Details for: GOLIM4

Gene ID: 27333

Symbol: GOLIM4

Ensembl ID: ENSG00000173905

Description: golgi integral membrane protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 341.6048
    Cell Significance Index: -53.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.8134
    Cell Significance Index: -50.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.3985
    Cell Significance Index: -57.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 119.9241
    Cell Significance Index: -48.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.8317
    Cell Significance Index: -57.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.2756
    Cell Significance Index: -48.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.3017
    Cell Significance Index: -55.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.0019
    Cell Significance Index: -58.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.2763
    Cell Significance Index: -56.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.2156
    Cell Significance Index: -26.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.4216
    Cell Significance Index: 51.2700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.1807
    Cell Significance Index: 51.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4171
    Cell Significance Index: 109.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1334
    Cell Significance Index: 46.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8732
    Cell Significance Index: 53.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.7846
    Cell Significance Index: 44.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5592
    Cell Significance Index: 309.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5068
    Cell Significance Index: 193.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3646
    Cell Significance Index: 104.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3404
    Cell Significance Index: 29.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2314
    Cell Significance Index: 69.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1838
    Cell Significance Index: 192.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1075
    Cell Significance Index: 129.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9146
    Cell Significance Index: 17.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7738
    Cell Significance Index: 76.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6886
    Cell Significance Index: 304.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6789
    Cell Significance Index: 23.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6137
    Cell Significance Index: 84.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5554
    Cell Significance Index: 9.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5412
    Cell Significance Index: 34.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5219
    Cell Significance Index: 27.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5207
    Cell Significance Index: 18.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3963
    Cell Significance Index: 71.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3713
    Cell Significance Index: 9.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3221
    Cell Significance Index: 61.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2929
    Cell Significance Index: 186.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2594
    Cell Significance Index: 3.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2420
    Cell Significance Index: 15.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2247
    Cell Significance Index: 45.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2074
    Cell Significance Index: 25.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1661
    Cell Significance Index: 8.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1411
    Cell Significance Index: 3.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1259
    Cell Significance Index: 8.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1017
    Cell Significance Index: 1.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0841
    Cell Significance Index: 1.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0590
    Cell Significance Index: 111.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0578
    Cell Significance Index: 52.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0573
    Cell Significance Index: 77.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0553
    Cell Significance Index: 38.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0529
    Cell Significance Index: 0.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0487
    Cell Significance Index: 2.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0410
    Cell Significance Index: 18.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0383
    Cell Significance Index: 58.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0167
    Cell Significance Index: 9.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0136
    Cell Significance Index: 0.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0117
    Cell Significance Index: 8.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0062
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0529
    Cell Significance Index: -0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0557
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0757
    Cell Significance Index: -56.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1012
    Cell Significance Index: -57.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1034
    Cell Significance Index: -37.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1058
    Cell Significance Index: -66.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1556
    Cell Significance Index: -44.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2013
    Cell Significance Index: -34.3800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2092
    Cell Significance Index: -2.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2358
    Cell Significance Index: -16.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3141
    Cell Significance Index: -66.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3623
    Cell Significance Index: -42.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3790
    Cell Significance Index: -48.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4427
    Cell Significance Index: -50.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4664
    Cell Significance Index: -48.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4856
    Cell Significance Index: -13.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5098
    Cell Significance Index: -4.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5278
    Cell Significance Index: -27.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5876
    Cell Significance Index: -3.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5973
    Cell Significance Index: -19.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6141
    Cell Significance Index: -45.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6288
    Cell Significance Index: -49.8000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.6291
    Cell Significance Index: -4.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6526
    Cell Significance Index: -30.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7114
    Cell Significance Index: -10.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7329
    Cell Significance Index: -19.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7413
    Cell Significance Index: -18.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7775
    Cell Significance Index: -16.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8105
    Cell Significance Index: -49.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8325
    Cell Significance Index: -43.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8875
    Cell Significance Index: -59.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9120
    Cell Significance Index: -24.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0064
    Cell Significance Index: -24.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0705
    Cell Significance Index: -22.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0863
    Cell Significance Index: -23.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0864
    Cell Significance Index: -32.0000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1029
    Cell Significance Index: -19.0700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.1390
    Cell Significance Index: -18.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.1709
    Cell Significance Index: -16.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2910
    Cell Significance Index: -31.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Golgi Integral Membrane Protein**: GOLIM4 is a transmembrane protein localized to the Golgi apparatus, a complex organelle involved in protein modification, sorting, and packaging. 2. **Widespread Expression**: GOLIM4 is expressed in multiple cell types, including astrocytes, Purkinje cells, enterocytes, and immune cells, such as decidual natural killer cells. 3. **Structural Homology**: GOLIM4 shares structural similarities with other Golgi integral membrane proteins, suggesting a conserved evolutionary function. 4. **Regulation of Vesicle-Mediated Transport**: GOLIM4 is involved in the regulation of vesicle-mediated transport, which is essential for maintaining cellular homeostasis and regulating cellular processes. **Pathways and Functions:** GOLIM4 is implicated in various cellular processes, including: 1. **Intra-Golgi and Retrograde Golgi-to-Er Trafficking**: GOLIM4 regulates the transport of proteins and lipids within the Golgi apparatus and between the Golgi apparatus and the endoplasmic reticulum. 2. **Membrane Trafficking**: GOLIM4 is involved in the regulation of membrane trafficking, including endocytic vesicle and exocytic vesicle formation and fusion. 3. **Synaptic Plasticity**: GOLIM4 is expressed in neurons and plays a role in regulating synaptic plasticity, a process essential for learning and memory. 4. **Cell Signaling**: GOLIM4 is involved in cell signaling pathways, including the regulation of immune responses and inflammation. 5. **Vesicle-Mediated Transport**: GOLIM4 regulates the transport of proteins and lipids within vesicles, which is essential for maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of GOLIM4 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: Mutations in the GOLI4 gene have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: GOLIM4 is overexpressed in certain types of cancer, including breast cancer and lung cancer. 3. **Immune Disorders**: GOLIM4 is involved in immune responses and inflammation, making it a potential target for the treatment of autoimmune diseases. 4. **Neurodevelopmental Disorders**: GOLIM4 is expressed in the developing brain and is involved in the regulation of synaptic plasticity, making it a potential target for the treatment of neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, GOLIM4 is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes, including synaptic plasticity, cell signaling, and immune responses. Further studies are needed to fully elucidate the functional significance of GOLIM4 and its implications for human disease.

