TAGLN3 | ENSG00000144834 | NCBI 29114

Details for: TAGLN3

Gene ID: 29114

Symbol: TAGLN3

Ensembl ID: ENSG00000144834

Description: transgelin 3

Associated with

Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Actin filament organization
(GO:0007015)
Central nervous system development
(GO:0007417)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.69
Marker Score: 4,455
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.43
Marker Score: 3,233
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.23
Marker Score: 6,569
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.65
Marker Score: 2,975
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.6
Marker Score: 957
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.56
Marker Score: 860
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.31
Marker Score: 2,323
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.16
Marker Score: 1,022
Cell Name: motor neuron (CL0000100)
Fold Change: 2.15
Marker Score: 1,277
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.62
Marker Score: 99,935
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.62
Marker Score: 15,438
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,169
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.57
Marker Score: 13,520
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.55
Marker Score: 14,559
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.51
Marker Score: 1,505
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.5
Marker Score: 22,410
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.44
Marker Score: 28,688
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.4
Marker Score: 2,166
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.39
Marker Score: 5,388
Cell Name: neuron (CL0000540)
Fold Change: 1.39
Marker Score: 5,669
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 870
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.36
Marker Score: 50,220
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.36
Marker Score: 14,045
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.34
Marker Score: 10,253
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.33
Marker Score: 50,387
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.2
Marker Score: 4,955
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.16
Marker Score: 487
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,812
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.15
Marker Score: 720
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.15
Marker Score: 395
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.04
Marker Score: 704
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.02
Marker Score: 424
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,819
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,044
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.97
Marker Score: 265
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.96
Marker Score: 439
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,349
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.88
Marker Score: 4,067
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,287
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.87
Marker Score: 663
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.81
Marker Score: 1,020
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.8
Marker Score: 852
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.78
Marker Score: 437
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,262
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.77
Marker Score: 739
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.76
Marker Score: 1,065
Cell Name: neural cell (CL0002319)
Fold Change: 0.75
Marker Score: 363
Cell Name: germ cell (CL0000586)
Fold Change: 0.75
Marker Score: 1,306
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.73
Marker Score: 686
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.72
Marker Score: 765
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: PP cell (CL0000696)
Fold Change: 0.71
Marker Score: 161
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.71
Marker Score: 224
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.71
Marker Score: 1,013
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.7
Marker Score: 1,181
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: Unknown (CL0002371)
Fold Change: 0.68
Marker Score: 727
Cell Name: mast cell (CL0000097)
Fold Change: 0.63
Marker Score: 367
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.62
Marker Score: 9,757
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.61
Marker Score: 326
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.61
Marker Score: 1,432
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.61
Marker Score: 3,187
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.6
Marker Score: 395
Cell Name: supporting cell (CL0000630)
Fold Change: 0.59
Marker Score: 1,111
Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.59
Marker Score: 189
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.58
Marker Score: 287
Cell Name: neutrophil (CL0000775)
Fold Change: 0.57
Marker Score: 347
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.57
Marker Score: 5,721
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 150
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.56
Marker Score: 268
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.52
Marker Score: 224
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.51
Marker Score: 215
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.51
Marker Score: 2,123
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.5
Marker Score: 619
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.5
Marker Score: 485
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.48
Marker Score: 1,613
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.48
Marker Score: 192
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.47
Marker Score: 1,613
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.45
Marker Score: 360
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.45
Marker Score: 236
Cell Name: B cell (CL0000236)
Fold Change: 0.44
Marker Score: 424
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.44
Marker Score: 160
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.44
Marker Score: 835
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.43
Marker Score: 1,264
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.43
Marker Score: 425
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.42
Marker Score: 92
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.42
Marker Score: 876
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.42
Marker Score: 217

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** TAGLN3 is a protein-coding gene that is encoded by the ENSG00000144834 gene locus. It is significantly expressed in glycinergic neurons, GABAergic amacrine cells, and other cell types involved in the central nervous system (CNS) and peripheral nervous system (PNS). TAGLN3 is also expressed in blood vessel endothelial cells, inhibitory motor neurons, and motor neurons, highlighting its role in the development and function of the CNS and PNS. **Pathways and Functions:** TAGLN3 is involved in several key pathways, including: 1. **Actin cytoskeleton organization**: TAGLN3 is a member of the transgelin family, which plays a crucial role in regulating actin filament organization and dynamics. This is essential for maintaining cell shape, motility, and intracellular transport. 2. **Negative regulation of transcription by RNA polymerase II**: TAGLN3 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. This interaction may play a role in regulating gene expression and preventing excessive transcription. 3. **Central nervous system development**: TAGLN3 is expressed in radial glial cells, which are involved in the development and migration of neurons during CNS development. 4. **Negative regulation of transcription by RNA polymerase II**: TAGLN3 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. This interaction may play a role in regulating gene expression and preventing excessive transcription. **Clinical Significance:** The clinical significance of TAGLN3 is an area of active research, with potential implications for various neurological and immunological disorders. Some potential areas of interest include: 1. **Neurological disorders**: TAGLN3 has been implicated in the development and progression of various neurological disorders, including Parkinson's disease, multiple sclerosis, and autism spectrum disorder. 2. **Immunological disorders**: TAGLN3 has been shown to play a role in regulating immune cell function and cytokine production, which may be relevant to the development of immunological disorders such as rheumatoid arthritis and lupus. 3. **Cancer**: TAGLN3 has been implicated in cancer development and progression, particularly in the context of glioblastoma and other CNS tumors. In conclusion, TAGLN3 is a gene with a wide range of expression and functional implications in the CNS and PNS. Further research is needed to fully elucidate the mechanisms by which TAGLN3 regulates actin cytoskeleton organization, transcriptional regulation, and immune cell function. The clinical significance of TAGLN3 is an area of active research, with potential implications for the development of new therapeutic strategies for various neurological and immunological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transgelin-3

Genular Protein ID: 2267345377

Symbol: TAGL3_HUMAN

Name: Transgelin-3

UniProtKB Accession Codes:

Q9UI15 D3DN64 Q96A74

Database IDs:

Citations:

PubMed ID: 11238712

Title: Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain.

PubMed ID: 11238712

DOI: 10.1046/j.1471-4159.2001.00176.x

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 199
Mass: 22473
Checksum: 09837A0CC2A0E157
Sequence:

MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA HFQKWLMDGT 
VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA ETYGVRTTDI FQTVDLWEGK 
DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS 
NKGASQAGMT GYGMPRQIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.