Details for: GNAO1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 337.9724
Cell Significance Index: -52.5700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 208.5211
Cell Significance Index: -52.8900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 111.1152
Cell Significance Index: -52.4600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 42.6374
Cell Significance Index: -52.5700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.4033
Cell Significance Index: -52.8900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.2819
Cell Significance Index: -11.5600 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 4.8204
Cell Significance Index: 37.1600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.8720
Cell Significance Index: 171.2700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.3248
Cell Significance Index: 125.9000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.9932
Cell Significance Index: 1073.6000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.9838
Cell Significance Index: 71.5600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.7508
Cell Significance Index: 78.5000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6857
Cell Significance Index: 538.7500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.5009
Cell Significance Index: 54.7600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.2985
Cell Significance Index: 141.2800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.5571
Cell Significance Index: 1076.9600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.5022
Cell Significance Index: 101.0100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.1604
Cell Significance Index: 15.4800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.8251
Cell Significance Index: 43.3200 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.7029
Cell Significance Index: 8.5200 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.6644
Cell Significance Index: 9.2900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5328
Cell Significance Index: 481.0500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.5027
Cell Significance Index: 8.6200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3749
Cell Significance Index: 37.0900 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.2921
Cell Significance Index: 3.3000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1444
Cell Significance Index: 23.4800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.0632
Cell Significance Index: 0.8200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0617
Cell Significance Index: 11.7400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0464
Cell Significance Index: 3.5600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0015
Cell Significance Index: -1.1400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0034
Cell Significance Index: -0.2100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0037
Cell Significance Index: -0.0400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0077
Cell Significance Index: -0.2700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0096
Cell Significance Index: -5.9700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0193
Cell Significance Index: -36.3000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0295
Cell Significance Index: -54.3600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0305
Cell Significance Index: -0.8800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0357
Cell Significance Index: -55.0000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0415
Cell Significance Index: -56.4400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0560
Cell Significance Index: -31.5600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0587
Cell Significance Index: -6.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0619
Cell Significance Index: -45.4000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0660
Cell Significance Index: -41.9400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0824
Cell Significance Index: -62.3500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0860
Cell Significance Index: -39.0200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0902
Cell Significance Index: -49.2600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1007
Cell Significance Index: -21.2100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1138
Cell Significance Index: -50.3000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1371
Cell Significance Index: -2.7100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1486
Cell Significance Index: -6.7400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1496
Cell Significance Index: -43.0500 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2013
Cell Significance Index: -3.4800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2109
Cell Significance Index: -36.0100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2166
Cell Significance Index: -39.0400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2339
Cell Significance Index: -34.0000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2504
Cell Significance Index: -49.7000 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.2707
Cell Significance Index: -2.9000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2737
Cell Significance Index: -37.5800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2792
Cell Significance Index: -19.3100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2949
Cell Significance Index: -5.9200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.3202
Cell Significance Index: -39.3700 - Cell Name: neural cell (CL0002319)
Fold Change: -0.3583
Cell Significance Index: -4.1800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3642
Cell Significance Index: -7.8900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3708
Cell Significance Index: -11.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3912
Cell Significance Index: -50.5400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4059
Cell Significance Index: -13.2900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4335
Cell Significance Index: -51.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4473
Cell Significance Index: -12.5000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.4539
Cell Significance Index: -58.1900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.4660
Cell Significance Index: -47.6100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4661
Cell Significance Index: -6.6800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.4771
Cell Significance Index: -28.6400 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.5117
Cell Significance Index: -5.3300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5120
Cell Significance Index: -59.6700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5157
Cell Significance Index: -58.8700 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.5266
Cell Significance Index: -5.0100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5296
Cell Significance Index: -11.2400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5299
Cell Significance Index: -55.1800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5518
Cell Significance Index: -63.2200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5553
Cell Significance Index: -17.7900 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.6054
Cell Significance Index: -7.6400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6183
Cell Significance Index: -38.9700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.6448
Cell Significance Index: -48.0600 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6817
Cell Significance Index: -8.5000 - Cell Name: neuron (CL0000540)
Fold Change: -0.7216
Cell Significance Index: -6.8400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7503
Cell Significance Index: -39.0800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7526
Cell Significance Index: -42.2300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.7535
Cell Significance Index: -16.2800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7894
Cell Significance Index: -50.9300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.7922
Cell Significance Index: -19.7600 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.8034
Cell Significance Index: -10.1400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8384
Cell Significance Index: -29.3700 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: -0.9251
Cell Significance Index: -10.6100 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.9358
Cell Significance Index: -10.7100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.0080
Cell Significance Index: -47.3800 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -1.0294
Cell Significance Index: -21.4900 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -1.1878
Cell Significance Index: -51.6500 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -1.1973
Cell Significance Index: -8.7100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.2001
Cell Significance Index: -14.8900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.2405
Cell Significance Index: -57.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3966438567
Symbol: GNAO_HUMAN
Name: Guanine nucleotide-binding protein G(o) subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1901650
Title: Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.
