Details for: YPEL1

Gene ID: 29799

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: YPEL1

Ensembl ID: ENSG00000100027

Description: yippee like 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 11.79
    rCSI 10.74%
    PRS 96.5
  • choroid plexus epithelial cell CL0000706
    CSI 5.2
    rCSI 8.51%
    PRS 81.44
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.39
    rCSI 9.84%
    PRS 75.78
  • radial glial cell CL0000681
    CSI 4.24
    rCSI 5.89%
    PRS 87.64
  • glial cell CL0000125
    CSI 3.81
    rCSI 14.5%
    PRS 82.23
  • glioblast CL0000030
    CSI 3.76
    rCSI 6.01%
    PRS 81.53
  • plasmacytoid dendritic cell, human CL0001058
    CSI 3.39
    rCSI 2.37%
    PRS 92.21
  • interneuron CL0000099
    CSI 3.23
    rCSI 6.48%
    PRS 82.55
  • neural crest cell CL0011012
    CSI 3.22
    rCSI 2.55%
    PRS 81.47
  • cerebellar granule cell CL0001031
    CSI 3.19
    rCSI 4.69%
    PRS 83.62
  • pro-B cell CL0000826
    CSI 3.13
    rCSI 2.59%
    PRS 90.83
  • naive B cell CL0000788
    CSI 2.95
    rCSI 2.53%
    PRS 93
  • activated type II NK T cell CL0000931
    CSI 2.73
    rCSI 3.08%
    PRS 96.43
  • precursor B cell CL0000817
    CSI 2.69
    rCSI 2.35%
    PRS 93.52
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 2.63
    rCSI 3.38%
    PRS 85.74
  • sncg GABAergic cortical interneuron CL4023015
    CSI 2.58
    rCSI 4.15%
    PRS 76.4
  • mucosal invariant T cell CL0000940
    CSI 2.48
    rCSI 2%
    PRS 94.43
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 2.42
    rCSI 14.26%
    PRS 75.75
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.24
    rCSI 2.68%
    PRS 75.33
  • Mueller cell CL0000636
    CSI 2.21
    rCSI 5.05%
    PRS 82.23
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.21
    rCSI 2.56%
    PRS 81.97
  • Bergmann glial cell CL0000644
    CSI 2.14
    rCSI 2.92%
    PRS 81.29
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.05
    rCSI 6.06%
    PRS 89.47
  • inhibitory interneuron CL0000498
    CSI 2.03
    rCSI 4.7%
    PRS 79.66
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.01
    rCSI 1.81%
    PRS 88.01
  • multi-ciliated epithelial cell CL0005012
    CSI 1.92
    rCSI 1.92%
    PRS 83.48
  • vascular leptomeningeal cell CL4023051
    CSI 1.92
    rCSI 3.36%
    PRS 85.2
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.89
    rCSI 2.67%
    PRS 86.67
  • direct pathway medium spiny neuron CL4023026
    CSI 1.88
    rCSI 45.13%
    PRS 72.99
  • neural cell CL0002319
    CSI 1.87
    rCSI 7.07%
    PRS 73.72
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.86
    rCSI 44.98%
    PRS 73.27
  • epithelial cell CL0000066
    CSI 1.83
    rCSI 2.81%
    PRS 77.76
  • amacrine cell CL0000561
    CSI 1.79
    rCSI 5.17%
    PRS 80.36
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.77
    rCSI 2.21%
    PRS 73.07
  • ependymal cell CL0000065
    CSI 1.77
    rCSI 3.6%
    PRS 70.9
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.67
    rCSI 2.15%
    PRS 76.42
  • peripheral nervous system neuron CL2000032
    CSI 1.64
    rCSI 2.23%
    PRS 82.5
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 1.59
    rCSI 3.45%
    PRS 77.91
  • GABAergic neuron CL0000617
    CSI 1.54
    rCSI 5.15%
    PRS 75.4
  • progenitor cell CL0011026
    CSI 1.47
    rCSI 3.12%
    PRS 83.22
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 1.45
    rCSI 5.64%
    PRS 97.45
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.32
    rCSI 2.32%
    PRS 74.73
  • glutamatergic neuron CL0000679
    CSI 1.28
    rCSI 2.63%
    PRS 77.28
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.24
    rCSI 2.07%
    PRS 75.27
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.21
    rCSI 2.9%
    PRS 78.23
  • cardiac neuron CL0010022
    CSI 1.21
    rCSI 3.87%
    PRS 87.57
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.18
    rCSI 2.88%
    PRS 72.99
  • large pre-B-II cell CL0000957
    CSI 1.14
    rCSI 3.25%
    PRS 90.3
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.11
    rCSI 3.46%
    PRS 76.62
  • neural progenitor cell CL0011020
    CSI 1.1
    rCSI 4.86%
    PRS 78.43
  • deuterosomal cell CL4033044
    CSI 1.03
    rCSI 3.49%
    PRS 84.47
  • retinal ganglion cell CL0000740
    CSI 0.91
    rCSI 2%
    PRS 78.03
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 0.79
    rCSI 2.61%
    PRS 77.24
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.62
    rCSI 2.23%
    PRS 73.2
  • central nervous system neuron CL2000029
    CSI 0.61
    rCSI 4.45%
    PRS 80.06
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.52
    rCSI 1.96%
    PRS 75.55
  • medium spiny neuron CL1001474
    CSI 0.4
    rCSI 3.44%
    PRS 80.49

