Details for: GRIK5

Gene ID: 2901

Symbol: GRIK5

Ensembl ID: ENSG00000105737

Description: glutamate ionotropic receptor kainate type subunit 5

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Cell projection
    (GO:0042995)
  • Endoplasmic reticulum
    (GO:0005783)
  • Excitatory postsynaptic potential
    (GO:0060079)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Hippocampal mossy fiber to ca3 synapse
    (GO:0098686)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Nucleoplasm
    (GO:0005654)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Regulation of synaptic vesicle fusion to presynaptic active zone membrane
    (GO:0031630)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.9687
    Cell Significance Index: -27.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.6207
    Cell Significance Index: -26.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.9554
    Cell Significance Index: -27.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3760
    Cell Significance Index: -5.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6106
    Cell Significance Index: 323.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1184
    Cell Significance Index: 27.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1110
    Cell Significance Index: 49.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1039
    Cell Significance Index: 74.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0656
    Cell Significance Index: 40.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9753
    Cell Significance Index: 349.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8957
    Cell Significance Index: 25.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7455
    Cell Significance Index: 515.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5942
    Cell Significance Index: 13.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5893
    Cell Significance Index: 37.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4762
    Cell Significance Index: 29.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2316
    Cell Significance Index: 5.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0671
    Cell Significance Index: 1.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0417
    Cell Significance Index: 78.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0386
    Cell Significance Index: 17.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0250
    Cell Significance Index: 34.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0188
    Cell Significance Index: 34.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0151
    Cell Significance Index: 23.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0061
    Cell Significance Index: 3.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0128
    Cell Significance Index: -0.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0226
    Cell Significance Index: -16.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0326
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0354
    Cell Significance Index: -26.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0418
    Cell Significance Index: -31.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0478
    Cell Significance Index: -26.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0523
    Cell Significance Index: -29.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0532
    Cell Significance Index: -33.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0803
    Cell Significance Index: -10.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0851
    Cell Significance Index: -15.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0936
    Cell Significance Index: -26.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0939
    Cell Significance Index: -18.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1337
    Cell Significance Index: -5.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1433
    Cell Significance Index: -17.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1514
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1547
    Cell Significance Index: -26.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1553
    Cell Significance Index: -32.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1745
    Cell Significance Index: -23.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1775
    Cell Significance Index: -20.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1880
    Cell Significance Index: -14.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1959
    Cell Significance Index: -20.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2044
    Cell Significance Index: -26.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2205
    Cell Significance Index: -4.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2406
    Cell Significance Index: -3.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2499
    Cell Significance Index: -25.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2534
    Cell Significance Index: -29.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2829
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3079
    Cell Significance Index: -10.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3085
    Cell Significance Index: -24.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3259
    Cell Significance Index: -17.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3263
    Cell Significance Index: -6.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3543
    Cell Significance Index: -3.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3560
    Cell Significance Index: -26.5300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3596
    Cell Significance Index: -4.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3763
    Cell Significance Index: -7.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4102
    Cell Significance Index: -21.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4108
    Cell Significance Index: -26.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4736
    Cell Significance Index: -16.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4751
    Cell Significance Index: -11.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5209
    Cell Significance Index: -13.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5304
    Cell Significance Index: -11.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5438
    Cell Significance Index: -25.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5486
    Cell Significance Index: -6.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5539
    Cell Significance Index: -11.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5869
    Cell Significance Index: -26.6000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5954
    Cell Significance Index: -8.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6071
    Cell Significance Index: -7.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6271
    Cell Significance Index: -29.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6277
    Cell Significance Index: -13.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6393
    Cell Significance Index: -6.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6563
    Cell Significance Index: -34.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6686
    Cell Significance Index: -11.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6984
    Cell Significance Index: -24.2700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7044
    Cell Significance Index: -8.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7160
    Cell Significance Index: -19.4900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7414
    Cell Significance Index: -9.8900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.7574
    Cell Significance Index: -5.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7696
    Cell Significance Index: -16.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8104
    Cell Significance Index: -28.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8148
    Cell Significance Index: -24.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8191
    Cell Significance Index: -21.9100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8330
    Cell Significance Index: -16.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8560
    Cell Significance Index: -5.8000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8710
    Cell Significance Index: -21.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8794
    Cell Significance Index: -25.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.8918
    Cell Significance Index: -10.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9070
    Cell Significance Index: -23.8500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.9113
    Cell Significance Index: -11.5000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9185
    Cell Significance Index: -18.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9319
    Cell Significance Index: -34.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9432
    Cell Significance Index: -27.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9435
    Cell Significance Index: -29.8400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.9679
    Cell Significance Index: -13.5900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9741
    Cell Significance Index: -12.9900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9800
    Cell Significance Index: -11.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9854
    Cell Significance Index: -28.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Kainate Receptor Subunit:** GRIK5 is a kainate receptor subunit, which is one of the four subunits that form the kainate receptor complex. This receptor is responsible for mediating the excitatory effects of glutamate in the brain. 2. **Ionotropic Activity:** GRIK5 is an ionotropic receptor, meaning it directly regulates the flow of ions across the cell membrane, influencing neuronal excitability and synaptic transmission. 3. **Glutamate Binding:** GRIK5 is activated by glutamate binding, which triggers a conformational change in the receptor, allowing ions to pass through the membrane. 4. **Regulation of Presynaptic Membrane Potential:** GRIK5 plays a crucial role in regulating the presynaptic membrane potential, influencing the release of neurotransmitters and synaptic transmission. **Pathways and Functions:** 1. **Activation of Ca-Permeable Kainate Receptor:** GRIK5 is involved in the activation of ca-permeable kainate receptors, which regulate the influx of calcium ions into the neuron, influencing neuronal excitability and synaptic transmission. 2. **Excitatory Postsynaptic Potential (EPSP):** GRIK5 contributes to the generation of EPSPs, a fundamental mechanism for neuronal excitation and synaptic plasticity. 3. **Hippocampal Mossy Fiber to CA3 Synapse:** GRIK5 is expressed in the hippocampus, where it plays a role in regulating the excitatory transmission between mossy fibers and CA3 neurons. 4. **Ionotropic Glutamate Receptor Signaling Pathway:** GRIK5 is part of the ionotropic glutamate receptor signaling pathway, which is essential for regulating neuronal excitability and synaptic transmission. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in GRIK5 expression and function have been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and schizophrenia. 2. **Synaptic Plasticity:** Dysregulation of GRIK5-mediated synaptic plasticity contributes to the pathogenesis of neurological disorders, highlighting the need for novel therapeutic strategies that target this receptor. 3. **Neuroprotective Effects:** GRIK5 may also possess neuroprotective properties, potentially offering a therapeutic target for neurodegenerative diseases. 4. **Development of Novel Therapeutics:** Understanding the functions and pathways mediated by GRIK5 is essential for the development of novel therapeutic strategies that target this receptor, offering new hope for the treatment of neurological disorders. In conclusion, GRIK5 is a critical component of kainate receptors, playing a pivotal role in regulating excitatory synaptic transmission and neuronal excitability. Further research on GRIK5 is essential for elucidating its role in neurological disorders and developing novel therapeutic strategies that target this receptor.

