Details for: DAPP1

Gene ID: 27071

Symbol: DAPP1

Ensembl ID: ENSG00000070190

Description: dual adaptor of phosphotyrosine and 3-phosphoinositides 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.1550
    Cell Significance Index: -11.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.0205
    Cell Significance Index: -9.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.3626
    Cell Significance Index: -11.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.5760
    Cell Significance Index: -12.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 25.2875
    Cell Significance Index: -13.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4975
    Cell Significance Index: -11.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8043
    Cell Significance Index: -12.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.4264
    Cell Significance Index: 177.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2379
    Cell Significance Index: -9.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0182
    Cell Significance Index: -11.9100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.3510
    Cell Significance Index: 40.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2435
    Cell Significance Index: -4.9100
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.2117
    Cell Significance Index: 5.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.5118
    Cell Significance Index: 21.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3905
    Cell Significance Index: 25.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2640
    Cell Significance Index: 11.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0048
    Cell Significance Index: 118.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7226
    Cell Significance Index: 130.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6956
    Cell Significance Index: 89.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5987
    Cell Significance Index: 69.7800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5633
    Cell Significance Index: 3.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5262
    Cell Significance Index: 64.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5222
    Cell Significance Index: 15.3400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.5188
    Cell Significance Index: 2.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4952
    Cell Significance Index: 13.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4766
    Cell Significance Index: 22.4000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.4710
    Cell Significance Index: 2.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4170
    Cell Significance Index: 79.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3517
    Cell Significance Index: 7.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2784
    Cell Significance Index: 19.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2664
    Cell Significance Index: 26.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2576
    Cell Significance Index: 7.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2540
    Cell Significance Index: 16.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2414
    Cell Significance Index: 106.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2374
    Cell Significance Index: 16.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1680
    Cell Significance Index: 151.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1323
    Cell Significance Index: 21.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1151
    Cell Significance Index: 12.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1140
    Cell Significance Index: 62.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1024
    Cell Significance Index: 6.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0686
    Cell Significance Index: 2.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0478
    Cell Significance Index: 0.7400
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.0414
    Cell Significance Index: 0.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0128
    Cell Significance Index: 0.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -14.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0089
    Cell Significance Index: -6.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0094
    Cell Significance Index: -14.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0113
    Cell Significance Index: -15.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0166
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0172
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0185
    Cell Significance Index: -11.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0238
    Cell Significance Index: -1.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0245
    Cell Significance Index: -13.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0282
    Cell Significance Index: -5.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0287
    Cell Significance Index: -13.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0309
    Cell Significance Index: -11.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0320
    Cell Significance Index: -9.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0341
    Cell Significance Index: -6.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0374
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0604
    Cell Significance Index: -6.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0609
    Cell Significance Index: -12.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0681
    Cell Significance Index: -8.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0697
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0755
    Cell Significance Index: -12.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0793
    Cell Significance Index: -11.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0818
    Cell Significance Index: -11.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0851
    Cell Significance Index: -3.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0853
    Cell Significance Index: -4.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0900
    Cell Significance Index: -6.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0965
    Cell Significance Index: -3.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1128
    Cell Significance Index: -11.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1137
    Cell Significance Index: -6.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1162
    Cell Significance Index: -8.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1166
    Cell Significance Index: -13.3600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1288
    Cell Significance Index: -0.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1366
    Cell Significance Index: -2.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1559
    Cell Significance Index: -12.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1667
    Cell Significance Index: -6.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1765
    Cell Significance Index: -11.8700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.2017
    Cell Significance Index: -0.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2104
    Cell Significance Index: -12.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2214
    Cell Significance Index: -11.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2306
    Cell Significance Index: -12.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2358
    Cell Significance Index: -14.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2411
    Cell Significance Index: -12.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2439
    Cell Significance Index: -10.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2649
    Cell Significance Index: -2.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2661
    Cell Significance Index: -9.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2937
    Cell Significance Index: -7.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2958
    Cell Significance Index: -11.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2963
    Cell Significance Index: -10.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2968
    Cell Significance Index: -7.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3030
    Cell Significance Index: -7.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3060
    Cell Significance Index: -8.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DAPP1 is a unique adaptor protein that binds to both phosphotyrosine and 3-phosphoinositides, which are crucial signaling molecules in immune cell activation. Its ability to interact with multiple signaling molecules makes it an essential component in the regulation of immune responses. The protein is highly expressed in cells involved in the adaptive immune system, including B cells, which are central to the humoral immune response. **Pathways and Functions:** DAPP1 plays a critical role in the signaling pathways that regulate immune cell activation, particularly in the context of B cell receptor (BCR) signaling. Upon activation of the BCR, DAPP1 is recruited to the plasma membrane, where it interacts with phosphatidylinositol-3,4,5-trisphosphate (PIP3) and phosphatidylinositol-3,4-bisphosphate (PIP2). These interactions trigger a cascade of downstream signaling events that lead to the generation of second messengers, such as inositol trisphosphate (IP3) and diacylglycerol (DAG). These second messengers ultimately activate various cellular responses, including calcium mobilization, protein kinase activation, and gene transcription. The functional significance of DAPP1 lies in its ability to modulate the strength and duration of B cell activation. By regulating the intensity of signaling, DAPP1 can influence the efficiency of immune responses, including the production of antibodies and the activation of immune cells. **Clinical Significance:** DAPP1 has significant implications for our understanding of immune-related diseases, particularly those involving B cell dysfunction. Alterations in DAPP1 expression or function have been implicated in various autoimmune and immunodeficiency disorders, including autoimmune hemolytic anemia, rheumatoid arthritis, and primary immunodeficiency diseases. Furthermore, DAPP1 may serve as a potential therapeutic target for the treatment of immune-related conditions. By modulating DAPP1 expression or function, researchers may be able to enhance or suppress immune responses, depending on the specific disease context. In conclusion, DAPP1 is a critical regulator of immune cell signaling, and its dysregulation can have significant consequences for human health. Further research into the functions and clinical implications of DAPP1 will provide valuable insights into the mechanisms of immune regulation and the development of novel therapeutic strategies for immune-related diseases.

