Details for: HTRA2

Gene ID: 27429

Symbol: HTRA2

Ensembl ID: ENSG00000115317

Description: HtrA serine peptidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.5932
    Cell Significance Index: -16.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 56.5849
    Cell Significance Index: -23.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.6783
    Cell Significance Index: -22.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.9653
    Cell Significance Index: -19.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.0417
    Cell Significance Index: -22.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.0473
    Cell Significance Index: -19.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.5504
    Cell Significance Index: -17.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.1444
    Cell Significance Index: -16.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5651
    Cell Significance Index: -21.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5548
    Cell Significance Index: -13.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4765
    Cell Significance Index: -5.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2941
    Cell Significance Index: 10.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0282
    Cell Significance Index: 928.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0227
    Cell Significance Index: 61.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9422
    Cell Significance Index: 102.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7909
    Cell Significance Index: 128.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6548
    Cell Significance Index: 42.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6220
    Cell Significance Index: 72.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5512
    Cell Significance Index: 65.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5128
    Cell Significance Index: 15.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4784
    Cell Significance Index: 33.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4706
    Cell Significance Index: 64.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4488
    Cell Significance Index: 7.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3467
    Cell Significance Index: 44.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3394
    Cell Significance Index: 17.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3371
    Cell Significance Index: 3.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2826
    Cell Significance Index: 13.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2823
    Cell Significance Index: 154.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2738
    Cell Significance Index: 7.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2647
    Cell Significance Index: 13.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2632
    Cell Significance Index: 12.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2377
    Cell Significance Index: 6.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2321
    Cell Significance Index: 14.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2222
    Cell Significance Index: 21.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2076
    Cell Significance Index: 10.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1804
    Cell Significance Index: 23.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1789
    Cell Significance Index: 79.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1674
    Cell Significance Index: 1.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1647
    Cell Significance Index: 4.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1644
    Cell Significance Index: 12.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1530
    Cell Significance Index: 2.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1465
    Cell Significance Index: 29.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1438
    Cell Significance Index: 3.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1322
    Cell Significance Index: 23.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1245
    Cell Significance Index: 3.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1131
    Cell Significance Index: 8.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1123
    Cell Significance Index: 22.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1044
    Cell Significance Index: 12.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0964
    Cell Significance Index: 3.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0928
    Cell Significance Index: 2.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0898
    Cell Significance Index: 17.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0799
    Cell Significance Index: 3.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0770
    Cell Significance Index: 53.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0666
    Cell Significance Index: 1.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0493
    Cell Significance Index: 17.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0464
    Cell Significance Index: 1.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0119
    Cell Significance Index: -21.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0146
    Cell Significance Index: -22.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0157
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0189
    Cell Significance Index: -1.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0265
    Cell Significance Index: -16.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0305
    Cell Significance Index: -22.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0326
    Cell Significance Index: -0.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0362
    Cell Significance Index: -20.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0418
    Cell Significance Index: -26.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0431
    Cell Significance Index: -19.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0437
    Cell Significance Index: -1.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0564
    Cell Significance Index: -0.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0568
    Cell Significance Index: -16.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0593
    Cell Significance Index: -10.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0668
    Cell Significance Index: -1.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0782
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1104
    Cell Significance Index: -12.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1167
    Cell Significance Index: -16.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1171
    Cell Significance Index: -7.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1235
    Cell Significance Index: -26.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1472
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2086
    Cell Significance Index: -21.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2239
    Cell Significance Index: -17.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2307
    Cell Significance Index: -17.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2420
    Cell Significance Index: -14.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2643
    Cell Significance Index: -17.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2814
    Cell Significance Index: -15.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3892
    Cell Significance Index: -4.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4090
    Cell Significance Index: -9.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4105
    Cell Significance Index: -2.4800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4324
    Cell Significance Index: -2.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4533
    Cell Significance Index: -20.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4832
    Cell Significance Index: -12.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4928
    Cell Significance Index: -18.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4984
    Cell Significance Index: -14.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5033
    Cell Significance Index: -17.6300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.5203
    Cell Significance Index: -5.8900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5236
    Cell Significance Index: -7.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine protease activity**: HTRA2 exhibits serine protease activity, which is essential for its role in protein degradation and apoptosis. 2. **Mitochondrial localization**: HTRA2 is primarily localized to the mitochondrial intermembrane space, where it is involved in mitochondrial protein degradation and regulation of mitochondrial function. 3. **Apoptosis regulation**: HTRA2 is involved in the regulation of apoptosis, both as an initiator and an executor of the apoptotic pathway, depending on the cellular context. 4. **Cell cycle regulation**: HTRA2 can regulate the cell cycle, particularly in the negative regulation of cell cycle progression. 5. **Interactions with other proteins**: HTRA2 interacts with various proteins, including other HtrA family members, caspases, and mitochondrial proteins, to regulate cellular processes. **Pathways and Functions:** 1. **Intrinsic apoptotic signaling pathway**: HTRA2 is involved in the intrinsic apoptotic signaling pathway, regulating the activation of caspases and the execution of cell death. 2. **Mitochondrial protein degradation**: HTRA2 is responsible for the degradation of mitochondrial proteins, which is essential for maintaining mitochondrial function and preventing mitochondrial dysfunction. 3. **Protein quality control**: HTRA2 is involved in protein quality control, regulating the degradation of misfolded or damaged proteins. 4. **Regulation of the cell cycle**: HTRA2 can regulate the cell cycle, particularly in the negative regulation of cell cycle progression. 5. **Regulation of oxidative stress**: HTRA2 can regulate oxidative stress, particularly in the context of mitochondrial function and protein degradation. **Clinical Significance:** 1. **Cancer**: HTRA2 has been implicated in various types of cancer, including breast, ovarian, and lung cancer, where it is involved in the regulation of apoptosis and protein degradation. 2. **Neurodegenerative diseases**: HTRA2 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of mitochondrial function and protein degradation. 3. **Cardiovascular disease**: HTRA2 has been implicated in cardiovascular disease, particularly in the context of atherosclerosis and cardiac hypertrophy, where it is involved in the regulation of protein degradation and apoptosis. 4. **Immunological disorders**: HTRA2 has been implicated in immunological disorders, including autoimmune diseases and immunodeficiency disorders, where it is involved in the regulation of immune cell function and apoptosis. In conclusion, HTRA2 is a multifunctional enzyme that plays a critical role in various cellular processes, including apoptosis, protein degradation, and regulation of the cell cycle. Its implications in various diseases highlight the need for further research into the molecular mechanisms underlying its functions and the potential therapeutic applications of HTRA2 as a target for disease intervention.

