Details for: SLC25A24

Gene ID: 29957

Symbol: SLC25A24

Ensembl ID: ENSG00000085491

Description: solute carrier family 25 member 24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 213.1856
    Cell Significance Index: -33.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.9643
    Cell Significance Index: -31.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 79.7917
    Cell Significance Index: -32.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.7956
    Cell Significance Index: -31.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.4420
    Cell Significance Index: -36.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.0983
    Cell Significance Index: -34.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.3283
    Cell Significance Index: -31.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8704
    Cell Significance Index: -33.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.6248
    Cell Significance Index: -33.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4109
    Cell Significance Index: -33.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1399
    Cell Significance Index: -21.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.7799
    Cell Significance Index: 94.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.5337
    Cell Significance Index: 40.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4056
    Cell Significance Index: 391.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7796
    Cell Significance Index: 193.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2734
    Cell Significance Index: 57.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2054
    Cell Significance Index: 119.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0976
    Cell Significance Index: 599.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9016
    Cell Significance Index: 162.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8618
    Cell Significance Index: 18.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8566
    Cell Significance Index: 44.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7488
    Cell Significance Index: 21.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7145
    Cell Significance Index: 6.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6887
    Cell Significance Index: 10.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6352
    Cell Significance Index: 48.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6277
    Cell Significance Index: 125.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6017
    Cell Significance Index: 73.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5011
    Cell Significance Index: 68.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4713
    Cell Significance Index: 24.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4414
    Cell Significance Index: 24.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3951
    Cell Significance Index: 24.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3715
    Cell Significance Index: 7.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2955
    Cell Significance Index: 2.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2894
    Cell Significance Index: 127.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2440
    Cell Significance Index: 87.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2254
    Cell Significance Index: 14.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2145
    Cell Significance Index: 10.8400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2062
    Cell Significance Index: 2.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2043
    Cell Significance Index: 5.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1879
    Cell Significance Index: 2.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1845
    Cell Significance Index: 5.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1731
    Cell Significance Index: 4.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1715
    Cell Significance Index: 12.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1679
    Cell Significance Index: 31.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1642
    Cell Significance Index: 4.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1616
    Cell Significance Index: 20.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1577
    Cell Significance Index: 1.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1462
    Cell Significance Index: 3.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1419
    Cell Significance Index: 6.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1014
    Cell Significance Index: 2.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0990
    Cell Significance Index: 3.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0914
    Cell Significance Index: 2.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0527
    Cell Significance Index: 9.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0302
    Cell Significance Index: 56.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0286
    Cell Significance Index: 25.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0261
    Cell Significance Index: 48.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0254
    Cell Significance Index: 39.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0253
    Cell Significance Index: 1.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0227
    Cell Significance Index: 1.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0153
    Cell Significance Index: 9.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0111
    Cell Significance Index: 1.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0038
    Cell Significance Index: 2.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0016
    Cell Significance Index: 0.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0217
    Cell Significance Index: -16.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0265
    Cell Significance Index: -0.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0358
    Cell Significance Index: -5.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0563
    Cell Significance Index: -5.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0723
    Cell Significance Index: -15.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0728
    Cell Significance Index: -8.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0827
    Cell Significance Index: -9.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0945
    Cell Significance Index: -27.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0976
    Cell Significance Index: -11.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1001
    Cell Significance Index: -1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1002
    Cell Significance Index: -19.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1185
    Cell Significance Index: -1.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1228
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1359
    Cell Significance Index: -15.5200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1700
    Cell Significance Index: -2.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1845
    Cell Significance Index: -8.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1952
    Cell Significance Index: -4.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2067
    Cell Significance Index: -6.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2078
    Cell Significance Index: -7.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2082
    Cell Significance Index: -2.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2173
    Cell Significance Index: -7.5500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2301
    Cell Significance Index: -3.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2326
    Cell Significance Index: -6.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2375
    Cell Significance Index: -5.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2594
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2980
    Cell Significance Index: -31.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3335
    Cell Significance Index: -26.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3913
    Cell Significance Index: -23.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4657
    Cell Significance Index: -27.9600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5118
    Cell Significance Index: -3.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5765
    Cell Significance Index: -30.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC25A24 is a mitochondrial inner membrane protein that exhibits adenine nucleotide transmembrane transporter activity, allowing for the exchange of ATP and inorganic phosphate across the mitochondrial membrane. This protein also displays calcium ion binding capabilities, enabling it to participate in calcium homeostasis within the cell. Additionally, SLC25A24 has been implicated in cellular responses to oxidative stress and calcium ion, highlighting its importance in maintaining mitochondrial function and overall cellular health. **Pathways and Functions:** The primary function of SLC25A24 is to regulate mitochondrial ATP production by facilitating the exchange of ATP and inorganic phosphate. This process is essential for maintaining mitochondrial energy homeostasis, particularly in high-energy-demanding cells such as neurons and muscle cells. Furthermore, SLC25A24 has been shown to interact with other mitochondrial proteins, including those involved in calcium homeostasis, to regulate mitochondrial function and overall cellular health. One of the key pathways regulated by SLC25A24 is the adenine nucleotide transmembrane transporter (ANT) pathway, which involves the transport of ATP and inorganic phosphate across the mitochondrial membrane. This pathway plays a critical role in maintaining mitochondrial energy homeostasis and is essential for regulating cellular metabolism. **Clinical Significance:** Dysregulation of SLC25A24 has been implicated in various diseases, including neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. These diseases are characterized by mitochondrial dysfunction and impaired energy metabolism, which can be attributed to alterations in SLC25A24 expression or function. Furthermore, SLC25A24 has been implicated in cancer development and progression, particularly in solid tumors such as breast cancer and lung cancer. Overexpression of SLC25A24 has been observed in these tumors, suggesting that it may play a role in promoting cancer cell growth and survival. In addition, SLC25A24 has been shown to be involved in cardiovascular disease, particularly in hypertension and cardiac remodeling. Dysregulation of SLC25A24 has been implicated in the development of cardiac hypertrophy and fibrosis, highlighting its importance in maintaining cardiac function and overall cardiovascular health. In conclusion, SLC25A24 is a critical gene that plays a significant role in maintaining mitochondrial function and calcium homeostasis. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. Further research is needed to fully elucidate the functions and clinical significance of SLC25A24, but it is clear that this gene is an essential component of cellular homeostasis and overall health.

