Details for: PCDHB1

Gene ID: 29930

Symbol: PCDHB1

Ensembl ID: ENSG00000171815

Description: protocadherin beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2971
    Cell Significance Index: 1.6200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0929
    Cell Significance Index: 1.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0130
    Cell Significance Index: 0.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0038
    Cell Significance Index: 0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0023
    Cell Significance Index: 0.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0015
    Cell Significance Index: 0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0008
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0025
    Cell Significance Index: -0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0046
    Cell Significance Index: -0.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0103
    Cell Significance Index: -1.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0115
    Cell Significance Index: -1.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0119
    Cell Significance Index: -2.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0125
    Cell Significance Index: -1.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0152
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0159
    Cell Significance Index: -1.9600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0159
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0164
    Cell Significance Index: -2.2500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0184
    Cell Significance Index: -0.3600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0212
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0245
    Cell Significance Index: -2.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0256
    Cell Significance Index: -2.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0258
    Cell Significance Index: -1.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0264
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0279
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0294
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0309
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0335
    Cell Significance Index: -0.3700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0348
    Cell Significance Index: -0.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0349
    Cell Significance Index: -0.7300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0374
    Cell Significance Index: -0.6000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0380
    Cell Significance Index: -0.5700
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0384
    Cell Significance Index: -0.3900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0406
    Cell Significance Index: -0.4700
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0435
    Cell Significance Index: -0.4500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0438
    Cell Significance Index: -0.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0442
    Cell Significance Index: -5.7100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0452
    Cell Significance Index: -0.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0453
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0453
    Cell Significance Index: -0.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0455
    Cell Significance Index: -1.4900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0459
    Cell Significance Index: -0.3300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0477
    Cell Significance Index: -0.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0500
    Cell Significance Index: -1.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0527
    Cell Significance Index: -1.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0533
    Cell Significance Index: -6.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0543
    Cell Significance Index: -2.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0549
    Cell Significance Index: -0.7700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0552
    Cell Significance Index: -0.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0576
    Cell Significance Index: -4.4200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0598
    Cell Significance Index: -0.4500
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0617
    Cell Significance Index: -0.6900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0662
    Cell Significance Index: -0.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0671
    Cell Significance Index: -0.7300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0682
    Cell Significance Index: -0.6600
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0689
    Cell Significance Index: -0.7300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0701
    Cell Significance Index: -0.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0730
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0738
    Cell Significance Index: -0.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0754
    Cell Significance Index: -1.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0758
    Cell Significance Index: -1.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0761
    Cell Significance Index: -0.5200
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0773
    Cell Significance Index: -0.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0781
    Cell Significance Index: -2.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0781
    Cell Significance Index: -5.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0782
    Cell Significance Index: -1.6600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0784
    Cell Significance Index: -0.6500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0845
    Cell Significance Index: -0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0846
    Cell Significance Index: -3.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0869
    Cell Significance Index: -1.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0898
    Cell Significance Index: -2.3600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0902
    Cell Significance Index: -2.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0905
    Cell Significance Index: -1.5600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0920
    Cell Significance Index: -1.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0964
    Cell Significance Index: -2.1100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0966
    Cell Significance Index: -1.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0971
    Cell Significance Index: -1.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0974
    Cell Significance Index: -3.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0975
    Cell Significance Index: -2.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0985
    Cell Significance Index: -2.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0992
    Cell Significance Index: -2.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0999
    Cell Significance Index: -1.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Adhesion:** PCDHB1 mediates homophilic cell adhesion, which is essential for maintaining tissue structure and cellular organization. This adhesion is mediated through calcium ion binding, which stabilizes the protocadherin complex and allows for cell-cell interactions. 2. **Developmental Processes:** PCDHB1 is involved in nervous system development, particularly in the formation of GABAergic interneurons and radial glial cells in the cerebral cortex. Its expression is also crucial for the development of epithelial tissues, such as the intestine and colon. 3. **Cell Type-Specific Expression:** PCDHB1 is expressed in various cell types, including endothelial cells, epithelial cells, and neural cells, highlighting its broad functional significance. 4. **Calcium Ion Binding:** PCDHB1 binds calcium ions, which is essential for its function in cell adhesion and development. **Pathways and Functions:** 1. **Calcium Ion Binding:** PCDHB1 binds calcium ions, which stabilizes the protocadherin complex and allows for cell-cell interactions. 2. **Homophilic Cell Adhesion:** PCDHB1 mediates homophilic cell adhesion, which is essential for maintaining tissue structure and cellular organization. 3. **Nervous System Development:** PCDHB1 is involved in the formation of GABAergic interneurons and radial glial cells in the cerebral cortex, highlighting its critical role in nervous system development. 4. **Epithelial Tissue Development:** PCDHB1 is also involved in the development of epithelial tissues, such as the intestine and colon, underscoring its importance in tissue homeostasis. **Clinical Significance:** 1. **Cancer:** Alterations in PCDHB1 expression have been observed in various cancers, including colorectal cancer. This suggests that PCDHB1 may serve as a tumor suppressor gene or a marker for cancer diagnosis. 2. **Neurological Disorders:** Dysregulation of PCDHB1 expression has been implicated in neurological disorders, such as autism spectrum disorder and schizophrenia. This highlights the potential importance of PCDHB1 in brain development and function. 3. **Inflammatory Diseases:** PCDHB1 has been shown to regulate inflammatory responses in endothelial cells, suggesting its potential role in the pathogenesis of inflammatory diseases, such as atherosclerosis and arthritis. In conclusion, PCDHB1 is a critical gene involved in cell adhesion, development, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the functional significance of PCDHB1 and its potential therapeutic applications.

