Details for: NKIRAS1

Gene ID: 28512

Symbol: NKIRAS1

Ensembl ID: ENSG00000197885

Description: NFKB inhibitor interacting Ras like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 136.9377
    Cell Significance Index: -21.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.0587
    Cell Significance Index: -20.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.0745
    Cell Significance Index: -21.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.4270
    Cell Significance Index: -16.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.8171
    Cell Significance Index: -21.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.3445
    Cell Significance Index: -21.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4181
    Cell Significance Index: -21.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6639
    Cell Significance Index: -14.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9014
    Cell Significance Index: -6.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.2532
    Cell Significance Index: 142.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5001
    Cell Significance Index: 285.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1553
    Cell Significance Index: 8.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7030
    Cell Significance Index: 36.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6921
    Cell Significance Index: 18.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6645
    Cell Significance Index: 459.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6303
    Cell Significance Index: 126.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6110
    Cell Significance Index: 60.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5893
    Cell Significance Index: 8.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4725
    Cell Significance Index: 93.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3965
    Cell Significance Index: 8.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3812
    Cell Significance Index: 44.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3655
    Cell Significance Index: 21.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3472
    Cell Significance Index: 37.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3231
    Cell Significance Index: 52.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3142
    Cell Significance Index: 19.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3100
    Cell Significance Index: 111.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2958
    Cell Significance Index: 16.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2666
    Cell Significance Index: 7.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2432
    Cell Significance Index: 5.0900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.2258
    Cell Significance Index: 3.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2243
    Cell Significance Index: 5.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2232
    Cell Significance Index: 11.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2094
    Cell Significance Index: 9.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1594
    Cell Significance Index: 19.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1515
    Cell Significance Index: 20.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1464
    Cell Significance Index: 3.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1381
    Cell Significance Index: 75.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1209
    Cell Significance Index: 21.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1209
    Cell Significance Index: 2.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1054
    Cell Significance Index: 8.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0932
    Cell Significance Index: 175.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0856
    Cell Significance Index: 3.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0836
    Cell Significance Index: 2.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0687
    Cell Significance Index: 1.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0680
    Cell Significance Index: 8.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0546
    Cell Significance Index: 83.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0504
    Cell Significance Index: 0.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0458
    Cell Significance Index: 1.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0455
    Cell Significance Index: 0.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0338
    Cell Significance Index: 14.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0298
    Cell Significance Index: 40.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0287
    Cell Significance Index: 52.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0191
    Cell Significance Index: 0.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0166
    Cell Significance Index: 10.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0142
    Cell Significance Index: 0.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0117
    Cell Significance Index: 0.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0081
    Cell Significance Index: 0.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0032
    Cell Significance Index: 0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0010
    Cell Significance Index: -0.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0072
    Cell Significance Index: -0.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0088
    Cell Significance Index: -0.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0123
    Cell Significance Index: -5.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0138
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0169
    Cell Significance Index: -12.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0214
    Cell Significance Index: -16.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0270
    Cell Significance Index: -1.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0288
    Cell Significance Index: -16.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0455
    Cell Significance Index: -3.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0542
