Details for: ANGPTL3

Gene ID: 27329

Symbol: ANGPTL3

Ensembl ID: ENSG00000132855

Description: angiopoietin like 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 18.7927
    Cell Significance Index: 316.0800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 5.7962
    Cell Significance Index: 15.2900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 4.8375
    Cell Significance Index: 50.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1959
    Cell Significance Index: 36.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.8254
    Cell Significance Index: 111.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6319
    Cell Significance Index: 35.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.4159
    Cell Significance Index: 45.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2885
    Cell Significance Index: 255.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.0054
    Cell Significance Index: 14.8400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.8603
    Cell Significance Index: 3.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5847
    Cell Significance Index: 111.2800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4367
    Cell Significance Index: 2.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2998
    Cell Significance Index: 29.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2949
    Cell Significance Index: 6.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2709
    Cell Significance Index: 244.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2342
    Cell Significance Index: 14.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2187
    Cell Significance Index: 23.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1652
    Cell Significance Index: 26.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1048
    Cell Significance Index: 7.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0963
    Cell Significance Index: 1.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0715
    Cell Significance Index: 49.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0391
    Cell Significance Index: 0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0236
    Cell Significance Index: 17.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0192
    Cell Significance Index: 1.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0184
    Cell Significance Index: 0.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0105
    Cell Significance Index: 0.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0062
    Cell Significance Index: 9.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0043
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0035
    Cell Significance Index: 4.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0046
    Cell Significance Index: -0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0050
    Cell Significance Index: -1.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0064
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0067
    Cell Significance Index: -4.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0075
    Cell Significance Index: -1.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0080
    Cell Significance Index: -0.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0083
    Cell Significance Index: -3.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0091
    Cell Significance Index: -2.6200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0118
    Cell Significance Index: -0.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0128
    Cell Significance Index: -0.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0138
    Cell Significance Index: -0.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0145
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0189
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0208
    Cell Significance Index: -3.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0244
    Cell Significance Index: -3.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0255
    Cell Significance Index: -3.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0289
    Cell Significance Index: -3.5500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0299
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0310
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0315
    Cell Significance Index: -3.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0325
    Cell Significance Index: -0.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0339
    Cell Significance Index: -1.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0352
    Cell Significance Index: -3.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0395
    Cell Significance Index: -1.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0416
    Cell Significance Index: -1.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0422
    Cell Significance Index: -1.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0454
    Cell Significance Index: -1.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0457
    Cell Significance Index: -3.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0491
    Cell Significance Index: -2.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0514
    Cell Significance Index: -3.8300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0525
    Cell Significance Index: -0.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0545
    Cell Significance Index: -1.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0561
    Cell Significance Index: -0.9200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0568
    Cell Significance Index: -0.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0583
    Cell Significance Index: -2.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0630
    Cell Significance Index: -4.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0652
    Cell Significance Index: -1.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0664
    Cell Significance Index: -1.0000
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.0666
    Cell Significance Index: -0.6300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0668
    Cell Significance Index: -0.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0679
    Cell Significance Index: -2.5700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0714
    Cell Significance Index: -1.1500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0721
    Cell Significance Index: -0.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0744
    Cell Significance Index: -4.8000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0745
    Cell Significance Index: -0.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0752
    Cell Significance Index: -3.5400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0763
    Cell Significance Index: -0.9400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0774
    Cell Significance Index: -1.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0790
    Cell Significance Index: -2.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0810
    Cell Significance Index: -4.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0820
    Cell Significance Index: -1.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0832
    Cell Significance Index: -2.0000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0834
    Cell Significance Index: -1.1700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0887
    Cell Significance Index: -1.2600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0894
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0936
    Cell Significance Index: -0.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1028
    Cell Significance Index: -3.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1036
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1059
    Cell Significance Index: -1.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1066
    Cell Significance Index: -3.4900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1070
    Cell Significance Index: -0.9900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1073
    Cell Significance Index: -1.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1102
    Cell Significance Index: -3.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Angiogenic activity**: ANGPTL3 is a potent angiogenic factor, promoting the formation of new blood vessels and regulating vascular endothelial growth factor (VEGF) signaling. 2. **Lipid metabolism regulation**: ANGPTL3 inhibits lipoprotein lipase (LPL) activity, which is essential for lipolysis and lipid metabolism. This regulation has significant implications for lipid homeostasis and atherosclerosis. 3. **Cell migration and adhesion**: ANGPTL3 influences cell migration and adhesion, particularly in the context of angiogenesis and wound healing. 4. **Hormone regulation**: ANGPTL3 is responsive to hormone signaling, including insulin and glucagon, which highlights its role in metabolic regulation. **Pathways and Functions:** 1. **Acylglycerol homeostasis**: ANGPTL3 regulates the activity of acylglycerol lipase (AGL), which is involved in the hydrolysis of triglycerides. 2. **Angiogenesis**: ANGPTL3 promotes angiogenesis by stimulating VEGF signaling and regulating endothelial cell migration and proliferation. 3. **Cell-matrix adhesion**: ANGPTL3 influences cell-matrix adhesion, which is crucial for tissue development and repair. 4. **Glycerol metabolic process**: ANGPTL3 regulates glycerol metabolism, which is essential for lipid synthesis and storage. 5. **Cholesterol homeostasis**: ANGPTL3 modulates cholesterol homeostasis by regulating the activity of LPL and other enzymes involved in cholesterol metabolism. **Clinical Significance:** 1. **Atherosclerosis**: ANGPTL3 has been implicated in the development of atherosclerosis due to its role in regulating lipid metabolism and angiogenesis. 2. **Obesity and metabolic disorders**: ANGPTL3 dysregulation has been linked to obesity and metabolic disorders, such as type 2 diabetes and dyslipidemia. 3. **Cancer**: ANGPTL3 has been identified as a potential oncogene, promoting tumor growth and angiogenesis. 4. **Neurological disorders**: ANGPTL3 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates lipid metabolism and angiogenesis. In conclusion, ANGPTL3 is a multifunctional protein that plays a critical role in regulating lipid metabolism, angiogenesis, and cell migration. Its dysregulation has been implicated in various diseases, including atherosclerosis, obesity, and cancer. Further research is necessary to fully understand the mechanisms by which ANGPTL3 regulates these processes and to explore its therapeutic potential.