Genular Protein ID: 860176481

Symbol: PCDB1_HUMAN

Name: Protocadherin beta-1

UniProtKB Accession Codes:

Q9Y5F3 Q2M257

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10380929

Title: A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PubMed ID: 10380929

DOI: 10.1016/s0092-8674(00)80789-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 818
  • Mass: 90491
  • Checksum: 4697DC76EDB7D604
  • Sequence:
    • MAGTRRKSLQ NRQVGSLLIF LCISVGDATT IRYSVAEEME SGSFVANVAK DLGLEVGKLA 
ARGARLVSEG NKMHFRLHRK TGDLFVKEKL DRESLCGKAD PCVLHFEVVL VEPLQSFRAE 
VRVFDINDNA PVFLNKEPLL KIPESTPLGS RFPLQSAQDL DVGLNGLQNY TLSANGYFHL 
HTRFCSHGPK YAELVLNKPL DREEQPEVNL TITAVDGGSP PKSGTAHIHV VVLDVNDHVP 
QFSRLVYRAQ VSENSPNGSL VATVTAVDLD EGTNKAITYS LAQNPEAILK TFQIDPQNGE 
VRLRGPLDFE AIETYDIDIQ ATDGGGLSAH SKVLVEVVDV NDNPPEVMVS SVSSPLPEDS 
PPQTVVALFT IRDRDIRVGG KVTCFLREDL PFVIKPTFGN SYSLVTDRSL DREEVSGYNI 
TIVAMDTGPP SLSAETMIEV LISDVNDNPP IFREDSYILT VRENNSPAVF IGKVHAEDLD 
LGENAQITYS LLPPKNGDLS VFAYISINSG NGKLYALRTM DYEAIQDFQF VVKATDGGFL 
SLSSQVTVRV VVLDDNDNRP MILYPLQNGT LPCNDLVPRS AEAGYLVTKV VAVDGDSGQN 
SWLSYHLLKA TDLGLFSVQR QNGEIHTLRQ ISERDPMMQK LIILVQDHGQ PALSTTVSLN 
ILLVDGFSEP YLQFQDPTKH SRKVNPSTKY LVISLVILSF LFLLSVIVIF IIHVYQKIKY 
REKFTIQEHF YDDCNFSNNL VQGQGNGSLS RPCPYEMCSA TGTGNSEFRF LKRFMPNFPF 
PHATGEIKME AGSSLPPNSD RNKSQRLEGH DQVSDDYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.