Details for: TAF5L

Gene ID: 27097

Symbol: TAF5L

Ensembl ID: ENSG00000135801

Description: TATA-box binding protein associated factor 5 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 92.8347
    Cell Significance Index: -14.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.3209
    Cell Significance Index: -15.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 35.7640
    Cell Significance Index: -16.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.5840
    Cell Significance Index: -14.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 25.2078
    Cell Significance Index: -16.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.7370
    Cell Significance Index: -14.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8310
    Cell Significance Index: -15.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0436
    Cell Significance Index: -16.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0522
    Cell Significance Index: -15.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6335
    Cell Significance Index: -11.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0202
    Cell Significance Index: -6.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1753
    Cell Significance Index: 16.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0283
    Cell Significance Index: 101.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7973
    Cell Significance Index: 719.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7579
    Cell Significance Index: 45.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6880
    Cell Significance Index: 74.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6094
    Cell Significance Index: 27.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5575
    Cell Significance Index: 14.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5563
    Cell Significance Index: 90.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4838
    Cell Significance Index: 25.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4249
    Cell Significance Index: 9.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4224
    Cell Significance Index: 84.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3432
    Cell Significance Index: 68.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2895
    Cell Significance Index: 6.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2696
    Cell Significance Index: 48.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2469
    Cell Significance Index: 7.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2374
    Cell Significance Index: 85.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2138
    Cell Significance Index: 14.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2076
    Cell Significance Index: 5.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1979
    Cell Significance Index: 15.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1919
    Cell Significance Index: 23.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1880
    Cell Significance Index: 130.0500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1609
    Cell Significance Index: 1.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1473
    Cell Significance Index: 80.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1276
    Cell Significance Index: 56.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1181
    Cell Significance Index: 7.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1098
    Cell Significance Index: 20.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0882
    Cell Significance Index: 5.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0836
    Cell Significance Index: 2.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0747
    Cell Significance Index: 4.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0732
    Cell Significance Index: 4.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0714
    Cell Significance Index: 3.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0702
    Cell Significance Index: 1.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0662
    Cell Significance Index: 1.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0606
    Cell Significance Index: 2.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0599
    Cell Significance Index: 2.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0551
    Cell Significance Index: 7.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0469
    Cell Significance Index: 3.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0181
    Cell Significance Index: 3.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0166
    Cell Significance Index: 0.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0109
    Cell Significance Index: 1.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0016
    Cell Significance Index: -0.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -3.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0070
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0117
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0159
    Cell Significance Index: -11.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0184
    Cell Significance Index: -0.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0188
    Cell Significance Index: -2.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0193
    Cell Significance Index: -10.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0334
    Cell Significance Index: -4.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0346
    Cell Significance Index: -0.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0398
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0428
    Cell Significance Index: -9.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0431
    Cell Significance Index: -5.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0431
    Cell Significance Index: -5.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0445
    Cell Significance Index: -12.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0514
    Cell Significance Index: -5.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0547
    Cell Significance Index: -3.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0656
    Cell Significance Index: -1.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0710
    Cell Significance Index: -3.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0808
    Cell Significance Index: -9.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0833
    Cell Significance Index: -9.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1343
    Cell Significance Index: -10.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1432
    Cell Significance Index: -14.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1619
    Cell Significance Index: -4.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1737
    Cell Significance Index: -10.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1772
    Cell Significance Index: -4.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1860
    Cell Significance Index: -14.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1937
    Cell Significance Index: -4.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1939
    Cell Significance Index: -4.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2400
    Cell Significance Index: -4.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2609
    Cell Significance Index: -13.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2635
    Cell Significance Index: -13.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2657
    Cell Significance Index: -5.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2812
    Cell Significance Index: -9.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2821
    Cell Significance Index: -4.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2931
    Cell Significance Index: -6.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3018
    Cell Significance Index: -2.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3091
    Cell Significance Index: -4.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3116
    Cell Significance Index: -9.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3121
    Cell Significance Index: -9.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3139
    Cell Significance Index: -2.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAF5L exhibits several key characteristics that distinguish it from other proteins. These include: 1. **Histone Acetyltransferase (HAT) activity**: TAF5L possesses HAT activity, which enables it to acetylate histones, leading to chromatin remodeling and transcriptional activation. 2. **Association with chromatin-remodeling complexes**: TAF5L interacts with various chromatin-remodeling complexes, including the histone acetyltransferase complex, to regulate chromatin organization and transcription. 3. **Transcriptional coactivator activity**: TAF5L acts as a transcriptional coactivator, enhancing the recruitment of RNA polymerase II to gene promoters and facilitating transcriptional activation. 4. **Regulation of somatic stem cell maintenance**: TAF5L is essential for the maintenance of somatic stem cells, including intestinal crypt stem cells and cardiac muscle myoblasts. **Pathways and Functions:** TAF5L is involved in various pathways and processes, including: 1. **Chromatin modifying enzymes**: TAF5L regulates chromatin structure and function through its HAT activity and association with chromatin-remodeling complexes. 2. **Chromatin organization**: TAF5L plays a crucial role in maintaining chromatin organization, ensuring the proper assembly and function of chromatin structures. 3. **DNA repair**: TAF5L is involved in the regulation of DNA repair pathways, including the repair of DNA damage and the maintenance of genome stability. 4. **Transcription by RNA polymerase II**: TAF5L enhances the recruitment of RNA polymerase II to gene promoters, facilitating transcriptional activation. 5. **Transcriptional regulation**: TAF5L regulates transcriptional activity by modulating the recruitment of transcription factors and coactivators. **Clinical Significance:** TAF5L dysregulation has been implicated in various diseases, including: 1. **Cancer**: TAF5L mutations have been identified in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: TAF5L has been implicated in neurological disorders, including Huntington's disease and Parkinson's disease. 3. **Stem cell disorders**: TAF5L dysregulation has been linked to stem cell disorders, including hematological malignancies and solid tumors. In conclusion, TAF5L is a critical regulator of transcription and chromatin organization, playing a pivotal role in the regulation of gene expression, DNA repair, and somatic stem cell maintenance. Its dysregulation has significant clinical implications, highlighting the need for further research into the molecular mechanisms underlying TAF5L function and its role in disease.

