Details for: GSPT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 395.3513
Cell Significance Index: -61.5000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 261.3118
Cell Significance Index: -66.2800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 154.8962
Cell Significance Index: -73.1300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 147.0990
Cell Significance Index: -59.7600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 132.7313
Cell Significance Index: -68.2800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 108.8638
Cell Significance Index: -73.0500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 63.1741
Cell Significance Index: -60.3200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 50.8007
Cell Significance Index: -62.6400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 24.7867
Cell Significance Index: -66.4000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 18.2486
Cell Significance Index: -72.0100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 17.2003
Cell Significance Index: -52.8300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.7212
Cell Significance Index: -30.0300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.5203
Cell Significance Index: 48.0300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.0253
Cell Significance Index: 365.1000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.8097
Cell Significance Index: 222.5200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8033
Cell Significance Index: 361.7400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.7100
Cell Significance Index: 45.6600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5998
Cell Significance Index: 260.1900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.5626
Cell Significance Index: 81.1700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.5228
Cell Significance Index: 113.4900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5066
Cell Significance Index: 298.9900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.4593
Cell Significance Index: 68.5900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3483
Cell Significance Index: 37.6800 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.2605
Cell Significance Index: 162.8500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2604
Cell Significance Index: 688.3400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.1136
Cell Significance Index: 30.3100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9961
Cell Significance Index: 46.4500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9030
Cell Significance Index: 8.3200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8727
Cell Significance Index: 119.8400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8404
Cell Significance Index: 301.4400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7522
Cell Significance Index: 81.8200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.7314
Cell Significance Index: 1348.9100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6036
Cell Significance Index: 266.8500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5458
Cell Significance Index: 15.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.4715
Cell Significance Index: 725.7900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4568
Cell Significance Index: 32.3100 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.4330
Cell Significance Index: 2.6700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3878
Cell Significance Index: 350.1400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3694
Cell Significance Index: 63.0800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3578
Cell Significance Index: 27.4600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3290
Cell Significance Index: 227.5600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2826
Cell Significance Index: 8.1000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2501
Cell Significance Index: 16.1400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2126
Cell Significance Index: 25.0700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1864
Cell Significance Index: 10.4600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1690
Cell Significance Index: 32.1700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1647
Cell Significance Index: 4.3300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1591
Cell Significance Index: 20.3900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1035
Cell Significance Index: 194.9300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0807
Cell Significance Index: 109.7900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0590
Cell Significance Index: 3.9700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0357
Cell Significance Index: 27.0500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0278
Cell Significance Index: 17.6700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0266
Cell Significance Index: 19.5300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0112
Cell Significance Index: -1.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0118
Cell Significance Index: -5.3500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0195
Cell Significance Index: -14.4200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0495
Cell Significance Index: -30.9000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1009
Cell Significance Index: -56.9000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1124
Cell Significance Index: -6.9100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1142
Cell Significance Index: -11.6700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1591
Cell Significance Index: -5.5300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1845
Cell Significance Index: -3.9300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1924
Cell Significance Index: -40.5300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2118
Cell Significance Index: -11.0300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2126
Cell Significance Index: -61.1700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2359
Cell Significance Index: -34.2900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2863
Cell Significance Index: -1.7300 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.3312
Cell Significance Index: -5.0300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3383
Cell Significance Index: -9.0600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3546
Cell Significance Index: -6.9200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3720
Cell Significance Index: -9.3000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3791
Cell Significance Index: -23.9000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3983
Cell Significance Index: -45.6400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4502
Cell Significance Index: -52.4700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4795
Cell Significance Index: -33.1600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4807
Cell Significance Index: -54.8700 - Cell Name: peg cell (CL4033014)
Fold Change: -0.4952
Cell Significance Index: -11.4400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4983
Cell Significance Index: -8.5400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.5857
Cell Significance Index: -10.3500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5881
Cell Significance Index: -61.2400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5955
Cell Significance Index: -47.1700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6857
Cell Significance Index: -11.4800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7012
Cell Significance Index: -31.0200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7494
Cell Significance Index: -33.9700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.7712
Cell Significance Index: -27.1000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7738
Cell Significance Index: -29.3000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7973
Cell Significance Index: -41.8600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.8657
Cell Significance Index: -18.1200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.9622
Cell Significance Index: -28.2600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9741
Cell Significance Index: -25.0400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.0109
Cell Significance Index: -25.8300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.1232
Cell Significance Index: -18.9200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.1378
Cell Significance Index: -32.4700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1412
Cell Significance Index: -69.9700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1924
Cell Significance Index: -38.1900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.2438
Cell Significance Index: -33.2700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.2802
Cell Significance Index: -18.9000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.3754
Cell Significance Index: -50.4900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.5322
Cell Significance Index: -48.8000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2924532603
Symbol: ERF3A_HUMAN
Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2511002
Title: A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells.