Genular Protein ID: 2194260348

Symbol: DAPP1_HUMAN

Name: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

UniProtKB Accession Codes:

Q9UN19 Q8TCK5 Q9UHF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10432293

Title: DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.

PubMed ID: 10432293

DOI: 10.1042/bj3420007

PubMed ID: 10770799

Title: A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.

PubMed ID: 10770799

DOI: 10.1084/jem.191.8.1319

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10983984

Title: Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.

PubMed ID: 10983984

DOI: 10.1016/s1097-2765(00)00037-x

Sequence Information:

  • Length: 280
  • Mass: 32194
  • Checksum: 4A7F686B55146241
  • Sequence:
    • MGRAELLEGK MSTQDPSDLW SRSDGEAELL QDLGWYHGNL TRHAAEALLL SNGCDGSYLL 
RDSNETTGLY SLSVRAKDSV KHFHVEYTGY SFKFGFNEFS SLKDFVKHFA NQPLIGSETG 
TLMVLKHPYP RKVEEPSIYE SVRVHTAMQT GRTEDDLVPT APSLGTKEGY LTKQGGLVKT 
WKTRWFTLHR NELKYFKDQM SPEPIRILDL TECSAVQFDY SQERVNCFCL VFPFRTFYLC 
AKTGVEADEW IKILRWKLSQ IRKQLNQGEG TIRSRSFIFK

Genular Protein ID: 1811625992

Symbol: J3KNB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KNB3

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 263
  • Mass: 30175
  • Checksum: C4BCA4679D019D85
  • Sequence:
    • MGRAELLEGK MSTQDPSDLW SRSDGEAELL QDLGWYHGNL TRHAAEALLL SNGCDGSYLL 
RDSNETTGLY SLSVRAKDSV KHFHVEYTGY SFKFGFNEFS SLKDFVKHFA NQPLIGSETG 
TLMVLKHPYP RKVEEPSIYE SVRVHTAMQT GRTEDDLVPT APSLGTKEGY LTKQGGLVKT 
WKTRWFTLHR NELKYFKDQM SPEPIRILDL TECSAVQFDY SQERVNCFCL VFPFRTFYLC 
AKTGVEADEW IKILRWKLVK DKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.