SFN | ENSG00000175793 | NCBI 2810

Details for: SFN

Gene ID: 2810

Symbol: SFN

Ensembl ID: ENSG00000175793

Description: stratifin

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Apoptosis
(R-HSA-109581)
Cell cycle
(R-HSA-1640170)
Cell cycle checkpoints
(R-HSA-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Disease
(R-HSA-1643685)
Foxo-mediated transcription
(R-HSA-9614085)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Membrane trafficking
(R-HSA-199991)
Programmed cell death
(R-HSA-5357801)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-HSA-6804114)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Camp/pka signal transduction
(GO:0141156)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Establishment of skin barrier
(GO:0061436)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Keratinization
(GO:0031424)
Keratinocyte development
(GO:0003334)
Keratinocyte proliferation
(GO:0043616)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Negative regulation of stem cell proliferation
(GO:2000647)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Phosphoserine residue binding
(GO:0050815)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of epidermal cell differentiation
(GO:0045606)
Positive regulation of protein export from nucleus
(GO:0046827)
Positive regulation of protein localization
(GO:1903829)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Protein kinase binding
(GO:0019901)
Protein kinase c inhibitor activity
(GO:0008426)
Protein localization
(GO:0008104)
Protein sequestering activity
(GO:0140311)
Regulation of cell-cell adhesion
(GO:0022407)
Regulation of cell cycle
(GO:0051726)
Regulation of epidermal cell division
(GO:0010482)
Regulation of protein localization
(GO:0032880)
Release of cytochrome c from mitochondria
(GO:0001836)
Signal transduction
(GO:0007165)
Stem cell proliferation
(GO:0072089)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 79.6634
Cell Significance Index: 236.9200
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 47.7430
Cell Significance Index: 410.2600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 35.7812
Cell Significance Index: -24.0100
Cell Name: epidermal cell (CL0000362)
Fold Change: 23.0474
Cell Significance Index: 51.9600
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 21.3346
Cell Significance Index: 24.5600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 18.1410
Cell Significance Index: -17.3200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.9188
Cell Significance Index: -29.2500
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 7.4384
Cell Significance Index: 46.0400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 5.9394
Cell Significance Index: 692.1700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 5.3964
Cell Significance Index: 80.8600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 5.0432
Cell Significance Index: 261.9800
Cell Name: precursor cell (CL0011115)
Fold Change: 4.2068
Cell Significance Index: 31.9000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.1286
Cell Significance Index: 1825.3600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 4.1179
Cell Significance Index: 186.6500
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 3.5405
Cell Significance Index: 50.4000
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.4288
Cell Significance Index: 19.6600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.2321
Cell Significance Index: 228.5900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.0425
Cell Significance Index: 87.6600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.9206
Cell Significance Index: 26.9000
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.7849
Cell Significance Index: 28.8200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.5266
Cell Significance Index: 70.6100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.2336
Cell Significance Index: 48.3900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.9182
Cell Significance Index: 11.8100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.6586
Cell Significance Index: -3.6300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.6370
Cell Significance Index: 201.2900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.5315
Cell Significance Index: 114.1400
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.4966
Cell Significance Index: 22.7300
Cell Name: lactocyte (CL0002325)
Fold Change: 1.3702
Cell Significance Index: 177.0300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2556
Cell Significance Index: 226.3500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2508
Cell Significance Index: 75.0900
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 1.0589
Cell Significance Index: 7.6200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9265
Cell Significance Index: 100.7700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8747
Cell Significance Index: 86.5300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8729
Cell Significance Index: 23.7600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7751
Cell Significance Index: 126.0600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7109
Cell Significance Index: 15.1400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6362
Cell Significance Index: 347.4400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5533
Cell Significance Index: 26.0100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5024
Cell Significance Index: 34.7500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4612
Cell Significance Index: 416.4600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4259
Cell Significance Index: 13.6400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2957
Cell Significance Index: 10.3900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2635
Cell Significance Index: 199.4800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1893
Cell Significance Index: 36.0200
Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.0756
Cell Significance Index: 1.0600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0350
Cell Significance Index: 21.8400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0251
Cell Significance Index: 0.2600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0071
Cell Significance Index: -5.2900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0076
Cell Significance Index: -0.3900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0095
Cell Significance Index: -0.1300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0142
Cell Significance Index: -26.7000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0159
Cell Significance Index: -8.9800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0255
Cell Significance Index: -1.1900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0293
Cell Significance Index: -21.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0323
Cell Significance Index: -20.5100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0354