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [YPEL1](/details-gene/29799) (yippee like 1) is a protein-coding gene located on chromosome 22. Its protein product is localized to the [nucleus](/details-go/GO:0005634) and is associated with [metal ion binding](/details-go/GO:0046872) ([GO:0046872](https://www.ebi.ac.uk/QuickGO/term/GO:0046872)), suggesting a potential role in regulating nuclear processes such as transcription or enzymatic activity. **Overall**, expression data reveals a highly specific and significant role for [YPEL1](/details-gene/29799) in the immune system, particularly within [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913)s, where it exhibits its highest cell significance index. It also shows notable expression in a diverse range of cell types within the central nervous system, including glial and neural precursor cells, indicating a pleiotropic function across different biological systems. ## Cellular Roles and Expression Landscape The expression profile of [YPEL1](/details-gene/29799) is characterized by a strong and specific enrichment in distinct cell populations. The gene's most significant association is with [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (CSI: 11.79), where it stands out as a top marker, suggesting a crucial role in the function or maintenance of this key adaptive immune cell subset. Beyond its role in T cells, [YPEL1](/details-gene/29799) demonstrates a significant presence in the central nervous system. It is highly expressed in several neural and glial cell types, including [choroid plexus epithelial cell](/details-cell/CL0000706), [astrocyte of the cerebral cortex](/details-cell/CL0002605), [radial glial cell](/details-cell/CL0000681), and [glial cell](/details-cell/CL0000125)s in general. Its expression in progenitor populations like [neural crest cell](/details-cell/CL0011012)s and [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) points towards a potential involvement in neurodevelopment. Additionally, [YPEL1](/details-gene/29799) is expressed in various stages of B cell development, including [pro-B cell](/details-cell/CL0000826)s, [naive B cell](/details-cell/CL0000788)s, and [precursor B cell](/details-cell/CL0000817)s, as well as in other immune cells such as [plasmacytoid dendritic cell, human](/details-cell/CL0001058) and [activated type II NK T cell](/details-cell/CL0000931). This broad but specific expression pattern highlights a dual role for [YPEL1](/details-gene/29799) in both the adaptive immune system and the central nervous system. ## Pathways and Molecular Function The functional annotation of [YPEL1](/details-gene/29799) is currently limited, with its primary known molecular function being [metal ion binding](/details-go/GO:0046872) ([GO:0046872](https://www.ebi.ac.uk/QuickGO/term/GO:0046872)). Its localization within the [nucleus](/details-go/GO:0005634) ([GO:0005634](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)) suggests that it may function as a metal-dependent transcription factor, a cofactor for nuclear enzymes, or play a role in chromatin organization. The YPEL gene family was first identified and characterized across multiple eukaryotic species, highlighting its evolutionary conservation, though its precise molecular activities remain an area of active investigation [Link](https://doi.org/10.1016/j.gene.2004.06.014). Further research is required to place [YPEL1](/details-gene/29799) into specific cellular pathways and to understand how its metal-binding capacity contributes to its function in T cells and neural cells. ## Research Directions The distinct expression pattern of [YPEL1](/details-gene/29799), particularly its high significance in effector memory T cells, provides a foundation for several testable hypotheses. 1. Given its pronounced expression in [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913)s, [YPEL1](/details-gene/29799) may be a critical nuclear factor required for the establishment or long-term persistence of T cell memory. Its depletion could impair the ability of these cells to mount a recall response to secondary antigen exposure. 2. The consistent expression of [YPEL1](/details-gene/29799) across various glial and neural progenitor cells suggests it plays a fundamental role in the homeostatic maintenance or differentiation of these lineages within the central nervous system. A key experiment to test the first hypothesis would be to use a T-cell-specific conditional knockout model. By generating a mouse with [YPEL1](/details-gene/29799) deleted specifically in the T cell lineage (e.g., using a *Cd4-Cre* system) and subjecting these mice to a viral infection model like LCMV, researchers could assess the impact on the formation, maintenance, and functionality of the memory CD8+ T cell pool. Single-cell RNA sequencing and ATAC-seq on [YPEL1](/details-gene/29799)-deficient memory T cells could then elucidate the specific transcriptional and chromatin-level programs regulated by this protein. From a therapeutic perspective, [YPEL1](/details-gene/29799) is an intriguing but challenging target. As an intracellular nuclear protein, it is not amenable to targeting by monoclonal antibodies. However, its high specificity for effector memory T cells suggests it could serve as a valuable biomarker for this population in health and disease. If it proves to be a master regulator of T cell longevity, developing strategies to modulate its activity or downstream pathways could offer a novel approach to enhance the durability of T-cell-based immunotherapies for cancer or to improve vaccine responses. Inhibition of its function could potentially be explored in contexts of T-cell-mediated autoimmunity.

Genular Protein ID: 2395259619

Symbol: YPEL1_HUMAN

Name: Protein yippee-like 1

UniProtKB Accession Codes:

O60688 Q65ZA1 Q6GLI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15556292

Title: Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species.

PubMed ID: 15556292

DOI: 10.1016/j.gene.2004.06.014

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 119
  • Mass: 13575
  • Checksum: E91C058FA8C6D81F
  • Sequence:
    • MVKMTKSKTF QAYLPNCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG 
PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKFIIELA HMIKDNGWE