Details for: CARD10

Gene ID: 29775

Symbol: CARD10

Ensembl ID: ENSG00000100065

Description: caspase recruitment domain family member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 18.9102
    Cell Significance Index: -7.7900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.6435
    Cell Significance Index: 60.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0050
    Cell Significance Index: -8.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.0281
    Cell Significance Index: 49.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7281
    Cell Significance Index: 49.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.5583
    Cell Significance Index: 23.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2515
    Cell Significance Index: 136.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0556
    Cell Significance Index: 22.8700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.0412
    Cell Significance Index: 8.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9965
    Cell Significance Index: 899.7700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.8623
    Cell Significance Index: 9.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8366
    Cell Significance Index: 37.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6142
    Cell Significance Index: 21.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5075
    Cell Significance Index: 13.8200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4724
    Cell Significance Index: 6.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4304
    Cell Significance Index: 4.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3446
    Cell Significance Index: 9.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3104
    Cell Significance Index: 61.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3101
    Cell Significance Index: 6.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2938
    Cell Significance Index: 15.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2873
    Cell Significance Index: 5.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2845
    Cell Significance Index: 3.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1790
    Cell Significance Index: 22.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1773
    Cell Significance Index: 17.5400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.1660
    Cell Significance Index: 0.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1656
    Cell Significance Index: 4.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1555
    Cell Significance Index: 84.9300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1487
    Cell Significance Index: 0.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1426
    Cell Significance Index: 2.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1403
    Cell Significance Index: 26.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1024
    Cell Significance Index: 11.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0779
    Cell Significance Index: 1.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0646
    Cell Significance Index: 0.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0609
    Cell Significance Index: 2.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0445
    Cell Significance Index: 81.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0442
    Cell Significance Index: 7.9700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0360
    Cell Significance Index: 0.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0330
    Cell Significance Index: 1.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0289
    Cell Significance Index: 44.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0268
    Cell Significance Index: 11.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0253
    Cell Significance Index: 3.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0249
    Cell Significance Index: 0.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0024
    Cell Significance Index: 3.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0022
    Cell Significance Index: -0.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0047
    Cell Significance Index: -1.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0052
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0129
    Cell Significance Index: -8.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0162
    Cell Significance Index: -4.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0183
    Cell Significance Index: -8.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0184
    Cell Significance Index: -2.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0293
    Cell Significance Index: -3.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0297
    Cell Significance Index: -5.9600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0303
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0352
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0358
    Cell Significance Index: -7.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0361
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0408
    Cell Significance Index: -5.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0439
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0478
    Cell Significance Index: -1.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0510
    Cell Significance Index: -3.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0521
    Cell Significance Index: -7.1600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0555
    Cell Significance Index: -0.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0691
    Cell Significance Index: -4.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0730
    Cell Significance Index: -7.6100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0780
    Cell Significance Index: -0.6600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0783
    Cell Significance Index: -0.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0784
    Cell Significance Index: -2.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0816
    Cell Significance Index: -6.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0824
    Cell Significance Index: -4.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0825
    Cell Significance Index: -2.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0881
    Cell Significance Index: -1.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0918
    Cell Significance Index: -0.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0959
    Cell Significance Index: -4.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0992
    Cell Significance Index: -6.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1072
    Cell Significance Index: -8.2300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1077
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1256
    Cell Significance Index: -0.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1303
    Cell Significance Index: -8.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1401
    Cell Significance Index: -2.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1470
    Cell Significance Index: -3.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1494
    Cell Significance Index: -5.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1501
    Cell Significance Index: -1.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1537
    Cell Significance Index: -8.6200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1735
    Cell Significance Index: -1.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1751
    Cell Significance Index: -9.2000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1807
    Cell Significance Index: -2.0200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1833
    Cell Significance Index: -2.6100
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1864
    Cell Significance Index: -1.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1899
    Cell Significance Index: -2.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1922
    Cell Significance Index: -5.6600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1950
    Cell Significance Index: -1.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1979
    Cell Significance Index: -8.7600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2036
    Cell Significance Index: -1.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2070
    Cell Significance Index: -7.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CARD10 is a member of the caspase recruitment domain (CARD) family, which is characterized by its ability to interact with other proteins through specific domains. The CARD10 protein is primarily expressed in hematopoietic cells, including granulocytes, monocytes, and lymphocytes, as well as in epithelial cells of the kidney and intestines. Its expression is also observed in early T lineage precursors, cerebral cortex GABAergic interneurons, and radial glial cells. **Pathways and Functions:** CARD10 is involved in several signaling pathways, including: 1. **Activation of NF-κB-inducing kinase activity**: CARD10 interacts with NF-κB-inducing kinase (NIK), a protein that plays a crucial role in the activation of NF-κB, a transcription factor involved in immune responses and inflammation. 2. **Card domain binding**: The CARD10 protein binds to other CARD-containing proteins, facilitating the formation of signaling complexes that regulate various cellular processes. 3. **Regulation of apoptotic process**: CARD10 has been shown to regulate apoptosis, or programmed cell death, by interacting with pro-apoptotic and anti-apoptotic proteins. 4. **Signaling receptor complex adaptor activity**: CARD10 acts as an adaptor protein, facilitating the assembly of signaling complexes that regulate cell migration, differentiation, and survival. **Clinical Significance:** CARD10's involvement in immune regulation and apoptosis makes it a potential target for the treatment of various diseases, including: 1. **Autoimmune disorders**: CARD10's role in regulating immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: CARD10's involvement in apoptosis and cell migration makes it a potential target for the treatment of cancer, particularly in the context of immune checkpoint therapies. 3. **Neurological disorders**: CARD10's expression in GABAergic interneurons and radial glial cells makes it a potential target for the treatment of neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, CARD10 is a multifaceted gene that plays a crucial role in various cellular processes, including immune regulation, cell migration, and apoptosis. Its involvement in multiple signaling pathways and its potential as a therapeutic target make it an area of great interest for researchers and clinicians alike. **Recommendations:** Further research is needed to fully elucidate the mechanisms by which CARD10 regulates immune responses and non-immune related processes. Potential therapeutic strategies could include: 1. **Targeting CARD10 with small molecules**: Small molecule inhibitors that specifically target CARD10 could provide a novel treatment option for autoimmune and cancer diseases. 2. **Gene therapy**: Gene therapy approaches that aim to modulate CARD10 expression could provide a novel treatment option for diseases characterized by dysregulated immune responses. 3. **Immunotherapy**: Immunotherapies that target CARD10 could provide a novel approach to modulating immune responses and treating autoimmune diseases. Overall, CARD10 is a gene that warrants further investigation, and its potential as a therapeutic target makes it an area of great interest for researchers and clinicians alike.