Cell Significance Index: -4.8600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0377
Cell Significance Index: -6.4400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0404
Cell Significance Index: -1.0800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0481
Cell Significance Index: -10.1300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0500
Cell Significance Index: -6.4100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0560
Cell Significance Index: -6.3900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0599
Cell Significance Index: -27.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0661
Cell Significance Index: -23.7000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0809
Cell Significance Index: -23.2700
Cell Name: eosinophil (CL0000771)
Fold Change: -0.0854
Cell Significance Index: -0.7600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0907
Cell Significance Index: -1.0300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1101
Cell Significance Index: -2.8300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1106
Cell Significance Index: -21.9500
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1281
Cell Significance Index: -0.8500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1377
Cell Significance Index: -27.6200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1445
Cell Significance Index: -14.7600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1451
Cell Significance Index: -21.0900
Cell Name: enterocyte (CL0000584)
Fold Change: -0.1805
Cell Significance Index: -1.1200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1819
Cell Significance Index: -20.8500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2168
Cell Significance Index: -5.4200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2358
Cell Significance Index: -5.8900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2400
Cell Significance Index: -28.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2657
Cell Significance Index: -16.7500
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.2721
Cell Significance Index: -2.8700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2764
Cell Significance Index: -21.8900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2863
Cell Significance Index: -17.5500
Cell Name: stem cell (CL0000034)
Fold Change: -0.3165
Cell Significance Index: -2.3000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3383
Cell Significance Index: -17.6200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3450
Cell Significance Index: -9.8900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3696
Cell Significance Index: -24.8500
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.3782
Cell Significance Index: -4.1500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3802
Cell Significance Index: -5.7300
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.4043
Cell Significance Index: -4.0000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4070
Cell Significance Index: -14.9400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4099
Cell Significance Index: -26.4500
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.4133
Cell Significance Index: -5.3400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4316
Cell Significance Index: -33.1200
Cell Name: colonocyte (CL1000347)
Fold Change: -0.4337
Cell Significance Index: -2.6800
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.4715
Cell Significance Index: -3.9000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5083
Cell Significance Index: -31.2400
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.5115
Cell Significance Index: -4.0700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5660
Cell Significance Index: -16.6700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5934
Cell Significance Index: -33.3000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6357
Cell Significance Index: -33.3800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6520
Cell Significance Index: -22.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Cell cycle regulation**: Stratifin interacts with cyclin B and Cdk1 to regulate the G2/M checkpoint and prevent excessive cell proliferation. 2. **Apoptosis regulation**: Stratifin has been shown to regulate apoptosis by interacting with pro-apoptotic proteins and preventing their activity. 3. **Keratinocyte development**: Stratifin is essential for the development and differentiation of keratinocytes, the primary cell type of the epidermis. 4. **Epithelial cell regulation**: Stratifin is expressed in various epithelial cells, including those of the prostate, urethra, esophagus, and colon. 5. **Stem cell regulation**: Stratifin has been implicated in the regulation of stem cell proliferation and differentiation. **Pathways and Functions** 1. **Activation of Bad**: Stratifin interacts with Bad, a pro-apoptotic protein, to prevent its activity and promote cell survival. 2. **Translocation to mitochondria**: Stratifin has been shown to translocate to the mitochondria in response to DNA damage, where it regulates the release of cytochrome c and initiation of apoptosis. 3. **Regulation of cyclin B and Cdk1**: Stratifin interacts with cyclin B and Cdk1 to regulate the G2/M checkpoint and prevent excessive cell proliferation. 4. **Rho GTPase pathway**: Stratifin interacts with Rho GTPases to regulate cell growth, differentiation, and survival. 5. **Foxo-mediated transcription**: Stratifin regulates the activity of Foxo transcription factors, which are involved in the regulation of cell cycle and apoptosis. **Clinical Significance** 1. **Cancer**: Stratifin has been implicated in the development and progression of various cancers, including prostate, breast, and colon cancer. 2. **Infectious diseases**: Stratifin has been shown to interact with SARS-CoV-1 and SARS-CoV-2, suggesting its potential role in the regulation of host immune responses to viral infections. 3. **Inflammatory diseases**: Stratifin has been implicated in the regulation of inflammation and immune responses in various inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 4. **Neurological diseases**: Stratifin has been shown to interact with proteins involved in the regulation of neuronal survival and differentiation, suggesting its potential role in the development of neurological diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, the stratifin gene plays a critical role in various cellular processes, including cell cycle regulation, apoptosis, and keratinocyte development. Its expression is significantly observed in various epithelial cells, and its interactions with multiple signaling pathways suggest its potential role in the regulation of various diseases, including cancer, infectious diseases, and inflammatory diseases. Further research is needed to fully understand the functions and clinical significance of stratifin.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

