Details for: KLHL20

Gene ID: 27252

Symbol: KLHL20

Ensembl ID: ENSG00000076321

Description: kelch like family member 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.3194
    Cell Significance Index: -28.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.1259
    Cell Significance Index: -28.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.4446
    Cell Significance Index: -31.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.9743
    Cell Significance Index: -25.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.2639
    Cell Significance Index: -26.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.2507
    Cell Significance Index: -29.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.8703
    Cell Significance Index: -29.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6938
    Cell Significance Index: -30.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3700
    Cell Significance Index: -16.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2727
    Cell Significance Index: 85.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1836
    Cell Significance Index: 23.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0648
    Cell Significance Index: 211.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0024
    Cell Significance Index: 56.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0009
    Cell Significance Index: 44.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9925
    Cell Significance Index: 199.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9708
    Cell Significance Index: 36.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6651
    Cell Significance Index: 51.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6642
    Cell Significance Index: 72.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6591
    Cell Significance Index: 18.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6127
    Cell Significance Index: 36.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6061
    Cell Significance Index: 217.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6003
    Cell Significance Index: 97.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5625
    Cell Significance Index: 9.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5043
    Cell Significance Index: 6.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4241
    Cell Significance Index: 382.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4206
    Cell Significance Index: 6.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3358
    Cell Significance Index: 33.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3272
    Cell Significance Index: 22.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3126
    Cell Significance Index: 59.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3103
    Cell Significance Index: 7.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2591
    Cell Significance Index: 46.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2551
    Cell Significance Index: 6.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2516
    Cell Significance Index: 5.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2477
    Cell Significance Index: 34.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2239
    Cell Significance Index: 27.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2181
    Cell Significance Index: 150.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1606
    Cell Significance Index: 71.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1484
    Cell Significance Index: 9.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1468
    Cell Significance Index: 4.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1329
    Cell Significance Index: 8.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1110
    Cell Significance Index: 14.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0768
    Cell Significance Index: 41.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0676
    Cell Significance Index: 11.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0570
    Cell Significance Index: 36.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0495
    Cell Significance Index: 93.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0310
    Cell Significance Index: 14.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0283
    Cell Significance Index: 0.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0268
    Cell Significance Index: 0.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0243
    Cell Significance Index: 1.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0214
    Cell Significance Index: 39.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0199
    Cell Significance Index: 30.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0029
    Cell Significance Index: 0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0100
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0241
    Cell Significance Index: -3.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0250
    Cell Significance Index: -18.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0262
    Cell Significance Index: -14.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0275
    Cell Significance Index: -20.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0367
    Cell Significance Index: -1.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0570
    Cell Significance Index: -0.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0581
    Cell Significance Index: -6.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0594
    Cell Significance Index: -3.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0794
    Cell Significance Index: -8.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0796
    Cell Significance Index: -16.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0816
    Cell Significance Index: -23.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0984
    Cell Significance Index: -6.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1053
    Cell Significance Index: -12.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1056
    Cell Significance Index: -5.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1261
    Cell Significance Index: -5.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1428
    Cell Significance Index: -2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1580
    Cell Significance Index: -20.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2064
    Cell Significance Index: -10.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2209
    Cell Significance Index: -25.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2221
    Cell Significance Index: -2.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2306
    Cell Significance Index: -10.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2606
    Cell Significance Index: -27.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2640
    Cell Significance Index: -19.6800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2751
    Cell Significance Index: -3.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2761
    Cell Significance Index: -14.3800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2847
    Cell Significance Index: -1.7200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2940
    Cell Significance Index: -4.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2957
    Cell Significance Index: -9.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3048
    Cell Significance Index: -7.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3316
    Cell Significance Index: -4.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3395
    Cell Significance Index: -26.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3416
    Cell Significance Index: -7.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3452
    Cell Significance Index: -9.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3640
    Cell Significance Index: -7.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4137
    Cell Significance Index: -11.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4256
    Cell Significance Index: -11.1900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4257
    Cell Significance Index: -5.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4456
    Cell Significance Index: -9.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4561
    Cell Significance Index: -15.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4964
    Cell Significance Index: -7.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5185
    Cell Significance Index: -31.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5303
    Cell Significance Index: -16.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5306
    Cell Significance Index: -7.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5409
    Cell Significance Index: -17.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLHL20 is a member of the kelch-like family of proteins, which are known for their role in protein-protein interactions and regulation of signaling pathways. The protein encoded by KLHL20 is a 121-kDa protein with a unique structure, featuring a kelch domain and a ubiquitin ligase activity. This dual functionality allows KLHL20 to play a critical role in the regulation of protein ubiquitination and degradation, a key process in the immune system. **Pathways and Functions:** KLHL20 is involved in various cellular processes, including: 1. **Adaptive Immune System:** KLHL20 is part of the Cul3-ring ubiquitin ligase complex, which plays a crucial role in the regulation of immune responses, particularly in the context of antigen processing and presentation. 2. **Antigen Processing and Presentation:** KLHL20 is involved in the ubiquitination and proteasome degradation of antigens, which is essential for the presentation of antigens to T-cells. 3. **Apoptotic Regulation:** KLHL20 has been shown to regulate the negative feedback of apoptotic processes, ensuring the proper functioning of immune cells. 4. **Protein Binding and Modification:** KLHL20 interacts with various proteins, including those involved in protein ubiquitination, modification, and degradation. **Clinical Significance:** The dysregulation of KLHL20 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Alterations in KLHL20 expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** KLHL20 has been shown to be downregulated in certain types of cancer, including glioblastoma and breast cancer. 3. **Neurological Disorders:** KLHL20 has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. **Conclusion:** In conclusion, KLHL20 is a gene that plays a critical role in regulating immune responses and cellular processes. Its involvement in various pathways, including antigen processing and presentation, apoptotic regulation, and protein binding and modification, highlights its importance in maintaining cellular homeostasis. Further research is needed to fully elucidate the mechanisms by which KLHL20 regulates immune responses and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Further Research:** Conduct in-depth studies to elucidate the mechanisms by which KLHL20 regulates immune responses and cellular processes. 2. **Therapeutic Targeting:** Investigate the potential of KLHL20 as a therapeutic target for autoimmune disorders, cancer, and neurological disorders. 3. **Cellular Modeling:** Utilize cellular models to study the effects of KLHL20 dysregulation on cellular processes and immune responses. By advancing our understanding of KLHL20, we can unlock new avenues for the treatment of various diseases and improve our comprehension of the intricate mechanisms that govern immune function and cellular regulation.