Genular Protein ID: 2103103413

Symbol: GOLI4_HUMAN

Name: Golgi integral membrane protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9201717

Title: Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein.

PubMed ID: 9201717

DOI: 10.1091/mbc.8.6.1073

PubMed ID: 11598199

Title: Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein.

PubMed ID: 11598199

DOI: 10.1091/mbc.12.10.3152

PubMed ID: 15331763

Title: A cycling cis-Golgi protein mediates endosome-to-Golgi traffic.

PubMed ID: 15331763

DOI: 10.1091/mbc.e04-05-0366

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 696
  • Mass: 81880
  • Checksum: A3BA9AE3D52F7174
  • Sequence:
  • MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY QQHQESLSAQ 
    LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL NKGRQDSNSR YSALNVQHQM 
    LKSQHEELKK QHSDLEEEHR KQGEDFSRTF NDHKQKYLQL QQEKEQELSK LKETVYNLRE 
    ENRQLRKAHQ DIHTQLQDVK QQHKNLLSEH EQLVVTLEDH KSALAAAQTQ VAEYKQLKDT 
    LNRIPSLRKP DPAEQQNVTQ VAHSPQGYNT AREKPTREVQ EVSRNNDVWQ NHEAVPGRAE 
    DTKLYAPTHK EAEFQAPPEP IQQEVERREP EEHQVEEEHR KALEEEEMEQ VGQAEHLEEE 
    HDPSPEEQDR EWKEQHEQRE AANLLEGHAR AEVYPSAKPM IKFQSPYEEQ LEQQRLAVQQ 
    VEEAQQLREH QEALHQQRLQ GHLLRQQEQQ QQQVAREMAL QRQAELEEGR PQHQEQLRQQ 
    AHYDAMDNDI VQGAEDQGIQ GEEGAYERDN QHQDEAEGDP GNRHEPREQG PREADPESEA 
    DRAAVEDINP ADDPNNQGED EFEEAEQVRE ENLPDENEEQ KQSNQKQENT EVEEHLVMAG 
    NPDQQEDNVD EQYQEEAEEE VQEDLTEEKK RELEHNAEET YGENDENTDD KNNDGEEQEV 
    RDDNRPKGRE EHYEEEEEEE EDGAAVAEKS HRRAEM

Genular Protein ID: 3970975899

Symbol: F8W785_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 668
  • Mass: 78760
  • Checksum: C9F96F2C4750AE31
  • Sequence:
  • MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY QQHQESLSAQ 
    LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL NKGRQDSNSR YSALNVQHQM 
    LKSQHEELKK QHSDLEEEHR KQGEDFSRTF NDHKQKYLQL QQEKEQELSK LKETVYNLRE 
    ENRQLRKAHQ DIHTQLQDVK TQVAEYKQLK DTLNRIPSLR KPDPAEQQNV TQVAHSPQGY 
    NTAREKPTRE VQEVSRNNDV WQNHEAVPGR AEDTKLYAPT HKEAEFQAPP EPIQQEVERR 
    EPEEHQVEEE HRKALEEEEM EQVGQAEHLE EEHDPSPEEQ DREWKEQHEQ REAANLLEGH 
    ARAEVYPSAK PMIKFQSPYE EQLEQQRLAV QQVEEAQQLR EHQEALHQQR LQGHLLRQQE 
    QQQQQVAREM ALQRQAELEE GRPQHQEQLR QQAHYDAMDN DIVQGAEDQG IQGEEGAYER 
    DNQHQDEAEG DPGNRHEPRE QGPREADPES EADRAAVEDI NPADDPNNQG EDEFEEAEQV 
    REENLPDENE EQKQSNQKQE NTEVEEHLVM AGNPDQQEDN VDEQYQEEAE EEVQEDLTEE 
    KKRELEHNAE ETYGENDENT DDKNNDGEEQ EVRDDNRPKG REEHYEEEEE EEEDGAAVAE 
    KSHRRAEM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.