Details for: CXCL1

Gene ID: 2919

Symbol: CXCL1

Ensembl ID: ENSG00000163739

Description: C-X-C motif chemokine ligand 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.4800
    Cell Significance Index: -20.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.6788
    Cell Significance Index: -20.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 49.5694
    Cell Significance Index: -20.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.9504
    Cell Significance Index: -20.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.5254
    Cell Significance Index: -16.8700
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 17.0254
    Cell Significance Index: 97.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3428
    Cell Significance Index: -20.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.7163
    Cell Significance Index: 307.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 9.2368
    Cell Significance Index: 152.2100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 5.7617
    Cell Significance Index: 41.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1089
    Cell Significance Index: -20.1600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.2607
    Cell Significance Index: 20.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6409
    Cell Significance Index: 341.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 2.2399
    Cell Significance Index: 255.6800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.2113
    Cell Significance Index: 22.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4150
    Cell Significance Index: 772.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3620
    Cell Significance Index: 101.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1444
    Cell Significance Index: 217.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9512
    Cell Significance Index: 25.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7073
    Cell Significance Index: 69.9700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.6321
    Cell Significance Index: 1.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5917
    Cell Significance Index: 534.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4413
    Cell Significance Index: 20.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4271
    Cell Significance Index: 19.3600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4135
    Cell Significance Index: 2.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3749
    Cell Significance Index: 60.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3559
    Cell Significance Index: 6.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2986
    Cell Significance Index: 34.2100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.2336
    Cell Significance Index: 1.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2292
    Cell Significance Index: 28.1800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2177
    Cell Significance Index: 0.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2061
    Cell Significance Index: 9.6100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1803
    Cell Significance Index: 1.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1444
    Cell Significance Index: 1.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1429
    Cell Significance Index: 8.5800
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.1323
    Cell Significance Index: 0.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1271
    Cell Significance Index: 8.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1045
    Cell Significance Index: 79.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0554
    Cell Significance Index: 34.5900
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.0546
    Cell Significance Index: 0.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0356
    Cell Significance Index: 0.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0078
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0028
    Cell Significance Index: -0.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0049
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0064
    Cell Significance Index: -1.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0074
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0107
    Cell Significance Index: -20.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0130
    Cell Significance Index: -24.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0149
    Cell Significance Index: -0.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0158
    Cell Significance Index: -24.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0178
    Cell Significance Index: -24.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0205
    Cell Significance Index: -3.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0257
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0268
    Cell Significance Index: -19.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0300
    Cell Significance Index: -0.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0306
    Cell Significance Index: -19.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0319
    Cell Significance Index: -14.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0466
    Cell Significance Index: -5.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0497
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0513
    Cell Significance Index: -10.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0571
    Cell Significance Index: -25.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0677
    Cell Significance Index: -8.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0752
    Cell Significance Index: -21.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0925
    Cell Significance Index: -5.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0934
    Cell Significance Index: -2.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1005
    Cell Significance Index: -5.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1032
    Cell Significance Index: -20.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1036
    Cell Significance Index: -20.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1243
    Cell Significance Index: -3.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1346
    Cell Significance Index: -19.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1354
    Cell Significance Index: -13.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1610
    Cell Significance Index: -3.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1688
    Cell Significance Index: -4.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1909
    Cell Significance Index: -22.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1942
    Cell Significance Index: -20.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1984
    Cell Significance Index: -3.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2179
    Cell Significance Index: -4.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2480
    Cell Significance Index: -12.9200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2887
    Cell Significance Index: -4.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2937
    Cell Significance Index: -22.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3037
    Cell Significance Index: -8.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3142
    Cell Significance Index: -21.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3273
    Cell Significance Index: -9.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3465
    Cell Significance Index: -12.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3711
    Cell Significance Index: -22.8100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3789
    Cell Significance Index: -4.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3945
    Cell Significance Index: -3.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4150
    Cell Significance Index: -23.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4328
    Cell Significance Index: -9.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4659
    Cell Significance Index: -24.4600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.4798
    Cell Significance Index: -2.9600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4944
    Cell Significance Index: -7.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5157
    Cell Significance Index: -13.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5338
    Cell Significance Index: -18.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5410
    Cell Significance Index: -23.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5445
    Cell Significance Index: -14.5700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5528
    Cell Significance Index: -7.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5832
    Cell Significance Index: -20.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCL1 exhibits several key characteristics that distinguish it from other chemokines: 1. **Chemotactic activity**: CXCL1 has a strong chemotactic activity, which attracts immune cells, such as neutrophils, to sites of inflammation. 2. **Receptor specificity**: CXCL1 binds specifically to CXCR1, a receptor that is expressed on various immune cells, including neutrophils, monocytes, and eosinophils. 3. **Inflammatory response**: CXCL1 is upregulated in response to inflammatory stimuli, such as LPS and antimicrobial peptides, which are released by pathogens or damaged tissues. 4. **Cellular localization**: CXCL1 is expressed in various tissues, including the mammary gland, small intestine, and respiratory tract, where it plays a role in regulating immune responses and tissue homeostasis. **Pathways and Functions** CXCL1 mediates its effects through the CXCR1 receptor, which activates a signaling cascade that regulates various cellular processes, including: 1. **Chemotaxis**: CXCL1 induces chemotaxis in immune cells, such as neutrophils, which migrate towards the site of inflammation. 2. **Degranulation**: CXCL1 stimulates degranulation in neutrophils, releasing antimicrobial peptides and other inflammatory mediators. 3. **Proliferation**: CXCL1 regulates cell proliferation in various cell types, including immune cells and epithelial cells. 4. **Inflammation**: CXCL1 contributes to the development of inflammation by recruiting immune cells to sites of inflammation. **Clinical Significance** CXCL1 has significant implications in various diseases, including: 1. **Inflammatory disorders**: CXCL1 is upregulated in inflammatory disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD), where it contributes to tissue damage and inflammation. 2. **Cancer**: CXCL1 is overexpressed in various types of cancer, including breast, lung, and prostate cancer, where it promotes tumor growth and metastasis. 3. **Infectious diseases**: CXCL1 is involved in the regulation of immune responses to infections, such as bacterial and viral infections, where it recruits immune cells to sites of infection. 4. **Autoimmune diseases**: CXCL1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it contributes to tissue damage and inflammation. In conclusion, CXCL1 is a key chemokine that plays a crucial role in regulating immune responses, including inflammation, chemotaxis, and cell proliferation. Its dysregulation has significant implications in various diseases, including inflammatory disorders, cancer, infectious diseases, and autoimmune diseases.