Genular Protein ID: 4062772840

Symbol: KLH20_HUMAN

Name: Kelch-like protein 20

UniProtKB Accession Codes:

Q9Y2M5 B3KMA0 B4DUR0 Q5TZF2 Q5ZF45 Q9H457

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14668487

Title: Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells.

PubMed ID: 14668487

DOI: 10.1091/mbc.e03-07-0531

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14528312

Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.

PubMed ID: 14528312

DOI: 10.1038/ncb1056

PubMed ID: 17395875

Title: The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis.

PubMed ID: 17395875

DOI: 10.1161/01.res.0000265844.56493.ac

PubMed ID: 20389280

Title: The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.

PubMed ID: 20389280

DOI: 10.1038/emboj.2010.62

PubMed ID: 21840486

Title: A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.

PubMed ID: 21840486

DOI: 10.1016/j.ccr.2011.07.008

PubMed ID: 21670212

Title: PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth.

PubMed ID: 21670212

DOI: 10.1083/jcb.201103015

PubMed ID: 24768539

Title: K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking.

PubMed ID: 24768539

DOI: 10.1016/j.molcel.2014.03.035

PubMed ID: 25619834

Title: KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.

PubMed ID: 25619834

DOI: 10.1038/onc.2014.435

Sequence Information:

  • Length: 609
  • Mass: 67955
  • Checksum: FA05E3FE8341B422
  • Sequence:
    • MEGKPMRRCT NIRPGETGMD VTSRCTLGDP NKLPEGVPQP ARMPYISDKH PRQTLEVINL 
LRKHRELCDV VLVVGAKKIY AHRVILSACS PYFRAMFTGE LAESRQTEVV IRDIDERAME 
LLIDFAYTSQ ITVEEGNVQT LLPAACLLQL AEIQEACCEF LKRQLDPSNC LGIRAFADTH 
SCRELLRIAD KFTQHNFQEV MESEEFMLLP ANQLIDIISS DELNVRSEEQ VFNAVMAWVK 
YSIQERRPQL PQVLQHVRLP LLSPKFLVGT VGSDPLIKSD EECRDLVDEA KNYLLLPQER 
PLMQGPRTRP RKPIRCGEVL FAVGGWCSGD AISSVERYDP QTNEWRMVAS MSKRRCGVGV 
SVLDDLLYAV GGHDGSSYLN SVERYDPKTN QWSSDVAPTS TCRTSVGVAV LGGFLYAVGG 
QDGVSCLNIV ERYDPKENKW TRVASMSTRR LGVAVAVLGG FLYAVGGSDG TSPLNTVERY 
NPQENRWHTI APMGTRRKHL GCAVYQDMIY AVGGRDDTTE LSSAERYNPR TNQWSPVVAM 
TSRRSGVGLA VVNGQLMAVG GFDGTTYLKT IEVFDPDANT WRLYGGMNYR RLGGGVGVIK 
MTHCESHIW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.