Details for: GRIK5

Gene ID: 2901

Symbol: GRIK5

Ensembl ID: ENSG00000105737

Description: glutamate ionotropic receptor kainate type subunit 5

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Endoplasmic reticulum
    (GO:0005783)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Hippocampal mossy fiber to ca3 synapse
    (GO:0098686)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Nucleoplasm
    (GO:0005654)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Regulation of synaptic vesicle fusion to presynaptic active zone membrane
    (GO:0031630)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.76
    Marker Score: 16587
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.71
    Marker Score: 16206
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.67
    Marker Score: 14329
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.61
    Marker Score: 61188
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.57
    Marker Score: 96434
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.56
    Marker Score: 6035
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.55
    Marker Score: 57344
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.54
    Marker Score: 11808
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.52
    Marker Score: 2343
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.43
    Marker Score: 28372
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.41
    Marker Score: 4033
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.4
    Marker Score: 5797
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.39
    Marker Score: 20729
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.26
    Marker Score: 2117
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7662.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.13
    Marker Score: 2485
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17476
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.07
    Marker Score: 22733
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.03
    Marker Score: 4772
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.02
    Marker Score: 574
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.02
    Marker Score: 4154
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.01
    Marker Score: 592
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.01
    Marker Score: 419
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2529
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.98
    Marker Score: 32988
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.96
    Marker Score: 401
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.94
    Marker Score: 1337
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5333
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.93
    Marker Score: 359
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.91
    Marker Score: 409
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.88
    Marker Score: 401
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.84
    Marker Score: 490
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.83
    Marker Score: 483
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.82
    Marker Score: 3442
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.82
    Marker Score: 4395
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.74
    Marker Score: 203
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.74
    Marker Score: 1694
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.72
    Marker Score: 226
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.71
    Marker Score: 343
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.69
    Marker Score: 2312
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.65
    Marker Score: 4881
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.64
    Marker Score: 904
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1211.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1297
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.6
    Marker Score: 199
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.59
    Marker Score: 711
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.58
    Marker Score: 302
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.58
    Marker Score: 3018
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.57
    Marker Score: 764
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 448
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.56
    Marker Score: 627
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.54
    Marker Score: 413
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.53
    Marker Score: 574
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.52
    Marker Score: 634
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.52
    Marker Score: 509.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.52
    Marker Score: 339.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.48
    Marker Score: 140
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.48
    Marker Score: 411
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 307
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.46
    Marker Score: 229
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1226
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.45
    Marker Score: 453
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.43
    Marker Score: 455
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.42
    Marker Score: 402
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.42
    Marker Score: 522
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.41
    Marker Score: 1470
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 248
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.41
    Marker Score: 139
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 194
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.39
    Marker Score: 453
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.39
    Marker Score: 338
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.37
    Marker Score: 461
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.35
    Marker Score: 181
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.35
    Marker Score: 119
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.34
    Marker Score: 337
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.34
    Marker Score: 100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.33
    Marker Score: 162
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.33
    Marker Score: 828
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.32
    Marker Score: 1351
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.32
    Marker Score: 117
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.31
    Marker Score: 594
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 192
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.3
    Marker Score: 76
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.29
    Marker Score: 219
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.28
    Marker Score: 2857
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.28
    Marker Score: 93
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.27
    Marker Score: 101

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Other Information

**Key characteristics:** - GRIK5 is a transmembrane protein that is expressed in a variety of brain regions, including the cerebral cortex, hippocampus, and cerebellum. - It is a ligand-gated channel that is permeable to calcium ions. - Activation of GRIK5 by glutamate binding opens a channel that allows calcium ions to enter the cell. - This calcium influx causes a variety of cellular responses, including the generation of an EPSP. **Pathways and functions:** - GRIK5 is involved in a variety of cellular processes, including: - Activation of the EPSP - Modulation of synaptic vesicle fusion to the presynaptic active zone membrane - Synaptic transmission - Neurotransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential **Clinical significance:** - Mutations in GRIK5 have been linked to a number of neurodevelopmental disorders, including autism spectrum disorder, schizophrenia, and epilepsy. - GRIK5 is a potential target for the treatment of these disorders. **Additional information:** - GRIK5 is a member of the glutamate receptor family of ion channels. - It is a ligand-gated channel, which means that it opens when a ligand binds to its receptor. - Activation of GRIK5 is a complex process that involves both conformational changes and changes in intracellular signaling pathways.

Genular Protein ID: 3594545167

Symbol: GRIK5_HUMAN

Name: Glutamate receptor ionotropic, kainate 5

UniProtKB Accession Codes:

Q16478 Q8WWG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1321949

Title: Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit.

PubMed ID: 1321949

Sequence Information:

  • Length: 980
  • Mass: 109265
  • Checksum: 72466FFF64079388
  • Sequence:
    • MPAELLLLLI VAFASPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ INGIIEVPAK 
ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP ASASTVSHIC GEKEIPHIKV 
GPEETPRLQY LRFASVSLYP SNEDVSLAVS RILKSFNYPS ASLICAKAEC LLRLEELVRG 
FLISKETLSV RMLDDSRDPT PLLKEIRDDK VSTIIIDANA SISHLILRKA SELGMTSAFY 
KYILTTMDFP ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYLGP 
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL RMVEYDGLTG 
RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN ATTLDINLSQ TLANKTLVVT 
TILENPYVMR RPNFQALSGN ERFEGFCVDM LRELAELLRF RYRLRLVEDG LYGAPEPNGS 
WTGMVGELIN RKADLAVAAF TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD 
PFSPAVWLFM LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV PVESADDLAD 
QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV FVKSTEEGIA RVLNSRYAFL 
LESTMNEYHR RLNCNLTQIG GLLDTKGYGI GMPLGSPFRD EITLAILQLQ ENNRLEILKR 
KWWEGGRCPK EEDHRAKGLG MENIGGIFIV LICGLIIAVF VAVMEFIWST RRSAESEEVS 
VCQEMLQELR HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 
SAHGGPQRLL DDPGPPSGAR PAAPTPCTHV RVCQECRRIQ ALRASGAGAP PRGLGVPAEA 
TSPPRPRPGP AGPRELAEHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.