Details for: SFN

Gene ID: 2810

Symbol: SFN

Ensembl ID: ENSG00000175793

Description: stratifin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.46
    Marker Score: 10,883
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.51
    Marker Score: 2,766
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.4
    Marker Score: 1,151
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.32
    Marker Score: 10,418
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.27
    Marker Score: 25,565
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.26
    Marker Score: 20,818
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.07
    Marker Score: 26,456
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.91
    Marker Score: 1,693
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.74
    Marker Score: 13,172
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.71
    Marker Score: 13,332
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.61
    Marker Score: 2,748
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.54
    Marker Score: 4,163
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.52
    Marker Score: 894
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5
    Marker Score: 3,676
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.49
    Marker Score: 602
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.45
    Marker Score: 3,165
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.41
    Marker Score: 17,953
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.37
    Marker Score: 5,834
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.33
    Marker Score: 1,225
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.13
    Marker Score: 3,425
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2,005
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2
    Marker Score: 26,835
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.97
    Marker Score: 4,477
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.96
    Marker Score: 714
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.76
    Marker Score: 436
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.74
    Marker Score: 4,132
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.73
    Marker Score: 11,247
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.68
    Marker Score: 1,405
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.67
    Marker Score: 8,775
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.66
    Marker Score: 2,560
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.58
    Marker Score: 6,100
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.58
    Marker Score: 679
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.56
    Marker Score: 2,481
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.52
    Marker Score: 750
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.5
    Marker Score: 1,751
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.44
    Marker Score: 901
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.4
    Marker Score: 1,551
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.4
    Marker Score: 938
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.39
    Marker Score: 5,395
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.35
    Marker Score: 391
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.35
    Marker Score: 697
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.33
    Marker Score: 558
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.33
    Marker Score: 1,605
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2,489
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.24
    Marker Score: 1,189
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.24
    Marker Score: 638
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.22
    Marker Score: 1,380
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.2
    Marker Score: 2,120
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.19
    Marker Score: 411
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.15
    Marker Score: 364
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,025
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1
    Marker Score: 288
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.97
    Marker Score: 246
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.95
    Marker Score: 32,965
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.94
    Marker Score: 439
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,335
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.92
    Marker Score: 345
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.91
    Marker Score: 623
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.9
    Marker Score: 1,643
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,279
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.86
    Marker Score: 208
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.84
    Marker Score: 13,452
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.83
    Marker Score: 734
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.82
    Marker Score: 568
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,324
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.77
    Marker Score: 1,761
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,174
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.75
    Marker Score: 336
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11,598
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.73
    Marker Score: 210
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 664
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.71
    Marker Score: 144
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.71
    Marker Score: 200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.71
    Marker Score: 275
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 462
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.69
    Marker Score: 586
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.69
    Marker Score: 611
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.68
    Marker Score: 176
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.67
    Marker Score: 470
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.65
    Marker Score: 452
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.63
    Marker Score: 283
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1,275
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.63
    Marker Score: 233
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.6
    Marker Score: 368
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.59
    Marker Score: 157

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell cycle regulation**: Stratifin interacts with cyclin B and Cdk1 to regulate the G2/M checkpoint and prevent excessive cell proliferation. 2. **Apoptosis regulation**: Stratifin has been shown to regulate apoptosis by interacting with pro-apoptotic proteins and preventing their activity. 3. **Keratinocyte development**: Stratifin is essential for the development and differentiation of keratinocytes, the primary cell type of the epidermis. 4. **Epithelial cell regulation**: Stratifin is expressed in various epithelial cells, including those of the prostate, urethra, esophagus, and colon. 5. **Stem cell regulation**: Stratifin has been implicated in the regulation of stem cell proliferation and differentiation. **Pathways and Functions** 1. **Activation of Bad**: Stratifin interacts with Bad, a pro-apoptotic protein, to prevent its activity and promote cell survival. 2. **Translocation to mitochondria**: Stratifin has been shown to translocate to the mitochondria in response to DNA damage, where it regulates the release of cytochrome c and initiation of apoptosis. 3. **Regulation of cyclin B and Cdk1**: Stratifin interacts with cyclin B and Cdk1 to regulate the G2/M checkpoint and prevent excessive cell proliferation. 4. **Rho GTPase pathway**: Stratifin interacts with Rho GTPases to regulate cell growth, differentiation, and survival. 5. **Foxo-mediated transcription**: Stratifin regulates the activity of Foxo transcription factors, which are involved in the regulation of cell cycle and apoptosis. **Clinical Significance** 1. **Cancer**: Stratifin has been implicated in the development and progression of various cancers, including prostate, breast, and colon cancer. 2. **Infectious diseases**: Stratifin has been shown to interact with SARS-CoV-1 and SARS-CoV-2, suggesting its potential role in the regulation of host immune responses to viral infections. 3. **Inflammatory diseases**: Stratifin has been implicated in the regulation of inflammation and immune responses in various inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 4. **Neurological diseases**: Stratifin has been shown to interact with proteins involved in the regulation of neuronal survival and differentiation, suggesting its potential role in the development of neurological diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, the stratifin gene plays a critical role in various cellular processes, including cell cycle regulation, apoptosis, and keratinocyte development. Its expression is significantly observed in various epithelial cells, and its interactions with multiple signaling pathways suggest its potential role in the regulation of various diseases, including cancer, infectious diseases, and inflammatory diseases. Further research is needed to fully understand the functions and clinical significance of stratifin.

Genular Protein ID: 2701815280

Symbol: 1433S_HUMAN

Name: 14-3-3 protein sigma

UniProtKB Accession Codes:

P31947 Q6FH30 Q6FH51 Q96DH0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 2 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1390337

Title: Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.

PubMed ID: 1390337

PubMed ID: 8515476

Title: Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.

PubMed ID: 8515476

DOI: 10.1006/jmbi.1993.1346

PubMed ID: 9659898

Title: 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression.

PubMed ID: 9659898

DOI: 10.1016/s1097-2765(00)80002-7

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 15282546

Title: Exportin 7 defines a novel general nuclear export pathway.

PubMed ID: 15282546

DOI: 10.1038/sj.emboj.7600338

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18382127

Title: CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.

PubMed ID: 18382127

DOI: 10.4161/cc.7.5.5701

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19640509

Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 19640509

DOI: 10.1016/j.biopsych.2009.05.033

PubMed ID: 19592491

Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

PubMed ID: 19592491

DOI: 10.1074/jbc.m109.026237

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21625211

Title: COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma.

PubMed ID: 21625211

DOI: 10.1038/onc.2011.192

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 15731107

Title: A structural basis for 14-3-3sigma functional specificity.

PubMed ID: 15731107

DOI: 10.1074/jbc.m500982200

PubMed ID: 22634725

Title: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.

PubMed ID: 22634725

DOI: 10.1016/j.jsb.2012.05.010

PubMed ID: 28202711

Title: Structural interface between LRRK2 and 14-3-3 protein.

PubMed ID: 28202711

DOI: 10.1042/bcj20161078

Sequence Information:

  • Length: 248
  • Mass: 27774
  • Checksum: 7F4B44E3AA59ECE6
  • Sequence:
    • MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 
VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY 
LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 
YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 
EAPQEPQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.