Details for: CIDEB

Gene ID: 27141

Symbol: CIDEB

Ensembl ID: ENSG00000136305

Description: cell death inducing DFFA like effector b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 32.5307
    Cell Significance Index: -5.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.9887
    Cell Significance Index: -5.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.2164
    Cell Significance Index: 139.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6352
    Cell Significance Index: -5.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9411
    Cell Significance Index: -5.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5429
    Cell Significance Index: 44.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4850
    Cell Significance Index: 89.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.4684
    Cell Significance Index: -4.5100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.3588
    Cell Significance Index: 3.6400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.3024
    Cell Significance Index: 8.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9911
    Cell Significance Index: 107.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9851
    Cell Significance Index: 14.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9741
    Cell Significance Index: 96.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8509
    Cell Significance Index: 768.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5953
    Cell Significance Index: 41.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5646
    Cell Significance Index: 91.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4749
    Cell Significance Index: 6.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4722
    Cell Significance Index: 10.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3717
    Cell Significance Index: 70.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3376
    Cell Significance Index: 7.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2831
    Cell Significance Index: 2.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2560
    Cell Significance Index: 50.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2018
    Cell Significance Index: 5.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1800
    Cell Significance Index: 2.5800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.1598
    Cell Significance Index: 1.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1529
    Cell Significance Index: 2.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1469
    Cell Significance Index: 2.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1429
    Cell Significance Index: 2.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1406
    Cell Significance Index: 3.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1381
    Cell Significance Index: 6.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1361
    Cell Significance Index: 3.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1184
    Cell Significance Index: 52.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1162
    Cell Significance Index: 1.3200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0823
    Cell Significance Index: 0.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0754
    Cell Significance Index: 1.0800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0663
    Cell Significance Index: 0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0431
    Cell Significance Index: 5.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0397
    Cell Significance Index: 4.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0390
    Cell Significance Index: 1.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0342
    Cell Significance Index: 2.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0287
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0281
    Cell Significance Index: 4.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0165
    Cell Significance Index: 1.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0141
    Cell Significance Index: 0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0131
    Cell Significance Index: 0.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0123
    Cell Significance Index: 0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0077
    Cell Significance Index: 1.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0039
    Cell Significance Index: 0.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0029
    Cell Significance Index: 0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0020
    Cell Significance Index: 0.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0016
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0040
    Cell Significance Index: -0.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0042
    Cell Significance Index: -2.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0100
    Cell Significance Index: -6.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0137
    Cell Significance Index: -6.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0141
    Cell Significance Index: -5.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0157
    Cell Significance Index: -4.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0186
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0197
    Cell Significance Index: -2.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0228
    Cell Significance Index: -4.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0254
    Cell Significance Index: -3.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0275
    Cell Significance Index: -0.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0290
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0304
    Cell Significance Index: -6.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0313
    Cell Significance Index: -0.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0356
    Cell Significance Index: -1.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0376
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0389
    Cell Significance Index: -5.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0415
    Cell Significance Index: -3.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0508
    Cell Significance Index: -1.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0516
    Cell Significance Index: -1.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0527
    Cell Significance Index: -3.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0527
    Cell Significance Index: -2.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0555
    Cell Significance Index: -5.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0594
    Cell Significance Index: -2.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0616
    Cell Significance Index: -1.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0623
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0681
    Cell Significance Index: -1.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0693
    Cell Significance Index: -5.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0747
    Cell Significance Index: -1.2800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0755
    Cell Significance Index: -1.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0787
    Cell Significance Index: -6.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0803
    Cell Significance Index: -1.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0834
    Cell Significance Index: -2.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0862
    Cell Significance Index: -3.7500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0931
    Cell Significance Index: -0.7700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0964
    Cell Significance Index: -1.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0994
    Cell Significance Index: -5.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1039
    Cell Significance Index: -5.8300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1173
    Cell Significance Index: -1.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CIDEB is a member of the DFFA-like effector family, characterized by its ability to induce cell death in response to DNA damage. The protein exhibits a unique structure, consisting of a DFFA-like domain and a lipid-binding motif. CIDEB is highly expressed in enterocytes, where it plays a critical role in regulating lipid metabolism and apoptosis. The protein's expression is also detected in myeloid dendritic cells, suggesting its involvement in immune responses. **Pathways and Functions:** CIDEB is involved in several cellular pathways, including: 1. **Apoptotic process:** CIDEB is a key regulator of apoptosis, particularly in response to DNA damage. The protein's ability to induce cell death helps maintain tissue homeostasis and prevent the accumulation of damaged cells. 2. **Bile acid signaling pathway:** CIDEB is also involved in the regulation of bile acid signaling, which is critical for lipid metabolism and detoxification. 3. **Copii-coated vesicle:** CIDEB is a component of the Copii-coated vesicle, a specialized organelle involved in lipid droplet fusion and lipid storage. 4. **Lipid droplet fusion:** CIDEB plays a crucial role in regulating lipid droplet fusion, which is essential for lipid storage and metabolism. 5. **Triglyceride metabolic process:** CIDEB is involved in regulating triglyceride metabolic processes, including lipid storage and degradation. **Clinical Significance:** CIDEB's involvement in apoptosis and lipid metabolism makes it a potential therapeutic target for various diseases, including: 1. **Atherosclerosis:** CIDEB's role in lipid metabolism and apoptosis suggests its potential as a therapeutic target for atherosclerosis. 2. **Cancer:** CIDEB's ability to induce cell death in response to DNA damage makes it a potential therapeutic target for cancer treatment. 3. **Neurological disorders:** CIDEB's expression in cerebral cortex GABAergic interneurons and forebrain radial glial cells suggests its potential involvement in neurological disorders, such as Alzheimer's disease. In conclusion, CIDEB is a multifunctional protein involved in regulating apoptosis, lipid metabolism, and immune responses. Its involvement in various cellular pathways and its clinical significance make it an important target for further research and potential therapeutic applications.

Genular Protein ID: 3906119432

Symbol: CIDEB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UHD4 D3DS73 Q546V8 Q9NNW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10619428

Title: Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.

PubMed ID: 10619428

DOI: 10.1016/s0092-8674(00)81672-4

PubMed ID: 9564035

Title: CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.

PubMed ID: 9564035

DOI: 10.1093/emboj/17.9.2526

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429024

Title: Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family.

PubMed ID: 12429024

DOI: 10.1042/bj20020656

PubMed ID: 27282740

Title: Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A.

PubMed ID: 27282740

DOI: 10.1038/srep27778

PubMed ID: 35939579

Title: Germline Mutations in CIDEB and Protection against Liver Disease.

PubMed ID: 35939579

DOI: 10.1056/nejmoa2117872

Sequence Information:

  • Length: 219
  • Mass: 24678
  • Checksum: E0B4E5EF1F7C912D
  • Sequence:
    • MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG LTAATRQELL 
AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM VLQSGQSWSP TRSGVLSYGL 
GRERPKHSKD IARFTFDVYK QNPRDLFGSL NVKATFYGLY SMSCDFQGLG PKKVLRELLR 
WTSTLLQGLG HMLLGISSTL RHAVEGAEQW QQKGRLHSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.