Details for: IGHV3 74

Gene ID: 28408

Symbol: IGHV3 74

Ensembl ID: ENSG00000224650

Description: immunoglobulin heavy variable 3-74

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9081
    Cell Significance Index: 13.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8088
    Cell Significance Index: 25.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7923
    Cell Significance Index: 17.1700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7793
    Cell Significance Index: 8.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7745
    Cell Significance Index: 19.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4879
    Cell Significance Index: 17.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2582
    Cell Significance Index: 33.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1833
    Cell Significance Index: 34.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1825
    Cell Significance Index: 10.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1267
    Cell Significance Index: 1.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0764
    Cell Significance Index: 8.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0563
    Cell Significance Index: 2.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0306
    Cell Significance Index: 2.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0044
    Cell Significance Index: 4.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0021
    Cell Significance Index: 0.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0019
    Cell Significance Index: -0.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0052
    Cell Significance Index: -2.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0082
    Cell Significance Index: -0.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0097
    Cell Significance Index: -0.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0107
    Cell Significance Index: -1.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0231
    Cell Significance Index: -3.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0241
    Cell Significance Index: -2.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0313
    Cell Significance Index: -3.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0368
    Cell Significance Index: -4.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0369
    Cell Significance Index: -2.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0415
    Cell Significance Index: -0.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0427
    Cell Significance Index: -2.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0437
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0474
    Cell Significance Index: -5.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0498
    Cell Significance Index: -2.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0523
    Cell Significance Index: -4.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0596
    Cell Significance Index: -1.6000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0661
    Cell Significance Index: -0.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0671
    Cell Significance Index: -5.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0842
    Cell Significance Index: -2.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0901
    Cell Significance Index: -2.3700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0994
    Cell Significance Index: -1.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1225
    Cell Significance Index: -3.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1229
    Cell Significance Index: -3.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1232
    Cell Significance Index: -3.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1283
    Cell Significance Index: -4.7100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1341
    Cell Significance Index: -0.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1359
    Cell Significance Index: -3.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1361
    Cell Significance Index: -1.9100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1441
    Cell Significance Index: -1.6100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1467
    Cell Significance Index: -1.8200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1477
    Cell Significance Index: -2.0100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1554
    Cell Significance Index: -2.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1555
    Cell Significance Index: -3.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1566
    Cell Significance Index: -7.3600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1586
    Cell Significance Index: -2.3200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1633
    Cell Significance Index: -1.9300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1695
    Cell Significance Index: -2.7500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1721
    Cell Significance Index: -2.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1732
    Cell Significance Index: -4.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1766
    Cell Significance Index: -2.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1794
    Cell Significance Index: -4.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1889
    Cell Significance Index: -2.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1948
    Cell Significance Index: -4.5000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1951
    Cell Significance Index: -1.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1976
    Cell Significance Index: -2.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1978
    Cell Significance Index: -3.6600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2003
    Cell Significance Index: -2.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2054
    Cell Significance Index: -2.6300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2072
    Cell Significance Index: -1.7100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2074
    Cell Significance Index: -2.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2081
    Cell Significance Index: -2.6300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2099
    Cell Significance Index: -3.0600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2137
    Cell Significance Index: -2.9300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2141
    Cell Significance Index: -3.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2155
    Cell Significance Index: -2.9900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2212
    Cell Significance Index: -2.2600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2226
    Cell Significance Index: -2.8800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2230
    Cell Significance Index: -2.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2232
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2240
    Cell Significance Index: -2.1500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2259
    Cell Significance Index: -2.3300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2384
    Cell Significance Index: -2.5100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2387
    Cell Significance Index: -2.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2416
    Cell Significance Index: -3.1600
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.2424
    Cell Significance Index: -2.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2446
    Cell Significance Index: -3.6100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2460
    Cell Significance Index: -2.9200
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2503
    Cell Significance Index: -1.9100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2522
    Cell Significance Index: -3.1500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.2523
    Cell Significance Index: -2.9300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2538
    Cell Significance Index: -2.7000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2547
    Cell Significance Index: -3.0100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.2547
    Cell Significance Index: -2.7500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2572
    Cell Significance Index: -3.2300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2578
    Cell Significance Index: -2.8200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2664
    Cell Significance Index: -2.7100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2676
    Cell Significance Index: -3.2300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2767
    Cell Significance Index: -2.9800
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2777
    Cell Significance Index: -3.1500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2778
    Cell Significance Index: -2.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-74 gene belongs to the immunoglobulin heavy variable (IGHV) family, which is responsible for encoding the variable region of the heavy chain of immunoglobulins. The IGHV3-74 gene is characterized by its unique structure, which allows it to bind to specific antigens through the formation of complementarity-determining regions (CDRs). The IGHV3-74 gene is also notable for its high expression levels in various tissues, including the gastrointestinal tract, where it is co-expressed with other immunoglobulin genes. **Pathways and Functions:** The IGHV3-74 gene is involved in several key pathways and functions, including: 1. **Antigen Binding:** The IGHV3-74 gene plays a crucial role in the binding of immunoglobulins to specific antigens, which is essential for the recognition and elimination of pathogens. 2. **Immunoglobulin Complex Formation:** The IGHV3-74 gene is involved in the formation of immunoglobulin complexes, which are essential for the activation of immune cells and the production of cytokines. 3. **Immunoglobulin-Mediated Immune Response:** The IGHV3-74 gene is involved in the regulation of the immunoglobulin-mediated immune response, which is essential for the defense against infections. 4. **Plasma Membrane Expression:** The IGHV3-74 gene is expressed on the surface of plasma cells, which are specialized immune cells that produce immunoglobulins. **Significantly Expressed Cells:** The IGHV3-74 gene is expressed in various tissues, including: 1. **Enterocytes of Epithelium of Large Intestine:** The IGHV3-74 gene is expressed in enterocytes, which are specialized cells that line the gastrointestinal tract. 2. **Colon Goblet Cell:** The IGHV3-74 gene is expressed in goblet cells, which are specialized cells that produce mucus in the gastrointestinal tract. 3. **Granulocyte Monocyte Progenitor Cell:** The IGHV3-74 gene is expressed in granulocyte monocyte progenitor cells, which are precursor cells that give rise to granulocytes and monocytes. 4. **Intestinal Crypt Stem Cell of Small Intestine:** The IGHV3-74 gene is expressed in intestinal crypt stem cells, which are stem cells that give rise to epithelial cells in the small intestine. **Clinical Significance:** The IGHV3-74 gene has significant clinical implications, particularly in the context of gastrointestinal diseases. For example: 1. **Inflammatory Bowel Disease:** The IGHV3-74 gene has been implicated in the pathogenesis of inflammatory bowel disease (IBD), which is characterized by chronic inflammation of the gastrointestinal tract. 2. **Cancer:** The IGHV3-74 gene has been found to be overexpressed in certain types of cancer, including colorectal cancer. 3. **Immune-Mediated Diseases:** The IGHV3-74 gene has been implicated in the pathogenesis of immune-mediated diseases, including autoimmune diseases such as rheumatoid arthritis and lupus. In conclusion, the IGHV3-74 gene is a crucial component of the human immune system, with significant implications for our understanding of immune function and disease. Further research is needed to fully elucidate the role of the IGHV3-74 gene in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.