Details for: RNF115

Gene ID: 27246

Symbol: RNF115

Ensembl ID: ENSG00000265491

Description: ring finger protein 115

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.5875
    Cell Significance Index: -72.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 144.0959
    Cell Significance Index: -58.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.3412
    Cell Significance Index: -67.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.5076
    Cell Significance Index: -72.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.8910
    Cell Significance Index: -59.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.1666
    Cell Significance Index: -62.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.0454
    Cell Significance Index: -64.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.7610
    Cell Significance Index: -41.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.6085
    Cell Significance Index: 118.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.4005
    Cell Significance Index: 107.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.7280
    Cell Significance Index: 209.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1451
    Cell Significance Index: 430.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9109
    Cell Significance Index: 37.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8676
    Cell Significance Index: 370.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.4536
    Cell Significance Index: 21.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3240
    Cell Significance Index: 474.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2187
    Cell Significance Index: 46.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.1843
    Cell Significance Index: 120.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1392
    Cell Significance Index: 50.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0991
    Cell Significance Index: 57.2500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.0654
    Cell Significance Index: 17.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0160
    Cell Significance Index: 118.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9195
    Cell Significance Index: 51.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9125
    Cell Significance Index: 631.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8641
    Cell Significance Index: 140.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6911
    Cell Significance Index: 1301.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6671
    Cell Significance Index: 40.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6557
    Cell Significance Index: 90.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5943
    Cell Significance Index: 107.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5253
    Cell Significance Index: 35.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5124
    Cell Significance Index: 63.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4984
    Cell Significance Index: 8.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4905
    Cell Significance Index: 31.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4879
    Cell Significance Index: 13.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4323
    Cell Significance Index: 196.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4232
    Cell Significance Index: 231.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3548
    Cell Significance Index: 21.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3424
    Cell Significance Index: 151.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3088
    Cell Significance Index: 19.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2753
    Cell Significance Index: 174.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2527
    Cell Significance Index: 228.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2498
    Cell Significance Index: 4.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2224
    Cell Significance Index: 28.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2022
    Cell Significance Index: 4.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1905
    Cell Significance Index: 2.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1606
    Cell Significance Index: 7.5500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1455
    Cell Significance Index: 2.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1422
    Cell Significance Index: 262.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1358
    Cell Significance Index: 14.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1197
    Cell Significance Index: 3.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1071
    Cell Significance Index: 164.9200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0633
    Cell Significance Index: 0.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0383
    Cell Significance Index: 2.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0238
    Cell Significance Index: 4.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0131
    Cell Significance Index: 1.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0042
    Cell Significance Index: 5.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0062
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0310
    Cell Significance Index: -22.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0368
    Cell Significance Index: -5.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0435
    Cell Significance Index: -5.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0574
    Cell Significance Index: -43.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0753
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0771
    Cell Significance Index: -57.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0802
    Cell Significance Index: -3.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0933
    Cell Significance Index: -17.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0978
    Cell Significance Index: -3.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1049
    Cell Significance Index: -7.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1139
    Cell Significance Index: -64.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1164
    Cell Significance Index: -72.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2235
    Cell Significance Index: -10.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2324
    Cell Significance Index: -66.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2783
    Cell Significance Index: -19.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3080
    Cell Significance Index: -35.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3172
    Cell Significance Index: -8.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3232
    Cell Significance Index: -4.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3246
    Cell Significance Index: -68.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3589
    Cell Significance Index: -9.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3711
    Cell Significance Index: -10.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4307
    Cell Significance Index: -9.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4418
    Cell Significance Index: -12.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4668
    Cell Significance Index: -24.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5469
    Cell Significance Index: -14.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5986
    Cell Significance Index: -12.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6728
    Cell Significance Index: -9.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7245
    Cell Significance Index: -57.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7443
    Cell Significance Index: -17.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7663
    Cell Significance Index: -16.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9240
    Cell Significance Index: -32.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0608
    Cell Significance Index: -65.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1853
    Cell Significance Index: -14.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2177
    Cell Significance Index: -30.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2184
    Cell Significance Index: -25.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2365
    Cell Significance Index: -39.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3302
    Cell Significance Index: -43.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3608
    Cell Significance Index: -31.4400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.4274
    Cell Significance Index: -18.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4533
    Cell Significance Index: -38.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.4544
    Cell Significance Index: -18.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4614
    Cell Significance Index: -51.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.4761
    Cell Significance Index: -37.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF115 is a member of the ring finger protein family, characterized by its unique structure and function. Its enzymatic activity is attributed to its RING domain, which facilitates the transfer of ubiquitin molecules to target proteins. This process, known as ubiquitination, is a crucial mechanism for protein degradation, modification, and regulation of protein-protein interactions. RNF115 is specifically involved in the ubiquitination of proteins, including those involved in immune responses, such as MHC class I molecules and antigen-presenting cells. **Pathways and Functions:** RNF115 is implicated in several key pathways, including: 1. **Adaptive Immune System:** RNF115 regulates the ubiquitination and degradation of MHC class I molecules, which are essential for the presentation of antigens to T-cells. This process is vital for the activation of specific immune responses. 2. **Antigen Processing:** RNF115 is involved in the ubiquitination and degradation of antigens, facilitating their presentation to T-cells via MHC class I molecules. 3. **Class I MHC Mediated Antigen Processing and Presentation:** RNF115 regulates the ubiquitination and degradation of antigens, ensuring their presentation to T-cells via MHC class I molecules. 4. **Cytoplasmic and Cytosolic Processes:** RNF115 is involved in the ubiquitination and degradation of proteins in the cytoplasm and cytosol, regulating various cellular processes, including protein degradation and signaling pathways. 5. **Negative Regulation of Epidermal Growth Factor Receptor Signaling:** RNF115 negatively regulates the ubiquitination and degradation of the epidermal growth factor receptor (EGFR), which is involved in cell proliferation and survival. **Clinical Significance:** RNF115 has been implicated in various diseases, including: 1. **Cancer:** RNF115 has been shown to regulate the ubiquitination and degradation of tumor suppressor proteins, contributing to cancer progression. 2. **Autoimmune Diseases:** RNF115 has been implicated in the regulation of immune responses, including those involved in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological Disorders:** RNF115 has been shown to regulate the ubiquitination and degradation of proteins involved in neuronal function, contributing to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RNF115 is a multifunctional protein that plays a critical role in regulating immune responses, protein degradation, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms and clinical significance of RNF115.

