Details for: PSMC3IP

Gene ID: 29893

Symbol: PSMC3IP

Ensembl ID: ENSG00000131470

Description: PSMC3 interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.0211
    Cell Significance Index: -7.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.5831
    Cell Significance Index: -10.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.1447
    Cell Significance Index: -10.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.3566
    Cell Significance Index: -8.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.7144
    Cell Significance Index: -8.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2201
    Cell Significance Index: -10.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7385
    Cell Significance Index: -10.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6609
    Cell Significance Index: -10.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0532
    Cell Significance Index: 22.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7564
    Cell Significance Index: 74.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7176
    Cell Significance Index: 45.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4772
    Cell Significance Index: 90.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4434
    Cell Significance Index: 4.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3824
    Cell Significance Index: 22.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3532
    Cell Significance Index: 57.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3515
    Cell Significance Index: 38.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3258
    Cell Significance Index: 6.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2279
    Cell Significance Index: 26.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2144
    Cell Significance Index: 7.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2142
    Cell Significance Index: 42.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1394
    Cell Significance Index: 7.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1340
    Cell Significance Index: 15.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1333
    Cell Significance Index: 1.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1329
    Cell Significance Index: 120.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1249
    Cell Significance Index: 3.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1225
    Cell Significance Index: 15.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1131
    Cell Significance Index: 61.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1120
    Cell Significance Index: 49.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0966
    Cell Significance Index: 4.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0891
    Cell Significance Index: 1.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0753
    Cell Significance Index: 5.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0744
    Cell Significance Index: 1.9000
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0733
    Cell Significance Index: 0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0625
    Cell Significance Index: 8.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0563
    Cell Significance Index: 38.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0482
    Cell Significance Index: 1.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0482
    Cell Significance Index: 1.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0408
    Cell Significance Index: 1.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0397
    Cell Significance Index: 2.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0389
    Cell Significance Index: 7.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0317
    Cell Significance Index: 5.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0316
    Cell Significance Index: 3.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0315
    Cell Significance Index: 1.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0206
    Cell Significance Index: 7.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0156
    Cell Significance Index: 0.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0150
    Cell Significance Index: 0.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0109
    Cell Significance Index: 0.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0080
    Cell Significance Index: 0.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0057
    Cell Significance Index: 0.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0048
    Cell Significance Index: 0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0013
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0078
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0078
    Cell Significance Index: -1.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0108
    Cell Significance Index: -7.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0158
    Cell Significance Index: -0.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0174
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0179
    Cell Significance Index: -11.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0189
    Cell Significance Index: -10.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0191
    Cell Significance Index: -8.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0259
    Cell Significance Index: -7.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0287
    Cell Significance Index: -1.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0443
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0447
    Cell Significance Index: -7.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0459
    Cell Significance Index: -1.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0471
    Cell Significance Index: -6.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0498
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0527
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0595
    Cell Significance Index: -12.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0621
    Cell Significance Index: -1.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0622
    Cell Significance Index: -3.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0683
    Cell Significance Index: -5.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0761
    Cell Significance Index: -2.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0762
    Cell Significance Index: -3.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0812
    Cell Significance Index: -2.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0927
    Cell Significance Index: -2.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0981
    Cell Significance Index: -10.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1068
    Cell Significance Index: -8.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1155
    Cell Significance Index: -2.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1179
    Cell Significance Index: -9.3400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1320
    Cell Significance Index: -1.8500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1344
    Cell Significance Index: -1.0200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1365
    Cell Significance Index: -0.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1396
    Cell Significance Index: -9.3900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1459
    Cell Significance Index: -2.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1478
    Cell Significance Index: -3.8000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1486
    Cell Significance Index: -2.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1520
    Cell Significance Index: -2.2900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1568
    Cell Significance Index: -2.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1818
    Cell Significance Index: -8.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1943
    Cell Significance Index: -5.5700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1969
    Cell Significance Index: -1.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2130
    Cell Significance Index: -2.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PSMC3IP is a protein-coding gene that interacts with the PSMC3 gene, which is involved in the ubiquitin-proteasome pathway. This interaction is crucial for the proper functioning of the PSMC3 complex, which is composed of multiple subunits. The PSMC3IP protein is highly expressed in germ cells, neural progenitor cells, and other cell types involved in reproduction and development. Its expression is also observed in certain types of cancer cells, suggesting its potential involvement in tumorigenesis. **Pathways and Functions** PSMC3IP is involved in several cellular pathways, including: 1. **Meiosis**: PSMC3IP plays a crucial role in meiotic recombination, a process that ensures the proper segregation of chromosomes during meiosis. It interacts with the PSMC3 complex to facilitate the exchange of genetic material between homologous chromosomes. 2. **Cell Cycle**: PSMC3IP is involved in the regulation of the cell cycle, particularly in the G2/M phase. It interacts with other proteins to regulate the progression of the cell cycle and prevent aberrant cell proliferation. 3. **DNA-templated Transcription**: PSMC3IP is involved in the regulation of DNA-templated transcription, a process that involves the coordinated transcription of genes along the chromosome. 4. **Recombination Activator Activity**: PSMC3IP interacts with the recombination activator protein 1 (RPA1) to facilitate the exchange of genetic material between homologous chromosomes. **Clinical Significance** Abnormalities in PSMC3IP have been linked to various diseases, including: 1. **Infertility**: PSMC3IP mutations have been associated with infertility in males and females, suggesting its importance in meiotic recombination. 2. **Cancer**: PSMC3IP overexpression has been observed in certain types of cancer, including ovarian cancer and breast cancer, suggesting its potential involvement in tumorigenesis. 3. **Neurological Disorders**: PSMC3IP mutations have been associated with certain neurological disorders, including autism and schizophrenia, suggesting its potential involvement in brain development and function. In conclusion, PSMC3IP is an essential gene involved in various cellular processes, including meiosis, cell cycle regulation, and DNA-templated transcription. Its abnormalities have been linked to various diseases, highlighting its potential as a therapeutic target for the treatment of infertility, cancer, and neurological disorders.

