Details for: PCDHB1

Gene ID: 29930

Symbol: PCDHB1

Ensembl ID: ENSG00000171815

Description: protocadherin beta 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.4
    Marker Score: 2,413
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2,003
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,177
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,826
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,839
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,064
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.74
    Marker Score: 431
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 486
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.47
    Marker Score: 521
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.37
    Marker Score: 696
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4,858
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 597
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.21
    Marker Score: 406
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 120
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.19
    Marker Score: 402
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.19
    Marker Score: 10,636
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 91
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 145
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 66
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.15
    Marker Score: 7,744
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 232
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.12
    Marker Score: 167
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.11
    Marker Score: 241
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.1
    Marker Score: 908
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.1
    Marker Score: 306
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 144
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.09
    Marker Score: 197
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.09
    Marker Score: 239
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 145
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.08
    Marker Score: 161
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.07
    Marker Score: 244
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 67
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.06
    Marker Score: 11
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 64
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.04
    Marker Score: 81
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 57
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.04
    Marker Score: 108
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.04
    Marker Score: 9
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.03
    Marker Score: 88
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.03
    Marker Score: 71
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.03
    Marker Score: 48
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.03
    Marker Score: 11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Adhesion:** PCDHB1 mediates homophilic cell adhesion, which is essential for maintaining tissue structure and cellular organization. This adhesion is mediated through calcium ion binding, which stabilizes the protocadherin complex and allows for cell-cell interactions. 2. **Developmental Processes:** PCDHB1 is involved in nervous system development, particularly in the formation of GABAergic interneurons and radial glial cells in the cerebral cortex. Its expression is also crucial for the development of epithelial tissues, such as the intestine and colon. 3. **Cell Type-Specific Expression:** PCDHB1 is expressed in various cell types, including endothelial cells, epithelial cells, and neural cells, highlighting its broad functional significance. 4. **Calcium Ion Binding:** PCDHB1 binds calcium ions, which is essential for its function in cell adhesion and development. **Pathways and Functions:** 1. **Calcium Ion Binding:** PCDHB1 binds calcium ions, which stabilizes the protocadherin complex and allows for cell-cell interactions. 2. **Homophilic Cell Adhesion:** PCDHB1 mediates homophilic cell adhesion, which is essential for maintaining tissue structure and cellular organization. 3. **Nervous System Development:** PCDHB1 is involved in the formation of GABAergic interneurons and radial glial cells in the cerebral cortex, highlighting its critical role in nervous system development. 4. **Epithelial Tissue Development:** PCDHB1 is also involved in the development of epithelial tissues, such as the intestine and colon, underscoring its importance in tissue homeostasis. **Clinical Significance:** 1. **Cancer:** Alterations in PCDHB1 expression have been observed in various cancers, including colorectal cancer. This suggests that PCDHB1 may serve as a tumor suppressor gene or a marker for cancer diagnosis. 2. **Neurological Disorders:** Dysregulation of PCDHB1 expression has been implicated in neurological disorders, such as autism spectrum disorder and schizophrenia. This highlights the potential importance of PCDHB1 in brain development and function. 3. **Inflammatory Diseases:** PCDHB1 has been shown to regulate inflammatory responses in endothelial cells, suggesting its potential role in the pathogenesis of inflammatory diseases, such as atherosclerosis and arthritis. In conclusion, PCDHB1 is a critical gene involved in cell adhesion, development, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the functional significance of PCDHB1 and its potential therapeutic applications.

Genular Protein ID: 860176481

Symbol: PCDB1_HUMAN

Name: Protocadherin beta-1

UniProtKB Accession Codes:

Q9Y5F3 Q2M257

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10380929

Title: A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PubMed ID: 10380929

DOI: 10.1016/s0092-8674(00)80789-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 818
  • Mass: 90491
  • Checksum: 4697DC76EDB7D604
  • Sequence:
    • MAGTRRKSLQ NRQVGSLLIF LCISVGDATT IRYSVAEEME SGSFVANVAK DLGLEVGKLA 
ARGARLVSEG NKMHFRLHRK TGDLFVKEKL DRESLCGKAD PCVLHFEVVL VEPLQSFRAE 
VRVFDINDNA PVFLNKEPLL KIPESTPLGS RFPLQSAQDL DVGLNGLQNY TLSANGYFHL 
HTRFCSHGPK YAELVLNKPL DREEQPEVNL TITAVDGGSP PKSGTAHIHV VVLDVNDHVP 
QFSRLVYRAQ VSENSPNGSL VATVTAVDLD EGTNKAITYS LAQNPEAILK TFQIDPQNGE 
VRLRGPLDFE AIETYDIDIQ ATDGGGLSAH SKVLVEVVDV NDNPPEVMVS SVSSPLPEDS 
PPQTVVALFT IRDRDIRVGG KVTCFLREDL PFVIKPTFGN SYSLVTDRSL DREEVSGYNI 
TIVAMDTGPP SLSAETMIEV LISDVNDNPP IFREDSYILT VRENNSPAVF IGKVHAEDLD 
LGENAQITYS LLPPKNGDLS VFAYISINSG NGKLYALRTM DYEAIQDFQF VVKATDGGFL 
SLSSQVTVRV VVLDDNDNRP MILYPLQNGT LPCNDLVPRS AEAGYLVTKV VAVDGDSGQN 
SWLSYHLLKA TDLGLFSVQR QNGEIHTLRQ ISERDPMMQK LIILVQDHGQ PALSTTVSLN 
ILLVDGFSEP YLQFQDPTKH SRKVNPSTKY LVISLVILSF LFLLSVIVIF IIHVYQKIKY 
REKFTIQEHF YDDCNFSNNL VQGQGNGSLS RPCPYEMCSA TGTGNSEFRF LKRFMPNFPF 
PHATGEIKME AGSSLPPNSD RNKSQRLEGH DQVSDDYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.