Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 79.6634
Cell Significance Index: 236.9200 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 47.7430
Cell Significance Index: 410.2600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 35.7812
Cell Significance Index: -24.0100 - Cell Name: epidermal cell (CL0000362)
Fold Change: 23.0474
Cell Significance Index: 51.9600 - Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 21.3346
Cell Significance Index: 24.5600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 18.1410
Cell Significance Index: -17.3200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.9188
Cell Significance Index: -29.2500 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 7.4384
Cell Significance Index: 46.0400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 5.9394
Cell Significance Index: 692.1700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 5.3964
Cell Significance Index: 80.8600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 5.0432
Cell Significance Index: 261.9800 - Cell Name: precursor cell (CL0011115)
Fold Change: 4.2068
Cell Significance Index: 31.9000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.1286
Cell Significance Index: 1825.3600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 4.1179
Cell Significance Index: 186.6500 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 3.5405
Cell Significance Index: 50.4000 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.4288
Cell Significance Index: 19.6600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.2321
Cell Significance Index: 228.5900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.0425
Cell Significance Index: 87.6600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.9206
Cell Significance Index: 26.9000 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.7849
Cell Significance Index: 28.8200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.5266
Cell Significance Index: 70.6100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.2336
Cell Significance Index: 48.3900 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.9182
Cell Significance Index: 11.8100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.6586
Cell Significance Index: -3.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.6370
Cell Significance Index: 201.2900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.5315
Cell Significance Index: 114.1400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.4966
Cell Significance Index: 22.7300 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.3702
Cell Significance Index: 177.0300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2556
Cell Significance Index: 226.3500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2508
Cell Significance Index: 75.0900 - Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 1.0589
Cell Significance Index: 7.6200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9265
Cell Significance Index: 100.7700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8747
Cell Significance Index: 86.5300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8729
Cell Significance Index: 23.7600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7751
Cell Significance Index: 126.0600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7109
Cell Significance Index: 15.1400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6362
Cell Significance Index: 347.4400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5533
Cell Significance Index: 26.0100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5024
Cell Significance Index: 34.7500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4612
Cell Significance Index: 416.4600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4259
Cell Significance Index: 13.6400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2957
Cell Significance Index: 10.3900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2635
Cell Significance Index: 199.4800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1893
Cell Significance Index: 36.0200 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.0756
Cell Significance Index: 1.0600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0350
Cell Significance Index: 21.8400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0251
Cell Significance Index: 0.2600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0071
Cell Significance Index: -5.2900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0076
Cell Significance Index: -0.3900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0095
Cell Significance Index: -0.1300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0142
Cell Significance Index: -26.7000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0159
Cell Significance Index: -8.9800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0255
Cell Significance Index: -1.1900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0293
Cell Significance Index: -21.4800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0323
Cell Significance Index: -20.5100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0354
Cell Significance Index: -4.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0377
Cell Significance Index: -6.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0404
Cell Significance Index: -1.0800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0481
Cell Significance Index: -10.1300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0500
Cell Significance Index: -6.4100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0560
Cell Significance Index: -6.3900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0599
Cell Significance Index: -27.1700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0661
Cell Significance Index: -23.7000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0809
Cell Significance Index: -23.2700 - Cell Name: eosinophil (CL0000771)
Fold Change: -0.0854
Cell Significance Index: -0.7600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0907
Cell Significance Index: -1.0300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1101
Cell Significance Index: -2.8300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1106
Cell Significance Index: -21.9500 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1281
Cell Significance Index: -0.8500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1377
Cell Significance Index: -27.6200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1445
Cell Significance Index: -14.7600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1451
Cell Significance Index: -21.0900 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.1805
Cell Significance Index: -1.1200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1819
Cell Significance Index: -20.8500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2168
Cell Significance Index: -5.4200 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2358
Cell Significance Index: -5.8900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2400
Cell Significance Index: -28.3100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2657
Cell Significance Index: -16.7500 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.2721
Cell Significance Index: -2.8700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2764
Cell Significance Index: -21.8900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2863
Cell Significance Index: -17.5500 - Cell Name: stem cell (CL0000034)
Fold Change: -0.3165
Cell Significance Index: -2.3000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3383
Cell Significance Index: -17.6200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3450
Cell Significance Index: -9.8900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3696
Cell Significance Index: -24.8500 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.3782
Cell Significance Index: -4.1500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3802
Cell Significance Index: -5.7300 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.4043
Cell Significance Index: -4.0000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4070
Cell Significance Index: -14.9400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4099
Cell Significance Index: -26.4500 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.4133
Cell Significance Index: -5.3400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4316
Cell Significance Index: -33.1200 - Cell Name: colonocyte (CL1000347)
Fold Change: -0.4337
Cell Significance Index: -2.6800 - Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.4715
Cell Significance Index: -3.9000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5083
Cell Significance Index: -31.2400 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.5115
Cell Significance Index: -4.0700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5660
Cell Significance Index: -16.6700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5934
Cell Significance Index: -33.3000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6357
Cell Significance Index: -33.3800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6520
Cell Significance Index: -22.6600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2701815280
Symbol: 1433S_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1390337
Title: Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.
PubMed ID: 1390337
PubMed ID: 8515476
Title: Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.
PubMed ID: 8515476
PubMed ID: 9659898
Title: 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression.
PubMed ID: 9659898
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 15282546
Title: Exportin 7 defines a novel general nuclear export pathway.
PubMed ID: 15282546
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18382127
Title: CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.
PubMed ID: 18382127
DOI: 10.4161/cc.7.5.5701
PubMed ID: 19172738
Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
PubMed ID: 19172738
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19640509
Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.
PubMed ID: 19640509
PubMed ID: 19592491
Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
PubMed ID: 19592491
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21625211
Title: COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma.
PubMed ID: 21625211
DOI: 10.1038/onc.2011.192
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23572552
Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
PubMed ID: 23572552
PubMed ID: 24124604
Title: Stratifin (14-3-3 sigma) limits plakophilin-3 exchange with the desmosomal plaque.
PubMed ID: 24124604
PubMed ID: 26047703
Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.
PubMed ID: 26047703
PubMed ID: 15731107
Title: A structural basis for 14-3-3sigma functional specificity.
PubMed ID: 15731107
PubMed ID: 22634725
Title: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.
PubMed ID: 22634725
PubMed ID: 28202711
Title: Structural interface between LRRK2 and 14-3-3 protein.
PubMed ID: 28202711
DOI: 10.1042/bcj20161078
PubMed ID: 33159816
Title: The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.
PubMed ID: 33159816
PubMed ID: 37797010
Title: PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.
PubMed ID: 37797010
Sequence Information:
- Length: 248
- Mass: 27774
- Checksum: 7F4B44E3AA59ECE6
- Sequence:
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.