Details for: GRIK2

Gene ID: 2898

Symbol: GRIK2

Ensembl ID: ENSG00000164418

Description: glutamate ionotropic receptor kainate type subunit 2

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Activation of na-permeable kainate receptors
    (R-HSA-451307)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Behavioral fear response
    (GO:0001662)
  • Chemical synaptic transmission
    (GO:0007268)
  • Dendrite cytoplasm
    (GO:0032839)
  • Detection of cold stimulus involved in thermoception
    (GO:0120169)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Extracellularly glutamate-gated ion channel activity
    (GO:0005234)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Glutamatergic synapse
    (GO:0098978)
  • Hippocampal mossy fiber to ca3 synapse
    (GO:0098686)
  • Identical protein binding
    (GO:0042802)
  • Inhibitory postsynaptic potential
    (GO:0060080)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Modulation of excitatory postsynaptic potential
    (GO:0098815)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Mossy fiber rosette
    (GO:0097471)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of synaptic transmission, glutamatergic
    (GO:0051967)
  • Neuronal action potential
    (GO:0019228)
  • Neuron apoptotic process
    (GO:0051402)
  • Pdz domain binding
    (GO:0030165)
  • Perikaryon
    (GO:0043204)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of synaptic transmission
    (GO:0050806)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Presynaptic modulation of chemical synaptic transmission
    (GO:0099171)
  • Receptor clustering
    (GO:0043113)
  • Regulation of jnk cascade
    (GO:0046328)
  • Regulation of long-term neuronal synaptic plasticity
    (GO:0048169)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Regulation of short-term neuronal synaptic plasticity
    (GO:0048172)
  • Scaffold protein binding
    (GO:0097110)
  • Snare binding
    (GO:0000149)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Terminal bouton
    (GO:0043195)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)
  • Ubiquitin conjugating enzyme binding
    (GO:0031624)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 11.25
    Marker Score: 84796
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 11.16
    Marker Score: 58524
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 10.5
    Marker Score: 56410
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 8.68
    Marker Score: 19954
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.78
    Marker Score: 6729
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.51
    Marker Score: 20872
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 4.12
    Marker Score: 2390
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 3.91
    Marker Score: 1291
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.88
    Marker Score: 4837
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.74
    Marker Score: 2812
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.61
    Marker Score: 121770
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.5
    Marker Score: 11728
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.28
    Marker Score: 1042
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.26
    Marker Score: 1828
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.99
    Marker Score: 8516
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58176
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22103
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42796
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.8
    Marker Score: 4703
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.74
    Marker Score: 104053
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10852
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.48
    Marker Score: 8815
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.44
    Marker Score: 90019
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.39
    Marker Score: 2956
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9149
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 2.2
    Marker Score: 739
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.15
    Marker Score: 651
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20076
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127718
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.08
    Marker Score: 798.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.04
    Marker Score: 21088
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8256
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.95
    Marker Score: 818
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18326
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.91
    Marker Score: 2574
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.9
    Marker Score: 911
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.89
    Marker Score: 3585
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16147
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.87
    Marker Score: 4481
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.85
    Marker Score: 7703
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.77
    Marker Score: 37714
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2551
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.62
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.61
    Marker Score: 3282
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.6
    Marker Score: 829
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.6
    Marker Score: 1841
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.56
    Marker Score: 1356
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.56
    Marker Score: 938
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167296
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.45
    Marker Score: 2647
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.37
    Marker Score: 507
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.36
    Marker Score: 1642.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.35
    Marker Score: 792
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.34
    Marker Score: 802
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.34
    Marker Score: 600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.32
    Marker Score: 920
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.32
    Marker Score: 1645
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19159
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.22
    Marker Score: 423
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4793
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71785
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48011
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.97
    Marker Score: 1072.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.96
    Marker Score: 854
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.95
    Marker Score: 434.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.94
    Marker Score: 16667
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5312
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.79
    Marker Score: 17683
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 374
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.78
    Marker Score: 452
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.76
    Marker Score: 365
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.75
    Marker Score: 1759
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 671
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.72
    Marker Score: 3008
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.71
    Marker Score: 316
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.71
    Marker Score: 200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7
    Marker Score: 845
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.69
    Marker Score: 171
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.69
    Marker Score: 7008
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.68
    Marker Score: 277
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.68
    Marker Score: 644
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.68
    Marker Score: 213
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.67
    Marker Score: 4009
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.66
    Marker Score: 437

