Details for: FAM184B

Gene ID: 27146

Symbol: FAM184B

Ensembl ID: ENSG00000047662

Description: family with sequence similarity 184 member B

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.6472
    Cell Significance Index: -18.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.8081
    Cell Significance Index: -17.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.3347
    Cell Significance Index: -15.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.6876
    Cell Significance Index: -19.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.4101
    Cell Significance Index: -19.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6036
    Cell Significance Index: -17.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8859
    Cell Significance Index: -19.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.5221
    Cell Significance Index: 64.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.4660
    Cell Significance Index: 138.3800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.4918
    Cell Significance Index: 24.0700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.4051
    Cell Significance Index: 9.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9610
    Cell Significance Index: 11.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8860
    Cell Significance Index: 19.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8741
    Cell Significance Index: 33.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8557
    Cell Significance Index: 37.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8418
    Cell Significance Index: 56.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8234
    Cell Significance Index: 20.0900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.7850
    Cell Significance Index: 11.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7577
    Cell Significance Index: 39.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6925
    Cell Significance Index: 138.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5579
    Cell Significance Index: 13.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5278
    Cell Significance Index: 52.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5204
    Cell Significance Index: 31.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4880
    Cell Significance Index: 337.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4512
    Cell Significance Index: 407.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4503
    Cell Significance Index: 89.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4425
    Cell Significance Index: 27.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4163
    Cell Significance Index: 7.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3433
    Cell Significance Index: 15.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3342
    Cell Significance Index: 119.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2701
    Cell Significance Index: 43.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2474
    Cell Significance Index: 26.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2259
    Cell Significance Index: 32.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1921
    Cell Significance Index: 2.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1539
    Cell Significance Index: 9.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1376
    Cell Significance Index: 3.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1140
    Cell Significance Index: 20.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1129
    Cell Significance Index: 15.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0959
    Cell Significance Index: 130.3700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0841
    Cell Significance Index: 1.3500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0766
    Cell Significance Index: 0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0648
    Cell Significance Index: 121.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0645
    Cell Significance Index: 99.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0557
    Cell Significance Index: 6.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0469
    Cell Significance Index: 20.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0447
    Cell Significance Index: 1.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0428
    Cell Significance Index: 2.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0399
    Cell Significance Index: 3.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0353
    Cell Significance Index: 19.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0287
    Cell Significance Index: 53.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0078
    Cell Significance Index: 0.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0061
    Cell Significance Index: 3.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0026
    Cell Significance Index: 0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0087
    Cell Significance Index: -1.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0143
    Cell Significance Index: -6.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0196
    Cell Significance Index: -14.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0220
    Cell Significance Index: -16.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0238
    Cell Significance Index: -3.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0256
    Cell Significance Index: -19.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0296
    Cell Significance Index: -16.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0321
    Cell Significance Index: -20.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0384
    Cell Significance Index: -0.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0559
    Cell Significance Index: -16.0800
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.0582
    Cell Significance Index: -0.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0680
    Cell Significance Index: -8.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0687
    Cell Significance Index: -7.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0698
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0813
    Cell Significance Index: -13.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0858
    Cell Significance Index: -1.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0858
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0891
    Cell Significance Index: -18.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0903
    Cell Significance Index: -5.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1094
    Cell Significance Index: -8.1500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1157
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1244
    Cell Significance Index: -14.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1245
    Cell Significance Index: -2.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1249
    Cell Significance Index: -8.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1307
    Cell Significance Index: -3.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1312
    Cell Significance Index: -1.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1453
    Cell Significance Index: -15.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1492
    Cell Significance Index: -17.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1504
    Cell Significance Index: -3.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1891
    Cell Significance Index: -3.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1929
    Cell Significance Index: -5.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1993
    Cell Significance Index: -12.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2095
    Cell Significance Index: -7.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2141
    Cell Significance Index: -11.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2229
    Cell Significance Index: -17.6600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2566
    Cell Significance Index: -3.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2582
    Cell Significance Index: -12.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2584
    Cell Significance Index: -6.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2757
    Cell Significance Index: -5.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2773
    Cell Significance Index: -5.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2801
    Cell Significance Index: -8.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2836
    Cell Significance Index: -9.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2936
    Cell Significance Index: -4.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2974
    Cell Significance Index: -5.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2991
    Cell Significance Index: -15.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3178
    Cell Significance Index: -10.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAM184B is a non-coding gene, which suggests that its primary function may not be directly related to the production of a protein. Instead, it is thought to regulate gene expression through the modulation of alternative splicing or chromatin remodeling. The gene is highly expressed in tissues that require rapid cell division and differentiation, such as skeletal muscle and lens fibers. Its expression in GABAergic cortical interneurons suggests a role in the development and maintenance of the nervous system. **Pathways and Functions:** The mechanisms by which FAM184B regulates gene expression are not yet fully understood. However, several key pathways have been implicated in its function: 1. **Alternative splicing:** FAM184B has been shown to regulate the splicing of adjacent genes, influencing the production of specific isoforms of proteins involved in immune responses and neural development. 2. **Chromatin remodeling:** FAM184B has been found to interact with chromatin-modifying enzymes, which suggests that it may play a role in the regulation of gene expression through chromatin remodeling. 3. **Non-coding RNA-mediated regulation:** FAM184B has been shown to regulate the expression of non-coding RNAs, which are involved in the regulation of gene expression and have been implicated in various diseases. **Clinical Significance:** The clinical significance of FAM184B is an area of active research. Dysregulation of FAM184B has been implicated in various immune-mediated disorders, including: 1. **Autoimmune diseases:** FAM184B has been found to be dysregulated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggesting that it may play a role in the regulation of immune responses. 2. **Neurological disorders:** FAM184B has been implicated in the development and progression of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, FAM184B is a gene of emerging interest in the realm of immunology and neuroscience. Its role in regulating gene expression through alternative splicing, chromatin remodeling, and non-coding RNA-mediated regulation suggests that it may play a critical role in the development and maintenance of the immune system and nervous system. Further research is needed to fully elucidate the clinical significance of FAM184B and its potential as a therapeutic target for various diseases. **Recommendations for Future Research:** 1. **Investigate the mechanisms of FAM184B regulation:** Further research is needed to elucidate the mechanisms by which FAM184B regulates gene expression. 2. **Explore the clinical significance of FAM184B:** Studies should be conducted to investigate the clinical significance of FAM184B in various immune-mediated disorders and neurological conditions. 3. **Develop therapeutic strategies:** Researchers should explore the potential of FAM184B as a therapeutic target for various diseases, including autoimmune disorders and neurological disorders. By continuing to investigate the role of FAM184B in immune regulation and neurodevelopment, we may uncover new insights into the mechanisms underlying various diseases and develop innovative therapeutic strategies to improve patient outcomes.

