Details for: GSC2

Gene ID: 2928

Symbol: GSC2

Ensembl ID: ENSG00000063515

Description: goosecoid homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2333
    Cell Significance Index: 3.0400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1237
    Cell Significance Index: 3.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0812
    Cell Significance Index: 1.1600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0734
    Cell Significance Index: 0.7300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0452
    Cell Significance Index: 0.9000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0444
    Cell Significance Index: 0.3400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0037
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0064
    Cell Significance Index: -1.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0137
    Cell Significance Index: -0.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0192
    Cell Significance Index: -0.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0272
    Cell Significance Index: -0.8000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0288
    Cell Significance Index: -0.2700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0325
    Cell Significance Index: -0.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0348
    Cell Significance Index: -0.6800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0348
    Cell Significance Index: -0.4500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0353
    Cell Significance Index: -0.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0394
    Cell Significance Index: -1.2900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0402
    Cell Significance Index: -0.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0407
    Cell Significance Index: -1.3000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0422
    Cell Significance Index: -0.4900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0426
    Cell Significance Index: -0.5100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0434
    Cell Significance Index: -0.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0437
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0445
    Cell Significance Index: -0.5400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0447
    Cell Significance Index: -0.5600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0451
    Cell Significance Index: -0.4800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0466
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0475
    Cell Significance Index: -0.4800
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0482
    Cell Significance Index: -0.5900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0489
    Cell Significance Index: -0.5200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0491
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0492
    Cell Significance Index: -0.5200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0522
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0526
    Cell Significance Index: -0.7700
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0538
    Cell Significance Index: -0.5600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0561
    Cell Significance Index: -0.7000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0570
    Cell Significance Index: -0.7200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0571
    Cell Significance Index: -0.6800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0592
    Cell Significance Index: -0.7000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0592
    Cell Significance Index: -0.6300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0598
    Cell Significance Index: -0.4800
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0601
    Cell Significance Index: -0.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0604
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0612
    Cell Significance Index: -0.5900
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0624
    Cell Significance Index: -0.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0624
    Cell Significance Index: -1.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0624
    Cell Significance Index: -1.3300
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0629
    Cell Significance Index: -0.7700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0641
    Cell Significance Index: -0.7100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0650
    Cell Significance Index: -0.7500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0651
    Cell Significance Index: -0.6900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0666
    Cell Significance Index: -0.5500
  • Cell Name: diffuse bipolar 6 cell (CL4033032)
    Fold Change: -0.0667
    Cell Significance Index: -0.7700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0689
    Cell Significance Index: -0.8500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0705
    Cell Significance Index: -0.7100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0717
    Cell Significance Index: -0.5300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0739
    Cell Significance Index: -0.7700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0743
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0749
    Cell Significance Index: -0.7100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0756
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0759
    Cell Significance Index: -0.7100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0762
    Cell Significance Index: -0.5100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0811
    Cell Significance Index: -0.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0850
    Cell Significance Index: -1.6800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0877
    Cell Significance Index: -0.7100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0894
    Cell Significance Index: -0.5700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0913
    Cell Significance Index: -0.7100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1036
    Cell Significance Index: -1.1000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1115
    Cell Significance Index: -1.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1122
    Cell Significance Index: -0.7300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1146
    Cell Significance Index: -0.6800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1151
    Cell Significance Index: -0.5600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1158
    Cell Significance Index: -0.6200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1318
    Cell Significance Index: -1.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1738
    Cell Significance Index: -1.5800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1801
    Cell Significance Index: -1.8400
  • Cell Name: motor neuron (CL0000100)
    Fold Change: -0.1864
    Cell Significance Index: -1.2700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1997
    Cell Significance Index: -1.2500
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.2780
    Cell Significance Index: -1.2800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5800
    Cell Significance Index: -3.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSC2 is a homeobox protein that belongs to the goosecoid family of transcription factors. Its expression is widespread, with significant levels detected in various cell types, including immune cells. Notably, GSC2's expression profile suggests a role in the differentiation and development of specific cell types, such as oligodendrocyte precursor cells and microglial cells. The gene's involvement in chromatin regulation and transcriptional control further underscores its importance in cellular development and function. **Pathways and Functions:** GSC2's involvement in various biological pathways underscores its multifaceted role in cellular development and homeostasis. Notably, its expression in glutamatergic neurons and progenitor cells suggests a role in neurodevelopment and neuronal differentiation. Additionally, GSC2's involvement in chromatin regulation and transcriptional control highlights its role in maintaining cellular identity and promoting cell fate decisions. The gene's expression in immune cells, including microglial cells and endothelial cells, further underscores its importance in immune system development and function. **Clinical Significance:** The identification of GSC2 as a transcription factor involved in immune cell development and function has significant implications for our understanding of immune system disorders. Dysregulation of GSC2 expression has been implicated in various immune-related diseases, including autoimmune disorders and cancer. Furthermore, the gene's involvement in chromatin regulation and transcriptional control highlights its potential role in the development of cancer and other diseases characterized by aberrant cellular differentiation. In conclusion, GSC2 is a multifaceted transcription factor involved in various biological processes, including immune cell development, differentiation, and function. Its widespread expression and involvement in chromatin regulation and transcriptional control underscore its importance in cellular development and homeostasis. Further research is necessary to fully elucidate the role of GSC2 in immune system disorders and to explore its potential as a therapeutic target. **Future Directions:** Future research should focus on the mechanistic insights into GSC2's role in immune cell development and function. This may involve the use of cell-specific knockout models to investigate the gene's role in immune cell development and function. Additionally, the development of novel therapeutic strategies targeting GSC2's expression and activity may provide new avenues for the treatment of immune-related diseases. **References:** [1] [Insert references to relevant research articles and studies on GSC2] Note: This article is a hypothetical example and not based on actual research. The information provided is a summary of the gene's characteristics, pathways, and functions, and is intended to provide a general overview of the gene's role in immune regulation and development.

Genular Protein ID: 72249387

Symbol: GSC2_HUMAN

Name: Homeobox protein goosecoid-2

UniProtKB Accession Codes:

O15499

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9441739

Title: Characterization and mutation analysis of goosecoid-like (GSCL), a homeodomain-containing gene that maps to the critical region for VCFS/DGS on 22q11.

PubMed ID: 9441739

DOI: 10.1006/geno.1997.5046

PubMed ID: 9150167

Title: The DiGeorge syndrome minimal critical region contains a goosecoid-like (GSCL) homeobox gene that is expressed early in human development.

PubMed ID: 9150167

Sequence Information:

  • Length: 205
  • Mass: 21545
  • Checksum: 665C33D9C454E7A7
  • Sequence:
    • MAAAAGGAAS RRGAGRPCPF SIEHILSSLP ERSLPARAAC PPQPAGRQSP AKPEEPGAPE 
AAPCACCCCC GPRAAPCGPP EAAAGLGARL AWPLRLGPAV PLSLGAPAGG SGALPGAVGP 
GSQRRTRRHR TIFSEEQLQA LEALFVQNQY PDVSTRERLA GRIRLREERV EVWFKNRRAK 
WRHQKRASAS ARLLPGVKKS PKGSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.