Details for: GNAO1

Gene ID: 2775

Symbol: GNAO1

Ensembl ID: ENSG00000087258

Description: G protein subunit alpha o1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 337.9724
    Cell Significance Index: -52.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 208.5211
    Cell Significance Index: -52.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.1152
    Cell Significance Index: -52.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.6374
    Cell Significance Index: -52.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.4033
    Cell Significance Index: -52.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.2819
    Cell Significance Index: -11.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.8204
    Cell Significance Index: 37.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.8720
    Cell Significance Index: 171.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3248
    Cell Significance Index: 125.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.9932
    Cell Significance Index: 1073.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.9838
    Cell Significance Index: 71.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.7508
    Cell Significance Index: 78.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6857
    Cell Significance Index: 538.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.5009
    Cell Significance Index: 54.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2985
    Cell Significance Index: 141.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5571
    Cell Significance Index: 1076.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.5022
    Cell Significance Index: 101.0100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.1604
    Cell Significance Index: 15.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8251
    Cell Significance Index: 43.3200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.7029
    Cell Significance Index: 8.5200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.6644
    Cell Significance Index: 9.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5328
    Cell Significance Index: 481.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5027
    Cell Significance Index: 8.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3749
    Cell Significance Index: 37.0900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2921
    Cell Significance Index: 3.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1444
    Cell Significance Index: 23.4800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0632
    Cell Significance Index: 0.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0617
    Cell Significance Index: 11.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0464
    Cell Significance Index: 3.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0034
    Cell Significance Index: -0.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0096
    Cell Significance Index: -5.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0193
    Cell Significance Index: -36.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0295
    Cell Significance Index: -54.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0305
    Cell Significance Index: -0.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0357
    Cell Significance Index: -55.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0415
    Cell Significance Index: -56.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0560
    Cell Significance Index: -31.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0587
    Cell Significance Index: -6.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0619
    Cell Significance Index: -45.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0660
    Cell Significance Index: -41.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0824
    Cell Significance Index: -62.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0860
    Cell Significance Index: -39.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0902
    Cell Significance Index: -49.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1007
    Cell Significance Index: -21.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1138
    Cell Significance Index: -50.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1371
    Cell Significance Index: -2.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1486
    Cell Significance Index: -6.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1496
    Cell Significance Index: -43.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2013
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2109
    Cell Significance Index: -36.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2166
    Cell Significance Index: -39.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2339
    Cell Significance Index: -34.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2504
    Cell Significance Index: -49.7000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2707
    Cell Significance Index: -2.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2737
    Cell Significance Index: -37.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2792
    Cell Significance Index: -19.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2949
    Cell Significance Index: -5.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3202
    Cell Significance Index: -39.3700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3583
    Cell Significance Index: -4.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3642
    Cell Significance Index: -7.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3708
    Cell Significance Index: -11.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3912
    Cell Significance Index: -50.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4059
    Cell Significance Index: -13.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4335
    Cell Significance Index: -51.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4473
    Cell Significance Index: -12.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4539
    Cell Significance Index: -58.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4660
    Cell Significance Index: -47.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4661
    Cell Significance Index: -6.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4771
    Cell Significance Index: -28.6400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5117
    Cell Significance Index: -5.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5120
    Cell Significance Index: -59.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5157
    Cell Significance Index: -58.8700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5266
    Cell Significance Index: -5.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5296
    Cell Significance Index: -11.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5299
    Cell Significance Index: -55.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5518
    Cell Significance Index: -63.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5553
    Cell Significance Index: -17.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6054
    Cell Significance Index: -7.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6183
    Cell Significance Index: -38.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6448
    Cell Significance Index: -48.0600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6817
    Cell Significance Index: -8.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7216
    Cell Significance Index: -6.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7503
    Cell Significance Index: -39.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7526
    Cell Significance Index: -42.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7535
    Cell Significance Index: -16.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7894
    Cell Significance Index: -50.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7922
    Cell Significance Index: -19.7600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8034
    Cell Significance Index: -10.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8384
    Cell Significance Index: -29.3700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.9251
    Cell Significance Index: -10.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.9358
    Cell Significance Index: -10.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.0080
    Cell Significance Index: -47.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.0294
    Cell Significance Index: -21.4900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.1878
    Cell Significance Index: -51.6500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.1973
    Cell Significance Index: -8.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.2001
    Cell Significance Index: -14.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.2405
    Cell Significance Index: -57.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GNAO1 is a member of the G protein subunit alpha family, which consists of four subunits (α, β, γ, and δ). The α subunit, in particular, is responsible for binding to G-protein coupled receptors (GPCRs) and modulating downstream signaling pathways. GNAO1 is characterized by its ability to interact with a wide range of GPCRs, including those involved in dopamine, serotonin, and opioid receptor signaling. This versatility in GPCR interaction underscores the gene's role in regulating complex signaling networks that underpin various physiological processes. **Pathways and Functions:** GNAO1 is involved in multiple signaling pathways, including: 1. **Adenylate cyclase-modulating G protein-coupled receptor signaling pathway**: GNAO1 modulates adenylate cyclase activity, influencing cAMP levels and downstream signaling pathways that regulate cellular responses to GPCR activation. 2. **Beta-catenin independent Wnt signaling**: GNAO1 interacts with Wnt signaling components, modulating the activity of Wnt/β-catenin transcriptional pathways, which are critical for development, cell proliferation, and differentiation. 3. **Ca2+ pathway**: GNAO1 regulates calcium-dependent signaling pathways, influencing the activity of calcium channels and pumps, which are essential for neuronal function and immune responses. 4. **Corticotropin-releasing hormone receptor 1 binding**: GNAO1 interacts with corticotropin-releasing hormone receptors, modulating the activity of the hypothalamic-pituitary-adrenal (HPA) axis, which regulates stress responses and immune function. **Clinical Significance:** Dysregulation of GNAO1 has been implicated in various neurological and psychiatric disorders, including: 1. **Schizophrenia**: Studies have shown that GNAO1 variants are associated with schizophrenia, suggesting a link between GNAO1 dysfunction and the development of this disorder. 2. **Bipolar disorder**: GNAO1 variants have also been linked to bipolar disorder, highlighting the gene's potential role in regulating mood regulation and emotional responses. 3. **Neurodevelopmental disorders**: GNAO1 is expressed in developing neurons and has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD). In conclusion, GNAO1 is a critical G protein subunit alpha that plays a pivotal role in regulating complex signaling networks that underpin various physiological processes, including immune responses and neurological functions. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the need for further research into the gene's function and its potential therapeutic applications.

