Details for: ZC3H7A

Gene ID: 29066

Symbol: ZC3H7A

Ensembl ID: ENSG00000122299

Description: zinc finger CCCH-type containing 7A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 260.7602
    Cell Significance Index: -40.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.1515
    Cell Significance Index: -40.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.3187
    Cell Significance Index: -44.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.8169
    Cell Significance Index: -36.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.4759
    Cell Significance Index: -41.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.8848
    Cell Significance Index: -37.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.6403
    Cell Significance Index: -42.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6335
    Cell Significance Index: -41.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9717
    Cell Significance Index: -43.3000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2850
    Cell Significance Index: -31.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8328
    Cell Significance Index: -21.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0411
    Cell Significance Index: 141.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3348
    Cell Significance Index: 264.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1529
    Cell Significance Index: 231.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0708
    Cell Significance Index: 116.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0104
    Cell Significance Index: 164.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9160
    Cell Significance Index: 54.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7006
    Cell Significance Index: 251.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6739
    Cell Significance Index: 92.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6649
    Cell Significance Index: 51.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6414
    Cell Significance Index: 35.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6311
    Cell Significance Index: 38.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5753
    Cell Significance Index: 11.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5576
    Cell Significance Index: 68.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5294
    Cell Significance Index: 366.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5289
    Cell Significance Index: 95.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4957
    Cell Significance Index: 447.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4798
    Cell Significance Index: 21.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4490
    Cell Significance Index: 52.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3313
    Cell Significance Index: 9.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3236
    Cell Significance Index: 176.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3192
    Cell Significance Index: 20.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2926
    Cell Significance Index: 18.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2711
    Cell Significance Index: 12.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2296
    Cell Significance Index: 29.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2153
    Cell Significance Index: 95.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2114
    Cell Significance Index: 2.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2070
    Cell Significance Index: 5.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1683
    Cell Significance Index: 316.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1516
    Cell Significance Index: 68.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1479
    Cell Significance Index: 14.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1275
    Cell Significance Index: 235.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1144
    Cell Significance Index: 176.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1090
    Cell Significance Index: 5.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1054
    Cell Significance Index: 66.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1039
    Cell Significance Index: 4.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0959
    Cell Significance Index: 18.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0877
    Cell Significance Index: 3.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0731
    Cell Significance Index: 12.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0701
    Cell Significance Index: 1.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0586
    Cell Significance Index: 79.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0148
    Cell Significance Index: 0.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0063
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0127
    Cell Significance Index: -9.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0188
    Cell Significance Index: -0.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0194
    Cell Significance Index: -2.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0194
    Cell Significance Index: -14.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0416
    Cell Significance Index: -31.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0447
    Cell Significance Index: -25.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0645
    Cell Significance Index: -3.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0677
    Cell Significance Index: -1.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0776
    Cell Significance Index: -2.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0844
    Cell Significance Index: -5.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0996
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1094
    Cell Significance Index: -23.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1162
    Cell Significance Index: -11.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1175
    Cell Significance Index: -0.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1267
    Cell Significance Index: -36.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1447
    Cell Significance Index: -3.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1563
    Cell Significance Index: -20.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1714
    Cell Significance Index: -3.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1755
    Cell Significance Index: -5.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2126
    Cell Significance Index: -24.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2128
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2179
    Cell Significance Index: -24.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2314
    Cell Significance Index: -4.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2356
    Cell Significance Index: -17.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2369
    Cell Significance Index: -27.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2404
    Cell Significance Index: -6.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2527
    Cell Significance Index: -26.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2834
    Cell Significance Index: -4.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2967
    Cell Significance Index: -8.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3059
    Cell Significance Index: -4.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3122
    Cell Significance Index: -5.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3453
    Cell Significance Index: -18.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4525
    Cell Significance Index: -35.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4723
    Cell Significance Index: -12.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4777
    Cell Significance Index: -10.4600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4917
    Cell Significance Index: -10.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5206
    Cell Significance Index: -8.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5776
    Cell Significance Index: -10.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6054
    Cell Significance Index: -19.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6230
    Cell Significance Index: -21.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6401
    Cell Significance Index: -39.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6486
    Cell Significance Index: -17.0600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7046
    Cell Significance Index: -10.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7391
    Cell Significance Index: -15.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7667
    Cell Significance Index: -10.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger CCCH Domain**: The ZC3H7A protein possesses a zinc finger CCCH domain, a conserved structural motif involved in protein-protein interactions and DNA binding. 2. **MicroRNA Binding and Processing**: ZC3H7A interacts with microRNAs, influencing their processing and regulation of gene expression. 3. **Metal Ion Binding**: The protein exhibits metal ion binding capabilities, which may contribute to its regulatory functions. 4. **Cell Type-Specific Expression**: ZC3H7A is significantly expressed in corneal endothelial cells, ciliary muscle cells, and neurons, highlighting its tissue-specific functions. **Pathways and Functions:** 1. **Post-Transcriptional Regulation of Gene Expression**: ZC3H7A modulates gene expression by regulating microRNA processing and binding, thereby influencing the expression of target genes. 2. **Metal Ion Binding**: The protein's metal ion binding capabilities may be involved in protein-protein interactions, DNA binding, or other cellular processes. 3. **MicroRNA Processing**: ZC3H7A interacts with microRNAs, influencing their biogenesis and regulation of gene expression. 4. **Nucleus**: The protein is localized to the nucleus, where it may participate in DNA binding, transcriptional regulation, or other nuclear processes. **Clinical Significance:** 1. **Eye Diseases**: ZC3H7A's involvement in corneal endothelial cells and lens epithelial cells suggests its potential role in eye diseases, such as corneal endothelial dysfunction or cataracts. 2. **Neurological Disorders**: The protein's expression in neurons implies its potential involvement in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer**: ZC3H7A's interaction with microRNAs and metal ion binding capabilities may contribute to its role in cancer development and progression. 4. **Regulatory Functions**: The protein's regulatory functions in post-transcriptional gene expression and microRNA processing may have implications for various diseases, including those affecting the nervous system, eye, and other tissues. In conclusion, the ZC3H7A gene is a complex, multifunctional protein with significant implications for various cellular processes. Further research is necessary to elucidate its precise functions and clinical significance in different diseases. As an immunologist, I am excited to explore the intricacies of this gene and its potential applications in understanding and treating various diseases.

