Details for: TRAJ5

Gene ID: 28750

Symbol: TRAJ5

Ensembl ID: ENSG00000211884

Description: T cell receptor alpha joining 5

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 5.9396
    Cell Significance Index: 116.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4152
    Cell Significance Index: 34.2800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5256
    Cell Significance Index: 7.6600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4496
    Cell Significance Index: 5.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2942
    Cell Significance Index: 3.8400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2630
    Cell Significance Index: 4.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0827
    Cell Significance Index: 1.8100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0288
    Cell Significance Index: 0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0021
    Cell Significance Index: -0.4300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0034
    Cell Significance Index: -0.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0111
    Cell Significance Index: -0.4900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0140
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0163
    Cell Significance Index: -0.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0177
    Cell Significance Index: -0.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0231
    Cell Significance Index: -0.4600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0288
    Cell Significance Index: -0.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0302
    Cell Significance Index: -0.3600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0304
    Cell Significance Index: -0.4100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0330
    Cell Significance Index: -0.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0330
    Cell Significance Index: -0.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0349
    Cell Significance Index: -0.6500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0356
    Cell Significance Index: -0.4200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0372
    Cell Significance Index: -0.4700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0378
    Cell Significance Index: -0.4500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0391
    Cell Significance Index: -0.5100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0395
    Cell Significance Index: -0.5300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0396
    Cell Significance Index: -0.4400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0404
    Cell Significance Index: -0.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0406
    Cell Significance Index: -0.5200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0407
    Cell Significance Index: -0.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0415
    Cell Significance Index: -0.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0441
    Cell Significance Index: -0.5400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0464
    Cell Significance Index: -0.4400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0474
    Cell Significance Index: -0.5600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0474
    Cell Significance Index: -0.5300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0474
    Cell Significance Index: -0.5100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0474
    Cell Significance Index: -0.5500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0475
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0485
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0501
    Cell Significance Index: -0.4600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0502
    Cell Significance Index: -0.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0505
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0513
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0531
    Cell Significance Index: -0.5600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0551
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0560
    Cell Significance Index: -0.6000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0561
    Cell Significance Index: -0.5200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0571
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0575
    Cell Significance Index: -0.5400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0595
    Cell Significance Index: -0.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0629
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0643
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0661
    Cell Significance Index: -0.6700
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0687
    Cell Significance Index: -0.5600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0709
    Cell Significance Index: -0.6200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0742
    Cell Significance Index: -0.6400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0765
    Cell Significance Index: -0.8800
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0780
    Cell Significance Index: -0.6400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0803
    Cell Significance Index: -0.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0822
    Cell Significance Index: -0.7900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0824
    Cell Significance Index: -0.8300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0881
    Cell Significance Index: -0.8000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0924
    Cell Significance Index: -0.7800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0951
    Cell Significance Index: -0.7400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0978
    Cell Significance Index: -0.6800
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0985
    Cell Significance Index: -0.9100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1027
    Cell Significance Index: -0.5500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2789
    Cell Significance Index: -0.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ5 is a gene that encodes a protein with a unique structure, consisting of an immunoglobulin-like domain and a transmembrane domain. This protein is specifically expressed in cells of the immune system, including alpha-beta T cells, which play a crucial role in adaptive immunity. The expression of TRAJ5 is also evident in other cell types, such as goblet cells, absorptive cells, and stem cells, which are involved in maintaining tissue homeostasis and immune tolerance. Notably, TRAJ5 is also expressed in neoplastic and abnormal cells, suggesting its potential role in cancer development and progression. **Pathways and Functions:** The exact mechanisms by which TRAJ5 regulates immune function are not fully elucidated, but several key pathways are thought to be involved. TRAJ5 is likely to interact with other proteins and receptors on the surface of immune cells, modulating signaling pathways that regulate T cell activation, proliferation, and differentiation. Specifically, TRAJ5 may influence the activity of the T cell receptor (TCR) complex, which is essential for recognizing and responding to antigens. Additionally, TRAJ5 may also interact with other immune-related proteins, such as cytokines and chemokines, to regulate the inflammatory response and tissue homeostasis. **Clinical Significance:** The clinical significance of TRAJ5 is an area of active research, with several potential implications for immunological disorders. Mutations or alterations in TRAJ5 expression have been implicated in various diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. For example, TRAJ5 may play a role in the development of autoimmune responses by modulating T cell activation and regulation. Furthermore, TRAJ5 may also contribute to the pathogenesis of inflammatory bowel disease by influencing the function of epithelial cells and the intestinal immune response. In cancer, TRAJ5 may serve as a biomarker for diagnosis or a therapeutic target for immunotherapy. In conclusion, TRAJ5 is a complex gene with a multifaceted role in immune regulation and tissue homeostasis. Further research is needed to elucidate the precise mechanisms by which TRAJ5 contributes to immune function and disease pathogenesis, but its clinical significance is already clear. Understanding the role of TRAJ5 in immunological disorders may lead to the development of novel therapeutic strategies and improved treatment outcomes for patients with autoimmune diseases, inflammatory bowel disease, and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.