Gene GTF2A2 - ENSG00000140307 | NCBI Gene ID: 2958

Details for: GTF2A2

Gene ID: 2958

Symbol: GTF2A2

Ensembl ID: ENSG00000140307

Description: general transcription factor IIA subunit 2

Associated with

Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcribes snrna genes
(R-HSA-6807505)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Cell junction
(GO:0030054)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Rna polymerase ii preinitiation complex assembly
(GO:0051123)
Tbp-class protein binding
(GO:0017025)
Transcription by rna polymerase ii
(GO:0006366)
Transcription factor tfiia complex
(GO:0005672)
Transcription factor tfiid complex
(GO:0005669)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.24
Marker Score: 3377
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.28
Marker Score: 3276
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.14
Marker Score: 5230
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.12
Marker Score: 1667
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.08
Marker Score: 3410
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.06
Marker Score: 8097.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.05
Marker Score: 7589
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.04
Marker Score: 2286
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.03
Marker Score: 2443.5
Cell Name: blood cell (CL0000081)
Fold Change: 2.03
Marker Score: 23589.5
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.03
Marker Score: 3364.5
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.99
Marker Score: 68798
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.98
Marker Score: 4142
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.98
Marker Score: 19947
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.97
Marker Score: 728
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.97
Marker Score: 2104
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.97
Marker Score: 1981
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.95
Marker Score: 66284
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.95
Marker Score: 25668
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.93
Marker Score: 4864
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.93
Marker Score: 7427
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.93
Marker Score: 12314
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.93
Marker Score: 2836
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.92
Marker Score: 6019
Cell Name: decidual cell (CL2000002)
Fold Change: 1.9
Marker Score: 8185.5
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.86
Marker Score: 2993
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.86
Marker Score: 5060
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.86
Marker Score: 3154
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.85
Marker Score: 1341.5
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.85
Marker Score: 2621
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.85
Marker Score: 5023
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.84
Marker Score: 736
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.84
Marker Score: 11979
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.84
Marker Score: 1944
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.83
Marker Score: 1636
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.83
Marker Score: 2913
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.82
Marker Score: 1150.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.82
Marker Score: 3170.5
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.81
Marker Score: 15601
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.81
Marker Score: 1933
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.81
Marker Score: 1700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8
Marker Score: 20314
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.8
Marker Score: 1129
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.8
Marker Score: 4226
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.79
Marker Score: 5309
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.79
Marker Score: 45818
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.79
Marker Score: 2753
Cell Name: mature T cell (CL0002419)
Fold Change: 1.79
Marker Score: 17699
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.78
Marker Score: 1918
Cell Name: plasmablast (CL0000980)
Fold Change: 1.78
Marker Score: 2365
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.77
Marker Score: 424
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.77
Marker Score: 7243.5
Cell Name: male germ cell (CL0000015)
Fold Change: 1.75
Marker Score: 505
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.75
Marker Score: 1748.5
Cell Name: Unknown (CL0002371)
Fold Change: 1.73
Marker Score: 1842
Cell Name: oocyte (CL0000023)
Fold Change: 1.73
Marker Score: 427
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.72
Marker Score: 13460
Cell Name: kidney cell (CL1000497)
Fold Change: 1.72
Marker Score: 1150
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.72
Marker Score: 10212.5
Cell Name: Unknown (CL0000548)
Fold Change: 1.71
Marker Score: 1248
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.71
Marker Score: 14872
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.71
Marker Score: 548
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.7
Marker Score: 808
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.7
Marker Score: 3870.5
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.7
Marker Score: 802
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.7
Marker Score: 2049
Cell Name: mature B cell (CL0000785)
Fold Change: 1.69
Marker Score: 1241
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.69
Marker Score: 1412
Cell Name: supporting cell (CL0000630)
Fold Change: 1.68
Marker Score: 3164.5
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.68
Marker Score: 1655
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.68
Marker Score: 2970
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.67
Marker Score: 93490
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.66
Marker Score: 999
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.66
Marker Score: 3227
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.65
Marker Score: 1678
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.65
Marker Score: 4548
Cell Name: stem cell (CL0000034)
Fold Change: 1.64
Marker Score: 3903
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.63
Marker Score: 16517.5
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.63
Marker Score: 856
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.62
Marker Score: 532
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.61
Marker Score: 573
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.61
Marker Score: 885.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.6
Marker Score: 822
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.59
Marker Score: 534
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.58
Marker Score: 3160.5
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.58
Marker Score: 3213
Cell Name: secretory cell (CL0000151)
Fold Change: 1.58
Marker Score: 2882
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.57
Marker Score: 1065
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.57
Marker Score: 1404
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.57
Marker Score: 10209
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.56
Marker Score: 1509
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.56
Marker Score: 1644
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.56
Marker Score: 1957.5
Cell Name: motor neuron (CL0000100)
Fold Change: 1.56
Marker Score: 926
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.56
Marker Score: 450
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.55
Marker Score: 411
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.55
Marker Score: 543
Cell Name: club cell (CL0000158)
Fold Change: 1.55
Marker Score: 1810
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.55
Marker Score: 1102
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.55
Marker Score: 11528