Genular Protein ID: 929580186

Symbol: Z3H7A_HUMAN

Name: Zinc finger CCCH domain-containing protein 7A

UniProtKB Accession Codes:

Q8IWR0 D3DUG5 Q9NPE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28431233

Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

PubMed ID: 28431233

DOI: 10.1016/j.molcel.2017.03.014

Sequence Information:

  • Length: 971
  • Mass: 110538
  • Checksum: A62D4EF6BC639181
  • Sequence:
    • MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG NDVYREHDWN 
NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS NMGFHDKVLE DCNIVLSLNA 
SNCKALYRKS KALSDLGRYK KAYDAVAKCS LAVPQDEHVI KLTQELAQKL GFKIRKAYVR 
AELSLKSVPG DGATKALNHS VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM 
PLTSILPLQV EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV 
MPSALVRGPL QTASVSPSMP FSASLLGTLP IGARYAPPPS FSEFYPPLTS SLEDFCSSLN 
SFSMSESKRD LSTSTSREGT PLNNSNSSLL LMNGPGSLFA SENFLGISSQ PRNDFGNFFG 
SAVTKPSSSV TPRHPLEGTH ELRQACQICF VKSGPKLMDF TYHANIDHKC KKDILIGRIK 
NVEDKSWKKI RPRPTKTNYE GPYYICKDVA AEEECRYSGH CTFAYCQEEI DVWTLERKGA 
FSREAFFGGN GKINLTVFKL LQEHLGEFIF LCEKCFDHKP RMISKRNKDN STACSHPVTK 
HEFEDNKCLV HILRETTVKY SKIRSFHGQC QLDLCRHEVR YGCLREDECF YAHSLVELKV 
WIMQNETGIS HDAIAQESKR YWQNLEANVP GAQVLGNQIM PGFLNMKIKF VCAQCLRNGQ 
VIEPDKNRKY CSAKARHSWT KDRRAMRVMS IERKKWMNIR PLPTKKQMPL QFDLCNHIAS 
GKKCQYVGNC SFAHSPEERE VWTYMKENGI QDMEQFYELW LKSQKNEKSE DIASQSNKEN 
GKQIHMPTDY AEVTVDFHCW MCGKNCNSEK QWQGHISSEK HKEKVFHTED DQYCWQHRFP 
TGYFSICDRY MNGTCPEGNS CKFAHGNAEL HEWEERRDAL KMKLNKARKD HLIGPNDNDF 
GKYSFLFKDL N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.