Details for: ATP2C1

Gene ID: 27032

Symbol: ATP2C1

Ensembl ID: ENSG00000017260

Description: ATPase secretory pathway Ca2+ transporting 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 454.0802
    Cell Significance Index: -70.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 265.8654
    Cell Significance Index: -67.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.9809
    Cell Significance Index: -73.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 147.0251
    Cell Significance Index: -59.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.0885
    Cell Significance Index: -67.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 109.0575
    Cell Significance Index: -73.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 62.5404
    Cell Significance Index: -59.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.8075
    Cell Significance Index: -73.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.5146
    Cell Significance Index: -68.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.2131
    Cell Significance Index: -65.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.8885
    Cell Significance Index: -74.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.3446
    Cell Significance Index: -22.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.5826
    Cell Significance Index: 56.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5777
    Cell Significance Index: 517.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.4662
    Cell Significance Index: 189.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9506
    Cell Significance Index: 109.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6626
    Cell Significance Index: 596.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6515
    Cell Significance Index: 101.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3923
    Cell Significance Index: 38.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3307
    Cell Significance Index: 216.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3125
    Cell Significance Index: 37.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2160
    Cell Significance Index: 53.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2107
    Cell Significance Index: 837.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1733
    Cell Significance Index: 78.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1712
    Cell Significance Index: 44.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1649
    Cell Significance Index: 126.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0001
    Cell Significance Index: 198.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9565
    Cell Significance Index: 22.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9382
    Cell Significance Index: 12.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9038
    Cell Significance Index: 11.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7551
    Cell Significance Index: 45.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5482
    Cell Significance Index: 15.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5190
    Cell Significance Index: 93.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4362
    Cell Significance Index: 53.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3925
    Cell Significance Index: 18.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3887
    Cell Significance Index: 17.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3090
    Cell Significance Index: 581.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3046
    Cell Significance Index: 166.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3028
    Cell Significance Index: 273.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2541
    Cell Significance Index: 345.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2367
    Cell Significance Index: 150.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1825
    Cell Significance Index: 9.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1704
    Cell Significance Index: 2.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1685
    Cell Significance Index: 74.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0962
    Cell Significance Index: 3.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0928
    Cell Significance Index: 12.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0886
    Cell Significance Index: 136.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0821
    Cell Significance Index: 2.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0689
    Cell Significance Index: 127.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0472
    Cell Significance Index: 4.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0224
    Cell Significance Index: 10.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0163
    Cell Significance Index: -12.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0264
    Cell Significance Index: -19.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0342
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0361
    Cell Significance Index: -22.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0369
    Cell Significance Index: -27.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0616
    Cell Significance Index: -8.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0691
    Cell Significance Index: -38.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0808
    Cell Significance Index: -5.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1261
    Cell Significance Index: -24.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1316
    Cell Significance Index: -2.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1568
    Cell Significance Index: -7.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1922
    Cell Significance Index: -19.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2279
    Cell Significance Index: -65.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2319
    Cell Significance Index: -29.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2456