Genular Protein ID: 3137260535

Symbol: TAF5L_HUMAN

Name: PCAF-associated factor 65 beta

UniProtKB Accession Codes:

O75529 Q5TDI5 Q5TDI6 Q8IW31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9674425

Title: Histone-like TAFs within the PCAF histone acetylase complex.

PubMed ID: 9674425

DOI: 10.1016/s0092-8674(00)81219-2

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11124703

Title: Characterization of 16 novel human genes showing high similarity to yeast sequences.

PubMed ID: 11124703

DOI: 10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h

PubMed ID: 9674419

Title: The TAFs in the HAT.

PubMed ID: 9674419

DOI: 10.1016/s0092-8674(00)81213-1

PubMed ID: 11564863

Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

PubMed ID: 11564863

DOI: 10.1128/mcb.21.20.6782-6795.2001

PubMed ID: 12601814

Title: Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.

PubMed ID: 12601814

DOI: 10.1002/pmic.200390030

Sequence Information:

  • Length: 589
  • Mass: 66155
  • Checksum: BBF0A1CDD17EE22E
  • Sequence:
    • MKRVRTEQIQ MAVSCYLKRR QYVDSDGPLK QGLRLSQTAE EMAANLTVQS ESGCANIVSA 
APCQAEPQQY EVQFGRLRNF LTDSDSQHSH EVMPLLYPLF VYLHLNLVQN SPKSTVESFY 
SRFHGMFLQN ASQKDVIEQL QTTQTIQDIL SNFKLRAFLD NKYVVRLQED SYNYLIRYLQ 
SDNNTALCKV LTLHIHLDVQ PAKRTDYQLY ASGSSSRSEN NGLEPPDMPS PILQNEAALE 
VLQESIKRVK DGPPSLTTIC FYAFYNTEQL LNTAEISPDS KLLAAGFDNS CIKLWSLRSK 
KLKSEPHQVD VSRIHLACDI LEEEDDEDDN AGTEMKILRG HCGPVYSTRF LADSSGLLSC 
SEDMSIRYWD LGSFTNTVLY QGHAYPVWDL DISPYSLYFA SGSHDRTARL WSFDRTYPLR 
IYAGHLADVD CVKFHPNSNY LATGSTDKTV RLWSAQQGNS VRLFTGHRGP VLSLAFSPNG 
KYLASAGEDQ RLKLWDLASG TLYKELRGHT DNITSLTFSP DSGLIASASM DNSVRVWDIR 
NTYCSAPADG SSSELVGVYT GQMSNVLSVQ FMACNLLLVT GITQENQEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.