Details for: IGHV1 12

Gene ID: 28471

Symbol: IGHV1 12

Ensembl ID: ENSG00000254174

Description: immunoglobulin heavy variable 1-12 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1626
    Cell Significance Index: 2.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0446
    Cell Significance Index: -0.4700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0665
    Cell Significance Index: -0.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0711
    Cell Significance Index: -0.7700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0712
    Cell Significance Index: -0.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0829
    Cell Significance Index: -0.8600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0840
    Cell Significance Index: -1.0300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0931
    Cell Significance Index: -0.8000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1030
    Cell Significance Index: -0.8700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1034
    Cell Significance Index: -0.9100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1036
    Cell Significance Index: -0.6900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1101
    Cell Significance Index: -1.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1129
    Cell Significance Index: -1.2500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1191
    Cell Significance Index: -1.6200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1225
    Cell Significance Index: -1.4500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1233
    Cell Significance Index: -1.4300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1245
    Cell Significance Index: -1.6000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1261
    Cell Significance Index: -1.4900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1264
    Cell Significance Index: -1.9200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1289
    Cell Significance Index: -1.4100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1361
    Cell Significance Index: -1.6200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1434
    Cell Significance Index: -2.0900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1461
    Cell Significance Index: -2.3500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1468
    Cell Significance Index: -1.7600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1505
    Cell Significance Index: -2.1100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1507
    Cell Significance Index: -2.0700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1615
    Cell Significance Index: -1.6500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1623
    Cell Significance Index: -2.1300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1636
    Cell Significance Index: -1.6700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1669
    Cell Significance Index: -2.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1686
    Cell Significance Index: -1.9900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1701
    Cell Significance Index: -1.9600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1754
    Cell Significance Index: -1.9600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1801
    Cell Significance Index: -2.3300
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1862
    Cell Significance Index: -0.8600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1907
    Cell Significance Index: -2.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1939
    Cell Significance Index: -1.8200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1968
    Cell Significance Index: -1.8000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2014
    Cell Significance Index: -2.6500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2115
    Cell Significance Index: -2.2500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2117
    Cell Significance Index: -2.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2134
    Cell Significance Index: -2.4600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2152
    Cell Significance Index: -2.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2234
    Cell Significance Index: -2.6400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2256
    Cell Significance Index: -2.9500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2276
    Cell Significance Index: -1.9400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2373
    Cell Significance Index: -2.2500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2403
    Cell Significance Index: -2.8400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2416
    Cell Significance Index: -2.6800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2433
    Cell Significance Index: -2.8000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2439
    Cell Significance Index: -2.6300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2608
    Cell Significance Index: -2.4400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2618
    Cell Significance Index: -2.4300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2631
    Cell Significance Index: -2.7700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2655
    Cell Significance Index: -2.6500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2696
    Cell Significance Index: -2.5100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2725
    Cell Significance Index: -2.9300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.2731
    Cell Significance Index: -2.8300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2781
    Cell Significance Index: -2.8200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.2808
    Cell Significance Index: -2.7700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.2970
    Cell Significance Index: -2.8100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2977
    Cell Significance Index: -2.6500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3106
    Cell Significance Index: -2.7700
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.3125
    Cell Significance Index: -2.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3163
    Cell Significance Index: -3.0400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.3178
    Cell Significance Index: -2.7700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3217
    Cell Significance Index: -2.7400
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.3410
    Cell Significance Index: -2.7400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.3554
    Cell Significance Index: -2.8400
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.3803
    Cell Significance Index: -2.9200
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.3997
    Cell Significance Index: -2.7700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.4132
    Cell Significance Index: -2.9200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.4271
    Cell Significance Index: -2.7800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4603
    Cell Significance Index: -2.5100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.4613
    Cell Significance Index: -3.0600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.5174
    Cell Significance Index: -2.7700
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.5218
    Cell Significance Index: -2.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV1-12 is a pseudogene, meaning that it lacks the ability to produce a functional protein. Despite this, it exhibits significant expression in multiple immune cell types, including CD4+ and CD8+ T cells, B cells, plasmablasts, and natural killer cells. This widespread expression suggests that IGHV1-12 may be involved in regulating immune cell development, differentiation, or function. Furthermore, the gene's expression in classical monocytes and IgA plasma cells highlights its potential role in modulating immune responses in distinct cellular contexts. **Pathways and Functions:** The mechanisms by which IGHV1-12 exerts its effects are not yet fully understood. However, several pathways have been implicated in its function. The gene is thought to interact with other immune-related genes, influencing the expression of cytokines, chemokines, and adhesion molecules. IGHV1-12 may also modulate the activity of immune cells through the regulation of signaling pathways, such as the NF-κB pathway. Additionally, the gene's expression in plasmablasts and IgA plasma cells suggests that it may play a role in the regulation of antibody production and immune responses against pathogens. **Clinical Significance:** The clinical implications of IGHV1-12 are multifaceted. Its expression in various immune cells suggests that the gene may be involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Furthermore, IGHV1-12 may contribute to the development of cancer by modulating the activity of immune cells, such as T cells and natural killer cells. Additionally, the gene's expression in classical monocytes and IgA plasma cells highlights its potential role in modulating immune responses in distinct cellular contexts, which may have implications for the treatment of infections and inflammatory diseases. In conclusion, IGHV1-12 is a pseudogene that plays a crucial role in modulating immune responses. Its widespread expression across various immune cells suggests that the gene is involved in regulating immune cell development, differentiation, or function. Further research is necessary to elucidate the mechanisms by which IGHV1-12 exerts its effects and to explore its clinical significance in the context of autoimmune diseases, cancer, and infectious diseases. **Future Directions:** Future studies should focus on investigating the molecular mechanisms by which IGHV1-12 regulates immune responses. This may involve the use of gene editing technologies, such as CRISPR/Cas9, to knockdown or knockout IGHV1-12 in specific cell types. Additionally, the expression of IGHV1-12 in distinct cellular contexts should be further explored to elucidate its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.