    Cell Significance Index: -31.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2511
    Cell Significance Index: -29.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2585
    Cell Significance Index: -54.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2746
    Cell Significance Index: -5.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2867
    Cell Significance Index: -18.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2953
    Cell Significance Index: -34.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3540
    Cell Significance Index: -4.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3609
    Cell Significance Index: -26.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4193
    Cell Significance Index: -14.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4491
    Cell Significance Index: -51.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5278
    Cell Significance Index: -11.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5384
    Cell Significance Index: -38.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5527
    Cell Significance Index: -28.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5762
    Cell Significance Index: -65.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5898
    Cell Significance Index: -14.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6082
    Cell Significance Index: -63.3300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.6086
    Cell Significance Index: -6.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6245
    Cell Significance Index: -9.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6659
    Cell Significance Index: -42.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7119
    Cell Significance Index: -19.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7218
    Cell Significance Index: -37.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7530
    Cell Significance Index: -20.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7879
    Cell Significance Index: -62.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8267
    Cell Significance Index: -17.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8933
    Cell Significance Index: -19.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0287
    Cell Significance Index: -63.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0397
    Cell Significance Index: -17.4000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.0736
    Cell Significance Index: -11.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1441
    Cell Significance Index: -36.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1523
    Cell Significance Index: -36.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1735
    Cell Significance Index: -38.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.2267
    Cell Significance Index: -17.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.2793
    Cell Significance Index: -33.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.2835
    Cell Significance Index: -18.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3013
    Cell Significance Index: -25.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **P-type ATPase**: The AT2C1 protein is a member of the P-type ATPase family, characterized by its ability to hydrolyze ATP and use the energy to transport ions across cellular membranes. 2. **Calcium transport**: AT2C1 is specifically responsible for transporting calcium ions across cellular membranes, maintaining calcium homeostasis within cells. 3. **Specific expression**: The gene is highly expressed in specific cell types, including Purkinje cells, astrocytes, and pigmented epithelial cells, suggesting its role in maintaining cellular homeostasis in these cells. 4. **Calcium-dependent signaling**: AT2C1 is involved in calcium-dependent signaling pathways, including cell-cell adhesion and the regulation of canonical NF-κB signaling. **Pathways and Functions** 1. **Calcium homeostasis**: AT2C1 plays a crucial role in maintaining calcium homeostasis within cells, particularly in the endoplasmic reticulum and Golgi apparatus. 2. **Calcium-dependent cell-cell adhesion**: AT2C1 is involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, regulating cell-cell interactions and tissue structure. 3. **Intracellular calcium ion homeostasis**: AT2C1 helps regulate intracellular calcium ion homeostasis, which is essential for various cellular processes, including signaling, muscle contraction, and neurotransmission. 4. **Golgi calcium ion homeostasis**: AT2C1 is involved in regulating Golgi calcium ion homeostasis, which is critical for protein synthesis, sorting, and transport. **Clinical Significance** 1. **Neurological disorders**: Mutations in the AT2C1 gene have been implicated in neurological disorders, such as epilepsy and Alzheimer's disease, highlighting its importance in maintaining calcium homeostasis in the brain. 2. **Cardiac function**: AT2C1 plays a crucial role in maintaining calcium homeostasis in cardiac myocytes, which is essential for cardiac function and rhythm regulation. 3. **Pigmentary epithelial disorders**: Mutations in the AT2C1 gene have been associated with pigmentary epithelial disorders, such as choroidal melanoma, highlighting its importance in maintaining calcium homeostasis in pigmentary epithelial cells. 4. **Cancer**: AT2C1 has been implicated in cancer development and progression, particularly in cells with altered calcium homeostasis, suggesting its potential as a therapeutic target. In conclusion, the ATP2C1 gene plays a critical role in maintaining calcium homeostasis within cells, particularly in the endoplasmic reticulum and Golgi apparatus. Its specific expression in various cell types highlights its importance in specific physiological processes, and its involvement in calcium-dependent signaling pathways underscores its significance in maintaining cellular homeostasis and function. Further research is needed to fully elucidate the clinical significance of AT2C1 and its potential as a therapeutic target in various diseases.

