Details for: GRIK2

Gene ID: 2898

Symbol: GRIK2

Ensembl ID: ENSG00000164418

Description: glutamate ionotropic receptor kainate type subunit 2

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Activation of na-permeable kainate receptors
    (R-HSA-451307)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Behavioral fear response
    (GO:0001662)
  • Calcium-mediated signaling
    (GO:0019722)
  • Chemical synaptic transmission
    (GO:0007268)
  • Dendrite cytoplasm
    (GO:0032839)
  • Detection of cold stimulus involved in thermoception
    (GO:0120169)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Extracellularly glutamate-gated ion channel activity
    (GO:0005234)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Glutamatergic synapse
    (GO:0098978)
  • Hippocampal mossy fiber to ca3 synapse
    (GO:0098686)
  • Identical protein binding
    (GO:0042802)
  • Inhibitory postsynaptic potential
    (GO:0060080)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Modulation of excitatory postsynaptic potential
    (GO:0098815)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Mossy fiber rosette
    (GO:0097471)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of synaptic transmission, glutamatergic
    (GO:0051967)
  • Neuronal action potential
    (GO:0019228)
  • Neuron apoptotic process
    (GO:0051402)
  • Pdz domain binding
    (GO:0030165)
  • Perikaryon
    (GO:0043204)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of synaptic transmission
    (GO:0050806)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Presynaptic modulation of chemical synaptic transmission
    (GO:0099171)
  • Receptor clustering
    (GO:0043113)
  • Regulation of jnk cascade
    (GO:0046328)
  • Regulation of long-term neuronal synaptic plasticity
    (GO:0048169)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Regulation of short-term neuronal synaptic plasticity
    (GO:0048172)
  • Scaffold protein binding
    (GO:0097110)
  • Snare binding
    (GO:0000149)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Terminal bouton
    (GO:0043195)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)
  • Ubiquitin conjugating enzyme binding
    (GO:0031624)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 16.8255
    Cell Significance Index: 288.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 9.1298
    Cell Significance Index: 3274.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 7.9097
    Cell Significance Index: 486.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 6.4424
    Cell Significance Index: 433.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.6373
    Cell Significance Index: 213.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.5240
    Cell Significance Index: 132.4800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 5.1687
    Cell Significance Index: 67.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.7269
    Cell Significance Index: 134.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 4.3275
    Cell Significance Index: 2993.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.1929
    Cell Significance Index: 185.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.4177
    Cell Significance Index: 685.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.8234
    Cell Significance Index: 158.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9058
    Cell Significance Index: 172.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6996
    Cell Significance Index: 631.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6980
    Cell Significance Index: 53.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.2974
    Cell Significance Index: 5.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2328
    Cell Significance Index: 429.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1601
    Cell Significance Index: 15.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1166
    Cell Significance Index: 179.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0589
    Cell Significance Index: 80.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0407
    Cell Significance Index: 8.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0258
    Cell Significance Index: 48.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0185
    Cell Significance Index: -2.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0502
    Cell Significance Index: -31.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0865
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1106
    Cell Significance Index: -81.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1313
    Cell Significance Index: -21.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1381
    Cell Significance Index: -101.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1426
    Cell Significance Index: -64.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1572
    Cell Significance Index: -119.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1776
    Cell Significance Index: -100.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1797
    Cell Significance Index: -79.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1894
    Cell Significance Index: -118.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1994
    Cell Significance Index: -108.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3013
    Cell Significance Index: -54.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3070
    Cell Significance Index: -88.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3176
    Cell Significance Index: -3.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3390
    Cell Significance Index: -4.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3410
    Cell Significance Index: -9.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3744
    Cell Significance Index: -46.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3830
    Cell Significance Index: -4.7500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4225
    Cell Significance Index: -4.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4576
    Cell Significance Index: -20.7400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4826
    Cell Significance Index: -6.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5284
    Cell Significance Index: -57.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5381
    Cell Significance Index: -113.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.5491
    Cell Significance Index: -93.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6462
    Cell Significance Index: -8.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7057
    Cell Significance Index: -14.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.7276
    Cell Significance Index: -99.9200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.7344
    Cell Significance Index: -7.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7808
    Cell Significance Index: -33.9500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7955
    Cell Significance Index: -9.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.8108
    Cell Significance Index: -103.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.8144
    Cell Significance Index: -105.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8587
    Cell Significance Index: -100.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8613
    Cell Significance Index: -24.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8636
    Cell Significance Index: -28.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9757
    Cell Significance Index: -101.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9965
    Cell Significance Index: -52.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0246
    Cell Significance Index: -117.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -1.0255
    Cell Significance Index: -104.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.1574
    Cell Significance Index: -80.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2213
    Cell Significance Index: -25.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.2310
    Cell Significance Index: -15.3500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.3220
    Cell Significance Index: -15.8100
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.3640
    Cell Significance Index: -12.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4013
    Cell Significance Index: -44.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.4094
    Cell Significance Index: -105.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4729
    Cell Significance Index: -90.3000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -1.5024
    Cell Significance Index: -17.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5051
    Cell Significance Index: -90.3600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.6210
    Cell Significance Index: -22.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.7336
    Cell Significance Index: -90.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.7834
    Cell Significance Index: -38.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.7989
    Cell Significance Index: -39.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.8588
    Cell Significance Index: -96.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8706
    Cell Significance Index: -46.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.9882
    Cell Significance Index: -69.6500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -2.0806
    Cell Significance Index: -26.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.1094
    Cell Significance Index: -98.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.2017
    Cell Significance Index: -103.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -2.4089
    Cell Significance Index: -32.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.5198
    Cell Significance Index: -80.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.5591
    Cell Significance Index: -65.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.5833
    Cell Significance Index: -64.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -2.7983
    Cell Significance Index: -29.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9079
    Cell Significance Index: -63.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.9661
    Cell Significance Index: -103.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.0126
    Cell Significance Index: -110.5900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -3.0221
    Cell Significance Index: -31.0700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -3.0880
    Cell Significance Index: -64.4500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -3.1298
    Cell Significance Index: -61.6000
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -3.1722
    Cell Significance Index: -39.4300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -3.2285
    Cell Significance Index: -64.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -3.2467
    Cell Significance Index: -69.4000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -3.3524
    Cell Significance Index: -106.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -3.4687
    Cell Significance Index: -91.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -3.4832
    Cell Significance Index: -94.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -3.6303
    Cell Significance Index: -90.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ionotropic receptor**: GRIK2 is a ligand-gated ion channel that allows the flow of monovalent cations (mainly potassium and sodium) into the neuron upon binding of glutamate. 2. **Kainate subtype**: GRIK2 is a subunit of the kainate type glutamate receptors, which are distinct from other glutamate receptor subtypes, such as AMPA and NMDA receptors. 3. **Heteromeric receptor**: GRIK2 forms functional heteromeric receptors with other subunits, such as GRIK1, GRIK4, and GRIK5, to modulate receptor properties and synaptic transmission. 4. **Regulatory roles**: GRIK2 is involved in various cellular processes, including regulation of neuronal excitability, synaptic plasticity, and fear responses. **Pathways and Functions** 1. **Excitatory postsynaptic potential (EPSP)**: GRIK2 receptors are responsible for generating EPSPs in response to glutamate binding, which are essential for learning and memory. 2. **Synaptic plasticity**: GRIK2 receptors modulate synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), which are critical for learning and memory. 3. **Fear response**: GRIK2 receptors are involved in the regulation of fear responses, particularly in the amygdala and the hippocampus. 4. **Thermoception**: GRIK2 receptors are also implicated in the detection of cold stimuli, which is mediated by the activation of TRPV1 channels. 5. **Neuronal excitability**: GRIK2 receptors modulate neuronal excitability, influencing the generation of action potentials and the regulation of neuronal firing patterns. **Clinical Significance** 1. **Neurological disorders**: Alterations in GRIK2 expression and function have been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and schizophrenia. 2. **Mood disorders**: GRIK2 receptors are involved in the regulation of mood and emotional responses, and dysregulation of these receptors has been linked to mood disorders, such as depression and anxiety. 3. **Pain modulation**: GRIK2 receptors are also involved in the regulation of pain modulation, and alterations in these receptors have been implicated in chronic pain conditions. 4. **Neurodevelopmental disorders**: GRIK2 receptors are essential for normal neurodevelopment, and alterations in these receptors have been linked to neurodevelopmental disorders, such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). In conclusion, the GRIK2 gene plays a critical role in the regulation of excitatory neurotransmission, synaptic plasticity, and fear responses in the central nervous system. Alterations in GRIK2 expression and function have been implicated in various neurological and psychiatric disorders, highlighting the importance of this gene in maintaining normal brain function and preventing disease.