PubMed ID: 1901650
PubMed ID: 3124840
Title: Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha.
PubMed ID: 3124840
PubMed ID: 10330115
Title: Identification and expression of GO1 and 2 alpha-subunit transcripts in human myometrium in relation to pregnancy.
PubMed ID: 10330115
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 29925951
Title: Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go.
PubMed ID: 29925951
PubMed ID: 23993195
Title: De Novo mutations in GNAO1, encoding a Galphao subunit of heterotrimeric G proteins, cause epileptic encephalopathy.
PubMed ID: 23993195
PubMed ID: 26485252
Title: Clinical whole-exome sequencing reveals a novel missense pathogenic variant of GNAO1 in a patient with infantile-onset epilepsy.
PubMed ID: 26485252
PubMed ID: 26060304
Title: Progressive movement disorder in brothers carrying a GNAO1 mutation responsive to deep brain stimulation.
PubMed ID: 26060304
PubMed ID: 27625011
Title: Recurrent GNAO1 mutations associated with developmental delay and a movement disorder.
PubMed ID: 27625011
PubMed ID: 27068059
Title: Clinical course of six children with GNAO1 mutations causing a severe and distinctive movement disorder.
PubMed ID: 27068059
PubMed ID: 27476654
Title: De novo mutations in SLC1A2 and CACNA1A are important causes of epileptic encephalopathies.
PubMed ID: 27476654
PubMed ID: 25966631
Title: Phenotypic spectrum of GNAO1 variants: epileptic encephalopathy to involuntary movements with severe developmental delay.
PubMed ID: 25966631
DOI: 10.1038/ejhg.2015.92
PubMed ID: 27864847
Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.
PubMed ID: 27864847
DOI: 10.1002/humu.23149
PubMed ID: 28357411
Title: GNAO1 encephalopathy: Broadening the phenotype and evaluating treatment and outcome.
PubMed ID: 28357411
PubMed ID: 29390993
Title: Efficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing.
PubMed ID: 29390993
PubMed ID: 34685729
Title: Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease.
PubMed ID: 34685729
Sequence Information:
- Length: 354
- Mass: 40051
- Checksum: 4F182926A8106E3E
- Sequence:
MGCTLSAEER AALERSKAIE KNLKEDGISA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG FSGEDVKQYK PVVYSNTIQS LAAIVRAMDT LGIEYGDKER KADAKMVCDV VSRMEDTEPF SAELLSAMMR LWGDSGIQEC FNRSREYQLN DSAKYYLDSL DRIGAADYQP TEQDILRTRV KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFGEKIK KSPLTICFPE YTGPNTYEDA AAYIQAQFES KNRSPNKEIY CHMTCATDTN NIQVVFDAVT DIIIANNLRG CGLY
Genular Protein ID: 1535747937
Symbol: B3KP89_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 354
- Mass: 39934
- Checksum: E1FA9988B5AF33EE
- Sequence:
MGCTLSAEER AALERSKAIE KNLKEDGISA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG FSGEDVKQYK PVVYSNTIQS LAAIVRAMDT LGIEYGDKER KADAKMVCDV VSRMEDTEPF SAELLSAMMR LWGGSGIQEC FNRSREYQLN GSAKYYLDSL DRIGAADYQP TEQDILRTRV KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFGEKIK KSPLTICFPE YTGPNTYEDA AAYIQAQFES KNRSPNKEIY CHMTCATDTN NIQVVFDAVT DIIIANNLRG CGLY
Genular Protein ID: 3597215471
Symbol: Q8N6I9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 302
- Mass: 34609
- Checksum: B6902F0B0AA8DE09
- Sequence:
MKIIHEDGFS GEDVKQYKPV VYSNTIQSLA AIVRAMDTLG IEYGDKERKA DAKMVCDVVS RMEDTEPFSA ELLSAMMRLW GDSGIQECFN RSREYQLNDS AKYYLDSLDR IGAADYQPTE QDILRTRVKT TGIVETHFTF KNLHFRLFDV GGQRSERKKW IHCFEDVTAI IFCVALSGYD QVLHEDETTN RMHESLMLFD SICNNKFFID TSIILFLNKK DLFGEKIKKS PLTICFPEYT GPNTYEDAAA YIQAQFESKN RSPNKEIYCH MTCATDTNNI QVVFDAVTDI IIANNLRGCG LY
Genular Protein ID: 2895488985
Symbol: Q6AWC5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 113
- Mass: 12951
- Checksum: D471775FFC6B29F8
- Sequence:
NRMHESLKLF DSICNNKWFT DTSIILFLNK KDIFEEKIKK SPLTICFPEY TGPSAFTEAV AYIQAQYESK NKSAHKEIYT HVTCATDTNN IQFVFDAVTD VIIAKNLRGC GLY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.