Details for: BBC3

Gene ID: 27113

Symbol: BBC3

Ensembl ID: ENSG00000105327

Description: BCL2 binding component 3

Associated with

  • Activation of bh3-only proteins
    (R-HSA-114452)
  • Activation of puma and translocation to mitochondria
    (R-HSA-139915)
  • Apoptosis
    (R-HSA-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-HSA-111453)
  • Foxo-mediated transcription
    (R-HSA-9614085)
  • Foxo-mediated transcription of cell death genes
    (R-HSA-9614657)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Intrinsic pathway for apoptosis
    (R-HSA-109606)
  • Programmed cell death
    (R-HSA-5357801)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Tp53 regulates transcription of cell death genes
    (R-HSA-5633008)
  • Tp53 regulates transcription of genes involved in cytochrome c release
    (R-HSA-6803204)
  • Transcriptional regulation by tp53
    (R-HSA-3700989)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic process
    (GO:0006915)
  • Apoptotic signaling pathway
    (GO:0097190)
  • Atpase binding
    (GO:0051117)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to ionizing radiation
    (GO:0071479)
  • Cytosol
    (GO:0005829)
  • Determination of adult lifespan
    (GO:0008340)
  • Dna damage response
    (GO:0006974)
  • Execution phase of apoptosis
    (GO:0097194)
  • Fibroblast apoptotic process
    (GO:0044346)
  • Intrinsic apoptotic signaling pathway
    (GO:0097193)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Lysosome
    (GO:0005764)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of growth
    (GO:0045926)
  • Positive regulation of cysteine-type endopeptidase activity
    (GO:2001056)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of establishment of protein localization to mitochondrion
    (GO:1903749)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of ire1-mediated unfolded protein response
    (GO:1903896)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of thymocyte apoptotic process
    (GO:0070245)
  • Protein binding
    (GO:0005515)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • T cell apoptotic process
    (GO:0070231)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.5477
    Cell Significance Index: -11.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.2728
    Cell Significance Index: -13.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.7601
    Cell Significance Index: -13.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3329
    Cell Significance Index: -12.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5056
    Cell Significance Index: -12.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3324
    Cell Significance Index: -13.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0992
    Cell Significance Index: 361.1800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.8144
    Cell Significance Index: 8.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.7414
    Cell Significance Index: -8.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7182
    Cell Significance Index: 73.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.2868
    Cell Significance Index: 295.4400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.8686
    Cell Significance Index: 11.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8016
    Cell Significance Index: 24.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3746
    Cell Significance Index: 102.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2197
    Cell Significance Index: 63.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9965
    Cell Significance Index: 108.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9736
    Cell Significance Index: 158.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9009
    Cell Significance Index: 42.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8763
    Cell Significance Index: 13.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7941
    Cell Significance Index: 22.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7938
    Cell Significance Index: 47.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7340
    Cell Significance Index: 21.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7005
    Cell Significance Index: 31.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6259
    Cell Significance Index: 13.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5338
    Cell Significance Index: 36.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5312
    Cell Significance Index: 101.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4523
    Cell Significance Index: 23.7500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4019
    Cell Significance Index: 5.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3337
    Cell Significance Index: 182.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3248
    Cell Significance Index: 143.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3233
    Cell Significance Index: 58.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2595
    Cell Significance Index: 9.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2376
    Cell Significance Index: 16.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2344
    Cell Significance Index: 23.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2040
    Cell Significance Index: 28.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1855
    Cell Significance Index: 3.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1778
    Cell Significance Index: 21.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1653
    Cell Significance Index: 33.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1605
    Cell Significance Index: 57.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1571
    Cell Significance Index: 3.6300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1499
    Cell Significance Index: 2.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1471
    Cell Significance Index: 2.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1060
    Cell Significance Index: 1.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1051
    Cell Significance Index: 4.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1027
    Cell Significance Index: 2.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0987
    Cell Significance Index: 3.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0709
    Cell Significance Index: 14.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0443
    Cell Significance Index: 5.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0371
    Cell Significance Index: 6.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0295
    Cell Significance Index: 0.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0272
    Cell Significance Index: 3.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0092
    Cell Significance Index: 12.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0064
    Cell Significance Index: 0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0028
    Cell Significance Index: -4.3600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0031
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0055