Genular Protein ID: 805050492

Symbol: GRIK2_HUMAN

Name: Glutamate receptor ionotropic, kainate 2

UniProtKB Accession Codes:

Q13002 A6NMY9 B5MCV0 D7RWZ3 D7RWZ4 D7RWZ5 D7RWZ6 D7RWZ7 Q8WWS1 Q96KS6 Q96KS7 Q96KS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 9 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EMBL 15 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 6 Rhea 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7536611

Title: Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.

PubMed ID: 7536611

PubMed ID: 8034316

Title: Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment.

PubMed ID: 8034316

DOI: 10.1006/geno.1994.1198

PubMed ID: 11675011

Title: Genomic organization of the human GRIK2 gene and characterization of multiple splicing variants.

PubMed ID: 11675011

DOI: 10.1016/s0378-1119(01)00611-4

PubMed ID: 20230879

Title: Novel spliced variants of ionotropic glutamate receptor GluR6 in normal human fibroblast and brain cells are transcribed by tissue specific promoters.

PubMed ID: 20230879

DOI: 10.1016/j.gene.2010.03.002

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 7523595

Title: RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.

PubMed ID: 7523595

DOI: 10.1046/j.1471-4159.1994.63051596.x

PubMed ID: 7696618

Title: RNA editing of human kainate receptor subunits.

