Details for: GSPT1

Gene ID: 2935

Symbol: GSPT1

Ensembl ID: ENSG00000103342

Description: G1 to S phase transition 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.6
    Marker Score: 4838
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.91
    Marker Score: 3520.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.54
    Marker Score: 6198
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.39
    Marker Score: 9263
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.34
    Marker Score: 2496
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.33
    Marker Score: 1832
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.09
    Marker Score: 2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.08
    Marker Score: 3067
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.03
    Marker Score: 7832
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.9
    Marker Score: 12406
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.87
    Marker Score: 1090
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.84
    Marker Score: 63618
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.83
    Marker Score: 2024
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.81
    Marker Score: 7548
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.81
    Marker Score: 1210
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.81
    Marker Score: 61433
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.8
    Marker Score: 2871
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.78
    Marker Score: 604
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.78
    Marker Score: 1208
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.78
    Marker Score: 4045
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.77
    Marker Score: 1659
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.75
    Marker Score: 2255
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.72
    Marker Score: 2758
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.71
    Marker Score: 714
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.71
    Marker Score: 598
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.7
    Marker Score: 6939
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.7
    Marker Score: 992
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.67
    Marker Score: 826
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.65
    Marker Score: 1782
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.64
    Marker Score: 1289
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.63
    Marker Score: 14020
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.62
    Marker Score: 8501
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.62
    Marker Score: 99420
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.61
    Marker Score: 12582
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.61
    Marker Score: 1369
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.6
    Marker Score: 1726
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.6
    Marker Score: 799
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.6
    Marker Score: 5919
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.59
    Marker Score: 379
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.58
    Marker Score: 25396
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.58
    Marker Score: 765
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.57
    Marker Score: 2790
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.56
    Marker Score: 450
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.55
    Marker Score: 1335
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.53
    Marker Score: 1041.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.53
    Marker Score: 953
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.52
    Marker Score: 39013
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.51
    Marker Score: 377
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.51
    Marker Score: 14386
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.51
    Marker Score: 4037
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.5
    Marker Score: 377
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.5
    Marker Score: 1262
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.49
    Marker Score: 1515
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.49
    Marker Score: 4189
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.49
    Marker Score: 1687
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.49
    Marker Score: 12758
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.48
    Marker Score: 847
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.48
    Marker Score: 16706
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.48
    Marker Score: 330
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.48
    Marker Score: 458
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.47
    Marker Score: 55903
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.47
    Marker Score: 685
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.46
    Marker Score: 1223.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.46
    Marker Score: 53996
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.46
    Marker Score: 1591
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.46
    Marker Score: 320
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.46
    Marker Score: 1576
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.45
    Marker Score: 13658
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.45
    Marker Score: 3293
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.44
    Marker Score: 559
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.44
    Marker Score: 602
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.43
    Marker Score: 1673
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.43
    Marker Score: 1793.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.43
    Marker Score: 394
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.43
    Marker Score: 2364
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.42
    Marker Score: 432
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.42
    Marker Score: 14649
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.42
    Marker Score: 2006
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.41
    Marker Score: 360
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.41
    Marker Score: 429
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.41
    Marker Score: 5436
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.4
    Marker Score: 955
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.4
    Marker Score: 402
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.39
    Marker Score: 3307
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.39
    Marker Score: 1395
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.39
    Marker Score: 5453
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.39
    Marker Score: 3497
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.38
    Marker Score: 1047
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.38
    Marker Score: 20669
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.38
    Marker Score: 349.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.37
    Marker Score: 2121
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.37
    Marker Score: 1609.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.37
    Marker Score: 911.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.37
    Marker Score: 1258
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.37
    Marker Score: 5717
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.36
    Marker Score: 2880
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.36
    Marker Score: 266
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.36
    Marker Score: 778
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.36
    Marker Score: 501
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.35
    Marker Score: 24006