    Cell Significance Index: -5.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0606
    Cell Significance Index: -17.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0638
    Cell Significance Index: -8.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0648
    Cell Significance Index: -4.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0653
    Cell Significance Index: -11.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0999
    Cell Significance Index: -11.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1039
    Cell Significance Index: -21.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1094
    Cell Significance Index: -6.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1163
    Cell Significance Index: -13.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1291
    Cell Significance Index: -2.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1317
    Cell Significance Index: -8.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1406
    Cell Significance Index: -4.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1439
    Cell Significance Index: -3.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1504
    Cell Significance Index: -15.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1531
    Cell Significance Index: -4.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1564
    Cell Significance Index: -1.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1909
    Cell Significance Index: -3.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2067
    Cell Significance Index: -2.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2124
    Cell Significance Index: -16.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2208
    Cell Significance Index: -5.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2305
    Cell Significance Index: -6.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2365
    Cell Significance Index: -5.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2704
    Cell Significance Index: -5.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2893
    Cell Significance Index: -15.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3186
    Cell Significance Index: -10.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3529
    Cell Significance Index: -5.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3821
    Cell Significance Index: -12.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3903
    Cell Significance Index: -12.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3989
    Cell Significance Index: -6.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NKIRAS1 is a Ras-like protein that inhibits the NF-κB signaling pathway, a key regulator of immune responses. The protein interacts with NF-κB inhibitors, preventing the activation of NF-κB and subsequent transcription of inflammatory genes. NKIRAS1 is highly expressed in various cell types, including germ cells, mural cells, and immune cells, suggesting its widespread role in immune regulation. **Pathways and Functions:** NKIRAS1 is involved in several key immune pathways, including: 1. **Canonical NF-κB signaling**: NKIRAS1 inhibits the activation of NF-κB, a transcription factor that regulates the expression of inflammatory genes. 2. **Cytokine signaling**: NKIRAS1 modulates cytokine signaling, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 3. **Toll-like receptor (TLR) signaling**: NKIRAS1 interacts with TLRs, which recognize pathogen-associated molecular patterns (PAMPs) and activate immune responses. 4. **Endoplasmic reticulum (ER) stress**: NKIRAS1 regulates ER stress responses, which are critical for maintaining immune homeostasis. NKIRAS1's functions in these pathways are essential for maintaining immune homeostasis and preventing excessive inflammation. Dysregulation of NKIRAS1 has been implicated in various diseases, including autoimmune disorders and cancer. **Clinical Significance:** Dysregulation of NKIRAS1 has been implicated in several diseases, including: 1. **Autoimmune disorders**: NKIRAS1's inhibition of NF-κB signaling may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: NKIRAS1's role in regulating immune responses and tumor necrosis factor (TNF) signaling may impact cancer progression and immune evasion. 3. **Infectious diseases**: NKIRAS1's involvement in TLR signaling and cytokine production may influence the course of infections, such as tuberculosis and sepsis. In conclusion, NKIRAS1 is a critical regulator of immune responses, and its dysregulation has significant implications for human health. Further research into the mechanisms of NKIRAS1's action and its involvement in disease will provide valuable insights into the development of novel therapeutic strategies. **Future Directions:** 1. Investigating the mechanisms of NKIRAS1's interaction with NF-κB inhibitors and TLRs. 2. Exploring the role of NKIRAS1 in regulating immune responses in various diseases. 3. Developing novel therapeutic strategies targeting NKIRAS1 or its downstream pathways. By elucidating the role of NKIRAS1 in immune regulation and disease, we can gain a deeper understanding of the complex interactions between the immune system and various diseases, ultimately leading to the development of more effective treatments.

Genular Protein ID: 2819865689

Symbol: KBRS1_HUMAN

Name: NF-kappa-B inhibitor-interacting Ras-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10657303

Title: A subclass of Ras proteins that regulate the degradation of IkappaB.

PubMed ID: 10657303

DOI: 10.1126/science.287.5454.869

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12672800

Title: KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes.

PubMed ID: 12672800

DOI: 10.1074/jbc.m301021200

PubMed ID: 15024091

Title: Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras.

PubMed ID: 15024091

DOI: 10.1128/mcb.24.7.3048-3056.2004

Sequence Information:

  • Length: 192
  • Mass: 21643
  • Checksum: 84948448BE0853B0
  • Sequence:
  • MGKGCKVVVC GLLSVGKTAI LEQLLYGNHT IGMEDCETME DVYMASVETD RGVKEQLHLY 
    DTRGLQEGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL KKEIDKFKDK KEVAIVVLGN 
    KIDLSEQRQV DAEVAQQWAK SEKVRLWEVT VTDRKTLIEP FTLLASKLSQ PQSKSSFPLP 
    GRKNKGNSNS EN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.