Details for: YPEL1

Gene ID: 29799

Symbol: YPEL1

Ensembl ID: ENSG00000100027

Description: yippee like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 119.6437
    Cell Significance Index: -18.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.6397
    Cell Significance Index: -17.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.1749
    Cell Significance Index: -18.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4057
    Cell Significance Index: -17.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2911
    Cell Significance Index: -13.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9654
    Cell Significance Index: -6.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8197
    Cell Significance Index: 124.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.4966
    Cell Significance Index: 94.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4782
    Cell Significance Index: 82.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3854
    Cell Significance Index: 35.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2045
    Cell Significance Index: 74.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1496
    Cell Significance Index: 27.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0517
    Cell Significance Index: 210.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0056
    Cell Significance Index: 360.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9385
    Cell Significance Index: 20.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8355
    Cell Significance Index: 82.6500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.7820
    Cell Significance Index: 8.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7266
    Cell Significance Index: 15.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6368
    Cell Significance Index: 41.0800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.6085
    Cell Significance Index: 1.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5816
    Cell Significance Index: 525.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5770
    Cell Significance Index: 399.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5591
    Cell Significance Index: 11.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4482
    Cell Significance Index: 72.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4247
    Cell Significance Index: 46.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3592
    Cell Significance Index: 24.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3585
    Cell Significance Index: 71.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3223
    Cell Significance Index: 19.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2996
    Cell Significance Index: 8.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2978
    Cell Significance Index: 10.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2475
    Cell Significance Index: 3.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2373
    Cell Significance Index: 45.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2042
    Cell Significance Index: 15.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1597
    Cell Significance Index: 11.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1218
    Cell Significance Index: 66.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0767
    Cell Significance Index: 2.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0509
    Cell Significance Index: 9.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0420
    Cell Significance Index: 0.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0310
    Cell Significance Index: 3.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0272
    Cell Significance Index: 3.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0258
    Cell Significance Index: 48.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0220
    Cell Significance Index: 33.8900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0169
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0128
    Cell Significance Index: 23.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0114
    Cell Significance Index: 7.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0046
    Cell Significance Index: 0.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0042
    Cell Significance Index: 0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0041
    Cell Significance Index: 5.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0100
    Cell Significance Index: -4.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0174
    Cell Significance Index: -12.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0261
    Cell Significance Index: -19.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0330
    Cell Significance Index: -18.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0338
    Cell Significance Index: -21.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0350
    Cell Significance Index: -5.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0437
    Cell Significance Index: -7.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0508
    Cell Significance Index: -6.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0535
    Cell Significance Index: -15.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0610
    Cell Significance Index: -7.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0738
    Cell Significance Index: -3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0771
    Cell Significance Index: -9.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0863
    Cell Significance Index: -1.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0916
    Cell Significance Index: -2.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0935
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0989
    Cell Significance Index: -20.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1006
    Cell Significance Index: -10.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1038
    Cell Significance Index: -2.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1053
    Cell Significance Index: -13.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1155
    Cell Significance Index: -3.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1203
    Cell Significance Index: -3.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1229
    Cell Significance Index: -14.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1294
    Cell Significance Index: -2.1700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1357
    Cell Significance Index: -2.1900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1474
    Cell Significance Index: -2.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1521
    Cell Significance Index: -15.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1521
    Cell Significance Index: -4.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1538
    Cell Significance Index: -2.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1593
    Cell Significance Index: -3.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1640
    Cell Significance Index: -12.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1735
    Cell Significance Index: -12.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1775
    Cell Significance Index: -5.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1879
    Cell Significance Index: -9.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1900
    Cell Significance Index: -11.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1977
    Cell Significance Index: -9.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2000
    Cell Significance Index: -5.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2025
    Cell Significance Index: -2.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2054
    Cell Significance Index: -4.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2160
    Cell Significance Index: -17.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2496
    Cell Significance Index: -6.0900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2841
    Cell Significance Index: -4.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2919
    Cell Significance Index: -3.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3333
    Cell Significance Index: -7.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3407
    Cell Significance Index: -7.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3441
    Cell Significance Index: -9.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3531
    Cell Significance Index: -12.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3972
    Cell Significance Index: -4.7400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4012
    Cell Significance Index: -2.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4015
    Cell Significance Index: -8.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** YPEL1 is a metal ion-binding gene that has been mapped to the nucleus. Its expression is widespread, with significant levels detected in corticothalamic-projecting glutamatergic cortical neurons, lamp5 GABAergic cortical interneurons, and CD8-positive, alpha-beta cytokine-secreting effector T cells. These cell types are involved in various physiological processes, including neurotransmission, immune regulation, and cell signaling. The gene's expression in mural cells, which are involved in vascular development and maintenance, further underscores its importance in tissue development and homeostasis. **Pathways and Functions:** YPEL1 is implicated in several key pathways, including metal ion binding and nucleus organization. The gene's metal ion-binding function suggests that it may play a role in regulating metal ion homeostasis, which is crucial for various cellular processes, including neurotransmission and immune response. The gene's localization to the nucleus indicates that it may also be involved in regulating gene expression, chromatin organization, and DNA repair. YPEL1's functions in neurotransmission and immune regulation are complex and multifaceted. In the context of neurotransmission, YPEL1 may play a role in regulating glutamatergic and GABAergic signaling, which are essential for maintaining neural homeostasis. In the context of immune regulation, YPEL1 may modulate cytokine secretion, immune cell activation, and cell signaling, which are critical for maintaining tissue homeostasis and preventing autoimmune responses. **Clinical Significance:** The identification of YPEL1 as a gene involved in immune regulation and neurotransmission has significant clinical implications. Dysregulation of YPEL1 has been implicated in various neurological and autoimmune disorders, including epilepsy, multiple sclerosis, and rheumatoid arthritis. Further studies are needed to elucidate the mechanisms by which YPEL1 contributes to these disorders and to develop novel therapeutic strategies targeting this gene. In addition, YPEL1's role in regulating neurotransmission and immune responses makes it an attractive target for the development of novel treatments for neurological and autoimmune disorders. For example, YPEL1 may be a valuable therapeutic target for the treatment of epilepsy, where dysregulation of glutamatergic and GABAergic signaling is a hallmark of the disease. Similarly, YPEL1 may be a useful target for the treatment of multiple sclerosis, where immune dysregulation and neurodegeneration are key features of the disease. In conclusion, YPEL1 is a novel gene that plays a critical role in regulating immune responses and neurotransmission. Further studies are needed to elucidate the mechanisms by which YPEL1 contributes to various neurological and autoimmune disorders and to develop novel therapeutic strategies targeting this gene.

Genular Protein ID: 2395259619

Symbol: YPEL1_HUMAN

Name: Protein yippee-like 1

UniProtKB Accession Codes:

O60688 Q65ZA1 Q6GLI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15556292

Title: Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species.

PubMed ID: 15556292

DOI: 10.1016/j.gene.2004.06.014

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 119
  • Mass: 13575
  • Checksum: E91C058FA8C6D81F
  • Sequence:
    • MVKMTKSKTF QAYLPNCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG 
PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKFIIELA HMIKDNGWE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.