.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4751
    Cell Significance Index: 26.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3343
    Cell Significance Index: 7.3200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.3332
    Cell Significance Index: 3.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.3188
    Cell Significance Index: 4.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2704
    Cell Significance Index: 54.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1389
    Cell Significance Index: 96.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1365
    Cell Significance Index: 74.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0460
    Cell Significance Index: 16.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0427
    Cell Significance Index: 0.7300
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0414
    Cell Significance Index: 0.2600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0303
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0134
    Cell Significance Index: 25.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0128
    Cell Significance Index: 23.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0033
    Cell Significance Index: 5.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0013
    Cell Significance Index: 0.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0030
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0076
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0197
    Cell Significance Index: -12.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0223
    Cell Significance Index: -10.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0258
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0264
    Cell Significance Index: -7.6000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0359
    Cell Significance Index: -0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0459
    Cell Significance Index: -6.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0490
    Cell Significance Index: -8.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0563
    Cell Significance Index: -11.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0617
    Cell Significance Index: -1.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0666
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0717
    Cell Significance Index: -12.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0777
    Cell Significance Index: -9.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0871
    Cell Significance Index: -11.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0946
    Cell Significance Index: -2.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0960
    Cell Significance Index: -10.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0963
    Cell Significance Index: -9.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0982
    Cell Significance Index: -11.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0984
    Cell Significance Index: -11.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0997
    Cell Significance Index: -7.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1100
    Cell Significance Index: -12.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1256
    Cell Significance Index: -9.9500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1302
    Cell Significance Index: -1.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1331
    Cell Significance Index: -8.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1385
    Cell Significance Index: -10.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1560
    Cell Significance Index: -9.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1626
    Cell Significance Index: -7.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1716
    Cell Significance Index: -6.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1875
    Cell Significance Index: -9.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1975
    Cell Significance Index: -10.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1979
    Cell Significance Index: -4.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2029
    Cell Significance Index: -5.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2110
    Cell Significance Index: -2.0000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2148
    Cell Significance Index: -1.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2187
    Cell Significance Index: -7.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2189
    Cell Significance Index: -9.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2194
    Cell Significance Index: -5.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2198
    Cell Significance Index: -7.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2249
    Cell Significance Index: -10.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2260
    Cell Significance Index: -11.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2463
    Cell Significance Index: -6.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2498
    Cell Significance Index: -9.1700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2503
    Cell Significance Index: -2.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2903
    Cell Significance Index: -3.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2947
    Cell Significance Index: -5.0500
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2957
    Cell Significance Index: -2.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2973
    Cell Significance Index: -10.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3063
    Cell Significance Index: -7.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3067
    Cell Significance Index: -9.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3186
    Cell Significance Index: -11.2000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3272
    Cell Significance Index: -4.1300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3335
    Cell Significance Index: -3.9300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3343
    Cell Significance Index: -2.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3373
    Cell Significance Index: -6.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3373
    Cell Significance Index: -9.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3393
    Cell Significance Index: -7.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3439
    Cell Significance Index: -10.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3516
    Cell Significance Index: -7.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3607
    Cell Significance Index: -9.1900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3730
    Cell Significance Index: -6.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3765
    Cell Significance Index: -9.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3792
    Cell Significance Index: -10.9300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3838
    Cell Significance Index: -2.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3905
    Cell Significance Index: -7.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3907
    Cell Significance Index: -11.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3921
    Cell Significance Index: -5.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3942
    Cell Significance Index: -10.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4196
    Cell Significance Index: -8.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4214
    Cell Significance Index: -8.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4241
    Cell Significance Index: -11.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4250
    Cell Significance Index: -10.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4266
    Cell Significance Index: -11.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4290
    Cell Significance Index: -11.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4302
    Cell Significance Index: -5.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAI1 is a member of the dynein family of proteins, which are integral to the structure and function of cilia. The gene encodes a protein that interacts with dynein heavy and light chains to form the axonemal intermediate chain. This protein is essential for the assembly and regulation of microtubule-based dynein arms, which are critical for ciliary motility and function. DNAI1 is highly conserved across species, suggesting its importance in various biological processes. **Pathways and Functions:** DNAI1 is involved in several key pathways, including: 1. **Cilia movement and motility**: DNAI1 plays a crucial role in the assembly and regulation of dynein axonemal particles, which are responsible for ciliary motility and function. 2. **Cytoskeletal motor activity**: DNAI1 interacts with dynein heavy and light chains to form the axonemal intermediate chain, which is essential for microtubule-based dynein arm assembly and regulation. 3. **Determination of left/right symmetry**: DNAI1 has been implicated in the development of left/right symmetry, a critical process in embryonic development. 4. **Heart development**: DNAI1 is involved in the development of the heart, where cilia play a critical role in cardiac function and development. **Clinical Significance:** Dysregulation of DNAI1 has been implicated in various diseases, including: 1. **Primary ciliary dyskinesia (PCD)**: PCD is a rare genetic disorder characterized by defective ciliary motility, leading to respiratory and sinus infections, as well as infertility. 2. **Kartagener syndrome**: Kartagener syndrome is a rare genetic disorder characterized by defective ciliary motility, leading to respiratory and sinus infections, as well as situs inversus (reversal of organs). 3. **Cardiac disorders**: DNAI1 has been implicated in the development of cardiac disorders, including arrhythmias and heart failure. In conclusion, DNAI1 is a critical gene involved in cilia function and development. Its dysregulation can lead to various diseases, highlighting the importance of understanding its role in human health and disease. Further research is needed to elucidate the mechanisms by which DNAI1 regulates cilia function and development, and to explore its therapeutic potential in diseases associated with ciliary dysfunction.

