Details for: RPA4

Gene ID: 29935

Symbol: RPA4

Ensembl ID: ENSG00000204086

Description: replication protein A4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.2150
    Cell Significance Index: 17.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6171
    Cell Significance Index: 117.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4696
    Cell Significance Index: 46.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3078
    Cell Significance Index: 18.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3041
    Cell Significance Index: 274.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2726
    Cell Significance Index: 29.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2460
    Cell Significance Index: 11.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2347
    Cell Significance Index: 38.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2253
    Cell Significance Index: 4.8800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1902
    Cell Significance Index: 2.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1898
    Cell Significance Index: 2.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1454
    Cell Significance Index: 4.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1429
    Cell Significance Index: 3.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1369
    Cell Significance Index: 9.4700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0935
    Cell Significance Index: 1.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0907
    Cell Significance Index: 1.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0728
    Cell Significance Index: 4.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0630
    Cell Significance Index: 0.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0427
    Cell Significance Index: 0.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0365
    Cell Significance Index: 7.3200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0361
    Cell Significance Index: 0.5400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0351
    Cell Significance Index: 0.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0341
    Cell Significance Index: 3.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0300
    Cell Significance Index: 0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0284
    Cell Significance Index: 1.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0276
    Cell Significance Index: 0.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0247
    Cell Significance Index: 0.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0237
    Cell Significance Index: 1.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0206
    Cell Significance Index: 1.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0107
    Cell Significance Index: 4.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0076
    Cell Significance Index: 0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0070
    Cell Significance Index: 0.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0066
    Cell Significance Index: 3.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0061
    Cell Significance Index: 0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0027
    Cell Significance Index: 0.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0027
    Cell Significance Index: 0.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0026
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0028
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0038
    Cell Significance Index: -0.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0046
    Cell Significance Index: -1.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0093
    Cell Significance Index: -1.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0113
    Cell Significance Index: -0.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0123
    Cell Significance Index: -0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0138
    Cell Significance Index: -2.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0154
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0175
    Cell Significance Index: -3.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0197
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0223
    Cell Significance Index: -2.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0240
    Cell Significance Index: -2.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0254
    Cell Significance Index: -0.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0269
    Cell Significance Index: -0.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0281
    Cell Significance Index: -1.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0299
    Cell Significance Index: -0.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0320
    Cell Significance Index: -2.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0339
    Cell Significance Index: -0.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0366
    Cell Significance Index: -0.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0367
    Cell Significance Index: -1.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0400
    Cell Significance Index: -1.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0401
    Cell Significance Index: -1.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0413
    Cell Significance Index: -2.3200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0417
    Cell Significance Index: -0.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0434
    Cell Significance Index: -2.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0443
    Cell Significance Index: -3.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0443
    Cell Significance Index: -1.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0447
    Cell Significance Index: -1.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0489
    Cell Significance Index: -1.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0515
    Cell Significance Index: -1.6400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0530
    Cell Significance Index: -0.6800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0620
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0621
    Cell Significance Index: -1.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0625
    Cell Significance Index: -3.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0658
    Cell Significance Index: -1.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0684
    Cell Significance Index: -1.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0753
    Cell Significance Index: -1.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0760
    Cell Significance Index: -2.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0781
    Cell Significance Index: -1.9500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0782
    Cell Significance Index: -1.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0796
    Cell Significance Index: -1.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0805
    Cell Significance Index: -1.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0812
    Cell Significance Index: -2.8200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0813
    Cell Significance Index: -0.5300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0853
    Cell Significance Index: -1.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0869
    Cell Significance Index: -1.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0917
    Cell Significance Index: -2.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0950
    Cell Significance Index: -2.3700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0969
    Cell Significance Index: -0.9200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0998
    Cell Significance Index: -1.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0998
    Cell Significance Index: -2.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1004
    Cell Significance Index: -1.9600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1006
    Cell Significance Index: -1.0500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1022
    Cell Significance Index: -2.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1062
    Cell Significance Index: -1.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPA4 is a small protein with a molecular weight of approximately 30 kDa. It is a member of the RPA complex, which is a heterotrimeric complex composed of RPA1, RPA2, RPA3, and RPA4. RPA4 is responsible for binding to single-stranded DNA and recruiting other factors necessary for DNA replication. It also plays a role in DNA damage repair and recombination. RPA4 has been shown to interact with various proteins, including DNA polymerases, helicases, and other RPA subunits. **Pathways and Functions** RPA4 is involved in several key pathways, including: 1. **DNA Replication**: RPA4 plays a crucial role in the initiation of DNA replication by binding to single-stranded DNA and recruiting other factors necessary for the unwinding of double-stranded DNA. 2. **DNA Damage Repair**: RPA4 is involved in the repair of double-strand breaks in DNA, particularly through the homologous recombination pathway. 3. **Single-Stranded DNA Binding**: RPA4 binds to single-stranded DNA and recruits other factors necessary for DNA replication and repair. 4. **Cell Cycle Regulation**: RPA4 is involved in the regulation of the cell cycle, particularly in the G1/S transition. 5. **Telomere Maintenance**: RPA4 has been shown to interact with telomeric DNA-binding proteins, suggesting a role in telomere maintenance. **Clinical Significance** RPA4 has been implicated in various diseases, including: 1. **Cancer**: RPA4 has been shown to be overexpressed in certain types of cancer, suggesting a role in tumor growth and survival. 2. **Neurodegenerative Diseases**: RPA4 has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of DNA replication and repair. 3. **Genetic Disorders**: RPA4 has been associated with genetic disorders such as Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased risk of cancer. In conclusion, RPA4 is a critical component of the RPA complex, playing a vital role in DNA replication, repair, and recombination. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining genome stability. Further research is needed to fully understand the role of RPA4 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 119867604

Symbol: RFA4_HUMAN

Name: Replication protein A 30 kDa subunit

UniProtKB Accession Codes:

Q13156 Q3SY03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7760808

Title: Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.

PubMed ID: 7760808

DOI: 10.1128/mcb.15.6.3119

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19116208

Title: An alternative form of replication protein a prevents viral replication in vitro.

PubMed ID: 19116208

DOI: 10.1074/jbc.m808963200

PubMed ID: 20545304

Title: Functions of alternative replication protein A in initiation and elongation.

PubMed ID: 20545304

DOI: 10.1021/bi100380n

PubMed ID: 19996105

Title: An alternative form of replication protein a expressed in normal human tissues supports DNA repair.

PubMed ID: 19996105

DOI: 10.1074/jbc.m109.079418

PubMed ID: 19942684

Title: A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.

PubMed ID: 19942684

DOI: 10.1093/nar/gkp1062

Sequence Information:

  • Length: 261
  • Mass: 28868
  • Checksum: 6A925FAEDBE21718
  • Sequence:
    • MSKSGFGSYG SISAADGASG GSDQLCERDA TPAIKTQRPK VRIQDVVPCN VNQLLSSTVF 
DPVFKVRGII VSQVSIVGVI RGAEKASNHI CYKIDDMTAK PIEARQWFGR EKVKQVTPLS 
VGVYVKVFGI LKCPTGTKSL EVLKIHVLED MNEFTVHILE TVNAHMMLDK ARRDTTVESV 
PVSPSEVNDA GDNDESHRNF IQDEVLRLIH ECPHQEGKSI HELRAQLCDL SVKAIKEAID 
YLTVEGHIYP TVDREHFKSA D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.