Details for: CXCL1

Gene ID: 2919

Symbol: CXCL1

Ensembl ID: ENSG00000163739

Description: C-X-C motif chemokine ligand 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1
    Marker Score: 105358
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.63
    Marker Score: 935
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.54
    Marker Score: 1252
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.42
    Marker Score: 2824
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.39
    Marker Score: 1030
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.05
    Marker Score: 462
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.95
    Marker Score: 3563
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.89
    Marker Score: 1078
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.79
    Marker Score: 516
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.75
    Marker Score: 4272
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.73
    Marker Score: 473
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.67
    Marker Score: 8197
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.64
    Marker Score: 1291
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.55
    Marker Score: 1628
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.53
    Marker Score: 390
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.42
    Marker Score: 590
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.39
    Marker Score: 347
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.38
    Marker Score: 347
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.31
    Marker Score: 45458
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.24
    Marker Score: 9247
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.13
    Marker Score: 440
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.11
    Marker Score: 377
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.07
    Marker Score: 715
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2072
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71797
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.98
    Marker Score: 13223
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.98
    Marker Score: 3775
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.97
    Marker Score: 611
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.96
    Marker Score: 305
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5248
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.89
    Marker Score: 2023
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.87
    Marker Score: 1430
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 645
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 330
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.79
    Marker Score: 778
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.78
    Marker Score: 453
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.76
    Marker Score: 357
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.73
    Marker Score: 974
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.73
    Marker Score: 650
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.72
    Marker Score: 1365
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2997
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.71
    Marker Score: 1124
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.7
    Marker Score: 480
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.7
    Marker Score: 6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.7
    Marker Score: 722
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.68
    Marker Score: 196
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.67
    Marker Score: 424
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.66
    Marker Score: 461
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.65
    Marker Score: 165
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.64
    Marker Score: 235
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.64
    Marker Score: 830
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.64
    Marker Score: 878
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.64
    Marker Score: 4156
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.63
    Marker Score: 1426
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.61
    Marker Score: 586
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.59
    Marker Score: 652
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.56
    Marker Score: 287
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.54
    Marker Score: 1384
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.54
    Marker Score: 919
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.54
    Marker Score: 462
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.54
    Marker Score: 216
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.54
    Marker Score: 341
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.53
    Marker Score: 3223
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.53
    Marker Score: 618
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.51
    Marker Score: 342
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5
    Marker Score: 539
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.48
    Marker Score: 1712
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 288
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.47
    Marker Score: 2493
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.47
    Marker Score: 151
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.47
    Marker Score: 214
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.46
    Marker Score: 706
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.44
    Marker Score: 1056
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 437
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.43
    Marker Score: 627
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.43
    Marker Score: 129
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 679
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.42
    Marker Score: 361
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.42
    Marker Score: 670
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 372
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.41
    Marker Score: 596
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.41
    Marker Score: 6551
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.4
    Marker Score: 201

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Other Information

**Key characteristics:** - Gene name: CXCL1 - Ensembl ID: ENSG00000163739 - Protein name: GROA_HUMAN - Cellular expression: Fibroblasts of mammary gland, epithelial cells of mammary gland, bronchial goblet cell, club cell, inflammatory cells, stromal cells of lamina propria of small intestine, secretory cells, fibroblasts of breast, respiratory goblet cell, basal cell of prostate epithelium **Pathways and functions:** - CXCL1 is a chemotactic factor that is produced by epithelial cells in the lung and other tissues. - It binds to the chemokine receptor CXCR2, which is expressed on immune cells. - This binding activates the receptor, which in turn triggers a cascade of intracellular events that leads to the migration of the immune cells to the site of inflammation or infection. - CXCL1 is also a growth factor that is produced by fibroblasts and epithelial cells. - It promotes the proliferation and survival of epithelial cells and inhibits the proliferation of fibroblasts. - CXCL1 plays a role in the development and maintenance of the lung. - It is involved in the regulation of inflammation and immune responses. **Clinical significance:** CXCL1 is a potential therapeutic target for a variety of diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cancer. Studies have shown that CXCL1 can be used to attract immune cells to sites of inflammation, where they can help to clear infection or tumor cells. This has led to the development of new therapies for a variety of diseases that are characterized by inflammation or cancer.

Genular Protein ID: 2987501019

Symbol: GROA_HUMAN

Name: Growth-regulated alpha protein

UniProtKB Accession Codes:

P09341 Q9UCR7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2890161

Title: Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells.

PubMed ID: 2890161

DOI: 10.1073/pnas.84.20.7188

PubMed ID: 2970963

Title: Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

PubMed ID: 2970963

DOI: 10.1002/j.1460-2075.1988.tb03042.x

PubMed ID: 2129556

Title: Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene.

PubMed ID: 2129556

DOI: 10.1093/nar/18.21.6453

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10095777

Title: Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.

PubMed ID: 10095777

DOI: 10.1046/j.1432-1327.1999.00166.x

PubMed ID: 2182761

Title: Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity.

PubMed ID: 2182761

DOI: 10.1084/jem.171.4.1091

PubMed ID: 2655583

Title: Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts.

PubMed ID: 2655583

DOI: 10.1042/bj2590585

PubMed ID: 1755384

Title: Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale.

PubMed ID: 1755384

DOI: 10.1007/978-1-4684-6009-4_12

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2670560

Title: Expression and secretion of gro/MGSA by stimulated human endothelial cells.

PubMed ID: 2670560

DOI: 10.1002/j.1460-2075.1989.tb03569.x

PubMed ID: 8397104

Title: 1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy.

PubMed ID: 8397104

DOI: 10.1016/0014-5793(93)80893-y

PubMed ID: 8089846

Title: The solution structure of melanoma growth stimulating activity.

PubMed ID: 8089846

DOI: 10.1006/jmbi.1994.1577

PubMed ID: 7806518

Title: Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy.

PubMed ID: 7806518

DOI: 10.1016/s0021-9258(20)30077-6

Sequence Information:

  • Length: 107
  • Mass: 11301
  • Checksum: 17048A6B4D765CA2
  • Sequence:
    • MARAALSAAP SNPRLLRVAL LLLLLVAAGR RAAGASVATE LRCQCLQTLQ GIHPKNIQSV 
NVKSPGPHCA QTEVIATLKN GRKACLNPAS PIVKKIIEKM LNSDKSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.