Genular Protein ID: 2157145312

Symbol: RN115_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y4L5 A8K3Y4 Q5T2V9 Q7Z2J2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16288031

Title: A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer.

PubMed ID: 16288031

DOI: 10.1158/0008-5472.can-05-2103

PubMed ID: 16925951

Title: Novel RING E3 ubiquitin ligases in breast cancer.

PubMed ID: 16925951

DOI: 10.1593/neo.06469

PubMed ID: 18819927

Title: Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.

PubMed ID: 18819927

DOI: 10.1158/1541-7786.mcr-08-0094

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20019814

Title: BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.

PubMed ID: 20019814

DOI: 10.1371/journal.ppat.1000700

PubMed ID: 23418353

Title: The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.

PubMed ID: 23418353

DOI: 10.1242/jcs.116129

PubMed ID: 24852021

Title: BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in a tetherin-independent manner.

PubMed ID: 24852021

DOI: 10.1371/journal.ppat.1004151

PubMed ID: 30689267

Title: Deubiquitinase ubiquitin-specific protease 9X regulates the stability and function of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells.

PubMed ID: 30689267

DOI: 10.1111/cas.13953

PubMed ID: 32980859

Title: RNF115 deletion inhibits autophagosome maturation and growth of gastric cancer.

PubMed ID: 32980859

DOI: 10.1038/s41419-020-03011-w

PubMed ID: 33139700

Title: RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA.

PubMed ID: 33139700

DOI: 10.1038/s41467-020-19318-3

PubMed ID: 35343654

Title: RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A and RAB13.

PubMed ID: 35343654

DOI: 10.1002/advs.202105391

Sequence Information:

  • Length: 304
  • Mass: 33703
  • Checksum: 22F0C8FCC0F55045
  • Sequence:
    • MAEASAAGAD SGAAVAAHRF FCHFCKGEVS PKLPEYICPR CESGFIEEVT DDSSFLGGGG 
SRIDNTTTTH FAELWGHLDH TMFFQDFRPF LSSSPLDQDN RANERGHQTH TDFWGARPPR 
LPLGRRYRSR GSSRPDRSPA IEGILQHIFA GFFANSAIPG SPHPFSWSGM LHSNPGDYAW 
GQTGLDAIVT QLLGQLENTG PPPADKEKIT SLPTVTVTQE QVDMGLECPV CKEDYTVEEE 
VRQLPCNHFF HSSCIVPWLE LHDTCPVCRK SLNGEDSTRQ SQSTEASASN RFSNDSQLHD 
RWTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.