Details for: ABT1

Gene ID: 29777

Symbol: ABT1

Ensembl ID: ENSG00000146109

Description: activator of basal transcription 1

Associated with

  • Dna binding
    (GO:0003677)
  • Endonucleolytic cleavage in 5'-ets of tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
    (GO:0000480)
  • Endonucleolytic cleavage in its1 to separate ssu-rrna from 5.8s rrna and lsu-rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
    (GO:0000447)
  • Endonucleolytic cleavage to generate mature 5'-end of ssu-rrna from (ssu-rrna, 5.8s rrna, lsu-rrna)
    (GO:0000472)
  • Nucleolus
    (GO:0005730)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna binding
    (GO:0003723)
  • Small-subunit processome assembly
    (GO:0034462)
  • Spinal cord motor neuron differentiation
    (GO:0021522)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription coactivator activity
    (GO:0003713)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 133.2731
    Cell Significance Index: -20.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.7900
    Cell Significance Index: -18.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.7437
    Cell Significance Index: -26.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.0233
    Cell Significance Index: -26.7600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.9987
    Cell Significance Index: -26.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2059
    Cell Significance Index: -23.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2974
    Cell Significance Index: -24.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9325
    Cell Significance Index: -15.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3526
    Cell Significance Index: -11.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 3.2326
    Cell Significance Index: 68.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6608
    Cell Significance Index: 184.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2480
    Cell Significance Index: -4.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9649
    Cell Significance Index: 319.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6299
    Cell Significance Index: 97.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2146
    Cell Significance Index: 141.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9656
    Cell Significance Index: 28.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8653
    Cell Significance Index: 598.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7480
    Cell Significance Index: 20.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7190
    Cell Significance Index: 15.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6788
    Cell Significance Index: 80.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5308
    Cell Significance Index: 5.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5296
    Cell Significance Index: 52.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5148
    Cell Significance Index: 227.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4986
    Cell Significance Index: 35.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4480
    Cell Significance Index: 5.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4300
    Cell Significance Index: 81.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4105
    Cell Significance Index: 74.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4004
    Cell Significance Index: 218.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3969
    Cell Significance Index: 48.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3933
    Cell Significance Index: 50.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3733
    Cell Significance Index: 27.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3606
    Cell Significance Index: 22.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3545
    Cell Significance Index: 48.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3071
    Cell Significance Index: 14.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2866
    Cell Significance Index: 14.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2679
    Cell Significance Index: 2.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2495
    Cell Significance Index: 11.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2114
    Cell Significance Index: 13.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1832
    Cell Significance Index: 23.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1825
    Cell Significance Index: 4.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1298
    Cell Significance Index: 25.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1212
    Cell Significance Index: 4.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1125
    Cell Significance Index: 19.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1087
    Cell Significance Index: 21.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0976
    Cell Significance Index: 1.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0900
    Cell Significance Index: 1.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0562
    Cell Significance Index: 1.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0503
    Cell Significance Index: 2.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0468
    Cell Significance Index: 1.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0246
    Cell Significance Index: 22.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0149
    Cell Significance Index: 0.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0125
    Cell Significance Index: 0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0090
    Cell Significance Index: 3.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0034
    Cell Significance Index: 0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0019
    Cell Significance Index: 1.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0054
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0100
    Cell Significance Index: -18.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0158
    Cell Significance Index: -29.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0189
    Cell Significance Index: -29.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0192
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0209
    Cell Significance Index: -13.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0213
    Cell Significance Index: -29.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0256
    Cell Significance Index: -0.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0310
    Cell Significance Index: -17.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0343
    Cell Significance Index: -21.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0353
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0401
    Cell Significance Index: -4.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0517
