GPS2 | ENSG00000132522 | NCBI 2874

Details for: GPS2

Gene ID: 2874

Symbol: GPS2

Ensembl ID: ENSG00000132522

Description: G protein pathway suppressor 2

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Disease
(R-HSA-1643685)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of mecp2 binding ability to the ncor/smrt complex
(R-HSA-9022537)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Pervasive developmental disorders
(R-HSA-9005895)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Viral infection pathways
(R-HSA-9824446)
B cell differentiation
(GO:0030183)
Cyclin binding
(GO:0030332)
Cytosol
(GO:0005829)
Gtpase inhibitor activity
(GO:0005095)
Jnk cascade
(GO:0007254)
Mitochondrion
(GO:0005739)
Negative regulation of b cell receptor signaling pathway
(GO:0050859)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of protein k63-linked ubiquitination
(GO:1900045)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to mitochondrial depolarisation
(GO:0098780)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)
Transcription repressor complex
(GO:0017053)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 179.8834
Cell Significance Index: -27.9800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 112.4019
Cell Significance Index: -28.5100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 70.3495
Cell Significance Index: -28.5800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 62.0158
Cell Significance Index: -31.9000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 30.2595
Cell Significance Index: -28.8900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.6748
Cell Significance Index: -29.1900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.3313
Cell Significance Index: -30.3600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.5088
Cell Significance Index: -29.6300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.3426
Cell Significance Index: -16.0700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.6562
Cell Significance Index: 75.0700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4615
Cell Significance Index: 290.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4412
Cell Significance Index: 177.2100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3393
Cell Significance Index: 241.4400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2337
Cell Significance Index: 134.1900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2056
Cell Significance Index: 34.7400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.0381
Cell Significance Index: 9.5600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.0063
Cell Significance Index: 26.9700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7527
Cell Significance Index: 122.4300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6808
Cell Significance Index: 14.7500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6582
Cell Significance Index: 45.5200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.6561
Cell Significance Index: 16.4000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.6435
Cell Significance Index: 7.3100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6171
Cell Significance Index: 17.6900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5554
Cell Significance Index: 71.2000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4738
Cell Significance Index: 12.6500
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.4616
Cell Significance Index: 11.5100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3646
Cell Significance Index: 50.0800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3634
Cell Significance Index: 72.9000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3495
Cell Significance Index: 9.5100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3360
Cell Significance Index: 5.0400
Cell Name: peg cell (CL4033014)
Fold Change: 0.3331
Cell Significance Index: 7.7000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3139
Cell Significance Index: 31.0500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3012
Cell Significance Index: 15.6900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2915
Cell Significance Index: 55.4800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2799
Cell Significance Index: 18.0600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2389
Cell Significance Index: 12.0800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2375
Cell Significance Index: 27.1100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2194
Cell Significance Index: 7.7100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1967
Cell Significance Index: 23.2000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1897
Cell Significance Index: 103.5900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1758
Cell Significance Index: 121.6100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1660
Cell Significance Index: 73.4100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1126
Cell Significance Index: 5.2900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1105
Cell Significance Index: 39.6300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1020
Cell Significance Index: 4.7600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0868
Cell Significance Index: 78.3300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0733
Cell Significance Index: 3.8100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0291
Cell Significance Index: 2.2400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0029
Cell Significance Index: -5.4000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0075
Cell Significance Index: -1.2900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0076
Cell Significance Index: -4.7600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0088
Cell Significance Index: -13.6000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0091
Cell Significance Index: -16.7600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0099
Cell Significance Index: -13.4300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0164
Cell Significance Index: -12.1300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0174
Cell Significance Index: -12.7400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0239
Cell Significance Index: -13.4700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0316
Cell Significance Index: -23.8900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0336
Cell Significance Index: -2.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0360
Cell Significance Index: -22.8600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0364
Cell Significance Index: -0.2200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0468
Cell Significance Index: -0.9700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0528
Cell Significance Index: -23.9800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0540
Cell Significance Index: -3.8200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0708
Cell Significance Index: -14.9100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0827
Cell Significance Index: -23.8000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0848
Cell Significance Index: -9.7200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0956
Cell Significance Index: -11.1400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1184
Cell Significance Index: -12.0900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1218
Cell Significance Index: -15.7300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1219
Cell Significance Index: -6.8400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1436
Cell Significance Index: -20.8700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1826
Cell Significance Index: -13.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1947
Cell Significance Index: -8.6100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2155
Cell Significance Index: -2.9400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2337
Cell Significance Index: -8.8500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2486
Cell Significance Index: -4.2600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2752
Cell Significance Index: -28.6500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3059
Cell Significance Index: -16.0600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3088
Cell Significance Index: -8.1200
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3238
Cell Significance Index: -6.3200
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3250
Cell Significance Index: -7.9300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3442
Cell Significance Index: -9.6200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3466
Cell Significance Index: -5.8000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3590
Cell Significance Index: -28.4300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4371
Cell Significance Index: -14.0000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4604
Cell Significance Index: -9.8100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4823
Cell Significance Index: -19.7600
Cell Name: glioblast (CL0000030)
Fold Change: -0.5112
Cell Significance Index: -3.2100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5205
Cell Significance Index: -31.9100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5472
Cell Significance Index: -19.1700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5514
Cell Significance Index: -19.1600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5712
Cell Significance Index: -16.7800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5864
Cell Significance Index: -6.9900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6100
Cell Significance Index: -19.9700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6217
Cell Significance Index: -19.8000
Cell Name: perivascular cell (CL4033054)
Fold Change: -0.6541
Cell Significance Index: -3.0200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6761
Cell Significance Index: -17.3800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6899
Cell Significance Index: -14.4400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6961
Cell Significance Index: -18.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** GPS2 is a non-coding RNA gene that is highly expressed in various cell types, including immune cells, epithelial cells, and stem cells. Its primary function is to act as a transcriptional corepressor, which means it regulates gene expression by interacting with transcription factors and co-regulators to either activate or repress transcription. GPS2 is also involved in the regulation of cell signaling pathways, including the G protein-coupled receptor (GPCR) pathway, the JNK cascade, and the NF-κB pathway. Its expression is tightly regulated during development and is essential for normal cell differentiation and function. **Pathways and Functions** GPS2 is involved in various cellular processes, including: 1. **Cell differentiation**: GPS2 regulates the expression of genes involved in cell differentiation, including those involved in the development of immune cells, epithelial cells, and stem cells. 2. **Metabolism**: GPS2 is involved in the regulation of lipid metabolism, including the regulation of cholesterol efflux and the metabolism of fatty acids. 3. **Immune responses**: GPS2 regulates the expression of genes involved in immune responses, including those involved in the activation and function of immune cells, such as T cells and B cells. 4. **Signaling pathways**: GPS2 interacts with various signaling pathways, including the GPCR pathway, the JNK cascade, and the NF-κB pathway, to regulate gene expression and cell function. **Clinical Significance** Dysregulation of GPS2 has been implicated in several diseases, including: 1. **Cancer**: GPS2 has been shown to regulate the expression of genes involved in cell proliferation and survival, making it a potential target for cancer therapy. 2. **Metabolic disorders**: GPS2 is involved in the regulation of lipid metabolism, and its dysregulation has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 3. **Neurodevelopmental disorders**: GPS2 has been shown to regulate the expression of genes involved in neurodevelopment, and its dysregulation has been implicated in neurodevelopmental disorders, such as Rett syndrome. 4. **Infectious diseases**: GPS2 regulates the expression of genes involved in immune responses, and its dysregulation has been implicated in infectious diseases, such as HIV and tuberculosis. In conclusion, GPS2 is a critical regulator of various cellular processes, including cell differentiation, metabolism, and immune responses. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human health and disease. As an immunologist, understanding the functions and pathways regulated by GPS2 is essential for developing new therapeutic strategies for immune-related diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GPS2_HUMAN