Genular Protein ID: 2987501019

Symbol: GROA_HUMAN

Name: Growth-regulated alpha protein

UniProtKB Accession Codes:

P09341 Q9UCR7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2890161

Title: Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells.

PubMed ID: 2890161

DOI: 10.1073/pnas.84.20.7188

PubMed ID: 2970963

Title: Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

PubMed ID: 2970963

DOI: 10.1002/j.1460-2075.1988.tb03042.x

PubMed ID: 2129556

Title: Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene.

PubMed ID: 2129556

DOI: 10.1093/nar/18.21.6453

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10095777

Title: Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.

PubMed ID: 10095777

DOI: 10.1046/j.1432-1327.1999.00166.x

PubMed ID: 2182761

Title: Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity.

PubMed ID: 2182761

DOI: 10.1084/jem.171.4.1091

PubMed ID: 2655583

Title: Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts.

PubMed ID: 2655583

DOI: 10.1042/bj2590585

PubMed ID: 1755384

Title: Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale.

PubMed ID: 1755384

DOI: 10.1007/978-1-4684-6009-4_12

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2670560

Title: Expression and secretion of gro/MGSA by stimulated human endothelial cells.

PubMed ID: 2670560

DOI: 10.1002/j.1460-2075.1989.tb03569.x

PubMed ID: 8397104

Title: 1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy.

PubMed ID: 8397104

DOI: 10.1016/0014-5793(93)80893-y

PubMed ID: 8089846

Title: The solution structure of melanoma growth stimulating activity.

PubMed ID: 8089846

DOI: 10.1006/jmbi.1994.1577

PubMed ID: 7806518

Title: Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy.

PubMed ID: 7806518

DOI: 10.1016/s0021-9258(20)30077-6

Sequence Information:

  • Length: 107
  • Mass: 11301
  • Checksum: 17048A6B4D765CA2
  • Sequence:
    • MARAALSAAP SNPRLLRVAL LLLLLVAAGR RAAGASVATE LRCQCLQTLQ GIHPKNIQSV 
NVKSPGPHCA QTEVIATLKN GRKACLNPAS PIVKKIIEKM LNSDKSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.