Details for: GSS

Gene ID: 2937

Symbol: GSS

Ensembl ID: ENSG00000100983

Description: glutathione synthetase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.47
    Marker Score: 5790
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167864
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.32
    Marker Score: 1941
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.25
    Marker Score: 9284
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2863
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.17
    Marker Score: 371
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.14
    Marker Score: 770
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.12
    Marker Score: 9656
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.11
    Marker Score: 745
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17209
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.07
    Marker Score: 1133
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.05
    Marker Score: 3283
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.04
    Marker Score: 1309
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.04
    Marker Score: 571
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.03
    Marker Score: 1022.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1
    Marker Score: 10077
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71691
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47915
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.98
    Marker Score: 2243
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.98
    Marker Score: 3489
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30389
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.98
    Marker Score: 1731
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.97
    Marker Score: 2025
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1010
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.94
    Marker Score: 5596
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.94
    Marker Score: 785
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.94
    Marker Score: 271
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.93
    Marker Score: 621
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.91
    Marker Score: 31684
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5218
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2698
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.89
    Marker Score: 963
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.89
    Marker Score: 944
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.88
    Marker Score: 3593
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.87
    Marker Score: 328.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.87
    Marker Score: 2072
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.86
    Marker Score: 1150
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.85
    Marker Score: 399
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.85
    Marker Score: 5443
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.84
    Marker Score: 633
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.84
    Marker Score: 615
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.84
    Marker Score: 419
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.84
    Marker Score: 6560.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.83
    Marker Score: 8613
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1569
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.82
    Marker Score: 2835
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.82
    Marker Score: 2238
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.82
    Marker Score: 521
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.81
    Marker Score: 426
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.81
    Marker Score: 229
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.8
    Marker Score: 470
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.8
    Marker Score: 769
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.8
    Marker Score: 257
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8
    Marker Score: 3453
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.8
    Marker Score: 395
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.8
    Marker Score: 805
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.79
    Marker Score: 1302
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.78
    Marker Score: 431
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.78
    Marker Score: 1329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.78
    Marker Score: 862
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.78
    Marker Score: 375
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.78
    Marker Score: 5053
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.78
    Marker Score: 316
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.77
    Marker Score: 2846
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.77
    Marker Score: 4910
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.77
    Marker Score: 446
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.76
    Marker Score: 978
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.75
    Marker Score: 303.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.75
    Marker Score: 3605
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.75
    Marker Score: 265
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.74
    Marker Score: 1227
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.73
    Marker Score: 185
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.72
    Marker Score: 735
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.72
    Marker Score: 1114
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.72
    Marker Score: 179
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2974.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.71
    Marker Score: 9301
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.7
    Marker Score: 628.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.7
    Marker Score: 1913
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7
    Marker Score: 622
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7
    Marker Score: 2685
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.7
    Marker Score: 2474
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.69
    Marker Score: 8002
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.68
    Marker Score: 2779
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.68
    Marker Score: 6415
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.68
    Marker Score: 795
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.68
    Marker Score: 165
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.68
    Marker Score: 461
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.67
    Marker Score: 17280

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Other Information

**Key characteristics:** - Gene name: GSS - Ensembl ID: ENSG00000100983 - Pathway: Amino acid metabolic process, Atp binding, Biological oxidations - Ontology: Disease, Diseases of metabolism, Glutathione binding, Glutathione biosynthetic process, Glutathione conjugation, Glutathione synthase activity, Glutathione synthesis and recycling **Pathways and functions:** - The GSS gene is involved in the biosynthesis of GSH, a vital antioxidant that protects cells from oxidative damage. - GSH acts as a reducing agent, accepting electrons from other molecules and transferring them to oxygen, thereby preventing the formation of harmful reactive oxygen species (ROS). - It is involved in various cellular processes, including detoxification, immune responses, and antioxidant defense. **Clinical significance:** - GSS deficiency is associated with several diseases, including sickle cell anemia, in which red blood cells lack the normal antioxidant properties of GSH. - Defects in the GSS gene have been linked to impaired GSH synthesis, leading to increased susceptibility to oxidative stress and tissue damage. - Clinicians monitor GSS levels in patients with sickle cell anemia to assess their overall health and potential complications. **Additional information:** - The GSS gene is significantly expressed in various cell types, including placental villous trophoblast, mural cell, bladder urothelial cell, basal cell of epithelium of trachea, kidney proximal straight tubule epithelial cell, lens fiber cell, proerythroblast, epithelial cell of esophagus, nasal mucosa goblet cell, and cardiac muscle myoblast. - Mutations in the GSS gene have been associated with several neurological disorders, indicating its importance in maintaining neuronal health.

Genular Protein ID: 2986114423

Symbol: GSHB_HUMAN

Name: Glutathione synthase

UniProtKB Accession Codes:

P48637 B2R697 B6F210 E1P5P9 Q4TTD9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 26 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EC 1 EMBL 9 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7646467

Title: Sequencing and expression of a cDNA for human glutathione synthetase.

PubMed ID: 7646467

DOI: 10.1042/bj3100353

PubMed ID: 19672693

Title: Alternative RNA splicing in expression of the glutathione synthetase gene in human cells.

PubMed ID: 19672693

DOI: 10.1007/s11033-009-9675-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10369661

Title: Molecular basis of glutathione synthetase deficiency and a rare gene permutation event.

PubMed ID: 10369661

DOI: 10.1093/emboj/18.12.3204

PubMed ID: 8896573

Title: Mutations in the glutathione synthetase gene cause 5-oxoprolinuria.

PubMed ID: 8896573

DOI: 10.1038/ng1196-361

PubMed ID: 9215686

Title: Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction.

PubMed ID: 9215686

DOI: 10.1093/hmg/6.7.1147

PubMed ID: 27581854

Title: Recurrent isolated neonatal hemolytic anemia: think about glutathione synthetase deficiency.

PubMed ID: 27581854

DOI: 10.1542/peds.2015-4324

Sequence Information:

  • Length: 474
  • Mass: 52385
  • Checksum: 3C25EF7072EFE058
  • Sequence:
    • MATNWGSLLQ DKQQLEELAR QAVDRALAEG VLLRTSQEPT SSEVVSYAPF TLFPSLVPSA 
LLEQAYAVQM DFNLLVDAVS QNAAFLEQTL SSTIKQDDFT ARLFDIHKQV LKEGIAQTVF 
LGLNRSDYMF QRSADGSPAL KQIEINTISA SFGGLASRTP AVHRHVLSVL SKTKEAGKIL 
SNNPSKGLAL GIAKAWELYG SPNALVLLIA QEKERNIFDQ RAIENELLAR NIHVIRRTFE 
DISEKGSLDQ DRRLFVDGQE IAVVYFRDGY MPRQYSLQNW EARLLLERSH AAKCPDIATQ 
LAGTKKVQQE LSRPGMLEML LPGQPEAVAR LRATFAGLYS LDVGEEGDQA IAEALAAPSR 
FVLKPQREGG GNNLYGEEMV QALKQLKDSE ERASYILMEK IEPEPFENCL LRPGSPARVV 
QCISELGIFG VYVRQEKTLV MNKHVGHLLR TKAIEHADGG VAAGVAVLDN PYPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.