SMIM24 | ENSG00000095932 | NCBI 284422

Details for: SMIM24

Gene ID: 284422

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SMIM24

Ensembl ID: ENSG00000095932

Description: small integral membrane protein 24

Cell Significance Landscape

Display Count:

Associated with

Biological_process
(GO:0008150)
Membrane
(GO:0016020)
Molecular_function
(GO:0003674)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

intestinal epithelial cell CL0002563

CSI 34.19

rCSI 35.74%

PRS 89.06
common myeloid progenitor CL0000049

CSI 29.32

rCSI 23.71%

PRS 92.29
granulocyte CL0000094

CSI 23.98

rCSI 36.63%

PRS 94.74
intestine goblet cell CL0019031

CSI 21.32

rCSI 18.92%

PRS 88.96
colonocyte CL1000347

CSI 20.77

rCSI 29.77%

PRS 89.41
hematopoietic stem cell CL0000037

CSI 19.26

rCSI 12.8%

PRS 92.65
small pre-B-II cell CL0000954

CSI 17.53

rCSI 16.85%

PRS 96.67
precursor B cell CL0000817

CSI 17.46

rCSI 15.29%

PRS 94.57
hematopoietic precursor cell CL0008001

CSI 16.2

rCSI 16.67%

PRS 96.1
paneth cell CL0000510

CSI 16.13

rCSI 23.81%

PRS 95.81
promyelocyte CL0000836

CSI 15.15

rCSI 21.84%

PRS 93.1
renal alpha-intercalated cell CL0005011

CSI 15.02

rCSI 20.08%

PRS 94.13
pro-B cell CL0000826

CSI 14.73

rCSI 12.2%

PRS 92.38
mucous neck cell CL0000651

CSI 13.01

rCSI 18.75%

PRS 93.66
enterocyte CL0000584

CSI 12.03

rCSI 19.4%

PRS 88.43
ionocyte CL0005006

CSI 11.43

rCSI 12.25%

PRS 92.58
M cell of gut CL0000682

CSI 11.32

rCSI 12.03%

PRS 93.23
stem cell CL0000034

CSI 10.52

rCSI 10.14%

PRS 87.48
myeloid lineage restricted progenitor cell CL0000839

CSI 10.14

rCSI 52.36%

PRS 97.43
pancreatic A cell CL0000171

CSI 9.77

rCSI 10.24%

PRS 92.99
pancreatic D cell CL0000173

CSI 9.51

rCSI 9.36%

PRS 92.93
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 9.22

rCSI 23.82%

PRS 88.85
early lymphoid progenitor CL0000936

CSI 9.17

rCSI 8.05%

PRS 94.12
intestinal crypt stem cell of small intestine CL0009017

CSI 9.12

rCSI 24.59%

PRS 93.13
epithelial cell of lung CL0000082

CSI 8.55

rCSI 7.09%

PRS 92.07
enteroendocrine cell CL0000164

CSI 8.49

rCSI 11.61%

PRS 89.72
epithelial cell CL0000066

CSI 7.95

rCSI 12.22%

PRS 79.95
foveolar cell of stomach CL0002179

CSI 7.71

rCSI 16.4%

PRS 93.1
megakaryocyte-erythroid progenitor cell CL0000050

CSI 7.45

rCSI 6.73%

PRS 90.07
fraction A pre-pro B cell CL0002045

CSI 6.82

rCSI 7.81%

PRS 94.75
epithelial cell of proximal tubule CL0002306

CSI 6.74

rCSI 16.46%

PRS 85.22
pancreatic ductal cell CL0002079

CSI 6.47

rCSI 12.59%

PRS 92.59
hematopoietic multipotent progenitor cell CL0000837

CSI 6.33

rCSI 15.22%

PRS 96.99
common lymphoid progenitor CL0000051

CSI 6.18

rCSI 8.26%

PRS 97.65
double negative thymocyte CL0002489

CSI 6.17

rCSI 4.29%

PRS 97.56
kidney collecting duct intercalated cell CL1001432

CSI 5.64

rCSI 40.27%

PRS 87.65
renal beta-intercalated cell CL0002201

CSI 5.63

rCSI 13.43%

PRS 91.44
enteroendocrine cell of small intestine CL0009006

CSI 5.46

rCSI 12.03%

PRS 93.73
small intestine goblet cell CL1000495

CSI 5.46

rCSI 11.95%

PRS 93.21
BEST4+ enteroycte CL4030026

CSI 4.91

rCSI 6.1%

PRS 90.99
kidney proximal convoluted tubule epithelial cell CL1000838

CSI 4.37

rCSI 46.36%

PRS 81.61
paneth cell of epithelium of small intestine CL1000343

CSI 4.15

rCSI 11.64%

PRS 93.93
brush cell CL0002204

CSI 4.14

rCSI 8.2%

PRS 93.77
type EC enteroendocrine cell CL0000577

CSI 4.04

rCSI 14.33%

PRS 92.43
erythroblast CL0000765

CSI 3.9

rCSI 10.35%

PRS 92
transit amplifying cell of small intestine CL0009012

CSI 3.88

rCSI 17.03%

PRS 94.19
enterocyte of epithelium of small intestine CL1000334

CSI 3.87

rCSI 59.82%

PRS 93.6
kidney epithelial cell CL0002518

CSI 3.79

rCSI 7.24%

PRS 97.37
transit amplifying cell of colon CL0009011

CSI 3.69

rCSI 4.34%

PRS 91.21
myofibroblast cell CL0000186

CSI 3.65

rCSI 5.06%

PRS 88.15
neutrophil CL0000775

CSI 3.62

rCSI 20.24%

PRS 88.74
type L enteroendocrine cell CL0002279

CSI 3.56

rCSI 6.68%

PRS 92.96
type B pancreatic cell CL0000169

CSI 3.55

rCSI 7.85%

PRS 91.31
