Details for: DIMT1

Gene ID: 27292

Symbol: DIMT1

Ensembl ID: ENSG00000086189

Description: DIM1 rRNA methyltransferase and ribosome maturation factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 144.0417
    Cell Significance Index: -22.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.0303
    Cell Significance Index: -18.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.6388
    Cell Significance Index: -24.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.1385
    Cell Significance Index: -25.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.0698
    Cell Significance Index: -21.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.7269
    Cell Significance Index: -24.5500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.0911
    Cell Significance Index: -25.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.8101
    Cell Significance Index: -24.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1766
    Cell Significance Index: -19.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3355
    Cell Significance Index: -25.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 6.0959
    Cell Significance Index: 1160.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8440
    Cell Significance Index: -12.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.0344
    Cell Significance Index: 80.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4006
    Cell Significance Index: 19.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1630
    Cell Significance Index: 69.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1389
    Cell Significance Index: 31.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0965
    Cell Significance Index: 9.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8383
    Cell Significance Index: 39.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7595
    Cell Significance Index: 46.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7293
    Cell Significance Index: 118.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6932
    Cell Significance Index: 89.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6917
    Cell Significance Index: 17.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6223
    Cell Significance Index: 17.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6073
    Cell Significance Index: 70.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5646
    Cell Significance Index: 113.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5387
    Cell Significance Index: 294.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5226
    Cell Significance Index: 27.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5004
    Cell Significance Index: 90.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4872
    Cell Significance Index: 33.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4558
    Cell Significance Index: 62.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4518
    Cell Significance Index: 55.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4340
    Cell Significance Index: 12.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4328
    Cell Significance Index: 10.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4241
    Cell Significance Index: 31.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4127
    Cell Significance Index: 11.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4037
    Cell Significance Index: 364.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3914
    Cell Significance Index: 18.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3528
    Cell Significance Index: 155.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3486
    Cell Significance Index: 3.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3476
    Cell Significance Index: 68.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3375
    Cell Significance Index: 23.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3013
    Cell Significance Index: 5.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2642
    Cell Significance Index: 94.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2444
    Cell Significance Index: 18.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2425
    Cell Significance Index: 28.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2343
    Cell Significance Index: 13.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1877
    Cell Significance Index: 12.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1543
    Cell Significance Index: 3.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1482
    Cell Significance Index: 25.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1456
    Cell Significance Index: 18.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1449
    Cell Significance Index: 14.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1026
    Cell Significance Index: 2.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0981
    Cell Significance Index: 67.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0932
    Cell Significance Index: 2.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0848
    Cell Significance Index: 2.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0715
    Cell Significance Index: 1.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0673
    Cell Significance Index: 1.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0564
    Cell Significance Index: 1.6300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0561
    Cell Significance Index: 0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0440
    Cell Significance Index: 67.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0356
    Cell Significance Index: 67.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0270
    Cell Significance Index: 49.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0116
    Cell Significance Index: 15.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0019
    Cell Significance Index: 1.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0029
    Cell Significance Index: -0.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0065
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0101
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -9.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0182
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0252
    Cell Significance Index: -3.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0294
    Cell Significance Index: -16.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0311
    Cell Significance Index: -1.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0399
    Cell Significance Index: -2.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0463
    Cell Significance Index: -0.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0469
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0488
    Cell Significance Index: -10.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0595
    Cell Significance Index: -2.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0662
    Cell Significance Index: -19.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0869
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0938
    Cell Significance Index: -10.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1442
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1620
    Cell Significance Index: -18.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1660
    Cell Significance Index: -10.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1748
    Cell Significance Index: -1.6100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1887
    Cell Significance Index: -1.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2049
    Cell Significance Index: -21.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2338
    Cell Significance Index: -4.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2732
    Cell Significance Index: -21.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2768
    Cell Significance Index: -7.4100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2784
    Cell Significance Index: -2.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2804
    Cell Significance Index: -1.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2922
    Cell Significance Index: -15.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2944
    Cell Significance Index: -14.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3325
    Cell Significance Index: -20.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3420
    Cell Significance Index: -3.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3815
    Cell Significance Index: -20.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4068
    Cell Significance Index: -6.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DIMT1 is a rRNA methyltransferase that belongs to the DIM1 family of enzymes. It is a crucial component of the ribosome biogenesis pathway, responsible for the methylation of rRNA. The gene is composed of 15 exons and 14 introns, and its expression is regulated by various cellular signals. DIMT1 is specifically expressed in cells that require high levels of protein synthesis, such as muscle cells and germ cells. The gene's expression is also influenced by the cellular environment, with changes in expression levels observed in response to different growth factors and cytokines. **Pathways and Functions** DIMT1 plays a central role in the regulation of ribosome biogenesis and function. The gene's primary function is to methylate rRNA, specifically at the adenine-1779 and adenine-1780 positions, which is essential for the proper assembly and functioning of ribosomes. This methylation event is necessary for the correct folding and assembly of rRNA into ribosomal subunits. DIMT1 also regulates the activity of other rRNA methyltransferases, such as DIM2 and DIM3, which are involved in the methylation of other rRNA modifications. DIMT1 is also involved in the regulation of other cellular processes, including cell growth, differentiation, and survival. The gene's expression is influenced by various cellular signals, including growth factors, cytokines, and hormones. DIMT1's expression is also regulated by epigenetic mechanisms, such as DNA methylation and histone modification. **Clinical Significance** DIMT1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. The gene's expression is altered in various cancer types, including prostate cancer, breast cancer, and lung cancer. DIMT1's expression is also observed in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In addition to its role in cancer, DIMT1 has been implicated in metabolic disorders, such as type 2 diabetes and obesity. The gene's expression is altered in response to changes in energy metabolism, and DIMT1's activity is required for the proper regulation of glucose and lipid metabolism. Overall, DIMT1 is a critical gene that plays a central role in the regulation of ribosome biogenesis and function. Its expression is highly regulated by various cellular signals, and its dysregulation has been implicated in various diseases. Further study of DIMT1's role in disease is necessary to fully understand its clinical significance.

