Details for: SLC43A3

Gene ID: 29015

Symbol: SLC43A3

Ensembl ID: ENSG00000134802

Description: solute carrier family 43 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.6132
    Cell Significance Index: -13.3500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 41.2099
    Cell Significance Index: -6.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.3767
    Cell Significance Index: -16.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.3132
    Cell Significance Index: -13.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 32.2521
    Cell Significance Index: -16.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.7370
    Cell Significance Index: -14.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9875
    Cell Significance Index: -14.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6027
    Cell Significance Index: -12.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.2942
    Cell Significance Index: 123.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0116
    Cell Significance Index: -15.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4451
    Cell Significance Index: -7.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2656
    Cell Significance Index: -10.0300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.7948
    Cell Significance Index: 19.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9981
    Cell Significance Index: 61.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8554
    Cell Significance Index: 14.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6072
    Cell Significance Index: 60.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.5387
    Cell Significance Index: 9.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5184
    Cell Significance Index: 24.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5156
    Cell Significance Index: 9.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4867
    Cell Significance Index: 10.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3917
    Cell Significance Index: 19.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3906
    Cell Significance Index: 50.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3713
    Cell Significance Index: 5.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3196
    Cell Significance Index: 51.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2648
    Cell Significance Index: 7.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2237
    Cell Significance Index: 201.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2182
    Cell Significance Index: 96.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2017
    Cell Significance Index: 38.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1923
    Cell Significance Index: 20.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1804
    Cell Significance Index: 21.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1638
    Cell Significance Index: 10.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0883
    Cell Significance Index: 61.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0862
    Cell Significance Index: 4.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0735
    Cell Significance Index: 1.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0704
    Cell Significance Index: 8.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0600
    Cell Significance Index: 45.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0484
    Cell Significance Index: 6.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0417
    Cell Significance Index: 0.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0378
    Cell Significance Index: 4.8500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0313
    Cell Significance Index: 0.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0272
    Cell Significance Index: 0.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0157
    Cell Significance Index: 0.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0032
    Cell Significance Index: -0.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0055
    Cell Significance Index: -0.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0062
    Cell Significance Index: -3.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0079
    Cell Significance Index: -4.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0083
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0149
    Cell Significance Index: -0.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0159
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0161
    Cell Significance Index: -24.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0171
    Cell Significance Index: -0.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0184
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0186
    Cell Significance Index: -25.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0207
    Cell Significance Index: -15.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0223
    Cell Significance Index: -14.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0256
    Cell Significance Index: -2.9300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0316
    Cell Significance Index: -0.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0319
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0321
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0362
    Cell Significance Index: -7.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0373
    Cell Significance Index: -13.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0381
    Cell Significance Index: -17.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0381
    Cell Significance Index: -10.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0521
    Cell Significance Index: -2.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0581
    Cell Significance Index: -1.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0669
    Cell Significance Index: -0.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0679
    Cell Significance Index: -12.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0734
    Cell Significance Index: -14.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0743
    Cell Significance Index: -8.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0750
    Cell Significance Index: -14.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0835
    Cell Significance Index: -5.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0877
    Cell Significance Index: -6.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0969
    Cell Significance Index: -14.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0973
    Cell Significance Index: -11.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1086
    Cell Significance Index: -8.3300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1126
    Cell Significance Index: -0.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1391
    Cell Significance Index: -10.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1742
    Cell Significance Index: -10.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1972
    Cell Significance Index: -15.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2060
    Cell Significance Index: -11.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2128
    Cell Significance Index: -6.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2569
    Cell Significance Index: -7.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2656
    Cell Significance Index: -16.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2769
    Cell Significance Index: -8.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3124
    Cell Significance Index: -8.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3252
    Cell Significance Index: -17.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3494
    Cell Significance Index: -5.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3533
    Cell Significance Index: -12.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3569
    Cell Significance Index: -7.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3628
    Cell Significance Index: -7.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3658
    Cell Significance Index: -14.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3661
    Cell Significance Index: -19.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3757
    Cell Significance Index: -16.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3887
    Cell Significance Index: -11.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transporter Function:** SLC43A3 exhibits a wide range of transporter activities, including adenine transmembrane activity, guanine transmembrane activity, fatty acid transmembrane activity, and xenobiotic transmembrane activity. 2. **Cellular Expression:** This gene is significantly expressed in various cell types, including erythroblast, fibroblasts, and epithelial cells, which suggests its importance in maintaining cellular homeostasis. 3. **Protein Structure:** The protein structure of SLC43A3 is characterized by a unique binding site for various molecules, allowing for its multifaceted transporter function. **Pathways and Functions:** 1. **Adenine and Guanine Transport:** SLC43A3 plays a crucial role in the transport of adenine and guanine across cellular membranes, which are essential for nucleotide synthesis and cellular energy production. 2. **Fatty Acid Transport:** The ability of SLC43A3 to transport fatty acids allows for the regulation of lipid metabolism and energy production in cells. 3. **Xenobiotic Transport:** As a xenobiotic transporter, SLC43A3 can facilitate the uptake of foreign substances, such as drugs and toxins, into cells, which is essential for their detoxification and elimination. 4. **Cellular Energy Production:** The transport of adenine and guanine by SLC43A3 contributes to the synthesis of ATP, which is essential for cellular energy production. **Clinical Significance:** 1. **Cancer Research:** The expression of SLC43A3 in various cancer cell types suggests its potential role in cancer development and progression. 2. **Neurological Disorders:** The transport of xenobiotics by SLC43A3 may contribute to the development of neurological disorders, such as neurodegenerative diseases, by facilitating the accumulation of toxic substances in the brain. 3. **Infectious Diseases:** The ability of SLC43A3 to transport adenine and guanine may contribute to the development of infectious diseases, such as HIV, by facilitating the replication of the virus. 4. **Pharmacological Applications:** The xenobiotic transporter activity of SLC43A3 may be exploited for the development of new therapeutic agents, such as drug delivery systems, to target specific cells or tissues. In conclusion, SLC43A3 is a multifaceted transporter with a wide range of functions in maintaining cellular homeostasis. Its clinical significance is evident in various diseases, including cancer, neurological disorders, and infectious diseases. Further research is needed to fully elucidate the functions of SLC43A3 and its potential applications in medicine.