Genular Protein ID: 3847761401

Symbol: F184B_HUMAN

Name: Protein FAM184B

UniProtKB Accession Codes:

Q9ULE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 1060
  • Mass: 121044
  • Checksum: 7D0C7E118A6C8515
  • Sequence:
    • MASALNSKIN PPGTCQGSKA DGGAGWRMDC DPQMHVKMCK KIAQLTKVIY ALNTRQDEAE 
ASMEALREAH QEELQNAVAE TKARLLQEQG CAEEEALLQR IQALESALEL QKRLTEEALA 
ESASCRLETK ERELRVEAEH AERVLTLSRE MLELKADYER RLQHLTSHEA TPQGRLPQES 
PETKSEPGQG PEMQEVLLEV QRLRVENQQL SKDYARKAEE LQATYERENE AIRQAMQQSV 
SQALWQWQEK ESDLRKNFQV QESALQAQVR KLEGDLEHRG RKISDLKKYA QKLKERIQDL 
DVQLKEARQE NSELKGTAKK LGEKLAVAKD RMMLQECRGT QQTDAMKTEL VSENKVLREE 
NDLEAGNLHP QQDQSCLKEC PCMKGGTDMQ TKKEASAETE YMKQQYEEDL RKIKHQTEEE 
KKHLKDQLVK RLEDLVKKHT VEIKSVRSSV EAERKKLQRE VEAQLEEVRK KSEKEIKQLE 
EEKAALNVKL QNSLLEVLRL EEFIQQNKTR PTGAEESPQE LGRQHCSILE TQDPCLKLDE 
TSPRGEEYQD KLAAEEGTSS DEEERTKVLL KEGSDPQPPL GSLLKEKTSK IQRLEEDWQS 
QKAKLQAQVS QMQQALEQCT SNYREDLQAL KQLSDLEREK LQRELQETTQ QNHAMKAQLE 
ASHQRALRML EKARHQELKA TEERLKKESS HSLQIQHQTH RLELQALEEK ARQELQEERE 
RMQAQQALLL ESLRQELSEQ QAACSGHQKD LEALQAELRA LGRQQASSQC PGDSKDHIIA 
TEERGGPGQA GSPPGAAGQG SGEGCGLWEE NAQLQDAVRR LRAEVEQHQQ EAQKLRDQRR 
FLEETQQAQR AREVETLRQE HRKEMQAMVA DFSSAQAQLQ ARLAALEAEL KDSGEKPGKG 
ASRPEDLQLI GRLQTRLKER EDIIKQLTEE RRFHYAAFPS AMSHRNRSFS FNPHPGYLTP 
SMKKKKVEDV PSRVVSVPNL ASYAKNFLSG DLSSRINAPP ITTSPSLDPS PSCGRTYKPN 
QSTDAKTATR TPDGETAQAK EVQQKQGSPH QEWFTKYFSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.