peptic cell CL0000155

CSI 3.23

rCSI 31.79%

PRS 94.83
colon epithelial cell CL0011108

CSI 3.06

rCSI 3.21%

PRS 89.15
renal intercalated cell CL0005010

CSI 2.8

rCSI 24.98%

PRS 97.99
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 2.75

rCSI 12.49%

PRS 97.53
goblet cell CL0000160

CSI 2.52

rCSI 2.38%

PRS 89.22
pulmonary ionocyte CL0017000

CSI 2.32

rCSI 2.82%

PRS 94.33
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.27

rCSI 3.22%

PRS 89.29
common dendritic progenitor CL0001029

CSI 2.08

rCSI 2.61%

PRS 95.41
transit amplifying cell CL0009010

CSI 1.84

rCSI 2.81%

PRS 94.3
thymocyte CL0000893

CSI 1.78

rCSI 6.33%

PRS 98.25
enteroendocrine cell of colon CL0009042

CSI 1.43

rCSI 6.69%

PRS 93.21
cord blood hematopoietic stem cell CL2000095

CSI 1.37

rCSI 26.28%

PRS 95.53
pancreatic PP cell CL0002275

CSI 1.32

rCSI 5.25%

PRS 94.11
enterocyte of epithelium of large intestine CL0002071

CSI 1.2

rCSI 6.28%

PRS 92.85
retinal cone cell CL0000573

CSI 1.14

rCSI 1.83%

PRS 84.1
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.99

rCSI 3.85%

PRS 98.05
eosinophil CL0000771

CSI 0.95

rCSI 6.22%

PRS 97.01
kidney granular cell CL0000648

CSI 0.7

rCSI 10.11%

PRS 91.48
P/D1 enteroendocrine cell CL0002268

CSI 0.46

rCSI 2.52%

PRS 93.55

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SMIM24](/details-gene/284422), or Small Integral Membrane Protein 24, is a protein-coding gene located on human chromosome 19p13.3. As its name suggests, it is annotated as an integral component of the membrane ([GO:0016020](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)). Expression data indicates a prominent role for [SMIM24](/details-gene/284422) within two major biological systems: the gastrointestinal epithelium and the hematopoietic system. It shows particularly high significance in [intestinal epithelial cells](/details-cell/CL0002563) and early hematopoietic progenitors, including [common myeloid progenitors](/details-cell/CL0000049) and [hematopoietic stem cells](/details-cell/CL0000037), suggesting its involvement in mucosal barrier function and blood cell development. The gene was identified as part of large-scale sequencing and cDNA collection projects ([Link](https://doi.org/10.1038/nature02399), [Link](https://doi.org/10.1101/gr.2596504)). ## Cellular Roles and Expression Landscape The **Overall** expression profile of [SMIM24](/details-gene/284422) highlights its significance in distinct cellular contexts, primarily within mucosal and hematopoietic tissues. Its most significant expression is observed in the [intestinal epithelial cell](/details-cell/CL0002563) lineage (CSI: 34.19), with high scores in specialized subtypes such as [intestine goblet cells](/details-cell/CL0019031) (CSI: 21.32), [colonocytes](/details-cell/CL1000347) (CSI: 20.77), [paneth cells](/details-cell/CL0000510) (CSI: 16.13), and [enterocytes](/details-cell/CL0000584) (CSI: 12.03). This strong and consistent signal across various intestinal epithelial types points towards a fundamental role in maintaining the structure or function of the gut mucosal barrier. Concurrently, [SMIM24](/details-gene/284422) is a significant gene in the hematopoietic hierarchy. It is highly ranked in primitive and progenitor cells, including [common myeloid progenitors](/details-cell/CL0000049) (CSI: 29.32), [hematopoietic stem cells](/details-cell/CL0000037) (CSI: 19.26), and general [hematopoietic precursor cells](/details-cell/CL0008001) (CSI: 16.20). The gene also shows notable significance in the B-cell development pathway, with high scores in [small pre-B-II cells](/details-cell/CL0000954) (CSI: 17.53), [precursor B cells](/details-cell/CL0000817) (CSI: 17.46), and [pro-B cells](/details-cell/CL0000826) (CSI: 14.73). Its expression in [granulocytes](/details-cell/CL0000094) (CSI: 23.98) and [promyelocytes](/details-cell/CL0000836) (CSI: 15.15) further extends its relevance to the myeloid lineage. This pattern suggests that [SMIM24](/details-gene/284422) may be involved in the maintenance, proliferation, or early differentiation