Details for: GSPT1

Gene ID: 2935

Symbol: GSPT1

Ensembl ID: ENSG00000103342

Description: G1 to S phase transition 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 395.3513
    Cell Significance Index: -61.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 261.3118
    Cell Significance Index: -66.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.8962
    Cell Significance Index: -73.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 147.0990
    Cell Significance Index: -59.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.7313
    Cell Significance Index: -68.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 108.8638
    Cell Significance Index: -73.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.1741
    Cell Significance Index: -60.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.8007
    Cell Significance Index: -62.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.7867
    Cell Significance Index: -66.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.2486
    Cell Significance Index: -72.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.2003
    Cell Significance Index: -52.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.7212
    Cell Significance Index: -30.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5203
    Cell Significance Index: 48.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0253
    Cell Significance Index: 365.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8097
    Cell Significance Index: 222.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8033
    Cell Significance Index: 361.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7100
    Cell Significance Index: 45.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5998
    Cell Significance Index: 260.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5626
    Cell Significance Index: 81.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5228
    Cell Significance Index: 113.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5066
    Cell Significance Index: 298.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4593
    Cell Significance Index: 68.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3483
    Cell Significance Index: 37.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2605
    Cell Significance Index: 162.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2604
    Cell Significance Index: 688.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1136
    Cell Significance Index: 30.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9961
    Cell Significance Index: 46.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9030
    Cell Significance Index: 8.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8727
    Cell Significance Index: 119.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8404
    Cell Significance Index: 301.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7522
    Cell Significance Index: 81.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.7314
    Cell Significance Index: 1348.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6036
    Cell Significance Index: 266.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5458
    Cell Significance Index: 15.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4715
    Cell Significance Index: 725.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4568
    Cell Significance Index: 32.3100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4330
    Cell Significance Index: 2.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3878
    Cell Significance Index: 350.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3694
    Cell Significance Index: 63.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3578
    Cell Significance Index: 27.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3290
    Cell Significance Index: 227.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2826
    Cell Significance Index: 8.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2501
    Cell Significance Index: 16.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2126
    Cell Significance Index: 25.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1864
    Cell Significance Index: 10.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1690
    Cell Significance Index: 32.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1647
    Cell Significance Index: 4.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1591
    Cell Significance Index: 20.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1035
    Cell Significance Index: 194.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0807
    Cell Significance Index: 109.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0590
    Cell Significance Index: 3.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0357
    Cell Significance Index: 27.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0278
    Cell Significance Index: 17.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0266
    Cell Significance Index: 19.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0112
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0195
    Cell Significance Index: -14.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0495
    Cell Significance Index: -30.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1009
    Cell Significance Index: -56.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1124
    Cell Significance Index: -6.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1142
    Cell Significance Index: -11.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1591
    Cell Significance Index: -5.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1845
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1924
    Cell Significance Index: -40.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2118
    Cell Significance Index: -11.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2126
    Cell Significance Index: -61.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2359
    Cell Significance Index: -34.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2863
    Cell Significance Index: -1.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3312
    Cell Significance Index: -5.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3383
    Cell Significance Index: -9.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3546
    Cell Significance Index: -6.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3720
    Cell Significance Index: -9.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3791
    Cell Significance Index: -23.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3983
    Cell Significance Index: -45.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4502
    Cell Significance Index: -52.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4795
    Cell Significance Index: -33.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4807
    Cell Significance Index: -54.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4952
    Cell Significance Index: -11.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4983
    Cell Significance Index: -8.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5857
    Cell Significance Index: -10.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5881
    Cell Significance Index: -61.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5955
    Cell Significance Index: -47.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6857
    Cell Significance Index: -11.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7012
    Cell Significance Index: -31.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7494
    Cell Significance Index: -33.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7712
    Cell Significance Index: -27.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7738
    Cell Significance Index: -29.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7973
    Cell Significance Index: -41.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8657
    Cell Significance Index: -18.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9622
    Cell Significance Index: -28.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9741
    Cell Significance Index: -25.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0109
    Cell Significance Index: -25.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.1232
    Cell Significance Index: -18.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1378
    Cell Significance Index: -32.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1412
    Cell Significance Index: -69.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1924
    Cell Significance Index: -38.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2438
    Cell Significance Index: -33.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2802
    Cell Significance Index: -18.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3754
    Cell Significance Index: -50.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5322
    Cell Significance Index: -48.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSPT1 is a GTP-binding protein that is highly expressed in various cell types, including neural progenitor cells, epithelial cells, and progenitor cells of mammary luminal epithelium. It is also found in the cytosol and nucleus, where it interacts with other proteins to regulate cell cycle progression and protein synthesis. GSPT1 is a GTPase, meaning it hydrolyzes GTP to GDP, and this process is essential for its function. The gene is significantly expressed in cells undergoing rapid proliferation, such as during development, wound healing, and cancer. **Pathways and Functions:** GSPT1 is involved in several key pathways, including: 1. **G1/S transition of the cell cycle**: GSPT1 regulates the transition from the G1 phase to the S phase by interacting with other proteins to activate the G1/S checkpoint. 2. **Translation termination**: GSPT1 is involved in the regulation of protein synthesis by interacting with translation release factors to terminate protein synthesis. 3. **Nonsense-mediated decay (NMD)**: GSPT1 is also involved in the regulation of NMD, a process that degrades aberrant mRNAs. 4. **Protein binding and methylation**: GSPT1 interacts with other proteins to regulate protein synthesis and modification, including protein methylation. **Clinical Significance:** GSPT1 has significant implications for various diseases, including: 1. **Cancer**: GSPT1 is overexpressed in many types of cancer, including breast, prostate, and lung cancer, where it promotes cell proliferation and survival. 2. **Neurological disorders**: GSPT1 is involved in the regulation of neural development and function, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental disorders**: GSPT1 is essential for normal development, and its dysregulation has been implicated in developmental disorders, such as autism and Down syndrome. 4. **Infectious diseases**: GSPT1 is involved in the regulation of immune responses, and its dysregulation has been implicated in infectious diseases, such as HIV and tuberculosis. In conclusion, GSPT1 is a critical regulator of cell cycle progression and protein synthesis, and its dysregulation has significant implications for various diseases. Further research is needed to fully understand the role of GSPT1 in human disease and to develop therapeutic strategies to target this gene in disease prevention and treatment.

