Gene GPS2 - ENSG00000132522 | NCBI Gene ID: 2874

Details for: GPS2

Gene ID: 2874

Symbol: GPS2

Ensembl ID: ENSG00000132522

Description: G protein pathway suppressor 2

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Disease
(R-HSA-1643685)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of mecp2 binding ability to the ncor/smrt complex
(R-HSA-9022537)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Pervasive developmental disorders
(R-HSA-9005895)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Viral infection pathways
(R-HSA-9824446)
B cell differentiation
(GO:0030183)
Cyclin binding
(GO:0030332)
Cytosol
(GO:0005829)
Gtpase inhibitor activity
(GO:0005095)
Jnk cascade
(GO:0007254)
Mitochondrion
(GO:0005739)
Negative regulation of b cell receptor signaling pathway
(GO:0050859)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of protein k63-linked ubiquitination
(GO:1900045)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to mitochondrial depolarisation
(GO:0098780)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)
Transcription repressor complex
(GO:0017053)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: germ cell (CL0000586)
Fold Change: 1.71
Marker Score: 2988
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.67
Marker Score: 4671
Cell Name: acinar cell (CL0000622)
Fold Change: 1.51
Marker Score: 1068.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.25
Marker Score: 42680
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.22
Marker Score: 826
Cell Name: male germ cell (CL0000015)
Fold Change: 1.12
Marker Score: 323
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.04
Marker Score: 5131
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.03
Marker Score: 417
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71662
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47887
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.99
Marker Score: 4237
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30389
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.97
Marker Score: 417
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.96
Marker Score: 1010
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.96
Marker Score: 954.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.95
Marker Score: 476
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.95
Marker Score: 686
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2391
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 478
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.93
Marker Score: 913
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 434
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.92
Marker Score: 326
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2696
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.9
Marker Score: 375
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.87
Marker Score: 891
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.87
Marker Score: 1255
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.87
Marker Score: 594.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.87
Marker Score: 508
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.84
Marker Score: 260
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.83
Marker Score: 4740
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.83
Marker Score: 8541
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.82
Marker Score: 237
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.82
Marker Score: 263
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.82
Marker Score: 751
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.81
Marker Score: 488
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.81
Marker Score: 755
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.8
Marker Score: 258
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.8
Marker Score: 963
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.79
Marker Score: 409
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.79
Marker Score: 1219
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.78
Marker Score: 236
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261
Cell Name: neuron (CL0000540)
Fold Change: 0.77
Marker Score: 3132
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.77
Marker Score: 307
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.76
Marker Score: 166
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.76
Marker Score: 447
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.76
Marker Score: 193
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.76
Marker Score: 268
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.75
Marker Score: 189
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.75
Marker Score: 552
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.75
Marker Score: 168
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.75
Marker Score: 191
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 572.5
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.75
Marker Score: 629
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.74
Marker Score: 934
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.74
Marker Score: 163
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.73
Marker Score: 361
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.73
Marker Score: 174
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 375
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.72
Marker Score: 784
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 0.72
Marker Score: 162
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.71
Marker Score: 176
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.71
Marker Score: 187
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.71
Marker Score: 188
Cell Name: neural cell (CL0002319)
Fold Change: 0.7
Marker Score: 339
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.7
Marker Score: 149
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.7
Marker Score: 1721
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.7
Marker Score: 191
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.69
Marker Score: 242
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.69
Marker Score: 136
Cell Name: microglial cell (CL0000129)
Fold Change: 0.69
Marker Score: 1262
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.68
Marker Score: 279
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.68
Marker Score: 3166
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.68
Marker Score: 138
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.68
Marker Score: 170
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.68
Marker Score: 165
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.68
Marker Score: 12133
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.68
Marker Score: 150
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2845.5
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.68
Marker Score: 187
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.68
Marker Score: 236
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.68
Marker Score: 189
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.67
Marker Score: 167
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.67
Marker Score: 442
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.67
Marker Score: 188
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.67
Marker Score: 280
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.66
Marker Score: 425
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.66
Marker Score: 973
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.66
Marker Score: 364
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.66
Marker Score: 248
Cell Name: brush cell (CL0002204)
Fold Change: 0.66
Marker Score: 600
Cell Name: Unknown (CL0000548)
Fold Change: 0.66
Marker Score: 478
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.65
Marker Score: 707
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.65
Marker Score: 6632
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 0.65
Marker Score: 181
Cell Name: erythroblast (CL0000765)
Fold Change: 0.65
Marker Score: 405
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.65
Marker Score: 186

Hover over a box to see details here...