events within the bone marrow. ## Pathways and Molecular Function Functional annotation for [SMIM24](/details-gene/284422) is currently broad. It is classified under the general Gene Ontology terms [Biological_process](/details-cell/GO:0008150) and [Molecular_function](/details-cell/GO:0003674). The most specific annotation is its localization as an integral component of the [Membrane](/details-cell/GO:0016020), which is consistent with its protein name. This membrane localization suggests that it could function as a receptor, channel, or adhesion molecule, mediating interactions between the cell and its environment. In the context of intestinal epithelium, this could relate to nutrient transport or cell-cell junctions. In hematopoietic precursors, it might play a role in sensing niche-derived signals that govern self-renewal or differentiation. ## Research Directions The dual-niche expression pattern of [SMIM24](/details-gene/284422) in both the gut epithelium and early hematopoietic cells raises intriguing questions about its specific function. ### Proposed Hypotheses: 1. **[SMIM24](/details-gene/284422) is essential for the differentiation or maintenance of specific hematopoietic lineages.** Its high significance in stem and progenitor populations ([common myeloid progenitor](/details-cell/CL0000049), [hematopoietic stem cell](/details-cell/CL0000037)) and B-cell precursors suggests it may be required for commitment to these fates. Its loss could lead to a bias in lineage output or a failure of progenitor maturation. 2. **[SMIM24](/details-gene/284422) functions in maintaining the integrity of the intestinal epithelial barrier.** Its strong expression across multiple absorptive and secretory cell types of the intestine ([enterocyte](/details-cell/CL0000584), [intestine goblet cell](/details-cell/CL0019031)) suggests a role in cell adhesion, polarity, or specialized functions like mucus production or antimicrobial defense. ### Experimental Approach: To test the hypothesis that [SMIM24](/details-gene/284422) is critical for hematopoietic differentiation (Hypothesis 1), a robust experimental plan would involve functional genomics in a primary cell model. One could utilize CRISPR-Cas9 to knock out [SMIM24](/details-gene/284422) in human CD34+ hematopoietic stem and progenitor cells (HSPCs). These modified HSPCs, alongside control cells, would then be cultured *in vitro* under conditions that promote differentiation towards myeloid and lymphoid lineages. The effects of the knockout could be quantified by performing colony-forming unit (CFU) assays to assess progenitor potential and by using multi-parameter flow cytometry to measure the frequency of mature cell types (e.g., granulocytes, monocytes, B cells) over time. ### Therapeutic Potential: As an integral membrane protein, [SMIM24](/details-gene/284422) is, in principle, an accessible target for antibody-based therapies. However, its widespread and significant expression in two critical and highly proliferative tissues—the intestinal lining and the hematopoietic stem/progenitor cell compartment—poses a major challenge for therapeutic development. Systemic inhibition of [SMIM24](/details-gene/284422) carries a high risk of severe on-target toxicities, such as bone marrow suppression and gastrointestinal damage. Therefore, its potential as a therapeutic target would likely be limited to contexts where its expression is aberrantly and specifically upregulated in a disease state, such as in certain leukemias or gastrointestinal cancers, which would require further investigation.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Small integral membrane protein 24

Genular Protein ID: 3828843401

Symbol: SIM24_HUMAN

Name: Small integral membrane protein 24

UniProtKB Accession Codes:

O75264 B9EJF4 Q9P059

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 130
Mass: 14964
Checksum: 678E332E2A13BCC7
Sequence:

METLGALLVL EFLLLSPVEA QQATEHRLKP WLVGLAAVVG FLFIVYLVLL ANRLWCSKAR 
AEDEEETTFR MESNLYQDQS EDKREKKEAK EKEEKRKKEK KTAKEGESNL GLDLEEKEPG 
DHERAKSTVM