Details for: ALG6
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: germ cell (CL0000586)
Fold Change: 1.44
Marker Score: 2,512 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.02
Marker Score: 942 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.02
Marker Score: 9,712 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.02
Marker Score: 4,012 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.01
Marker Score: 1,566 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.01
Marker Score: 8,700 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,751 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,975 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.98
Marker Score: 9,243 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,404 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.94
Marker Score: 57,862 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 481 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 436 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,716 - Cell Name: neuron (CL0000540)
Fold Change: 0.89
Marker Score: 3,624 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,291 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,947 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.84
Marker Score: 30,954 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.79
Marker Score: 2,135 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.78
Marker Score: 3,017 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,266 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.78
Marker Score: 246 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.76
Marker Score: 7,871 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 576 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 301 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.75
Marker Score: 11,190 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.75
Marker Score: 5,728 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.73
Marker Score: 3,045 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.73
Marker Score: 27,754 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.73
Marker Score: 11,430 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 374 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2,925 - Cell Name: brush cell (CL0002204)
Fold Change: 0.68
Marker Score: 618 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.67
Marker Score: 840 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.67
Marker Score: 13,326 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.66
Marker Score: 875 - Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.65
Marker Score: 779 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.64
Marker Score: 925 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.64
Marker Score: 644 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.62
Marker Score: 680 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.62
Marker Score: 360 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.6
Marker Score: 5,208 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.57
Marker Score: 1,166 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.57
Marker Score: 12,139 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.56
Marker Score: 451 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.56
Marker Score: 696 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.55
Marker Score: 232 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 433 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.54
Marker Score: 188 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.54
Marker Score: 263 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.53
Marker Score: 360 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.52
Marker Score: 737 - Cell Name: interneuron (CL0000099)
Fold Change: 0.51
Marker Score: 231 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.5
Marker Score: 1,182 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.5
Marker Score: 329 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.5
Marker Score: 478 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.49
Marker Score: 131 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.49
Marker Score: 2,013 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.49
Marker Score: 158 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.49
Marker Score: 294 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.49
Marker Score: 303 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.48
Marker Score: 310 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.48
Marker Score: 2,013 - Cell Name: basal cell (CL0000646)
Fold Change: 0.48
Marker Score: 617 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.47
Marker Score: 164 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.47
Marker Score: 260 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.47
Marker Score: 110 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.47
Marker Score: 233 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.47
Marker Score: 195 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.47
Marker Score: 2,795 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.47
Marker Score: 415 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.46
Marker Score: 192 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.46
Marker Score: 963 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.46
Marker Score: 397 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.45
Marker Score: 340 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.45
Marker Score: 132 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.45
Marker Score: 2,887 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.45
Marker Score: 990 - Cell Name: Unknown (CL0000548)
Fold Change: 0.45
Marker Score: 325 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.44
Marker Score: 180 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.44
Marker Score: 133 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.44
Marker Score: 744 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.43
Marker Score: 409 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.43
Marker Score: 1,601 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.43
Marker Score: 191 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.43
Marker Score: 198 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.43
Marker Score: 977 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.43
Marker Score: 504 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.43
Marker Score: 174 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.42
Marker Score: 83 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.42
Marker Score: 223 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.42
Marker Score: 473 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.41
Marker Score: 431 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.41
Marker Score: 607 - Cell Name: stem cell (CL0000034)
Fold Change: 0.41
Marker Score: 978 - Cell Name: podocyte (CL0000653)
Fold Change: 0.41
Marker Score: 152 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.41
Marker Score: 90
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 904435666
Symbol: ALG6_HUMAN
Name: Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10359825
Title: A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic.
PubMed ID: 10359825
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11106564
Title: Reduced heparan sulfate accumulation in enterocytes contributes to protein-losing enteropathy in a congenital disorder of glycosylation.
PubMed ID: 11106564
PubMed ID: 10914684
Title: Multi-allelic origin of congenital disorder of glycosylation (CDG)-Ic.
PubMed ID: 10914684
PubMed ID: 10924277
Title: Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic.
PubMed ID: 10924277
PubMed ID: 11558905
Title: The T911C (F304S) substitution in the human ALG6 gene is a common polymorphism and not a causal mutation of CDG-Ic.
PubMed ID: 11558905
PubMed ID: 11134235
Title: A broad spectrum of clinical presentations in congenital disorders of glycosylation I: a series of 26 cases.
PubMed ID: 11134235
DOI: 10.1136/jmg.38.1.14
PubMed ID: 12357336
Title: DHPLC analysis as a platform for molecular diagnosis of congenital disorders of glycosylation (CDG).
PubMed ID: 12357336
PubMed ID: 11875054
Title: A frequent mild mutation in ALG6 may exacerbate the clinical severity of patients with congenital disorder of glycosylation Ia (CDG-Ia) caused by phosphomannomutase deficiency.
PubMed ID: 11875054
DOI: 10.1093/hmg/11.5.599
PubMed ID: 14517965
Title: Identification of a frequent variant in ALG6, the cause of congenital disorder of glycosylation-Ic.
PubMed ID: 14517965
DOI: 10.1002/humu.9195
Sequence Information:
- Length: 507
- Mass: 58121
- Checksum: 8BAC4BA9B8E366B9
- Sequence:
MEKWYLMTVV VLIGLTVRWT VSLNSYSGAG KPPMFGDYEA QRHWQEITFN LPVKQWYFNS SDNNLQYWGL DYPPLTAYHS LLCAYVAKFI NPDWIALHTS RGYESQAHKL FMRTTVLIAD LLIYIPAVVL YCCCLKEIST KKKIANALCI LLYPGLILID YGHFQYNSVS LGFALWGVLG ISCDCDLLGS LAFCLAINYK QMELYHALPF FCFLLGKCFK KGLKGKGFVL LVKLACIVVA SFVLCWLPFF TEREQTLQVL RRLFPVDRGL FEDKVANIWC SFNVFLKIKD ILPRHIQLIM SFCSTFLSLL PACIKLILQP SSKGFKFTLV SCALSFFLFS FQVHEKSILL VSLPVCLVLS EIPFMSTWFL LVSTFSMLPL LLKDELLMPS VVTTMAFFIA CVTSFSIFEK TSEEELQLKS FSISVRKYLP CFTFLSRIIQ YLFLISVITM VLLTLMTVTL DPPQKLPDLF SVLVCFVSCL NFLFFLVYFN IIIMWDSKSG RNQKKIS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.