Genular Protein ID: 3966438567

Symbol: GNAO_HUMAN

Name: Guanine nucleotide-binding protein G(o) subunit alpha

UniProtKB Accession Codes:

P09471 P29777 Q8TD72 Q9UMV4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 19 EMDB 42 Ensembl 3 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1901650

Title: Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.

PubMed ID: 1901650

DOI: 10.1073/pnas.88.8.2974

PubMed ID: 3124840

Title: Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha.

PubMed ID: 3124840

DOI: 10.1016/0006-291x(88)90463-9

PubMed ID: 10330115

Title: Identification and expression of GO1 and 2 alpha-subunit transcripts in human myometrium in relation to pregnancy.

PubMed ID: 10330115

DOI: 10.1095/biolreprod60.6.1528

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 29925951

Title: Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.

PubMed ID: 29925951

DOI: 10.1038/s41586-018-0241-9

PubMed ID: 23993195

Title: De Novo mutations in GNAO1, encoding a Galphao subunit of heterotrimeric G proteins, cause epileptic encephalopathy.

PubMed ID: 23993195

DOI: 10.1016/j.ajhg.2013.07.014

PubMed ID: 26485252

Title: Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy.

PubMed ID: 26485252

DOI: 10.1016/j.cca.2015.10.011

PubMed ID: 26060304

Title: Progressive movement disorder in brothers carrying a GNAO1 mutation responsive to deep brain stimulation.

PubMed ID: 26060304

DOI: 10.1177/0883073815587945

PubMed ID: 27625011

Title: Recurrent GNAO1 mutations associated with developmental delay and a movement disorder.

PubMed ID: 27625011

DOI: 10.1177/0883073816666474

PubMed ID: 27068059

Title: Clinical course of six children with GNAO1 mutations causing a severe and distinctive movement disorder.