Genular Protein ID: 3401154890

Symbol: HTRA2_HUMAN

Name: Serine protease HTRA2, mitochondrial

UniProtKB Accession Codes:

O43464 Q9HBZ4 Q9P0Y3 Q9P0Y4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EC 2 ELM 1 EMBL 7 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10644717

Title: Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia.

PubMed ID: 10644717

DOI: 10.1074/jbc.275.4.2581

PubMed ID: 10971580

Title: Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

PubMed ID: 10971580

DOI: 10.1046/j.1432-1327.2000.01589.x

PubMed ID: 10995577

Title: Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif.

PubMed ID: 10995577

DOI: 10.1006/geno.2000.6263

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11583623

Title: A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.

PubMed ID: 11583623

DOI: 10.1016/s1097-2765(01)00341-0

PubMed ID: 10873535

Title: Expression, purification, and functional analysis of the human serine protease HtrA2.

PubMed ID: 10873535

DOI: 10.1006/prep.2000.1240

PubMed ID: 15200957

Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

PubMed ID: 15200957

DOI: 10.1016/j.molcel.2004.05.018

PubMed ID: 19502560

Title: THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

PubMed ID: 19502560

DOI: 10.1152/ajpheart.00234.2009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23479728

Title: Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.

PubMed ID: 23479728

DOI: 10.1074/jbc.m112.436113

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11967569

Title: Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.

PubMed ID: 11967569

DOI: 10.1038/nsb795

PubMed ID: 15961413

Title: Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

PubMed ID: 15961413

DOI: 10.1093/hmg/ddi215

PubMed ID: 18401856

Title: Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease.

PubMed ID: 18401856

DOI: 10.1002/humu.20713

PubMed ID: 18364387

Title: Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.

PubMed ID: 18364387

DOI: 10.1093/hmg/ddn096

PubMed ID: 25422467

Title: Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.

PubMed ID: 25422467

DOI: 10.1073/pnas.1419581111

PubMed ID: 27208207

Title: Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.

PubMed ID: 27208207

DOI: 10.1136/jmedgenet-2016-103922

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

PubMed ID: 27696117

Title: Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.

PubMed ID: 27696117

DOI: 10.1007/s10545-016-9977-2

Sequence Information:

  • Length: 458
  • Mass: 48841
  • Checksum: CEA955A7D0DD8C0D
  • Sequence:
    • MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR 
LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSRAWLAVA LGAGGAVLLL 
LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI ADVVEKTAPA VVYIEILDRH PFLGREVPIS 
NGSGFVVAAD GLIVTNAHVV ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL 
PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA 
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS SSGISGSQRR 
YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEQM 
VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL YVTPEVTE

Genular Protein ID: 1776977817

Symbol: A0A8Q3SIX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SIX7

Database IDs:

ARBA 1 CDD 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 426
  • Mass: 45357
  • Checksum: D4C33802B44BC453
  • Sequence:
    • MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR 
LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSRAWLAVA LGAGGAVLLL 
LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI ADVVEKTAPA VVYIEILDRH PFLGREVPIS 
NGSGFVVAAD GLIVTNAHVV ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL 
PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA 
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS SSGISGSQRR 
YIGVMMLTLS PRAGLRPGDV ILAIGEQMVQ NAEDVYEAVR TQSQLAVQIR RGRETLTLYV 
TPEVTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.