PubMed ID: 2511002
PubMed ID: 10493829
Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
PubMed ID: 10493829
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15987998
Title: Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.
PubMed ID: 15987998
PubMed ID: 16777602
Title: In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3.
PubMed ID: 16777602
PubMed ID: 19417104
Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
PubMed ID: 19417104
DOI: 10.1101/gad.1767209
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24486019
Title: Optimal translational termination requires C4 lysyl hydroxylation of eRF1.
PubMed ID: 24486019
PubMed ID: 30682371
Title: Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting.
PubMed ID: 30682371
PubMed ID: 19417105
Title: Structural insights into eRF3 and stop codon recognition by eRF1.
PubMed ID: 19417105
DOI: 10.1101/gad.1770109
PubMed ID: 20418951
Title: Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein.
PubMed ID: 20418951
PubMed ID: 27863242
Title: Decoding mammalian ribosome-mRNA states by translational GTPase complexes.
PubMed ID: 27863242
Sequence Information:
- Length: 499
- Mass: 55756
- Checksum: DE20482CCABC3576
- Sequence:
MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG PIRLPIVDKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR DEGKTIAIGK VLKLVPEKD
Genular Protein ID: 2731659231
Symbol: Q7KZX8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 498
- Mass: 55657
- Checksum: B47CE8DF1EF40C8A
- Sequence:
MELSEPIENG ETEMSPEESW EHKEEISEAE PGGGSLGDGR PPEESAHEMM EEEEEIPKPK SVVAPPGAPK KEHVNVVFIG HVDAGKSTIG GQIMYLTGMV DKRTLEKYER EAKEKNRETW YLSWALDTNQ EERDKGKTVE VGRAYFETEK KHFTILDAPG HKSFVPNMIG GASQADLAVL VISARKGEFE TGFEKGGQTR EHAMLAKTAG VKHLIVLINK MDDPTVNWSN ERYEECKEKL VPFLKKVGFN PKKDIHFMPC SGLTGANLKE QSDFCPWYIG LPFIPYLDNL PNFNRSVDGP IRLPIVDKYK DMGTVVLGKL ESGSICKGQQ LVMMPNKHNV EVLGILSDDV ETDTVAPGEN LKIRLKGIEE EEILPGFILC DPNNLCHSGR TFDAQIVIIE HKSIICPGYN AVLHIHTCIE EVEITALICL VDKKSGEKSK TRPRFVKQDQ VCIARLRTAG TICLETFKDF PQMGRFTLRD EGKTIAIGKV LKLVPEKD
Genular Protein ID: 3292335348
Symbol: B2RCT6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 499
- Mass: 55728
- Checksum: C8A455A54C382569
- Sequence:
MELSEPIVEN GETEMSPEES WEHKEEISEA EPGGGSLGDG RPPEESAHEM MEEEEEIPKP KSVVAPPGAP KKEHVNVVFI GHVDAGKSTI GGQIMYLTGM VDKRTLEKYE REAKEKNRET WYLSWALDTN QEERDKGKTV EVGRAYFETE KKHFTILDAP GHKSFVPNMI GGASQADLAV LVISARKGEF ETGFEKGGQT REHAMLAKTA GVKHLIVLIN KMDDPTVNWS NERYEECKEK LVPFLKKVGF NPKKDIHFMP CSGLTGANLK EQSDFCPWYI GLPFIPYLDN LPNFNRSVDG PIRLPIADKY KDMGTVVLGK LESGSICKGQ QLVMMPNKHN VEVLGILSDD VETDTVAPGE NLKIRLKGIE EEEILPGFIL CDPNNLCHSG RTFDAQIVII EHKSIICPGY NAVLHIHTCI EEVEITALIC LVDKKSGEKS KTRPRFVKQD QVCIARLRTA GTICLETFKD FPQMGRFTLR DEGKTIAIGK VLKLVPEKD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.