Genular Protein ID: 3594545167

Symbol: GRIK5_HUMAN

Name: Glutamate receptor ionotropic, kainate 5

UniProtKB Accession Codes:

Q16478 Q8WWG8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1321949

Title: Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit.

PubMed ID: 1321949

PubMed ID: 8730589

Title: Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.

PubMed ID: 8730589

DOI: 10.1113/jphysiol.1996.sp021295

PubMed ID: 14511640

Title: Trafficking and surface expression of the glutamate receptor subunit, KA2.

PubMed ID: 14511640

DOI: 10.1016/j.bbrc.2003.08.115

Sequence Information:

  • Length: 980
  • Mass: 109265
  • Checksum: 72466FFF64079388
  • Sequence:
    • MPAELLLLLI VAFASPSCQV LSSLRMAAIL DDQTVCGRGE RLALALAREQ INGIIEVPAK 
ARVEVDIFEL QRDSQYETTD TMCQILPKGV VSVLGPSSSP ASASTVSHIC GEKEIPHIKV 
GPEETPRLQY LRFASVSLYP SNEDVSLAVS RILKSFNYPS ASLICAKAEC LLRLEELVRG 
FLISKETLSV RMLDDSRDPT PLLKEIRDDK VSTIIIDANA SISHLILRKA SELGMTSAFY 
KYILTTMDFP ILHLDGIVED SSNILGFSMF NTSHPFYPEF VRSLNMSWRE NCEASTYLGP 
ALSAALMFDA VHVVVSAVRE LNRSQEIGVK PLACTSANIW PHGTSLMNYL RMVEYDGLTG 
RVEFNSKGQR TNYTLRILEK SRQGHREIGV WYSNRTLAMN ATTLDINLSQ TLANKTLVVT 
TILENPYVMR RPNFQALSGN ERFEGFCVDM LRELAELLRF RYRLRLVEDG LYGAPEPNGS 
WTGMVGELIN RKADLAVAAF TITAEREKVI DFSKPFMTLG ISILYRVHMG RKPGYFSFLD 
PFSPAVWLFM LLAYLAVSCV LFLAARLSPY EWYNPHPCLR ARPHILENQY TLGNSLWFPV 
GGFMQQGSEI MPRALSTRCV SGVWWAFTLI IISSYTANLA AFLTVQRMEV PVESADDLAD 
QTNIEYGTIH AGSTMTFFQN SRYQTYQRMW NYMQSKQPSV FVKSTEEGIA RVLNSRYAFL 
LESTMNEYHR RLNCNLTQIG GLLDTKGYGI GMPLGSPFRD EITLAILQLQ ENNRLEILKR 
KWWEGGRCPK EEDHRAKGLG MENIGGIFIV LICGLIIAVF VAVMEFIWST RRSAESEEVS 
VCQEMLQELR HAVSCRKTSR SRRRRRPGGP SRALLSLRAV REMRLSNGKL YSAGAGGDAG 
SAHGGPQRLL DDPGPPSGAR PAAPTPCTHV RVCQECRRIQ ALRASGAGAP PRGLGVPAEA 
TSPPRPRPGP AGPRELAEHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.