Details for: PCDH17

Gene ID: 27253

Symbol: PCDH17

Ensembl ID: ENSG00000118946

Description: protocadherin 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.6800
    Cell Significance Index: -41.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.2076
    Cell Significance Index: -36.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 13.5613
    Cell Significance Index: 296.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5903
    Cell Significance Index: -41.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5123
    Cell Significance Index: -18.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.7968
    Cell Significance Index: 145.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0668
    Cell Significance Index: 71.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9458
    Cell Significance Index: 654.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9450
    Cell Significance Index: 189.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8653
    Cell Significance Index: 310.3800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.5909
    Cell Significance Index: 3.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5669
    Cell Significance Index: 6.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5330
    Cell Significance Index: 3.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1505
    Cell Significance Index: 5.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1390
    Cell Significance Index: 2.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1384
    Cell Significance Index: 6.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1302
    Cell Significance Index: 8.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0189
    Cell Significance Index: -35.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0313
    Cell Significance Index: -57.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0332
    Cell Significance Index: -51.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0393
    Cell Significance Index: -24.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0418
    Cell Significance Index: -56.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0431
    Cell Significance Index: -24.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0517
    Cell Significance Index: -32.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0550
    Cell Significance Index: -40.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0569
    Cell Significance Index: -25.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0578
    Cell Significance Index: -43.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0772
    Cell Significance Index: -42.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0970
    Cell Significance Index: -44.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1035
    Cell Significance Index: -21.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1060
    Cell Significance Index: -12.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1141
    Cell Significance Index: -13.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1284
    Cell Significance Index: -36.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1365
    Cell Significance Index: -23.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1435
    Cell Significance Index: -20.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1459
    Cell Significance Index: -28.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1505
    Cell Significance Index: -27.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1527
    Cell Significance Index: -17.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1714
    Cell Significance Index: -4.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1795
    Cell Significance Index: -10.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2573
    Cell Significance Index: -32.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2650
    Cell Significance Index: -32.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2821
    Cell Significance Index: -28.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2990
    Cell Significance Index: -41.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3177
    Cell Significance Index: -41.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3469
    Cell Significance Index: -8.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4012
    Cell Significance Index: -41.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4798
    Cell Significance Index: -15.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4811
    Cell Significance Index: -6.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5081
    Cell Significance Index: -38.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5172
    Cell Significance Index: -40.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5369
    Cell Significance Index: -17.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5563
    Cell Significance Index: -41.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5765
    Cell Significance Index: -15.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5918
    Cell Significance Index: -31.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6402
    Cell Significance Index: -10.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6502
    Cell Significance Index: -16.2200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6552
    Cell Significance Index: -8.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6639
    Cell Significance Index: -18.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7520
    Cell Significance Index: -26.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8137
    Cell Significance Index: -49.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8645
    Cell Significance Index: -40.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8651
    Cell Significance Index: -44.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8953
    Cell Significance Index: -18.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9043
    Cell Significance Index: -31.6800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9197
    Cell Significance Index: -12.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9249
    Cell Significance Index: -19.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0079
    Cell Significance Index: -19.9300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0185
    Cell Significance Index: -17.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0492
    Cell Significance Index: -21.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0600
    Cell Significance Index: -49.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0710
    Cell Significance Index: -27.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1128
    Cell Significance Index: -25.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1493
    Cell Significance Index: -42.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1594
    Cell Significance Index: -25.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.2150
    Cell Significance Index: -21.4700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.2638
    Cell Significance Index: -15.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3071
    Cell Significance Index: -38.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.3222
    Cell Significance Index: -18.9400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.3338
    Cell Significance Index: -15.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.4207
    Cell Significance Index: -49.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.4268
    Cell Significance Index: -40.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.4659
    Cell Significance Index: -31.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5111
    Cell Significance Index: -40.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.5284
    Cell Significance Index: -31.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5389
    Cell Significance Index: -41.0900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.5474
    Cell Significance Index: -17.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.5782
    Cell Significance Index: -49.9200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -1.5796
    Cell Significance Index: -21.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.5848
    Cell Significance Index: -39.5200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.5919
    Cell Significance Index: -15.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.5997
    Cell Significance Index: -26.3600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.6043
    Cell Significance Index: -17.7000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.6054
    Cell Significance Index: -17.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6126
    Cell Significance Index: -43.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.6339
    Cell Significance Index: -28.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.6443
    Cell Significance Index: -17.6300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.6736
    Cell Significance Index: -32.9400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.6848
    Cell Significance Index: -42.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PCDH17 shares homology with other protocadherins, which are characterized by their ability to form homophilic cell adhesion domains. This domain is essential for the interaction between PCDH17 molecules on adjacent cells, leading to the formation of adherens junctions and the regulation of cell-cell adhesion. PCDH17 is also involved in the regulation of synaptic transmission, where it interacts with other synaptic proteins to modulate the release and uptake of neurotransmitters. **Pathways and Functions** PCDH17 is involved in several key pathways, including: 1. **Homophilic cell adhesion via plasma membrane adhesion molecules**: PCDH17 interacts with other protocadherins to form adherens junctions, which are essential for maintaining tissue structure and regulating cell migration. 2. **Regulation of synaptic transmission**: PCDH17 interacts with other synaptic proteins to modulate the release and uptake of neurotransmitters, leading to the regulation of synaptic plasticity and learning. 3. **Postsynaptic membrane assembly**: PCDH17 is involved in the formation of postsynaptic structures, including the postsynaptic density, which is essential for the regulation of synaptic transmission. 4. **Calcium ion binding**: PCDH17 has been shown to interact with calcium ions, which are essential for the regulation of synaptic transmission and the formation of synaptic structures. **Clinical Significance** PCDH17 has been implicated in several neurological disorders, including: 1. **Epilepsy**: PCDH17 has been shown to be a susceptibility gene for epilepsy, where it is involved in the regulation of synaptic transmission and the formation of seizure foci. 2. **Schizophrenia**: PCDH17 has been implicated in the pathogenesis of schizophrenia, where it is involved in the regulation of synaptic transmission and the formation of abnormal neural circuits. 3. **Autism spectrum disorder**: PCDH17 has been shown to be a susceptibility gene for autism spectrum disorder, where it is involved in the regulation of synaptic transmission and the formation of abnormal neural circuits. In conclusion, PCDH17 is a critical gene involved in cell-cell adhesion and synaptic transmission. Its dysregulation has been implicated in several neurological disorders, highlighting the importance of this gene in maintaining normal neural function. Further research is needed to elucidate the mechanisms by which PCDH17 regulates synaptic transmission and to identify potential therapeutic targets for the treatment of neurological disorders.

