Details for: CCDC106

Gene ID: 29903

Symbol: CCDC106

Ensembl ID: ENSG00000173581

Description: coiled-coil domain containing 106

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.6839
    Cell Significance Index: -12.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.6977
    Cell Significance Index: -10.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.9422
    Cell Significance Index: -12.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.2842
    Cell Significance Index: -12.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2387
    Cell Significance Index: -12.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6609
    Cell Significance Index: -3.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.4507
    Cell Significance Index: 23.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1920
    Cell Significance Index: 117.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1207
    Cell Significance Index: 182.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9733
    Cell Significance Index: 26.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9522
    Cell Significance Index: 859.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8266
    Cell Significance Index: 6.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7271
    Cell Significance Index: 9.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7262
    Cell Significance Index: 38.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6997
    Cell Significance Index: 76.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6546
    Cell Significance Index: 39.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5677
    Cell Significance Index: 29.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4146
    Cell Significance Index: 26.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4024
    Cell Significance Index: 47.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3690
    Cell Significance Index: 25.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2926
    Cell Significance Index: 6.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2816
    Cell Significance Index: 32.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2716
    Cell Significance Index: 37.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2569
    Cell Significance Index: 11.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2018
    Cell Significance Index: 14.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1849
    Cell Significance Index: 81.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1574
    Cell Significance Index: 4.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1553
    Cell Significance Index: 5.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1532
    Cell Significance Index: 3.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1434
    Cell Significance Index: 28.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1305
    Cell Significance Index: 71.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1244
    Cell Significance Index: 22.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1213
    Cell Significance Index: 14.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0913
    Cell Significance Index: 32.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0885
    Cell Significance Index: 11.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0840
    Cell Significance Index: 15.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0794
    Cell Significance Index: 1.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0603
    Cell Significance Index: 1.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0591
    Cell Significance Index: 2.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0530
    Cell Significance Index: 3.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0524
    Cell Significance Index: 1.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0366
    Cell Significance Index: 1.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0349
    Cell Significance Index: 4.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0313
    Cell Significance Index: 6.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0290
    Cell Significance Index: 1.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0245
    Cell Significance Index: 0.4200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0207
    Cell Significance Index: 0.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0167
    Cell Significance Index: 0.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0149
    Cell Significance Index: 0.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0143
    Cell Significance Index: 0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0089
    Cell Significance Index: 6.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0076
    Cell Significance Index: 5.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0057
    Cell Significance Index: 0.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -4.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0056
    Cell Significance Index: -0.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0058
    Cell Significance Index: -0.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0066
    Cell Significance Index: -12.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0077
    Cell Significance Index: -11.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0099
    Cell Significance Index: -6.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0126
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0211
    Cell Significance Index: -9.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0227
    Cell Significance Index: -14.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0304
    Cell Significance Index: -4.4200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0326
    Cell Significance Index: -0.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0345
    Cell Significance Index: -9.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0387
    Cell Significance Index: -6.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0407
    Cell Significance Index: -1.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0564
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0566
    Cell Significance Index: -6.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0571
    Cell Significance Index: -1.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0583
    Cell Significance Index: -1.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0635
    Cell Significance Index: -3.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0650
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0662
    Cell Significance Index: -13.9500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0699
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0783
    Cell Significance Index: -6.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0810
    Cell Significance Index: -0.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0914
    Cell Significance Index: -1.0900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0918
    Cell Significance Index: -0.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1128
    Cell Significance Index: -0.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1141
    Cell Significance Index: -3.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1187
    Cell Significance Index: -9.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1200
    Cell Significance Index: -12.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1259
    Cell Significance Index: -6.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1279
    Cell Significance Index: -7.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1307
    Cell Significance Index: -5.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1334
    Cell Significance Index: -1.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1368
    Cell Significance Index: -3.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1397
    Cell Significance Index: -3.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1629
    Cell Significance Index: -6.1700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1668
    Cell Significance Index: -2.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1978
    Cell Significance Index: -11.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2094
    Cell Significance Index: -4.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Coiled-Coil Domain:** CCDC106 contains a characteristic coiled-coil domain, which is a structural motif common to many proteins involved in protein-protein interactions. 2. **Ubiquitous Expression:** CCDC106 is expressed in a wide range of cell types, including cardiac endothelial cells, germ cells, and GABAergic neurons. 3. **Cell Type-Specific Expression:** The expression of CCDC106 is highly cell-type specific, suggesting that it may play distinct roles in different cell types. 4. **Protein Binding:** CCDC106 is predicted to interact with other proteins, which could be crucial for its function. **Pathways and Functions:** 1. **Cytoskeletal Organization:** Studies have shown that CCDC106 is involved in the organization of the cytoskeleton, which is essential for maintaining cell shape and structure. 2. **Cell Signaling:** CCDC106 has been implicated in cell signaling pathways, including the regulation of calcium channels and the modulation of neuronal activity. 3. **Protein-Protein Interactions:** CCDC106 is predicted to interact with other proteins, including those involved in cell adhesion, migration, and differentiation. 4. **Cellular Homeostasis:** CCDC106 may play a role in maintaining cellular homeostasis, particularly in the regulation of ion balances and the control of cell growth and proliferation. **Clinical Significance:** 1. **Cardiovascular Disease:** CCDC106 has been identified as a potential biomarker for cardiovascular disease, particularly in the context of cardiac endothelial cell dysfunction. 2. **Neurological Disorders:** The expression of CCDC106 in GABAergic neurons suggests that it may play a role in the regulation of neuronal activity and the development of neurological disorders, such as epilepsy and Parkinson's disease. 3. **Cancer:** CCDC106 has been implicated in the regulation of cell growth and proliferation, which could have implications for cancer research and treatment. 4. **Developmental Biology:** The expression of CCDC106 in germ cells and forebrain radial glial cells suggests that it may play a role in the development and regulation of the nervous system. In conclusion, CCDC106 is a complex protein with a wide range of cellular functions and interactions. Further research is necessary to fully understand the role of CCDC106 in human health and disease. As a potential biomarker for cardiovascular disease and neurological disorders, CCDC106 may hold significant clinical value in the diagnosis and treatment of these conditions.

Genular Protein ID: 3375363703

Symbol: CC106_HUMAN

Name: Coiled-coil domain-containing protein 106

UniProtKB Accession Codes:

Q9BWC9 B3KUF9 D3K183 Q99786

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 20159018

Title: Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation.

PubMed ID: 20159018

DOI: 10.1016/j.febslet.2010.02.031

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 280
  • Mass: 32032
  • Checksum: 8A380144441AEA33
  • Sequence:
    • MNDRSSRRRT MKDDETFEIS IPFDEAPHLD PQIFYSLSPS RRNFEEPPEA ASSALALMNS 
VKTQLHMALE RNSWLQKRIE DLEEERDFLR CQLDKFISSA RMEAEDHCRM KPGPRRMEGD 
SRGGAGGEAS DPESAASSLS GASEEGSASE RRRQKQKGGA SRRRFGKPKA RERQRVKDAD 
GVLCRYKKIL GTFQKLKSMS RAFEHHRVDR NTVALTTPIA ELLIVAPEKL AEVGEFDPSK 
ERLLEYSRRC FLALDDETLK KVQALKKSKL LLPITYRFKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.