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Other Information

**Key characteristics:** - GSPT1 is a GTP-binding protein that is localized to the nucleus. - It is a key component of the exon junction complex (ejc), which is responsible for mediating the exchange of RNA fragments between exons and intron. - GSPT1 is also a regulator of the expression of the Robo family of proteins, which are involved in cell cycle regulation. **Pathways and functions:** - GSPT1 is involved in a variety of cellular processes, including cell cycle progression, differentiation, and apoptosis. - It is a key regulator of lens epithelial cell proliferation and differentiation. - It is also involved in the regulation of the development of the mammary gland. **Clinical significance:** - Mutations in the GSPT1 gene have been linked to a number of human diseases, including cancer and developmental disorders. - GSPT1 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 2924532603

Symbol: ERF3A_HUMAN

Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

UniProtKB Accession Codes:

P15170 J3KQG6 Q96GF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 EMDB 2 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2511002

Title: A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells.

PubMed ID: 2511002

DOI: 10.1002/j.1460-2075.1989.tb08558.x

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15987998

Title: Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.

PubMed ID: 15987998

DOI: 10.1128/mcb.25.14.5801-5811.2005

PubMed ID: 16777602

Title: In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3.

PubMed ID: 16777602

DOI: 10.1016/j.cell.2006.04.035

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24486019

Title: Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

PubMed ID: 24486019

DOI: 10.1016/j.molcel.2013.12.028

PubMed ID: 30682371

Title: Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting.

PubMed ID: 30682371

DOI: 10.1016/j.cell.2018.12.030

PubMed ID: 19417105

Title: Structural insights into eRF3 and stop codon recognition by eRF1.

PubMed ID: 19417105

DOI: 10.1101/gad.1770109

PubMed ID: 20418951

Title: Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein.

PubMed ID: 20418951

DOI: 10.1371/journal.pone.0010169

PubMed ID: 27863242

Title: Decoding mammalian ribosome-mRNA states by translational GTPase complexes.

PubMed ID: 27863242

DOI: 10.1016/j.cell.2016.10.046

Sequence Information:

  • Length: 499
  • Mass: 55756
  • Checksum: DE20482CCABC3576
  • Sequence:
    • MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP 
KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET 
WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV 
LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK 
LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG 
PIRLPIVDKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE 
NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI 
EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR 
DEGKTIAIGK VLKLVPEKD

Genular Protein ID: 3292335348

Symbol: B2RCT6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RCT6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 3

Sequence Information:

  • Length: 499
  • Mass: 55728
  • Checksum: C8A455A54C382569
  • Sequence:
    • MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP 
KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET 
WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV 
LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK 
LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG 
PIRLPIADKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE 
NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI 
EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR 
DEGKTIAIGK VLKLVPEKD

Genular Protein ID: 2731659231

Symbol: Q7KZX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7KZX8

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 SAM 1 SUPFAM 3

Sequence Information:

  • Length: 498
  • Mass: 55657
  • Checksum: B47CE8DF1EF40C8A
  • Sequence:
    • MELSEPIENG ETEMSPEESW EHKEEISEAE PGGGSLGDGR PPEESAHEMM EEEEEIPKPK 
SVVAPPGAPK KEHVNVVFIG HVDAGKSTIG GQIMYLTGMV DKRTLEKYER EAKEKNRETW 
YLSWALDTNQ EERDKGKTVE VGRAYFETEK KHFTILDAPG HKSFVPNMIG GASQADLAVL 
VISARKGEFE TGFEKGGQTR EHAMLAKTAG VKHLIVLINK MDDPTVNWSN ERYEECKEKL 
VPFLKKVGFN PKKDIHFMPC SGLTGANLKE QSDFCPWYIG LPFIPYLDNL PNFNRSVDGP 
IRLPIVDKYK DMGTVVLGKL ESGSICKGQQ LVMMPNKHNV EVLGILSDDV ETDTVAPGEN 
LKIRLKGIEE EEILPGFILC DPNNLCHSGR TFDAQIVIIE HKSIICPGYN AVLHIHTCIE 
EVEITALICL VDKKSGEKSK TRPRFVKQDQ VCIARLRTAG TICLETFKDF PQMGRFTLRD 
EGKTIAIGKV LKLVPEKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.