    Cell Significance Index: -1.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0145
    Cell Significance Index: -1.4800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0153
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0157
    Cell Significance Index: -11.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0178
    Cell Significance Index: -11.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0210
    Cell Significance Index: -11.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0266
    Cell Significance Index: -12.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0651
    Cell Significance Index: -13.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0675
    Cell Significance Index: -7.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0785
    Cell Significance Index: -11.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0848
    Cell Significance Index: -2.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0959
    Cell Significance Index: -2.8300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0977
    Cell Significance Index: -0.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1041
    Cell Significance Index: -7.9900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1066
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1129
    Cell Significance Index: -0.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1138
    Cell Significance Index: -1.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1170
    Cell Significance Index: -12.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1177
    Cell Significance Index: -7.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1301
    Cell Significance Index: -2.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1380
    Cell Significance Index: -3.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1507
    Cell Significance Index: -9.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1584
    Cell Significance Index: -10.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1595
    Cell Significance Index: -12.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1701
    Cell Significance Index: -5.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1841
    Cell Significance Index: -11.2900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1943
    Cell Significance Index: -3.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1965
    Cell Significance Index: -5.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2008
    Cell Significance Index: -6.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2136
    Cell Significance Index: -7.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2214
    Cell Significance Index: -1.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2226
    Cell Significance Index: -4.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2286
    Cell Significance Index: -12.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2342
    Cell Significance Index: -11.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2381
    Cell Significance Index: -6.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2504
    Cell Significance Index: -6.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2610
    Cell Significance Index: -2.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2645
    Cell Significance Index: -8.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2666
    Cell Significance Index: -8.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BBC3 is a member of the Bcl-2 family of proteins, which are known for their role in regulating apoptosis. BBC3 is unique in its ability to bind to Bcl-2 family members, specifically Bcl-2, Bcl-xL, and Bcl-w, and inactivate them. This interaction prevents the anti-apoptotic Bcl-2 family members from inhibiting apoptosis, thereby promoting cell death. BBC3 is also involved in the regulation of Foxo-mediated transcription, which is essential for the expression of cell death genes. **Pathways and Functions** BBC3 is involved in several key pathways, including: 1. **Activation of Bcl-2-only proteins**: BBC3 binds to Bcl-2-only proteins, such as BAX and BAK, and activates them, leading to the activation of the intrinsic apoptotic pathway. 2. **Activation of cysteine-type endopeptidase activity**: BBC3 is involved in the activation of cysteine-type endopeptidase activity, which is essential for the activation of caspases, the key executioners of apoptosis. 3. **Translocation to mitochondria**: BBC3 is involved in the translocation of Puma to the mitochondria, which is essential for the release of cytochrome c and the activation of the intrinsic apoptotic pathway. 4. **Foxo-mediated transcription**: BBC3 is involved in the regulation of Foxo-mediated transcription, which is essential for the expression of cell death genes. **Clinical Significance** BBC3 has been implicated in various diseases, including cancer, where its overexpression can lead to the suppression of apoptosis and the promotion of tumor growth. In addition, BBC3 has been implicated in autoimmune diseases, such as rheumatoid arthritis, where its dysregulation can lead to the activation of immune cells. In cancer, the overexpression of BBC3 can lead to: 1. **Resistance to chemotherapy**: BBC3 can inhibit the activation of apoptosis, leading to the survival of cancer cells and the development of resistance to chemotherapy. 2. **Tumor growth and progression**: BBC3 can promote tumor growth and progression by suppressing apoptosis and promoting cell proliferation. 3. **Metastasis**: BBC3 can promote metastasis by enhancing the migratory and invasive properties of cancer cells. In autoimmune diseases, the dysregulation of BBC3 can lead to: 1. **Activation of immune cells**: BBC3 can activate immune cells, such as T cells and macrophages, leading to the activation of autoimmune responses. 2. **Inflammation**: BBC3 can promote inflammation by enhancing the production of pro-inflammatory cytokines. 3. **Tissue damage**: BBC3 can promote tissue damage by enhancing the production of matrix metalloproteinases, which can lead to the degradation of tissue structure. In conclusion, BBC3 is a critical gene involved in the regulation of apoptosis and is implicated in various diseases, including cancer and autoimmune diseases. Further research is needed to fully understand the role of BBC3 in these diseases and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 4229718373

Symbol: BBC3B_HUMAN

Name: Bcl-2-binding component 3, isoforms 3/4

UniProtKB Accession Codes:

Q96PG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11463392

Title: PUMA, a novel proapoptotic gene, is induced by p53.

PubMed ID: 11463392

DOI: 10.1016/s1097-2765(01)00214-3

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 261
  • Mass: 26498
  • Checksum: 47BE86F942BD0452
  • Sequence:
    • MKFGMGSAQA CPCQVPRAAS TTWVPCQICG PRERHGPRTP GGQLPGARRG PGPRRPAPLP 
ARPPGALGSV LRPLRARPGC RPRRPHPAAR CLPLRPHRPT RRHRRPGGFP LAWGSPQPAP 
RPAPGRSSAL ALAGGAAPGV ARAQRPGGSG GRSHPGGPGS PRGGGTVGPG DRGPAAADGG 
RPQRTVRAAE TRGAAAAPPL TLEGPVQSHH GTPALTQGPQ SPRDGAQLGA CTRPVDVRDS 
GGRPLPPPDT LASAGDFLCT M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.