Details for: TAGLN3

Gene ID: 29114

Symbol: TAGLN3

Ensembl ID: ENSG00000144834

Description: transgelin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.1456
    Cell Significance Index: 322.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9175
    Cell Significance Index: 384.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2531
    Cell Significance Index: 15.5400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.1365
    Cell Significance Index: 6.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7962
    Cell Significance Index: 285.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7860
    Cell Significance Index: 25.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6794
    Cell Significance Index: 41.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6005
    Cell Significance Index: 114.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5795
    Cell Significance Index: 12.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5523
    Cell Significance Index: 15.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3458
    Cell Significance Index: 23.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3298
    Cell Significance Index: 297.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2217
    Cell Significance Index: 3.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1136
    Cell Significance Index: 11.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1119
    Cell Significance Index: 1.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0609
    Cell Significance Index: 9.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0200
    Cell Significance Index: 0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0149
    Cell Significance Index: -9.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0156
    Cell Significance Index: -0.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0210
    Cell Significance Index: -38.7700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0215
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0244
    Cell Significance Index: -46.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0248
    Cell Significance Index: -38.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0259
    Cell Significance Index: -1.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0390
    Cell Significance Index: -53.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0396
    Cell Significance Index: -1.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0446
    Cell Significance Index: -19.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0463
    Cell Significance Index: -26.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0529
    Cell Significance Index: -2.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0556
    Cell Significance Index: -40.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0579
    Cell Significance Index: -31.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0638
    Cell Significance Index: -40.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0735
    Cell Significance Index: -8.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0974
    Cell Significance Index: -44.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1015
    Cell Significance Index: -21.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1253
    Cell Significance Index: -7.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1338
    Cell Significance Index: -38.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1340
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1594
    Cell Significance Index: -27.2200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1620
    Cell Significance Index: -1.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1836
    Cell Significance Index: -23.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2055
    Cell Significance Index: -40.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2062
    Cell Significance Index: -37.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2126
    Cell Significance Index: -9.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2165
    Cell Significance Index: -8.2000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2200
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2793
    Cell Significance Index: -40.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2852
    Cell Significance Index: -32.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2936
    Cell Significance Index: -36.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2972
    Cell Significance Index: -33.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3111
    Cell Significance Index: -36.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3348
    Cell Significance Index: -23.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3367
    Cell Significance Index: -46.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3823
    Cell Significance Index: -22.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3835
    Cell Significance Index: -27.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3842
    Cell Significance Index: -49.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3942
    Cell Significance Index: -40.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4521
    Cell Significance Index: -53.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5061
    Cell Significance Index: -40.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5336
    Cell Significance Index: -33.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5341
    Cell Significance Index: -14.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6141
    Cell Significance Index: -14.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6445
    Cell Significance Index: -49.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6576
    Cell Significance Index: -20.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6701
    Cell Significance Index: -17.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6703
    Cell Significance Index: -49.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6933
    Cell Significance Index: -17.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7205
    Cell Significance Index: -23.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7244
    Cell Significance Index: -37.7400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7257
    Cell Significance Index: -5.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7379
    Cell Significance Index: -14.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7440
    Cell Significance Index: -15.7900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7507
    Cell Significance Index: -4.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7920
    Cell Significance Index: -27.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8255
    Cell Significance Index: -38.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8387
    Cell Significance Index: -7.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8418
    Cell Significance Index: -43.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9204
    Cell Significance Index: -43.2600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9367
    Cell Significance Index: -7.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9373
    Cell Significance Index: -32.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9518
    Cell Significance Index: -20.5700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.9744
    Cell Significance Index: -10.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9862
    Cell Significance Index: -19.8000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9912
    Cell Significance Index: -12.3600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.0007
    Cell Significance Index: -16.4900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.0193
    Cell Significance Index: -11.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0616
    Cell Significance Index: -26.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.0988
    Cell Significance Index: -17.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1060
    Cell Significance Index: -23.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1349
    Cell Significance Index: -24.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1639
    Cell Significance Index: -24.1500
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -1.2108
    Cell Significance Index: -9.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2256
    Cell Significance Index: -36.1000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.2732
    Cell Significance Index: -16.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2741
    Cell Significance Index: -31.8500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.3387
    Cell Significance Index: -27.9400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.3469
    Cell Significance Index: -28.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3532
    Cell Significance Index: -28.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3759
    Cell Significance Index: -50.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAGLN3 is a protein-coding gene that is encoded by the ENSG00000144834 gene locus. It is significantly expressed in glycinergic neurons, GABAergic amacrine cells, and other cell types involved in the central nervous system (CNS) and peripheral nervous system (PNS). TAGLN3 is also expressed in blood vessel endothelial cells, inhibitory motor neurons, and motor neurons, highlighting its role in the development and function of the CNS and PNS. **Pathways and Functions:** TAGLN3 is involved in several key pathways, including: 1. **Actin cytoskeleton organization**: TAGLN3 is a member of the transgelin family, which plays a crucial role in regulating actin filament organization and dynamics. This is essential for maintaining cell shape, motility, and intracellular transport. 2. **Negative regulation of transcription by RNA polymerase II**: TAGLN3 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. This interaction may play a role in regulating gene expression and preventing excessive transcription. 3. **Central nervous system development**: TAGLN3 is expressed in radial glial cells, which are involved in the development and migration of neurons during CNS development. 4. **Negative regulation of transcription by RNA polymerase II**: TAGLN3 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. This interaction may play a role in regulating gene expression and preventing excessive transcription. **Clinical Significance:** The clinical significance of TAGLN3 is an area of active research, with potential implications for various neurological and immunological disorders. Some potential areas of interest include: 1. **Neurological disorders**: TAGLN3 has been implicated in the development and progression of various neurological disorders, including Parkinson's disease, multiple sclerosis, and autism spectrum disorder. 2. **Immunological disorders**: TAGLN3 has been shown to play a role in regulating immune cell function and cytokine production, which may be relevant to the development of immunological disorders such as rheumatoid arthritis and lupus. 3. **Cancer**: TAGLN3 has been implicated in cancer development and progression, particularly in the context of glioblastoma and other CNS tumors. In conclusion, TAGLN3 is a gene with a wide range of expression and functional implications in the CNS and PNS. Further research is needed to fully elucidate the mechanisms by which TAGLN3 regulates actin cytoskeleton organization, transcriptional regulation, and immune cell function. The clinical significance of TAGLN3 is an area of active research, with potential implications for the development of new therapeutic strategies for various neurological and immunological disorders.

Genular Protein ID: 2267345377

Symbol: TAGL3_HUMAN

Name: Transgelin-3

UniProtKB Accession Codes:

Q9UI15 D3DN64 Q96A74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11238712

Title: Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain.

PubMed ID: 11238712

DOI: 10.1046/j.1471-4159.2001.00176.x

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 199
  • Mass: 22473
  • Checksum: 09837A0CC2A0E157
  • Sequence:
    • MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA HFQKWLMDGT 
VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA ETYGVRTTDI FQTVDLWEGK 
DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS 
NKGASQAGMT GYGMPRQIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.