Genular Protein ID: 630330321

Symbol: DNAI1_HUMAN

Name: Dynein axonemal intermediate chain 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10577904

Title: Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia.

PubMed ID: 10577904

DOI: 10.1086/302683

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12509440

Title: Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.

PubMed ID: 12509440

DOI: 10.1074/jbc.m202325200

PubMed ID: 23664119

Title: Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance.

PubMed ID: 23664119

DOI: 10.1016/j.ajhg.2013.04.013

PubMed ID: 27120127

Title: Mutations in GAS8, a gene encoding a nexin-dynein regulatory complex subunit, cause primary ciliary dyskinesia with axonemal disorganization.

PubMed ID: 27120127

DOI: 10.1002/humu.23005

PubMed ID: 33263282

Title: Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins.

PubMed ID: 33263282

DOI: 10.7554/elife.58662

PubMed ID: 33139725

Title: CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.

PubMed ID: 33139725

DOI: 10.1038/s41467-020-19113-0

PubMed ID: 11231901

Title: Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome).

PubMed ID: 11231901

DOI: 10.1086/319511

PubMed ID: 25186273

Title: Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia.

PubMed ID: 25186273

DOI: 10.1183/09031936.00052014

Sequence Information:

  • Length: 699
  • Mass: 79283
  • Checksum: F7E2CF9D09A1F8BD
  • Sequence:
  • MIPASAKAPH KQPHKQSISI GRGTRKRDED SGTEVGEGTD EWAQSKATVR PPDQLELTDA 
    ELKEEFTRIL TANNPHAPQN IVRYSFKEGT YKPIGFVNQL AVHYTQVGNL IPKDSDEGRR 
    QHYRDELVAG SQESVKVISE TGNLEEDEEP KELETEPGSQ TDVPAAGAAE KVTEEELMTP 
    KQPKERKLTN QFNFSERASQ TYNNPVRDRE CQTEPPPRTN FSATANQWEI YDAYVEELEK 
    QEKTKEKEKA KTPVAKKSGK MAMRKLTSME SQTDDLIKLS QAAKIMERMV NQNTYDDIAQ 
    DFKYYDDAAD EYRDQVGTLL PLWKFQNDKA KRLSVTALCW NPKYRDLFAV GYGSYDFMKQ 
    SRGMLLLYSL KNPSFPEYMF SSNSGVMCLD IHVDHPYLVA VGHYDGNVAI YNLKKPHSQP 
    SFCSSAKSGK HSDPVWQVKW QKDDMDQNLN FFSVSSDGRI VSWTLVKRKL VHIDVIKLKV 
    EGSTTEVPEG LQLHPVGCGT AFDFHKEIDY MFLVGTEEGK IYKCSKSYSS QFLDTYDAHN 
    MSVDTVSWNP YHTKVFMSCS SDWTVKIWDH TIKTPMFIYD LNSAVGDVAW APYSSTVFAA 
    VTTDGKAHIF DLAINKYEAI CNQPVAAKKN RLTHVQFNLI HPIIIVGDDR GHIISLKLSP 
    NLRKMPKEKK GQEVQKGPAV EIAKLDKLLN LVREVKIKT

Genular Protein ID: 1535556040

Symbol: A0A087WWV9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 703
  • Mass: 79760
  • Checksum: EF6A6477C4C17A23
  • Sequence:
  • MIPASAKAPH KQPHKQSISI GRGTRKRDED SGTEVGEGTD EWAQSKATVR PPDQLELTDA 
    ELKEEFTRIL TANNPHAPQN IVRYSFKEGT YKPIGFVNQL AVHYTQVGNL IPKDSDEGRR 
    QHYRDELVAV SYQGSQESVK VISETGNLEE DEEPKELETE PGSQTDVPAA GAAEKVTEEE 
    LMTPKQPKER KLTNQFNFSE RASQTYNNPV RDRECQTEPP PRTNFSATAN QWEIYDAYVE 
    ELEKQEKTKE KEKAKTPVAK KSGKMAMRKL TSMESQTDDL IKLSQAAKIM ERMVNQNTYD 
    DIAQDFKYYD DAADEYRDQV GTLLPLWKFQ NDKAKRLSVT ALCWNPKYRD LFAVGYGSYD 
    FMKQSRGMLL LYSLKNPSFP EYMFSSNSGV MCLDIHVDHP YLVAVGHYDG NVAIYNLKKP 
    HSQPSFCSSA KSGKHSDPVW QVKWQKDDMD QNLNFFSVSS DGRIVSWTLV KRKLVHIDVI 
    KLKVEGSTTE VPEGLQLHPV GCGTAFDFHK EIDYMFLVGT EEGKIYKCSK SYSSQFLDTY 
    DAHNMSVDTV SWNPYHTKVF MSCSSDWTVK IWDHTIKTPM FIYDLNSAVG DVAWAPYSST 
    VFAAVTTDGK AHIFDLAINK YEAICNQPVA AKKNRLTHVQ FNLIHPIIIV GDDRGHIISL 
    KLSPNLRKMP KEKKGQEVQK GPAVEIAKLD KLLNLVREVK IKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.