Genular Protein ID: 2477261341

Symbol: AT2C1_HUMAN

Name: Calcium-transporting ATPase type 2C member 1

UniProtKB Accession Codes:

P98194 B2RAT7 B4DSW3 B7Z3X9 G3XAH8 G8JLN9 O76005 Q86V72 Q86V73 Q8N6V1 Q8NCJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 1 EMBL 18 EMDB 11 Ensembl 11 ExpressionAtlas 1 GO 28 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 1 RefSeq 14 Rhea 4 SABIO-RK 1 SFLD 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10615129

Title: Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease.

PubMed ID: 10615129

DOI: 10.1038/71701

PubMed ID: 10767338

Title: Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump.

PubMed ID: 10767338

DOI: 10.1093/hmg/9.7.1131

PubMed ID: 12707275

Title: Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1).

PubMed ID: 12707275

DOI: 10.1074/jbc.m300509200

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11124703

Title: Characterization of 16 novel human genes showing high similarity to yeast sequences.

PubMed ID: 11124703

DOI: 10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h

PubMed ID: 14632183

Title: Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.

PubMed ID: 14632183

DOI: 10.1046/j.1523-1747.2003.12528.x

PubMed ID: 15831496

Title: The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions.

PubMed ID: 15831496

DOI: 10.1074/jbc.m501026200

PubMed ID: 16192278

Title: Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses.

PubMed ID: 16192278

DOI: 10.1074/jbc.m506181200

PubMed ID: 16332677

Title: Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.

PubMed ID: 16332677

DOI: 10.1074/jbc.m511547200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20439740

Title: Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment.

PubMed ID: 20439740

DOI: 10.1073/pnas.1004702107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21187401

Title: Identification of a gain-of-function mutation in a Golgi P-type ATPase that enhances Mn2+ efflux and protects against toxicity.

PubMed ID: 21187401

DOI: 10.1073/pnas.1013642108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30923126

Title: An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1.

PubMed ID: 30923126

DOI: 10.1074/jbc.ra118.006250

PubMed ID: 11841554

Title: Hailey-Hailey disease: molecular and clinical characterization of novel mutations in the ATP2C1 gene.

PubMed ID: 11841554

DOI: 10.1046/j.0022-202x.2001.01675.x

PubMed ID: 11874499

Title: Analysis of ATP2C1 gene mutation in 10 unrelated Japanese families with Hailey-Hailey disease.

PubMed ID: 11874499

DOI: 10.1046/j.0022-202x.2001.01686.x

PubMed ID: 28035777

Title: Mendelian Disorders of Cornification Caused by Defects in Intracellular Calcium Pumps: Mutation Update and Database for Variants in ATP2A2 and ATP2C1 associated with Darier disease and Hailey-Hailey disease.

PubMed ID: 28035777

DOI: 10.1002/humu.23164

Sequence Information:

  • Length: 919
  • Mass: 100577
  • Checksum: 4C1495D58FDA7EA1
  • Sequence:
    • MKVARFQKIP NGENETMIPV LTSKKASELP VSEVASILQA DLQNGLNKCE VSHRRAFHGW 
NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMHQF DDAVSITVAI LIVVTVAFVQ 
EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 
LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG VVIGTGENSE 
FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 
LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 
TVTHIFTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 
LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 
GAYEQVIKYC TTYQSKGQTL TLTQQQRDVY QQEKARMGSA GLRVLALASG PELGQLTFLG 
LVGIIDPPRT GVKEAVTTLI ASGVSIKMIT GDSQETAVAI ASRLGLYSKT SQSVSGEEID 
AMDVQQLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV ALKAADIGVA 
MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK NFVRFQLSTS IAALTLISLA 
TLMNFPNPLN AMQILWINII MDGPPAQSLG VEPVDKDVIR KPPRNWKDSI LTKNLILKIL 
VSSIIIVCGT LFVFWRELRD NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS 
NRMFCYAVLG SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VAEIIKKVER 
SREKIQKHVS STSSSFLEV