Genular Protein ID: 4025367049

Symbol: ANGL3_HUMAN

Name: Angiopoietin-related protein 3

UniProtKB Accession Codes:

Q9Y5C1 A0JLS0 B1ALJ0 B2RCW1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EMBL 8 Ensembl 1 GO 34 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10644446

Title: Identification of a mammalian angiopoietin-related protein expressed specifically in liver.

PubMed ID: 10644446

DOI: 10.1006/geno.1999.6041

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11877390

Title: ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.

PubMed ID: 11877390

DOI: 10.1074/jbc.m109768200

PubMed ID: 12097324

Title: ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase.

PubMed ID: 12097324

DOI: 10.1074/jbc.m203215200

PubMed ID: 11788823

Title: Angptl3 regulates lipid metabolism in mice.

PubMed ID: 11788823

DOI: 10.1038/ng814

PubMed ID: 12565906

Title: Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes.

PubMed ID: 12565906

DOI: 10.1016/s0006-291x(02)03058-9

PubMed ID: 12909640

Title: Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.

PubMed ID: 12909640

DOI: 10.1074/jbc.m302861200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17110602

Title: Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase.

PubMed ID: 17110602

DOI: 10.1161/01.atv.0000252827.51626.89

PubMed ID: 17191020

Title: Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects.

PubMed ID: 17191020

DOI: 10.1159/000098153

PubMed ID: 18535744

Title: Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin alphaVbeta3.

PubMed ID: 18535744

DOI: 10.1111/j.1745-7270.2008.00421.x

PubMed ID: 19028676

Title: The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms.

PubMed ID: 19028676

DOI: 10.1074/jbc.m808477200

PubMed ID: 19318355

Title: Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

PubMed ID: 19318355

DOI: 10.1074/jbc.m807899200

PubMed ID: 19542565

Title: GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4.

PubMed ID: 19542565

DOI: 10.1194/jlr.m900145-jlr200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20581395

Title: Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases.

PubMed ID: 20581395

DOI: 10.1074/jbc.m110.144279

PubMed ID: 20837471

Title: O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids.

PubMed ID: 20837471

DOI: 10.1074/jbc.m110.156950

PubMed ID: 20942659

Title: Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.

PubMed ID: 20942659

DOI: 10.1056/nejmoa1002926

PubMed ID: 22566642

Title: Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells.

PubMed ID: 22566642

DOI: 10.1073/pnas.1203563109

PubMed ID: 23150577

Title: Atypical angiopoietin-like protein that regulates ANGPTL3.

PubMed ID: 23150577

DOI: 10.1073/pnas.1217552109

PubMed ID: 23661675

Title: Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids.

PubMed ID: 23661675

DOI: 10.1161/atvbaha.113.301397

PubMed ID: 25495645

Title: Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation.

PubMed ID: 25495645

DOI: 10.1042/bsr20140115

PubMed ID: 26204133

Title: Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.

PubMed ID: 26204133

DOI: 10.1210/jc.2015-1254

PubMed ID: 29713054

Title: Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.

PubMed ID: 29713054

DOI: 10.1038/s41598-018-25237-7

PubMed ID: 22095935

Title: Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels.

PubMed ID: 22095935

DOI: 10.1002/humu.21660

PubMed ID: 19075393

Title: Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

PubMed ID: 19075393

DOI: 10.1172/jci37118

PubMed ID: 25733326

Title: Clinical and genetic analysis of a family diagnosed with familial hypobetalipoproteinemia in which the proband was diagnosed with diabetes mellitus.

PubMed ID: 25733326

DOI: 10.1016/j.atherosclerosis.2015.02.031

PubMed ID: 25710887

Title: A novel role of angiopoietin-like-3 associated with podocyte injury.

PubMed ID: 25710887

DOI: 10.1038/pr.2015.38

Sequence Information:

  • Length: 460
  • Mass: 53637
  • Checksum: 6279465FEEB91F56
  • Sequence:
    • MFTIKLLLFI VPLVISSRID QDNSSFDSLS PEPKSRFAML DDVKILANGL LQLGHGLKDF 
VHKTKGQIND IFQKLNIFDQ SFYDLSLQTS EIKEEEKELR RTTYKLQVKN EEVKNMSLEL 
NSKLESLLEE KILLQQKVKY LEEQLTNLIQ NQPETPEHPE VTSLKTFVEK QDNSIKDLLQ 
TVEDQYKQLN QQHSQIKEIE NQLRRTSIQE PTEISLSSKP RAPRTTPFLQ LNEIRNVKHD 
GIPAECTTIY NRGEHTSGMY AIRPSNSQVF HVYCDVISGS PWTLIQHRID GSQNFNETWE 
NYKYGFGRLD GEFWLGLEKI YSIVKQSNYV LRIELEDWKD NKHYIEYSFY LGNHETNYTL 
HLVAITGNVP NAIPENKDLV FSTWDHKAKG HFNCPEGYSG GWWWHDECGE NNLNGKYNKP 
RAKSKPERRR GLSWKSQNGR LYSIKSTKML IHPTDSESFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.