Details for: RPA4

Gene ID: 29935

Symbol: RPA4

Ensembl ID: ENSG00000204086

Description: replication protein A4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,337
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.82
    Marker Score: 1,426
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.81
    Marker Score: 336
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,970
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.68
    Marker Score: 974
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.66
    Marker Score: 264
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 318
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 883
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.42
    Marker Score: 275
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.4
    Marker Score: 811
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6,229
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.38
    Marker Score: 542
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.33
    Marker Score: 119
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 303
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 171
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.27
    Marker Score: 500
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.26
    Marker Score: 64
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 359
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 91
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.19
    Marker Score: 178
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.18
    Marker Score: 1,081
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.15
    Marker Score: 158
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.14
    Marker Score: 560
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.14
    Marker Score: 95
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.14
    Marker Score: 92
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.13
    Marker Score: 142
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.13
    Marker Score: 80
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 153
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.11
    Marker Score: 70
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1
    Marker Score: 361
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1
    Marker Score: 87
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1
    Marker Score: 134
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.09
    Marker Score: 603
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.09
    Marker Score: 222
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.09
    Marker Score: 136
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.08
    Marker Score: 16
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.08
    Marker Score: 97
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.08
    Marker Score: 16
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.07
    Marker Score: 93
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.07
    Marker Score: 737
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 85
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.07
    Marker Score: 461
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.07
    Marker Score: 408
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.07
    Marker Score: 167
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.07
    Marker Score: 280
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.07
    Marker Score: 4,145
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.07
    Marker Score: 156

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPA4 is a small protein with a molecular weight of approximately 30 kDa. It is a member of the RPA complex, which is a heterotrimeric complex composed of RPA1, RPA2, RPA3, and RPA4. RPA4 is responsible for binding to single-stranded DNA and recruiting other factors necessary for DNA replication. It also plays a role in DNA damage repair and recombination. RPA4 has been shown to interact with various proteins, including DNA polymerases, helicases, and other RPA subunits. **Pathways and Functions** RPA4 is involved in several key pathways, including: 1. **DNA Replication**: RPA4 plays a crucial role in the initiation of DNA replication by binding to single-stranded DNA and recruiting other factors necessary for the unwinding of double-stranded DNA. 2. **DNA Damage Repair**: RPA4 is involved in the repair of double-strand breaks in DNA, particularly through the homologous recombination pathway. 3. **Single-Stranded DNA Binding**: RPA4 binds to single-stranded DNA and recruits other factors necessary for DNA replication and repair. 4. **Cell Cycle Regulation**: RPA4 is involved in the regulation of the cell cycle, particularly in the G1/S transition. 5. **Telomere Maintenance**: RPA4 has been shown to interact with telomeric DNA-binding proteins, suggesting a role in telomere maintenance. **Clinical Significance** RPA4 has been implicated in various diseases, including: 1. **Cancer**: RPA4 has been shown to be overexpressed in certain types of cancer, suggesting a role in tumor growth and survival. 2. **Neurodegenerative Diseases**: RPA4 has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of DNA replication and repair. 3. **Genetic Disorders**: RPA4 has been associated with genetic disorders such as Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased risk of cancer. In conclusion, RPA4 is a critical component of the RPA complex, playing a vital role in DNA replication, repair, and recombination. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining genome stability. Further research is needed to fully understand the role of RPA4 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 119867604

Symbol: RFA4_HUMAN

Name: Replication protein A 30 kDa subunit

UniProtKB Accession Codes:

Q13156 Q3SY03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 EMBL 8 Ensembl 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7760808

Title: Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.

PubMed ID: 7760808

DOI: 10.1128/mcb.15.6.3119

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19116208

Title: An alternative form of replication protein a prevents viral replication in vitro.

PubMed ID: 19116208

DOI: 10.1074/jbc.m808963200

PubMed ID: 20545304

Title: Functions of alternative replication protein A in initiation and elongation.

PubMed ID: 20545304

DOI: 10.1021/bi100380n

PubMed ID: 19996105

Title: An alternative form of replication protein a expressed in normal human tissues supports DNA repair.

PubMed ID: 19996105

DOI: 10.1074/jbc.m109.079418

PubMed ID: 19942684

Title: A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.

PubMed ID: 19942684

DOI: 10.1093/nar/gkp1062

Sequence Information:

  • Length: 261
  • Mass: 28868
  • Checksum: 6A925FAEDBE21718
  • Sequence:
    • MSKSGFGSYG SISAADGASG GSDQLCERDA TPAIKTQRPK VRIQDVVPCN VNQLLSSTVF 
DPVFKVRGII VSQVSIVGVI RGAEKASNHI CYKIDDMTAK PIEARQWFGR EKVKQVTPLS 
VGVYVKVFGI LKCPTGTKSL EVLKIHVLED MNEFTVHILE TVNAHMMLDK ARRDTTVESV 
PVSPSEVNDA GDNDESHRNF IQDEVLRLIH ECPHQEGKSI HELRAQLCDL SVKAIKEAID 
YLTVEGHIYP TVDREHFKSA D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.