PubMed ID: 27068059

DOI: 10.1016/j.pediatrneurol.2016.02.018

PubMed ID: 27476654

Title: De novo mutations in SLC1A2 and CACNA1A are important causes of epileptic encephalopathies.

PubMed ID: 27476654

DOI: 10.1016/j.ajhg.2016.06.003

PubMed ID: 25966631

Title: Phenotypic spectrum of GNAO1 variants: epileptic encephalopathy to involuntary movements with severe developmental delay.

PubMed ID: 25966631

DOI: 10.1038/ejhg.2015.92

PubMed ID: 27864847

Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.

PubMed ID: 27864847

DOI: 10.1002/humu.23149

PubMed ID: 28357411

Title: GNAO1 encephalopathy: Broadening the phenotype and evaluating treatment and outcome.

PubMed ID: 28357411

DOI: 10.1212/nxg.0000000000000143

PubMed ID: 29390993

Title: Efficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing.

PubMed ID: 29390993

DOI: 10.1186/s12920-018-0320-7

PubMed ID: 34685729

Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.

PubMed ID: 34685729

DOI: 10.3390/cells10102749

Sequence Information:

  • Length: 354
  • Mass: 40051
  • Checksum: 4F182926A8106E3E
  • Sequence:
    • MGCTLSAEER AALERSKAIE KNLKEDGISA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG 
FSGEDVKQYK PVVYSNTIQS LAAIVRAMDT LGIEYGDKER KADAKMVCDV VSRMEDTEPF 
SAELLSAMMR LWGDSGIQEC FNRSREYQLN DSAKYYLDSL DRIGAADYQP TEQDILRTRV 
KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET 
TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFGEKIK KSPLTICFPE YTGPNTYEDA 
AAYIQAQFES KNRSPNKEIY CHMTCATDTN NIQVVFDAVT DIIIANNLRG CGLY

Genular Protein ID: 1535747937

Symbol: B3KP89_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KP89

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 2 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 354
  • Mass: 39934
  • Checksum: E1FA9988B5AF33EE
  • Sequence:
    • MGCTLSAEER AALERSKAIE KNLKEDGISA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG 
FSGEDVKQYK PVVYSNTIQS LAAIVRAMDT LGIEYGDKER KADAKMVCDV VSRMEDTEPF 
SAELLSAMMR LWGGSGIQEC FNRSREYQLN GSAKYYLDSL DRIGAADYQP TEQDILRTRV 
KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET 
TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFGEKIK KSPLTICFPE YTGPNTYEDA 
AAYIQAQFES KNRSPNKEIY CHMTCATDTN NIQVVFDAVT DIIIANNLRG CGLY

Genular Protein ID: 3597215471

Symbol: Q8N6I9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N6I9

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 302
  • Mass: 34609
  • Checksum: B6902F0B0AA8DE09
  • Sequence:
    • MKIIHEDGFS GEDVKQYKPV VYSNTIQSLA AIVRAMDTLG IEYGDKERKA DAKMVCDVVS 
RMEDTEPFSA ELLSAMMRLW GDSGIQECFN RSREYQLNDS AKYYLDSLDR IGAADYQPTE 
QDILRTRVKT TGIVETHFTF KNLHFRLFDV GGQRSERKKW IHCFEDVTAI IFCVALSGYD 
QVLHEDETTN RMHESLMLFD SICNNKFFID TSIILFLNKK DLFGEKIKKS PLTICFPEYT 
GPNTYEDAAA YIQAQFESKN RSPNKEIYCH MTCATDTNNI QVVFDAVTDI IIANNLRGCG 
LY

Genular Protein ID: 2895488985

Symbol: Q6AWC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6AWC5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 IntAct 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 113
  • Mass: 12951
  • Checksum: D471775FFC6B29F8
  • Sequence:
    • NRMHESLKLF DSICNNKWFT DTSIILFLNK KDIFEEKIKK SPLTICFPEY TGPSAFTEAV 
AYIQAQYESK NKSAHKEIYT HVTCATDTNN IQFVFDAVTD VIIAKNLRGC GLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.