Details for: TRAJ14

Gene ID: 28741

Symbol: TRAJ14

Ensembl ID: ENSG00000211875

Description: T cell receptor alpha joining 14

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 9.5787
    Cell Significance Index: 187.2800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.4618
    Cell Significance Index: 31.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6705
    Cell Significance Index: 40.4700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3090
    Cell Significance Index: 4.0600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0935
    Cell Significance Index: 1.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0130
    Cell Significance Index: 0.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0123
    Cell Significance Index: 0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0022
    Cell Significance Index: -0.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0048
    Cell Significance Index: -0.9700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0063
    Cell Significance Index: -0.0800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0125
    Cell Significance Index: -0.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0130
    Cell Significance Index: -0.2200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0132
    Cell Significance Index: -0.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0258
    Cell Significance Index: -1.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0263
    Cell Significance Index: -0.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0380
    Cell Significance Index: -1.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0455
    Cell Significance Index: -0.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0463
    Cell Significance Index: -1.0000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0493
    Cell Significance Index: -0.9700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0552
    Cell Significance Index: -0.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0553
    Cell Significance Index: -1.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0572
    Cell Significance Index: -1.1400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0578
    Cell Significance Index: -0.7800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0728
    Cell Significance Index: -0.8200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0728
    Cell Significance Index: -0.8600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0749
    Cell Significance Index: -0.8300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0752
    Cell Significance Index: -0.9900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0779
    Cell Significance Index: -0.8800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0815
    Cell Significance Index: -0.7500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0842
    Cell Significance Index: -1.0800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0850
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0861
    Cell Significance Index: -1.2400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0872
    Cell Significance Index: -1.0300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0887
    Cell Significance Index: -0.8300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0899
    Cell Significance Index: -1.0900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0913
    Cell Significance Index: -1.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0927
    Cell Significance Index: -1.1400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0941
    Cell Significance Index: -1.0200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0944
    Cell Significance Index: -0.7000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0957
    Cell Significance Index: -1.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0963
    Cell Significance Index: -1.7800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0965
    Cell Significance Index: -1.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1050
    Cell Significance Index: -1.4000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1064
    Cell Significance Index: -0.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1118
    Cell Significance Index: -1.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1163
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1193
    Cell Significance Index: -1.1200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1250
    Cell Significance Index: -1.4700
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.1314
    Cell Significance Index: -1.3300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1338
    Cell Significance Index: -1.4100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1345
    Cell Significance Index: -1.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1346
    Cell Significance Index: -1.4200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1359
    Cell Significance Index: -1.4700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1363
    Cell Significance Index: -1.5600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1366
    Cell Significance Index: -1.3900
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1369
    Cell Significance Index: -1.5700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1405
    Cell Significance Index: -1.5700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1426
    Cell Significance Index: -1.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1443
    Cell Significance Index: -1.1100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.1528
    Cell Significance Index: -1.6500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1553
    Cell Significance Index: -2.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1634
    Cell Significance Index: -1.7800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1709
    Cell Significance Index: -1.6200
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1722
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1913
    Cell Significance Index: -1.7200
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1948
    Cell Significance Index: -1.7800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2054
    Cell Significance Index: -1.5700
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.2169
    Cell Significance Index: -1.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAJ14 is expressed in multiple cell types, including CD4+ and CD8+ T cells, alpha-beta thymocytes, innate lymphoid cells, and retinal rod cells. This widespread expression suggests that TRAJ14 plays a conserved role in various cell types. 2. **TCR Complexity:** TRAJ14 is a component of the TCR complex, which is formed by the association of TRAJ14 with other genes, such as TRAJ1, TRAJ2, and TRAJ3. This complex is essential for the proper functioning of alpha-beta T cells. 3. **Cell-type Specificity:** While TRAJ14 is expressed in multiple cell types, its specific functions and expression levels may vary between these cell types. For example, TRAJ14 may play a more significant role in the development and function of CD4+ T cells compared to CD8+ T cells. **Pathways and Functions:** 1. **TCR Complex Formation:** TRAJ14 is a critical component of the TCR complex, which is formed through the association of TRAJ14 with other genes. This complex is essential for the proper functioning of alpha-beta T cells. 2. **T Cell Development:** TRAJ14 is involved in the development of alpha-beta T cells, which are a subset of T cells crucial for adaptive immunity. The expression of TRAJ14 is necessary for the proper formation and maturation of alpha-beta T cells. 3. **Immune Cell Signaling:** TRAJ14 may also be involved in the signaling pathways that regulate immune cell function. For example, TRAJ14 may interact with other proteins to modulate the activation of T cells and the production of cytokines. 4. **Innate Lymphoid Cell Function:** TRAJ14 is also expressed in innate lymphoid cells, which are a subset of immune cells that play a key role in the early stages of immune responses. The function of TRAJ14 in innate lymphoid cells is not yet fully understood, but it may contribute to the regulation of innate immune responses. **Clinical Significance:** 1. **Immune-Related Disorders:** TRAJ14's involvement in immune cell development and function makes it a potential target for the treatment of immune-related disorders, such as autoimmune diseases and cancer. 2. **Cancer Immunotherapy:** TRAJ14's expression in alpha-beta T cells makes it a potential target for cancer immunotherapy. The modulation of TRAJ14 expression may enhance the functionality of alpha-beta T cells and improve the efficacy of cancer treatments. 3. **Infectious Diseases:** TRAJ14's expression in innate lymphoid cells makes it a potential target for the treatment of infectious diseases. The modulation of TRAJ14 expression may enhance the functionality of innate lymphoid cells and improve the efficacy of treatments for infectious diseases. 4. **Retinal Diseases:** TRAJ14's expression in retinal rod cells makes it a potential target for the treatment of retinal diseases. The modulation of TRAJ14 expression may improve the functionality of retinal rod cells and enhance visual acuity in patients with retinal diseases. In conclusion, TRAJ14 is a gene of enduring significance in the immune system, with a complex role in T cell development, function, and signaling. Further research is necessary to fully understand the mechanisms underlying TRAJ14's function and to explore its clinical potential in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.