Details for: INTU

Gene ID: 27152

Symbol: INTU

Ensembl ID: ENSG00000164066

Description: inturned planar cell polarity protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.3049
    Cell Significance Index: -45.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 174.2604
    Cell Significance Index: -44.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.4446
    Cell Significance Index: -37.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.6910
    Cell Significance Index: -36.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.6599
    Cell Significance Index: -45.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5229
    Cell Significance Index: -45.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.5339
    Cell Significance Index: -14.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.9730
    Cell Significance Index: 35.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.6202
    Cell Significance Index: 165.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.5589
    Cell Significance Index: 68.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5079
    Cell Significance Index: 57.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4301
    Cell Significance Index: 286.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2684
    Cell Significance Index: 125.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1572
    Cell Significance Index: 415.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1044
    Cell Significance Index: 67.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9917
    Cell Significance Index: 55.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9297
    Cell Significance Index: 839.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7787
    Cell Significance Index: 52.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7552
    Cell Significance Index: 57.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7168
    Cell Significance Index: 83.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6908
    Cell Significance Index: 477.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6688
    Cell Significance Index: 108.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5311
    Cell Significance Index: 57.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5163
    Cell Significance Index: 12.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4796
    Cell Significance Index: 95.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4087
    Cell Significance Index: 223.2000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3619
    Cell Significance Index: 5.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3287
    Cell Significance Index: 9.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2980
    Cell Significance Index: 8.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2525
    Cell Significance Index: 5.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2294
    Cell Significance Index: 31.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2292
    Cell Significance Index: 13.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2041
    Cell Significance Index: 10.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1944
    Cell Significance Index: 35.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1854
    Cell Significance Index: 2.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1812
    Cell Significance Index: 4.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1785
    Cell Significance Index: 22.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1560
    Cell Significance Index: 29.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1501
    Cell Significance Index: 66.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1483
    Cell Significance Index: 279.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0824
    Cell Significance Index: 10.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0728
    Cell Significance Index: 134.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0651
    Cell Significance Index: 88.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0630
    Cell Significance Index: 1.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0614
    Cell Significance Index: 94.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0603
    Cell Significance Index: 2.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0585
    Cell Significance Index: 37.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0559
    Cell Significance Index: 2.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0014
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0307
    Cell Significance Index: -22.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0382
    Cell Significance Index: -5.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0607
    Cell Significance Index: -44.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0633
    Cell Significance Index: -47.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0844
    Cell Significance Index: -47.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0893
    Cell Significance Index: -55.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1363
    Cell Significance Index: -39.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1928
    Cell Significance Index: -8.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1964
    Cell Significance Index: -10.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2143
    Cell Significance Index: -36.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2677
    Cell Significance Index: -56.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2799
    Cell Significance Index: -28.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2988
    Cell Significance Index: -38.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3103
    Cell Significance Index: -35.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3554
    Cell Significance Index: -37.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3787
    Cell Significance Index: -26.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3829
    Cell Significance Index: -45.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4227
    Cell Significance Index: -13.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4871
    Cell Significance Index: -36.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4992
    Cell Significance Index: -23.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5081
    Cell Significance Index: -40.2400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5409
    Cell Significance Index: -3.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5454
    Cell Significance Index: -9.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5504
    Cell Significance Index: -28.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5536
    Cell Significance Index: -11.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6108
    Cell Significance Index: -37.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6465
    Cell Significance Index: -9.5500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6625
    Cell Significance Index: -4.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6697
    Cell Significance Index: -18.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6797
    Cell Significance Index: -43.8500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.6919
    Cell Significance Index: -5.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7551
    Cell Significance Index: -17.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7573
    Cell Significance Index: -14.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7741
    Cell Significance Index: -16.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7922
    Cell Significance Index: -25.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7986
    Cell Significance Index: -26.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8118
    Cell Significance Index: -28.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8666
    Cell Significance Index: -23.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9220
    Cell Significance Index: -15.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9267
    Cell Significance Index: -23.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9321
    Cell Significance Index: -26.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9379
    Cell Significance Index: -18.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9620
    Cell Significance Index: -33.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9964
    Cell Significance Index: -26.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9981
    Cell Significance Index: -19.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0274
    Cell Significance Index: -17.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.0505
    Cell Significance Index: -15.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0526
    Cell Significance Index: -22.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0756
    Cell Significance Index: -31.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1006
    Cell Significance Index: -28.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** INTU is a conserved protein that belongs to the PCP family, which is characterized by its ability to regulate cellular polarity and cilia function. The protein INTU is specifically expressed in cells that require precise cilia function, such as ciliated cells and neurons. It is also involved in regulating the assembly and maintenance of cilia, as well as the transport of proteins and signaling molecules within cilia. INTU has been shown to interact with other proteins, including Smoothened, a key component of the Hedgehog signaling pathway, and modulate its activity. **Pathways and Functions:** INTU is involved in various signaling pathways, including: 1. **Smoothened signaling pathway**: INTU regulates the activity of Smoothened, a key component of the Hedgehog signaling pathway, which is involved in developmental processes such as limb development, neural tube formation, and spinal cord patterning. 2. **Cilium assembly and maintenance**: INTU regulates the assembly and maintenance of cilia, including the assembly of basal body complexes and the regulation of intraciliary transport. 3. **Intraciliary transport**: INTU regulates the transport of proteins and signaling molecules within cilia, which is essential for cilia function and signaling. 4. **Cell surface and cytoplasmic signaling**: INTU regulates cell surface and cytoplasmic signaling pathways, including the regulation of cell division, keratinocyte proliferation, and nervous system development. **Clinical Significance:** Dysregulation of INTU has been implicated in various diseases, including: 1. **Developmental disorders**: INTU dysregulation has been linked to developmental disorders such as limb malformations, neural tube defects, and spinal cord abnormalities. 2. **Neurological conditions**: INTU dysregulation has been implicated in neurological conditions such as autism spectrum disorder, schizophrenia, and Parkinson's disease. 3. **Ciliary disorders**: INTU dysregulation has been linked to ciliary disorders such as primary ciliary dyskinesia, which is characterized by respiratory and reproductive tract abnormalities. In conclusion, INTU is a critical gene involved in the regulation of cilia function and developmental processes. Its dysregulation has significant implications for human health, and further research is needed to fully understand its role in disease and to develop effective therapeutic strategies.