Genular Protein ID: 2017633575

Symbol: CAR10_HUMAN

Name: Caspase recruitment domain-containing protein 10

UniProtKB Accession Codes:

Q9BWT7 Q14CQ8 Q5TFG6 Q8NC81 Q9UGR5 Q9UGR6 Q9Y3H0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11259443

Title: CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with Bcl10 and activates NF-kappa B.

PubMed ID: 11259443

DOI: 10.1074/jbc.m102488200

PubMed ID: 11356195

Title: Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.

PubMed ID: 11356195

DOI: 10.1016/s0014-5793(01)02414-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27991920

Title: TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-kappaB activation and tumor progression.

PubMed ID: 27991920

DOI: 10.1038/onc.2016.430

PubMed ID: 32238915

Title: Mutant CARD10 in a family with progressive immunodeficiency and autoimmunity.

PubMed ID: 32238915

DOI: 10.1038/s41423-020-0423-x

Sequence Information:

  • Length: 1032
  • Mass: 115931
  • Checksum: 298AAC132778376A
  • Sequence:
    • MPGRAEAGEA EEEAGAGSGS EAEEDALWER IEGVRHRLAR ALNPAKLTPY LRQCRVIDEQ 
DEEEVLSTYR FPCRVNRTGR LMDILRCRGK RGYEAFLEAL EFYYPEHFTL LTGQEPAQRC 
SMILDEEGPE GLTQFLMTEV RRLREARKSQ LQREQQLQAR GRVLEEERAG LEQRLRDQQQ 
AQERCQRLRE DWEAGSLELL RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK 
VSRLEEECAL LRRARGPPPG AEEKEKEKEK EKEPDNVDLV SELRAENQRL TASLRELQEG 
LQQEASRPGA PGSERILLDI LEHDWREAQD SRQELCQKLH AVQGELQWAE ELRDQYLQEM 
EDLRLKHRTL QKDCDLYKHR MATVLAQLEE IEKERDQAIQ SRDRIQLQYS QSLIEKDQYR 
KQVRGLEAER DELLTTLTSL EGTKALLEVQ LQRAQGGTCL KACASSHSLC SNLSSTWSLS 
EFPSPLGGPE ATGEAAVMGG PEPHNSEEAT DSEKEINRLS ILPFPPSAGS ILRRQREEDP 
APPKRSFSSM SDITGSVTLK PWSPGLSSSS SSDSVWPLGK PEGLLARGCG LDFLNRSLAI 
RVSGRSPPGG PEPQDKGPDG LSFYGDRWSG AVVRRVLSGP GSARMEPREQ RVEAAGLEGA 
CLEAEAQQRT LLWNQGSTLP SLMDSKACQS FHEALEAWAK GPGAEPFYIR ANLTLPERAD 
PHALCVKAQE ILRLVDSAYK RRQEWFCTRV DPLTLRDLDR GTVPNYQRAQ QLLEVQEKCL 
PSSRHRGPRS NLKKRALDQL RLVRPKPVGA PAGDSPDQLL LEPCAEPERS LRPYSLVRPL 
LVSALRPVVL LPECLAPRLI RNLLDLPSSR LDFQVCPAES LSGEELCPSS APGAPKAQPA 
TPGLGSRIRA IQESVGKKHC LLELGARGVR ELVQNEIYPI VIHVEVTEKN VREVRGLLGR 
PGWRDSELLR QCRGSEQVLW GLPCSWVQVP AHEWGHAEEL AKVVRGRILQ EQARLVWVEC 
GSSRGCPSSS EA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.