Details for: CIDEB

Gene ID: 27141

Symbol: CIDEB

Ensembl ID: ENSG00000136305

Description: cell death inducing DFFA like effector b

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.76
    Marker Score: 2708
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.59
    Marker Score: 967
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.59
    Marker Score: 2574
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.33
    Marker Score: 23605
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.27
    Marker Score: 950
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.01
    Marker Score: 292
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 358
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.88
    Marker Score: 4208
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.87
    Marker Score: 2851
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.82
    Marker Score: 1922
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.77
    Marker Score: 781
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.71
    Marker Score: 5305
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 525.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.68
    Marker Score: 215
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.66
    Marker Score: 2752
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2774
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.65
    Marker Score: 167
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.63
    Marker Score: 158
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.59
    Marker Score: 413
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.56
    Marker Score: 136
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.56
    Marker Score: 408
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 177
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.53
    Marker Score: 3206
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.52
    Marker Score: 163
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.48
    Marker Score: 790
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.48
    Marker Score: 2072
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.48
    Marker Score: 1438
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.46
    Marker Score: 1334
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.45
    Marker Score: 3896
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.44
    Marker Score: 1629
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.41
    Marker Score: 265
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.41
    Marker Score: 3567
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.41
    Marker Score: 1292.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.41
    Marker Score: 1017.5
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.39
    Marker Score: 250
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.38
    Marker Score: 255
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.37
    Marker Score: 1309
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 239
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.36
    Marker Score: 335
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.35
    Marker Score: 347.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.34
    Marker Score: 2659
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.33
    Marker Score: 327
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.32
    Marker Score: 1706
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.31
    Marker Score: 71
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.31
    Marker Score: 350
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.31
    Marker Score: 1988
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.3
    Marker Score: 254
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.3
    Marker Score: 303
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.29
    Marker Score: 250
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.29
    Marker Score: 858
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.29
    Marker Score: 236
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.28
    Marker Score: 250
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.28
    Marker Score: 192
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.28
    Marker Score: 143
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.26
    Marker Score: 180
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.25
    Marker Score: 660
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 106
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.25
    Marker Score: 272
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.25
    Marker Score: 371
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.25
    Marker Score: 278
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.25
    Marker Score: 101
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.25
    Marker Score: 2480
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.25
    Marker Score: 123
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.24
    Marker Score: 255
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.24
    Marker Score: 147
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.24
    Marker Score: 652
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.24
    Marker Score: 89
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.24
    Marker Score: 48
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.24
    Marker Score: 334
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 98
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.24
    Marker Score: 237
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.23
    Marker Score: 1517
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.23
    Marker Score: 64
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.23
    Marker Score: 63
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.23
    Marker Score: 126
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.23
    Marker Score: 629
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.23
    Marker Score: 970
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 361
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.22
    Marker Score: 2601
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.22
    Marker Score: 423
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.22
    Marker Score: 141
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.22
    Marker Score: 353
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.22
    Marker Score: 537
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 69

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Other Information

**Key Characteristics** CIDEB is a gene that belongs to the DFFA-like effector family, which is involved in the regulation of cellular processes, including apoptosis and lipid metabolism. The protein encoded by CIDEB is a membrane-bound protein that interacts with various cellular components, including phospholipids, lipids, and other proteins. CIDEB has been shown to regulate the execution phase of apoptosis, particularly in response to DNA damage, and plays a critical role in the regulation of triglyceride metabolic processes and lipid storage. **Pathways and Functions** CIDEB is involved in several cellular pathways, including: 1. **Apoptotic Process**: CIDEB regulates the execution phase of apoptosis, particularly in response to DNA damage, and plays a critical role in the regulation of triglyceride metabolic processes and lipid storage. 2. **Bile Acid Signaling Pathway**: CIDEB has been shown to interact with bile acids and regulate their signaling pathways, which is important for the regulation of lipid metabolism and triglyceride storage. 3. **Copii-Coated Vesicle**: CIDEB is involved in the regulation of copii-coated vesicle formation and function, which is critical for the regulation of lipid metabolism and triglyceride storage. 4. **Intrinsic Apoptotic Signaling Pathway**: CIDEB regulates the intrinsic apoptotic signaling pathway in response to DNA damage, which is critical for the regulation of apoptosis and cell survival. **Clinical Significance** CIDEB has been implicated in various diseases, including: 1. **Metabolic Disorders**: CIDEB has been shown to play a critical role in the regulation of triglyceride metabolic processes and lipid storage, which is important for the development of metabolic disorders, such as obesity and type 2 diabetes. 2. **Neurodegenerative Diseases**: CIDEB has been implicated in the regulation of apoptosis and lipid metabolism in the brain, which is critical for the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CIDEB has been shown to regulate the execution phase of apoptosis in cancer cells, which is critical for the development of cancer therapies. In conclusion, CIDEB is a critical regulator of cellular processes, including apoptosis, lipid metabolism, and nutrient signaling. The gene has been implicated in various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Further research is needed to fully understand the role of CIDEB in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 3906119432

Symbol: CIDEB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UHD4 D3DS73 Q546V8 Q9NNW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10619428

Title: Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.

PubMed ID: 10619428

DOI: 10.1016/s0092-8674(00)81672-4

PubMed ID: 9564035

Title: CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.

PubMed ID: 9564035

DOI: 10.1093/emboj/17.9.2526

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429024

Title: Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family.

PubMed ID: 12429024

DOI: 10.1042/bj20020656

PubMed ID: 27282740

Title: Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A.

PubMed ID: 27282740

DOI: 10.1038/srep27778

PubMed ID: 35939579

Title: Germline Mutations in CIDEB and Protection against Liver Disease.

PubMed ID: 35939579

DOI: 10.1056/nejmoa2117872

Sequence Information:

  • Length: 219
  • Mass: 24678
  • Checksum: E0B4E5EF1F7C912D
  • Sequence:
    • MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG LTAATRQELL 
AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM VLQSGQSWSP TRSGVLSYGL 
GRERPKHSKD IARFTFDVYK QNPRDLFGSL NVKATFYGLY SMSCDFQGLG PKKVLRELLR 
WTSTLLQGLG HMLLGISSTL RHAVEGAEQW QQKGRLHSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.