Details for: TRAJ5

Gene ID: 28750

Symbol: TRAJ5

Ensembl ID: ENSG00000211884

Description: T cell receptor alpha joining 5

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: leukocyte (CL0000738)
    Fold Change: 4.2
    Marker Score: 2,413
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,816
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,581
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,659
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,730
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.59
    Marker Score: 444
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.51
    Marker Score: 835
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.41
    Marker Score: 715
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.02
    Marker Score: 880
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 8

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ5 is a gene that encodes a protein with a unique structure, consisting of an immunoglobulin-like domain and a transmembrane domain. This protein is specifically expressed in cells of the immune system, including alpha-beta T cells, which play a crucial role in adaptive immunity. The expression of TRAJ5 is also evident in other cell types, such as goblet cells, absorptive cells, and stem cells, which are involved in maintaining tissue homeostasis and immune tolerance. Notably, TRAJ5 is also expressed in neoplastic and abnormal cells, suggesting its potential role in cancer development and progression. **Pathways and Functions:** The exact mechanisms by which TRAJ5 regulates immune function are not fully elucidated, but several key pathways are thought to be involved. TRAJ5 is likely to interact with other proteins and receptors on the surface of immune cells, modulating signaling pathways that regulate T cell activation, proliferation, and differentiation. Specifically, TRAJ5 may influence the activity of the T cell receptor (TCR) complex, which is essential for recognizing and responding to antigens. Additionally, TRAJ5 may also interact with other immune-related proteins, such as cytokines and chemokines, to regulate the inflammatory response and tissue homeostasis. **Clinical Significance:** The clinical significance of TRAJ5 is an area of active research, with several potential implications for immunological disorders. Mutations or alterations in TRAJ5 expression have been implicated in various diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. For example, TRAJ5 may play a role in the development of autoimmune responses by modulating T cell activation and regulation. Furthermore, TRAJ5 may also contribute to the pathogenesis of inflammatory bowel disease by influencing the function of epithelial cells and the intestinal immune response. In cancer, TRAJ5 may serve as a biomarker for diagnosis or a therapeutic target for immunotherapy. In conclusion, TRAJ5 is a complex gene with a multifaceted role in immune regulation and tissue homeostasis. Further research is needed to elucidate the precise mechanisms by which TRAJ5 contributes to immune function and disease pathogenesis, but its clinical significance is already clear. Understanding the role of TRAJ5 in immunological disorders may lead to the development of novel therapeutic strategies and improved treatment outcomes for patients with autoimmune diseases, inflammatory bowel disease, and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.