Genular Protein ID: 62250599

Symbol: B4E295_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E295

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 9 Gene3D 4 InterPro 11 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 4 RuleBase 1 SFLD 2 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 903
  • Mass: 98674
  • Checksum: 3E1473B9458B7C5D
  • Sequence:
    • MIPVLTSKKA SELPVSEVAS ILQADLQNGL NKCEVSHRRA FHGWNEFDIS EDEPLWKKYI 
SQFKNPLIML LLASAVISVL MHQFDDAVSI TVAILIVVTV AFVQEYRSEK SLEELSKLVP 
PECHCVREGK LEHTLARDLV PGATVCLSVG DRVPADLRLF EAVDLSIDES SLTGETTPCS 
KVTAPQPAAT NGDLASRSNI AFMGTLVRCG KAKGVVIGTG ENSEFGEVFK MMQAEEAPIT 
PLQKSMDLLG KQLSFYSFGI IGIIMLVGWL LGKDILEMFT ISVSLAVAAI PEGLPIVVTV 
TLALGVMRMV KKRAIVKKLP IVETLGCCNV ICSDKTGTLT KNEMTVTHIF TSDGLHAEVT 
GVGYNQFGEV IVDGDVVHGF YNPAVSRIVE AGCVCNDAVI RNNTLMGKPT EGALIALAMK 
MGLDGLQQDY IRKAEYPFSS EQKWMAVKCV HRTQQDRPEI CFMKGAYEQV IKYCTTYQSK 
GQTLTLTQQQ RDVYQQEKAR MGSAGLRVLA LASGPELGQL TFLGLVGIID PPRTGVKEAV 
TTLIASGVSI KMITGDSQET AVAIASRLGL YSKTSQSVSG EEIDAMDVQQ LSQIVPKVAV 
FYRASPRHKM KIIKSLQKNG SVVAMTGDGV NDAVALKAAD IGVAMGQTGT DVCKEAADMI 
LVDDDFQTIM SAIEEGKGIY NNIKNFVRFQ LSTSIAALTL ISLATLMNFP NPLNAMQILW 
INIIMDGPPA QSLGVEPVDK DVIRKPPRNW KDSILTKNLI LKILVSSIII VCGTLFVFWR 
ELRDNVITPR DTTMTFTCFV FFDMFNALSS RSQTKSVFEI GLCSNRMFCY AVLGSIMGQL 
LVIYFPPLQK VFQTESLSIL DLLFLLGLTS SVCIVAEIIK KVERSREKIQ KHVSSTSSSF 
LEV

Genular Protein ID: 1189168302

Symbol: B4E2Q0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E2Q0

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 2 GO 5 Gene3D 4 GeneTree 1 HGNC 1 InterPro 11 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 4 RuleBase 1 SFLD 2 SMART 2 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 953
  • Mass: 104713
  • Checksum: 132AA4602598AE76
  • Sequence:
    • MDSLLPPSRF SYFKKYPLHA IRRYLSTLRN QRAEEQVARF QKIPNGENET MIPVLTSKKA 
SELPVSEVAS ILQADLQNGL NKCEVSHRRA FHGWNEFDIS EDEPLWKKYI SQFKNPLIML 
LLASAVISVL MHQFDDAVSI TVAILIVVTV AFVQEYRSEK SLEELSKLVP PECHCVREGK 
LEHTLARDLV PGDTVCLSVG DRVPADLRLF EAVDLSIDES SLTGETTPCS KVTAPQPAAT 
NGDLASRSNI AFMGTLVRCG KAKGVVIGTG ENSEFGEVFK MMQAEEAPKT PLQKSMDLLG 
KQLSFYSFGI IGIIMLVGWL LGKDILEMFT ISVSLAVAAI PEGLPIVVTV TLALGVMRMV 
KKRAIVKKLP IVETLGCCNV ICSDKTGTLT KNEMTVTHIF TSDGLHAEVT GVGYNQFGEV 
IVDGDVVHGF YNPAVSRIVE AGCVCNDAVI RNNTLMGKPT EGALIALAMK MGLDGLQQDY 
IRKAEYPFSS EQKWMAVKCV HRTQQDRPEI CFMKGAYEQV IKYCTTYQSK GQTLTLTQQQ 
RDVYQQEKAR MGSAGLRVLA LASGPELGQL TFLGLVGIID PPRTGVKEAV TTLIASGVSI 
KMITGDSQET AVAIASRLGL YSKTSQSVSG EEIDAMDVQQ LSQIVPKVAV FYRASPRHKM 
KIIKSLQKNG SVVAMTGDGV NDAVALKAAD IGVAMGQTGT DVCKEAADMI LVDDDFQTIM 
SAIEEGKGIY NNIKNFVRFQ LSTSIAALTL ISLATLMNFP NPLNAMQILW INIIMDGPPA 
QSLGVEPVDK DVIRKPPRNW KDSILTKNLI LKILVSSIII VCGTLFVFWR ELRDNVITPR 
DTTMTFTCFV FFDMFNALSS RSQTKSVFEI GLCSNRMFCY AVLGSIMGQL LVIYFPPLQK 
VFQTESLSIL DLLFLLGLTS SVCIVAEIIK KVERSREKIQ KHVSSTSSSF LEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.