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Other Information

**Key characteristics:** * The GRIK2 gene is located on chromosome 15q21.1. * It is a member of the glutamatergic glutamate receptor family. * The protein is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including granule cell, neuron associated cell (sensu Vertebrata), stellate neuron, macroglial cell, chromaffin cell, inhibitory interneuron, brainstem motor neuron, sympathetic neuron, cardiac neuron, and photoreceptor cell. **Pathways and functions:** * The GRIK2 gene is activated by glutamate binding to its ligand, which is an excitatory amino acid. * Activation of GRIK2 leads to the opening of ion channels in the plasma membrane, which allows calcium ions to enter the cell. * Calcium ions bind to a variety of intracellular proteins, including calmodulin and calcineurin, which then activate downstream signaling pathways that lead to a variety of cellular responses, including synaptic plasticity and learning and memory. **Clinical significance:** Mutations in the GRIK2 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. These disorders are characterized by abnormal synaptic plasticity and learning and memory deficits. **Additional information:** * The GRIK2 gene is a promising target for the treatment of neurological disorders. * There are a number of drugs that are currently being investigated as treatments for neurological disorders that target the GRIK2 receptor.

Genular Protein ID: 805050492

Symbol: GRIK2_HUMAN

Name: Glutamate receptor ionotropic, kainate 2

UniProtKB Accession Codes:

Q13002 A6NMY9 B5MCV0 D7RWZ3 D7RWZ4 D7RWZ5 D7RWZ6 D7RWZ7 Q8WWS1 Q96KS6 Q96KS7 Q96KS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EMBL 15 Ensembl 7 ExpressionAtlas 1 GO 40 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7536611

Title: Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.

PubMed ID: 7536611

PubMed ID: 8034316

Title: Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment.

PubMed ID: 8034316

DOI: 10.1006/geno.1994.1198

PubMed ID: 11675011

Title: Genomic organization of the human GRIK2 gene and characterization of multiple splicing variants.

PubMed ID: 11675011

DOI: 10.1016/s0378-1119(01)00611-4

PubMed ID: 20230879

Title: Novel spliced variants of ionotropic glutamate receptor GluR6 in normal human fibroblast and brain cells are transcribed by tissue specific promoters.

PubMed ID: 20230879

DOI: 10.1016/j.gene.2010.03.002

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 7523595

Title: RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.

PubMed ID: 7523595

DOI: 10.1046/j.1471-4159.1994.63051596.x

PubMed ID: 7696618

Title: RNA editing of human kainate receptor subunits.

PubMed ID: 7696618

DOI: 10.1097/00001756-199412000-00055

PubMed ID: 11744724

Title: The PDZ1 domain of SAP90. Characterization of structure and binding.

PubMed ID: 11744724

DOI: 10.1074/jbc.m109453200

PubMed ID: 22808340

Title: Modification and movement: Phosphorylation and SUMOylation regulate endocytosis of GluK2-containing kainate receptors.

PubMed ID: 22808340

DOI: 10.4161/cib.19195

PubMed ID: 31474366

Title: A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene.

PubMed ID: 31474366

DOI: 10.1016/j.cell.2019.07.034

PubMed ID: 21893069

Title: Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.

PubMed ID: 21893069

DOI: 10.1016/j.jmb.2011.08.043

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17847003

Title: A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation.

PubMed ID: 17847003

DOI: 10.1086/521275

PubMed ID: 28180184

Title: A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits.

PubMed ID: 28180184

DOI: 10.1212/nxg.0000000000000129

PubMed ID: 34375587

Title: Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.

PubMed ID: 34375587

DOI: 10.1016/j.ajhg.2021.07.007

Sequence Information:

  • Length: 908
  • Mass: 102583
  • Checksum: 5F34630524401E84
  • Sequence:
    • MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 
VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 
ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 
GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 
QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 
LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 
SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 
PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 
RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 
LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD 
VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 
VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SRRQSVLVKS 
NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 
AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 
EFLYKSKKNA QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR 
LPGKETMA

Genular Protein ID: 2271925665

Symbol: A8K0H7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K0H7

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 RuleBase 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 908
  • Mass: 102427
  • Checksum: BD2FC3CC9EA12682
  • Sequence:
    • MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 
VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 
ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 
GLIRLQELIK APSRYNLRLK IRQSPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 
QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 
LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 
SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 
PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 
RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 
LYRKPNGTNP GVFSFLNPLS PDIWMYILLA CLGVSCVLFV IARFSPYEWY NPHPCNPDSD 
VVENNFTLLN SFWFGVGALM RQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 
VERMESPIDS ADDLAKQTEI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SGRQSVLVKS 
NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 
AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 
EFLYKSKKNA QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR 
LPGKETMA

Genular Protein ID: 3467060042

Symbol: Q8IY40_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IY40

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 PharmGKB 1 RefSeq 3 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 353
  • Mass: 39918
  • Checksum: 52F7DD44B9031DFD
  • Sequence:
    • MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 
VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 
ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 
GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 
QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 
LQAPPKPDSG LLDGFMTMEF HSCCPGWSAM ARSHLTATSA SWVQAILLPQ PPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.