Genular Protein ID: 1168989101

Symbol: S43A3_HUMAN

Name: Protein FOAP-13

UniProtKB Accession Codes:

Q8NBI5 B4DNR8 E7EQD2 Q9NSS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 Rhea 8 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26455426

Title: Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals.

PubMed ID: 26455426

DOI: 10.1038/srep15057

PubMed ID: 30910793

Title: Characterization of 6-Mercaptopurine Transport by the SLC43A3-Encoded Nucleobase Transporter.

PubMed ID: 30910793

DOI: 10.1124/mol.118.114389

PubMed ID: 32339528

Title: Functional Analysis of the Role of Equilibrative Nucleobase Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in HepG2 Cells.

PubMed ID: 32339528

DOI: 10.1016/j.xphs.2020.04.013

Sequence Information:

  • Length: 491
  • Mass: 54529
  • Checksum: C6BC8E48F38B1D8C
  • Sequence:
    • MAGQGLPLHV ATLLTGLLEC LGFAGVLFGW PSLVFVFKNE DYFKDLCGPD AGPIGNATGQ 
ADCKAQDERF SLIFTLGSFM NNFMTFPTGY IFDRFKTTVA RLIAIFFYTT ATLIIAFTSA 
GSAVLLFLAM PMLTIGGILF LITNLQIGNL FGQHRSTIIT LYNGAFDSSS AVFLIIKLLY 
EKGISLRASF IFISVCSTWH VARTFLLMPR GHIPYPLPPN YSYGLCPGNG TTKEEKETAE 
HENRELQSKE FLSAKEETPG AGQKQELRSF WSYAFSRRFA WHLVWLSVIQ LWHYLFIGTL 
NSLLTNMAGG DMARVSTYTN AFAFTQFGVL CAPWNGLLMD RLKQKYQKEA RKTGSSTLAV 
ALCSTVPSLA LTSLLCLGFA LCASVPILPL QYLTFILQVI SRSFLYGSNA AFLTLAFPSE 
HFGKLFGLVM ALSAVVSLLQ FPIFTLIKGS LQNDPFYVNV MFMLAILLTF FHPFLVYREC 
RTWKESPSAI A

Genular Protein ID: 1101494544

Symbol: B0AZP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0AZP8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 491
  • Mass: 54499
  • Checksum: B77C9B1CE6CA4999
  • Sequence:
    • MAGQGLPLHV ATLLTGLLEC LGFAGVLFGW PSLVFVFKNE DYFKDLCGPD AGPIGNATGQ 
ADCKAQDERF SLIFTLGSFM NNFMTFPTGY IFDRFKTTVA RLIAIFFYTT ATLIIAFTSA 
GSAVLLFLAM PMLTIGGILF LITNLQIGNL FGQHRSTIIT LYNGAFDSSS AVFLIIKLLY 
EKGISLRASF IFISVCSTWH VARTFLLMPR GHIPYPLPPN YSYGLCPGNG TTKEEKETAE 
HENRELQSKE FLSAKEETPG AGQKQELRSF WSYAFSRRFA WHLVWLSVIQ LWHYLFIGTL 
NSLLTNMAGG DMARVSTYTN AFAFTQFGVL CAPWNGLLMD RLKQKYQKEA RKTGSSTLAV 
ALCSTVPSLA LTSLLCLGFA LCASVPILPL QYLTFILQVI GRSFLYGSNA AFLTLAFPSE 
HFGKLFGLVM ALSAVVSLLQ FPIFTLIKGS LQNDPFYVNV MFMLAILLTF FHPFLVYREC 
RTWKESPSAI A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.