    Cell Significance Index: -23.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0654
    Cell Significance Index: -2.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0656
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0680
    Cell Significance Index: -14.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0896
    Cell Significance Index: -25.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1303
    Cell Significance Index: -14.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1350
    Cell Significance Index: -3.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1498
    Cell Significance Index: -21.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1593
    Cell Significance Index: -4.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1988
    Cell Significance Index: -2.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2405
    Cell Significance Index: -25.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2412
    Cell Significance Index: -18.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2430
    Cell Significance Index: -1.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2564
    Cell Significance Index: -6.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2723
    Cell Significance Index: -21.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2839
    Cell Significance Index: -6.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2948
    Cell Significance Index: -8.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2983
    Cell Significance Index: -4.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3136
    Cell Significance Index: -17.6000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3365
    Cell Significance Index: -5.6600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3527
    Cell Significance Index: -2.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3535
    Cell Significance Index: -21.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3542
    Cell Significance Index: -2.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3544
    Cell Significance Index: -6.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3985
    Cell Significance Index: -5.5900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4089
    Cell Significance Index: -4.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4307
    Cell Significance Index: -11.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4464
    Cell Significance Index: -6.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4756
    Cell Significance Index: -8.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5103
    Cell Significance Index: -15.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5165
    Cell Significance Index: -22.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ABT1 is a transcriptional regulator that belongs to the TFIID subunit family. It is primarily expressed in cells that undergo rapid proliferation, such as hematopoietic cells, trophoblasts, and neural cells. ABT1 interacts with RNA polymerase II (RNAPII) and other transcriptional coactivators to facilitate the initiation of transcription. Its expression is tightly regulated, with significant fluctuations observed in various cell types during development and immune responses. **Pathways and Functions:** ABT1 is involved in several critical transcriptional pathways, including: 1. **DNA binding and transcriptional regulation**: ABT1 binds to specific DNA sequences, facilitating the recruitment of RNAPII and other transcriptional coactivators. This process is essential for the regulation of gene expression in various cell types. 2. **Endonucleolytic cleavage in rRNA transcripts**: ABT1 is involved in the processing of rRNA transcripts, which is essential for the assembly of the ribosome. This process is crucial for protein synthesis and cell growth. 3. **Transcriptional coactivator activity**: ABT1 interacts with other transcriptional coactivators, such as TFIID and TFIIB, to facilitate the recruitment of RNAPII and enhance transcriptional activity. 4. **Spinal cord motor neuron differentiation**: ABT1 is expressed in neural cells and plays a crucial role in the differentiation of motor neurons. **Clinical Significance:** The ABT1 gene has been implicated in various diseases, including: 1. **Immune disorders**: ABT1 is expressed in immune cells, such as T cells and dendritic cells, and plays a crucial role in regulating immune responses. Dysregulation of ABT1 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Neurological disorders**: ABT1 is expressed in neural cells and plays a crucial role in the development and maintenance of motor neurons. Dysregulation of ABT1 has been linked to neurological disorders, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy. 3. **Placental development**: ABT1 is expressed in trophoblasts and plays a crucial role in regulating placental development. Dysregulation of ABT1 has been linked to pregnancy complications, such as preeclampsia and placental insufficiency. In conclusion, the ABT1 gene is a critical transcriptional regulator that plays a vital role in regulating transcriptional processes in various cell types. Its dysregulation has been implicated in various diseases, including immune disorders, neurological disorders, and pregnancy complications. Further research is necessary to fully understand the role of ABT1 in human health and disease. **Recommendations for Future Research:** 1. Investigate the functional role of ABT1 in immune cells and its implications in autoimmune diseases. 2. Explore the relationship between ABT1 and neurological disorders, such as ALS and spinal muscular atrophy. 3. Investigate the role of ABT1 in placental development and its implications in pregnancy complications. By further elucidating the role of ABT1, we can gain a deeper understanding of its significance in human health and disease, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 4001295941

Symbol: ABT1_HUMAN

Name: Activator of basal transcription 1

UniProtKB Accession Codes:

Q9ULW3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10648625

Title: A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth.

PubMed ID: 10648625

DOI: 10.1128/mcb.20.4.1407-1418.2000

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19299493

Title: Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.

PubMed ID: 19299493

DOI: 10.1093/hmg/ddp134

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 272
  • Mass: 31079
  • Checksum: FB9B44192C16BD8A
  • Sequence:
    • MEAEESEKAA TEQEPLEGTE QTLDAEEEQE ESEEAACGSK KRVVPGIVYL GHIPPRFRPL 
HVRNLLSAYG EVGRVFFQAE DRFVRRKKKA AAAAGGKKRS YTKDYTEGWV EFRDKRIAKR 
VAASLHNTPM GARRRSPFRY DLWNLKYLHR FTWSHLSEHL AFERQVRRQR LRAEVAQAKR 
ETDFYLQSVE RGQRFLAADG DPARPDGSWT FAQRPTEQEL RARKAARPGG RERARLATAQ 
DKARSNKGLL ARIFGAPPPS ESMEGPSLVR DS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.