1433S_HUMAN

Genular Protein ID: 2701815280

Symbol: 1433S_HUMAN

Name: N/A

UniProtKB Accession Codes:

P31947 Q6FH30 Q6FH51 Q96DH0

Database IDs:

Citations:

PubMed ID: 1390337

Title: Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.

PubMed ID: 1390337

PubMed ID: 8515476

Title: Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.

PubMed ID: 8515476

DOI: 10.1006/jmbi.1993.1346

PubMed ID: 9659898

Title: 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression.

PubMed ID: 9659898

DOI: 10.1016/s1097-2765(00)80002-7

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 15282546

Title: Exportin 7 defines a novel general nuclear export pathway.

PubMed ID: 15282546

DOI: 10.1038/sj.emboj.7600338

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18382127

Title: CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.

PubMed ID: 18382127

DOI: 10.4161/cc.7.5.5701

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19640509

Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 19640509

DOI: 10.1016/j.biopsych.2009.05.033

PubMed ID: 19592491

Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

PubMed ID: 19592491

DOI: 10.1074/jbc.m109.026237

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21625211

Title: COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma.

PubMed ID: 21625211

DOI: 10.1038/onc.2011.192

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 24124604

Title: Stratifin (14-3-3 sigma) limits plakophilin-3 exchange with the desmosomal plaque.

PubMed ID: 24124604

DOI: 10.1371/journal.pone.0077012

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 15731107

Title: A structural basis for 14-3-3sigma functional specificity.

PubMed ID: 15731107

DOI: 10.1074/jbc.m500982200

PubMed ID: 22634725

Title: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.

PubMed ID: 22634725

DOI: 10.1016/j.jsb.2012.05.010

PubMed ID: 28202711

Title: Structural interface between LRRK2 and 14-3-3 protein.

PubMed ID: 28202711

DOI: 10.1042/bcj20161078

PubMed ID: 33159816

Title: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.

PubMed ID: 33159816

DOI: 10.1002/1873-3468.13993

PubMed ID: 37797010

Title: PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.

PubMed ID: 37797010

DOI: 10.1126/science.adg2253

Sequence Information:

Length: 248
Mass: 27774
Checksum: 7F4B44E3AA59ECE6
Sequence:

MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 
VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY 
LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 
YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 
EAPQEPQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SFN

Associated with

Cells (max top 100)

Other Information

Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells. PubMed ID: 1390337

Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. PubMed ID: 8515476

14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. PubMed ID: 9659898

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

Exportin 7 defines a novel general nuclear export pathway. PubMed ID: 15282546

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. PubMed ID: 18382127

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. PubMed ID: 19172738

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner. PubMed ID: 19640509

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. PubMed ID: 19592491

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma. PubMed ID: 21625211

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. PubMed ID: 23572552

Stratifin (14-3-3 sigma) limits plakophilin-3 exchange with the desmosomal plaque. PubMed ID: 24124604

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. PubMed ID: 26047703

A structural basis for 14-3-3sigma functional specificity. PubMed ID: 15731107

Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. PubMed ID: 22634725

Structural interface between LRRK2 and 14-3-3 protein. PubMed ID: 28202711

The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. PubMed ID: 33159816

PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. PubMed ID: 37797010