Genular Protein ID: 344588392

Symbol: HOP2_HUMAN

Name: Homologous-pairing protein 2 homolog

UniProtKB Accession Codes:

Q9P2W1 C5ILB7 Q14458 Q8WXG2 Q96HA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7490091

Title: Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.

PubMed ID: 7490091

DOI: 10.1006/geno.1995.1185

PubMed ID: 10806355

Title: Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene.

PubMed ID: 10806355

DOI: 10.1016/s0378-1119(00)00141-4

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 11739747

Title: Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors.

PubMed ID: 11739747

DOI: 10.1128/mcb.22.1.357-369.2002

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16407260

Title: Stimulation of DNA strand exchange by the human TBPIP/Hop2-Mnd1 complex.

PubMed ID: 16407260

DOI: 10.1074/jbc.m506506200

PubMed ID: 17716379

Title: Genomic and proteomic profiling I: leiomyomas in African Americans and Caucasians.

PubMed ID: 17716379

DOI: 10.1186/1477-7827-5-34

PubMed ID: 21963259

Title: XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription.

PubMed ID: 21963259

DOI: 10.1016/j.ajhg.2011.09.006

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 217
  • Mass: 24906
  • Checksum: 892B7D20CAA0A121
  • Sequence:
    • MSKGRAEAAA GAAGILLRYL QEQNRPYSSQ DVFGNLQREH GLGKAVVVKT LEQLAQQGKI 
KEKMYGKQKI YFADQDQFDM VSDADLQVLD GKIVALTAKV QSLQQSCRYM EAELKELSSA 
LTTPEMQKEI QELKKECAGY RERLKNIKAA TNHVTPEEKE QVYRERQKYC KEWRKRKRMA 
TELSDAILEG YPKSKKQFFE EVGIETDEDY NVTLPDP

Genular Protein ID: 1407340606

Symbol: K7ERB6_HUMAN

Name: N/A

UniProtKB Accession Codes:

K7ERB6

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 154
  • Mass: 18042
  • Checksum: EF97FCE9CD5DFAC0
  • Sequence:
    • MYGKQKIYFA DQDQFDMVSD ADLQVLDGKI VALTAKVQSL QQSCRYMEAE LKELSSALTT 
PEMQKEIQEL KKECAGYRER LKNIKAATNH VTPEEKEQVY RERQKYCKEW RKRKRMATEL 
SDAILEGYPK SKKQFFEEVG IETDEDYNVT LPDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.