Genular Protein ID: 2003659967

Symbol: GPS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13227 B4DXA1 Q6FHM8

Database IDs:

Citations:

PubMed ID: 8943324

Title: Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.

PubMed ID: 8943324

DOI: 10.1128/mcb.16.12.6698

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11931768

Title: The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

PubMed ID: 11931768

DOI: 10.1016/s1097-2765(02)00468-9

PubMed ID: 19858209

Title: G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation.

PubMed ID: 19858209

DOI: 10.1074/jbc.m109.062109

PubMed ID: 19481530

Title: GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

PubMed ID: 19481530

DOI: 10.1016/j.molcel.2009.05.006

PubMed ID: 19917673

Title: Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma.

PubMed ID: 19917673

DOI: 10.1096/fj.09-136283

PubMed ID: 20159957

Title: GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

PubMed ID: 20159957

DOI: 10.1101/gad.545110

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 24223774

Title: GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication.

PubMed ID: 24223774

DOI: 10.1371/journal.pone.0078195

PubMed ID: 24943844

Title: SUMOylation of GPS2 protein regulates its transcription-suppressing function.

PubMed ID: 24943844

DOI: 10.1091/mbc.e13-12-0733

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27270589

Title: Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.

PubMed ID: 27270589

DOI: 10.1038/nm.4114

PubMed ID: 27460081

Title: G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.

PubMed ID: 27460081

DOI: 10.1007/s13277-016-5220-x

PubMed ID: 29499132

Title: Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation.

PubMed ID: 29499132

DOI: 10.1016/j.molcel.2018.01.037

PubMed ID: 21240272

Title: Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.

PubMed ID: 21240272

DOI: 10.1038/nsmb.1983

Sequence Information:

Length: 327
Mass: 36689
Checksum: AE65DA578C978C9B
Sequence:

MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER RKKKEMEERM 
SLEETKEQIL KLEEKLLALQ EEKHQLFLQL KKVLHEEEKR RRKEQSDLTT LTSAAYQQSL 
TVHTGTHLLS MQGSPGGHNR PGTLMAADRA KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF 
QGSPGGAYGT AQPPPHYGPT QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ 
TGFLQPGGAL SLQKQMEHAN QQTGFSDSSS LRPMHPQALH PAPGLLASPQ LPVQMQPAGK 
SGFAATSQPG PRLPFIQHSQ NPRFYHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GPS2

Associated with

Cells (max top 100)

Other Information

Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. PubMed ID: 8943324

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. PubMed ID: 11931768

G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. PubMed ID: 19858209

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. PubMed ID: 19481530

Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma. PubMed ID: 19917673

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. PubMed ID: 20159957

ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PubMed ID: 22666460

GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication. PubMed ID: 24223774

SUMOylation of GPS2 protein regulates its transcription-suppressing function. PubMed ID: 24943844

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. PubMed ID: 27270589

G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma. PubMed ID: 27460081

Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation. PubMed ID: 29499132

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. PubMed ID: 21240272