Genular Protein ID: 513810993

Symbol: DIM1_HUMAN

Name: Dimethyladenosine transferase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11124703

Title: Characterization of 16 novel human genes showing high similarity to yeast sequences.

PubMed ID: 11124703

DOI: 10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25851604

Title: The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.

PubMed ID: 25851604

DOI: 10.1091/mbc.e15-02-0073

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 313
  • Mass: 35236
  • Checksum: 306B9D4A4F9494A6
  • Sequence:
  • MPKVKSGAIG RRRGRQEQRR ELKSAGGLMF NTGIGQHILK NPLIINSIID KAALRPTDVV 
    LEVGPGTGNM TVKLLEKAKK VVACELDPRL VAELHKRVQG TPVASKLQVL VGDVLKTDLP 
    FFDTCVANLP YQISSPFVFK LLLHRPFFRC AILMFQREFA LRLVAKPGDK LYCRLSINTQ 
    LLARVDHLMK VGKNNFRPPP KVESSVVRIE PKNPPPPINF QEWDGLVRIT FVRKNKTLSA 
    AFKSSAVQQL LEKNYRIHCS VHNIIIPEDF SIADKIQQIL TSTGFSDKRA RSMDIDDFIR 
    LLHGFNAEGI HFS

Genular Protein ID: 4103756890

Symbol: A0A0C4DGB1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 275
  • Mass: 30844
  • Checksum: C4DCB1D26ABB9C72
  • Sequence:
  • MPKVKSGAIG RRRGRQEQRR ELKSAGGLMF NTGIGQHILK NPLIINSIID KAALRPTDVV 
    LEVGPGTGNM TVKLLEKAKK VVACELDPRL VAELHKRVQG TPVASKLQVL VGDVLKTDLP 
    FFDTCVANLP YQISSPFVFK LLLHRPFFRC AILMFQREFA LRLVAKPGDK LYCRLSINTQ 
    LLARVDHLMK VGKNNFRPPP KVESSVVRIE PKNPPPPINF QEWDGLVRIT FVRKNKTLSA 
    AFKSSAVQQL LEKNYRIHCS VHNIVSAAVY PVKQI

Genular Protein ID: 961597528

Symbol: A8K9K8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 313
  • Mass: 35237
  • Checksum: 8068FD9C42F388D7
  • Sequence:
  • MPKVKSGAIG RRRGRQEQRR ELKSAGGLMF NTGIGQHILK NPLIINSIID KAALRPTDVV 
    LEVGPGTGNM TVKLLEKAKE VVACELDPRL VAELHKRVQG TPVASKLQVL VGDVLKTDLP 
    FFDTCVANLP YQISSPFVFK LLLHRPFFRC AILMFQREFA LRLVAKPGDK LYCRLSINTQ 
    LLARVDHLMK VGKNNFRPPP KVESSVVRIE PKNPPPPINF QEWDGLVRIT FVRKNKTLSA 
    AFKSSAVQQL LEKNYRIHCS VHNIIIPEDF SIADKIQQIL TSTGFSDKRA RSMDIDDFIR 
    LLHGFNAEGI HFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.