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**Key characteristics:** - GTF2A2 is a large protein with a molecular weight of approximately 170 kDa. - It is a member of the GTF2A family of transcription factors. - GTF2A2 is a key regulator of the expression of genes involved in inflammation, differentiation, and cell growth. **Pathways and functions:** - GTF2A2 is involved in the regulation of inflammation by promoting the expression of inflammatory genes. - It is also involved in the regulation of cell growth and differentiation by promoting the expression of growth factor genes. - GTF2A2 is involved in the regulation of the HIV life cycle by promoting the expression of genes involved in viral entry, replication, and assembly. **Clinical significance:** - GTF2A2 is a potential therapeutic target for the treatment of cancer and other diseases that are characterized by inflammation or abnormal cell growth. - Inhibition of GTF2A2 has been shown to inhibit inflammation and cancer growth. - Therefore, GTF2A2 is a promising target for the treatment of inflammatory and cancer diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription initiation factor IIA subunit 2
B2R506_HUMAN

Genular Protein ID: 234667665

Symbol: T2AG_HUMAN

Name: Transcription initiation factor IIA subunit 2

UniProtKB Accession Codes:

P52657 A8MYQ7 Q6FGB5

Database IDs:

Citations:

PubMed ID: 7958900

Title: Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription.

PubMed ID: 7958900

DOI: 10.1101/gad.8.19.2336

PubMed ID: 7958899

Title: Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription.

PubMed ID: 7958899

DOI: 10.1101/gad.8.19.2324

PubMed ID: 7724559

Title: Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription.

PubMed ID: 7724559

DOI: 10.1073/pnas.92.8.3313

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632777

Title: Simian virus 40 large T antigen stabilizes the TATA-binding protein-TFIIA complex on the TATA element.

PubMed ID: 9632777

DOI: 10.1128/mcb.18.7.3926

PubMed ID: 10567404

Title: A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PubMed ID: 10567404

DOI: 10.1074/jbc.274.48.34283

PubMed ID: 11005381

Title: Potential targets for HSF1 within the preinitiation complex.

PubMed ID: 11005381

DOI: 10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2

PubMed ID: 11030333

Title: TAC, a TBP-sans-TAFs complex containing the unprocessed TFIIAalphabeta precursor and the TFIIAgamma subunit.

PubMed ID: 11030333

DOI: 10.1016/s1097-2765(00)00052-6

Sequence Information:

Length: 109
Mass: 12457
Checksum: 938E7DC8B9982AE8
Sequence:

MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINAALAQ RVRNRVNFRG 
SLNTYRFCDN VWTFVLNDVE FREVTELIKV DKVKIVACDG KNTGSNTTE

Genular Protein ID: 1944191396

Symbol: B2R506_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R506

Database IDs:

Sequence Information:

Length: 109
Mass: 12505
Checksum: 3D808DC8B9982AF4
Sequence:

MAYQLYRNTT LGNSLQESLD ELIQSQQITP QLALQVLLQF DKAINAALAQ RVRNRVNFRG 
SLNTYRFCDN VWTFVLNYVE FREVTELIKV DKVKIVACDG KNTGSNTTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GTF2A2

Associated with

Cells (max top 100)

Other Information

Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription. PubMed ID: 7958900

Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription. PubMed ID: 7958899

Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription. PubMed ID: 7724559

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Simian virus 40 large T antigen stabilizes the TATA-binding protein-TFIIA complex on the TATA element. PubMed ID: 9632777

A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. PubMed ID: 10567404

Potential targets for HSF1 within the preinitiation complex. PubMed ID: 11005381

TAC, a TBP-sans-TAFs complex containing the unprocessed TFIIAalphabeta precursor and the TFIIAgamma subunit. PubMed ID: 11030333