Genular Protein ID: 2028602932

Symbol: SCMC1_HUMAN

Name: Mitochondrial Ca(2+)-dependent solute carrier protein 1

UniProtKB Accession Codes:

Q6NUK1 B7ZAI9 Q5T331 Q5T485 Q6PJJ9 Q705K4 Q9P129

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 52 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 12 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15054102

Title: Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.

PubMed ID: 15054102

DOI: 10.1074/jbc.m401417200

PubMed ID: 15123600

Title: Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution.

PubMed ID: 15123600

DOI: 10.1074/jbc.m400445200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22015608

Title: SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering.

PubMed ID: 22015608

DOI: 10.1038/cdd.2011.139

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 24332718

Title: A self-sequestered calmodulin-like Ca(2+) sensor of mitochondrial SCaMC carrier and its implication to Ca(2+)-dependent ATP-Mg/Pi transport.

PubMed ID: 24332718

DOI: 10.1016/j.str.2013.10.018

PubMed ID: 26164100

Title: Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier.

PubMed ID: 26164100

DOI: 10.1016/j.bbabio.2015.07.002

PubMed ID: 29100093

Title: De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction.

PubMed ID: 29100093

DOI: 10.1016/j.ajhg.2017.09.016

Sequence Information:

  • Length: 477
  • Mass: 53354
  • Checksum: F533D47B2457123F
  • Sequence:
    • MLRWLRDFVL PTAACQDAEQ PTRYETLFQA LDRNGDGVVD IGELQEGLRN LGIPLGQDAE 
EKIFTTGDVN KDGKLDFEEF MKYLKDHEKK MKLAFKSLDK NNDGKIEASE IVQSLQTLGL 
TISEQQAELI LQSIDVDGTM TVDWNEWRDY FLFNPVTDIE EIIRFWKHST GIDIGDSLTI 
PDEFTEDEKK SGQWWRQLLA GGIAGAVSRT STAPLDRLKI MMQVHGSKSD KMNIFGGFRQ 
MVKEGGIRSL WRGNGTNVIK IAPETAVKFW AYEQYKKLLT EEGQKIGTFE RFISGSMAGA 
TAQTFIYPME VMKTRLAVGK TGQYSGIYDC AKKILKHEGL GAFYKGYVPN LLGIIPYAGI 
DLAVYELLKS YWLDNFAKDS VNPGVMVLLG CGALSSTCGQ LASYPLALVR TRMQAQAMLE 
GSPQLNMVGL FRRIISKEGI PGLYRGITPN FMKVLPAVGI SYVVYENMKQ TLGVTQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.