PubMed ID: 7696618

DOI: 10.1097/00001756-199412000-00055

PubMed ID: 8730589

Title: Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.

PubMed ID: 8730589

DOI: 10.1113/jphysiol.1996.sp021295

PubMed ID: 11744724

Title: The PDZ1 domain of SAP90. Characterization of structure and binding.

PubMed ID: 11744724

DOI: 10.1074/jbc.m109453200

PubMed ID: 14511640

Title: Trafficking and surface expression of the glutamate receptor subunit, KA2.

PubMed ID: 14511640

DOI: 10.1016/j.bbrc.2003.08.115

PubMed ID: 22808340

Title: Modification and movement: Phosphorylation and SUMOylation regulate endocytosis of GluK2-containing kainate receptors.

PubMed ID: 22808340

DOI: 10.4161/cib.19195

PubMed ID: 31474366

Title: A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene.

PubMed ID: 31474366

DOI: 10.1016/j.cell.2019.07.034

PubMed ID: 21893069

Title: Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.

PubMed ID: 21893069

DOI: 10.1016/j.jmb.2011.08.043

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17847003

Title: A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation.

PubMed ID: 17847003

DOI: 10.1086/521275

PubMed ID: 28180184

Title: A gain-of-function mutation in the GRIK2 gene causes neurodevelopmental deficits.

PubMed ID: 28180184

DOI: 10.1212/nxg.0000000000000129

PubMed ID: 34375587

Title: Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.

PubMed ID: 34375587

DOI: 10.1016/j.ajhg.2021.07.007

Sequence Information:

  • Length: 908
  • Mass: 102583
  • Checksum: 5F34630524401E84
  • Sequence:
    • MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 
VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 
ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 
GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 
QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 
LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 
SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 
PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 
RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 
LYRKPNGTNP GVFSFLNPLS PDIWMYILLA YLGVSCVLFV IARFSPYEWY NPHPCNPDSD 
VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 
VERMESPIDS ADDLAKQTKI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SRRQSVLVKS 
NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 
AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 
EFLYKSKKNA QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR 
LPGKETMA

Genular Protein ID: 2271925665

Symbol: A8K0H7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K0H7

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 Rhea 1 RuleBase 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 908
  • Mass: 102427
  • Checksum: BD2FC3CC9EA12682
  • Sequence:
    • MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 
VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 
ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 
GLIRLQELIK APSRYNLRLK IRQSPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 
QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 
LQAPPKPDSG LLDGFMTTDA ALMYDAVHVV SVAVQQFPQM TVSSLQCNRH KPWRFGTRFM 
SLIKEAHWEG LTGRITFNKT NGLRTDFDLD VISLKEEGLE KIGTWDPASG LNMTESQKGK 
PANITDSLSN RSLIVTTILE EPYVLFKKSD KPLYGNDRFE GYCIDLLREL STILGFTYEI 
RLVEDGKYGA QDDANGQWNG MVRELIDHKA DLAVAPLAIT YVREKVIDFS KPFMTLGISI 
LYRKPNGTNP GVFSFLNPLS PDIWMYILLA CLGVSCVLFV IARFSPYEWY NPHPCNPDSD 
VVENNFTLLN SFWFGVGALM RQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 
VERMESPIDS ADDLAKQTEI EYGAVEDGAT MTFFKKSKIS TYDKMWAFMS SGRQSVLVKS 
NEEGIQRVLT SDYAFLMEST TIEFVTQRNC NLTQIGGLID SKGYGVGTPM GSPYRDKITI 
AILQLQEEGK LHMMKEKWWR GNGCPEEESK EASALGVQNI GGIFIVLAAG LVLSVFVAVG 
EFLYKSKKNA QLEKRSFCSA MVEELRMSLK CQRRLKHKPQ APVIVKTEEV INMHTFNDRR 
LPGKETMA

Genular Protein ID: 3467060042

Symbol: Q8IY40_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IY40

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 PharmGKB 1 RefSeq 3 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 353
  • Mass: 39918
  • Checksum: 52F7DD44B9031DFD
  • Sequence:
    • MKIIFPILSN PVFRRTVKLL LCLLWIGYSQ GTTHVLRFGG IFEYVESGPM GAEELAFRFA 
VNTINRNRTL LPNTTLTYDT QKINLYDSFE ASKKACDQLS LGVAAIFGPS HSSSANAVQS 
ICNALGVPHI QTRWKHQVSD NKDSFYVSLY PDFSSLSRAI LDLVQFFKWK TVTVVYDDST 
GLIRLQELIK APSRYNLRLK IRQLPADTKD AKPLLKEMKR GKEFHVIFDC SHEMAAGILK 
QALAMGMMTE YYHYIFTTLD LFALDVEPYR YSGVNMTGFR ILNTENTQVS SIIEKWSMER 
LQAPPKPDSG LLDGFMTMEF HSCCPGWSAM ARSHLTATSA SWVQAILLPQ PPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.