Genular Protein ID: 2924532603

Symbol: ERF3A_HUMAN

Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2511002

Title: A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells.

PubMed ID: 2511002

DOI: 10.1002/j.1460-2075.1989.tb08558.x

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15987998

Title: Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.

PubMed ID: 15987998

DOI: 10.1128/mcb.25.14.5801-5811.2005

PubMed ID: 16777602

Title: In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3.

PubMed ID: 16777602

DOI: 10.1016/j.cell.2006.04.035

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24486019

Title: Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

PubMed ID: 24486019

DOI: 10.1016/j.molcel.2013.12.028

PubMed ID: 30682371

Title: Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting.

PubMed ID: 30682371

DOI: 10.1016/j.cell.2018.12.030

PubMed ID: 19417105

Title: Structural insights into eRF3 and stop codon recognition by eRF1.

PubMed ID: 19417105

DOI: 10.1101/gad.1770109

PubMed ID: 20418951

Title: Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein.

PubMed ID: 20418951

DOI: 10.1371/journal.pone.0010169

PubMed ID: 27863242

Title: Decoding mammalian ribosome-mRNA states by translational GTPase complexes.

PubMed ID: 27863242

DOI: 10.1016/j.cell.2016.10.046

Sequence Information:

  • Length: 499
  • Mass: 55756
  • Checksum: DE20482CCABC3576
  • Sequence:
  • MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP 
    KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET 
    WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV 
    LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK 
    LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG 
    PIRLPIVDKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE 
    NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI 
    EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR 
    DEGKTIAIGK VLKLVPEKD

Genular Protein ID: 2731659231

Symbol: Q7KZX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 498
  • Mass: 55657
  • Checksum: B47CE8DF1EF40C8A
  • Sequence:
  • MELSEPIENG ETEMSPEESW EHKEEISEAE PGGGSLGDGR PPEESAHEMM EEEEEIPKPK 
    SVVAPPGAPK KEHVNVVFIG HVDAGKSTIG GQIMYLTGMV DKRTLEKYER EAKEKNRETW 
    YLSWALDTNQ EERDKGKTVE VGRAYFETEK KHFTILDAPG HKSFVPNMIG GASQADLAVL 
    VISARKGEFE TGFEKGGQTR EHAMLAKTAG VKHLIVLINK MDDPTVNWSN ERYEECKEKL 
    VPFLKKVGFN PKKDIHFMPC SGLTGANLKE QSDFCPWYIG LPFIPYLDNL PNFNRSVDGP 
    IRLPIVDKYK DMGTVVLGKL ESGSICKGQQ LVMMPNKHNV EVLGILSDDV ETDTVAPGEN 
    LKIRLKGIEE EEILPGFILC DPNNLCHSGR TFDAQIVIIE HKSIICPGYN AVLHIHTCIE 
    EVEITALICL VDKKSGEKSK TRPRFVKQDQ VCIARLRTAG TICLETFKDF PQMGRFTLRD 
    EGKTIAIGKV LKLVPEKD

Genular Protein ID: 3292335348

Symbol: B2RCT6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 499
  • Mass: 55728
  • Checksum: C8A455A54C382569
  • Sequence:
  • MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP 
    KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET 
    WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV 
    LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK 
    LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG 
    PIRLPIADKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE 
    NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI 
    EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR 
    DEGKTIAIGK VLKLVPEKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.