Genular Protein ID: 3041191191

Symbol: INTU_HUMAN

Name: Protein inturned

UniProtKB Accession Codes:

Q9ULD6 A1L4N5 D6RAE6 D6RBT4 Q4W5I8 Q86V55

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26644512

Title: The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.

PubMed ID: 26644512

DOI: 10.1083/jcb.201502043

PubMed ID: 35427153

Title: Structure of the ciliogenesis-associated CPLANE complex.

PubMed ID: 35427153

DOI: 10.1126/sciadv.abn0832

PubMed ID: 27158779

Title: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.

PubMed ID: 27158779

DOI: 10.1038/ng.3558

Sequence Information:

  • Length: 942
  • Mass: 105648
  • Checksum: F21BF6BC0EF7A8F8
  • Sequence:
    • MASVASCDSR PSSDELPGDP SSQEEDEDYD FEDRVSDSGS YSSASSDYDD LEPEWLDSVQ 
KNGELFYLEL SEDEEESLLP ETPTVNHVRF SENEIIIEDD YKERKKYEPK LKQFTKILRR 
KRLLPKRCNK KNSNDNGPVS ILKHQSNQKT GVIVQQRYKD VNVYVNPKKL TVIKAKEQLK 
LLEVLVGIIH QTKWSWRRTG KQGDGERLVV HGLLPGGSAM KSGQVLIGDV LVAVNDVDVT 
TENIERVLSC IPGPMQVKLT FENAYDVKRE TSHPRQKKTQ SNTSDLVKLL WGEEVEGIQQ 
SGLNTPHIIM YLTLQLDSET SKEEQEILYH YPMSEASQKL KSVRGIFLTL CDMLENVTGT 
QVTSSSLLLN GKQIHVAYWK ESDKLLLIGL PAEEVPLPRL RNMIENVIQT LKFMYGSLDS 
AFCQIENVPR LDHFFNLFFQ RALQPAKLHS SASPSAQQYD ASSAVLLDNL PGVRWLTLPL 
EIKMELDMAL SDLEAADFAE LSEDYYDMRR LYTILGSSLF YKGYLICSHL PKDDLIDIAV 
YCRHYCLLPL AAKQRIGQLI IWREVFPQHH LRPLADSSTE VFPEPEGRYF LLVVGLKHYM 
LCVLLEAGGC ASKAIGSPGP DCVYVDQVKT TLHQLDGVDS RIDERLASSP VPCLSCADWF 
LTGSREKTDS LTTSPILSRL QGTSKVATSP TCRRTLFGDY SLKTRKPSPS CSSGGSDNGC 
EGGEDDGFSP HTTPDAVRKQ RESQGSDGLE ESGTLLKVTK KKSTLPNPFH LGNLKKDLPE 
KELEIYNTVK LTSGPENTLF HYVALETVQG IFITPTLEEV AQLSGSIHPQ LIKNFHQCCL 
SIRAVFQQTL VEEKKKGLNS GDHSDSAKSV SSLNPVKEHG VLFECSPGNW TDQKKAPPVM 
AYWVVGRLFL HPKPQELYVC FHDSVTEIAI EIAFKLFFGL TL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.