**Key characteristics**: * GPS2 is a protein that is highly expressed in germ cells, CD8-positive and alpha-beta memory T cells, CD45RO-positive cells, acinar cells, fibroblasts of the mammary gland, proerythroblast, and male germ cells. * It is a negative regulator of gene expression. * It is involved in the regulation of lipid metabolism by pparalpha, which is a key regulator of energy metabolism. * It is also involved in the regulation of embryonic development and cancer. **Pathways and functions**: * GPS2 is involved in the regulation of lipid metabolism by pparalpha. * It is also involved in the regulation of embryonic development and cancer. * It is involved in the control of cell proliferation, differentiation, and apoptosis. * It is also involved in the regulation of inflammation and cell migration. **Clinical significance**: * Mutations in the GPS2 gene have been linked to a number of human diseases, including cancer, developmental disorders, and metabolic disorders. * GPS2 inhibitors are being investigated as a potential treatment for these diseases. **Additional notes**: * GPS2 is a complex protein that has a number of interacting domains. * It is a key regulator of gene expression, and its activity is regulated by a variety of factors, including growth factors, hormones, and cytokines. * It is a promising target for the treatment of human diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GPS2_HUMAN

Genular Protein ID: 2003659967

Symbol: GPS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13227 B4DXA1 Q6FHM8

Database IDs:

Citations:

PubMed ID: 8943324

Title: Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.

PubMed ID: 8943324

DOI: 10.1128/mcb.16.12.6698

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11931768

Title: The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

PubMed ID: 11931768

DOI: 10.1016/s1097-2765(02)00468-9

PubMed ID: 19858209

Title: G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation.

PubMed ID: 19858209

DOI: 10.1074/jbc.m109.062109

PubMed ID: 19481530

Title: GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

PubMed ID: 19481530

DOI: 10.1016/j.molcel.2009.05.006

PubMed ID: 19917673

Title: Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma.

PubMed ID: 19917673

DOI: 10.1096/fj.09-136283

PubMed ID: 20159957

Title: GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

PubMed ID: 20159957

DOI: 10.1101/gad.545110

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 24223774

Title: GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication.

PubMed ID: 24223774

DOI: 10.1371/journal.pone.0078195

PubMed ID: 24943844

Title: SUMOylation of GPS2 protein regulates its transcription-suppressing function.

PubMed ID: 24943844

DOI: 10.1091/mbc.e13-12-0733

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27270589

Title: Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.

PubMed ID: 27270589

DOI: 10.1038/nm.4114

PubMed ID: 27460081

Title: G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.

PubMed ID: 27460081

DOI: 10.1007/s13277-016-5220-x

PubMed ID: 29499132

Title: Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation.

PubMed ID: 29499132

DOI: 10.1016/j.molcel.2018.01.037

PubMed ID: 21240272

Title: Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.

PubMed ID: 21240272

DOI: 10.1038/nsmb.1983

Sequence Information:

Length: 327
Mass: 36689
Checksum: AE65DA578C978C9B
Sequence:

MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER RKKKEMEERM 
SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR RRKEQSDLTT LTSAAYQQSL 
TVHTGTHLLS MQGSPGGHNR PGTLMAADRA KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF 
QGSPGGAYGT AQPPPHYGPT QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ 
TGFLQPGGAL SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK 
SGFAATSQPG PRLPFIQHSQ NPRFYHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GPS2

Associated with

Cells (max top 100)

Other Information

Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. PubMed ID: 8943324

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. PubMed ID: 11931768

G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. PubMed ID: 19858209

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. PubMed ID: 19481530

Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma. PubMed ID: 19917673

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. PubMed ID: 20159957

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PubMed ID: 22666460

GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication. PubMed ID: 24223774

SUMOylation of GPS2 protein regulates its transcription-suppressing function. PubMed ID: 24943844

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. PubMed ID: 27270589

G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma. PubMed ID: 27460081

Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation. PubMed ID: 29499132

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. PubMed ID: 21240272