Genular Protein ID: 2989444799

Symbol: PCD17_HUMAN

Name: Protocadherin-17

UniProtKB Accession Codes:

O14917 A8K1R5 Q5VVW9 Q5VVX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17978184

Title: Genome-wide analyses of human perisylvian cerebral cortical patterning.

PubMed ID: 17978184

DOI: 10.1073/pnas.0706128104

Sequence Information:

  • Length: 1159
  • Mass: 126229
  • Checksum: F687502B563B4013
  • Sequence:
    • MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP AERGGGGRSK 
SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA KCQLSLEVFA NDKEICMIKV 
EIQDINDNAP SFSSDQIEMD ISENAAPGTR FPLTSAHDPD AGENGLRTYL LTRDDHGLFG 
LDVKSRGDGT KFPELVIQKA LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS 
PVFEAPSYLV ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT 
GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS IGFVSVRQGA 
LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG GGLGGPGGSV PFKLEENYDN 
FYTVVTDRPL DRETQDEYNV TIVARDGGSP PLNSTKSFAI KILDENDNPP RFTKGLYVLQ 
VHENNIPGEY LGSVLAQDPD LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF 
NFEQTKAFEF KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN 
AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP FWEDVTPVVE 
LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH HWDMSLPLIV TLSTISIILL 
AAMITIAVKC KRENKEIRTY NCRIAEYSHP QLGGGKGKKK KINKNDIMLV QSEVEERNAM 
NVMNVVSSPS LATSPMYFDY QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG 
TNASETPATR MSIIQTDNFP AEPNYMGSRQ QFVQSSSTFK DPERASLRDS GHGDSDQADS 
DQDTNKGSCC DMSVREALKM KTTSTKSQPL EQEPEECVNC TDECRVLGHS DRCWMPQFPA 
ANQAENADYR TNLFVPTVEA NVETETYETV NPTGKKTFCT FGKDKREHTI LIANVKPYLK 
AKRALSPLLQ EVPSASSSPT KACIEPCTST KGSLDGCEAK PGALAEASSQ YLPTDSQYLS 
PSKQPRDPPF MASDQMARVF ADVHSRASRD SSEMGAVLEQ LDHPNRDLGR ESVDAEEVVR 
EIDKLLQDCR GNDPVAVRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.