Details for: PILRB

Gene ID: 29990

Symbol: PILRB

Ensembl ID: ENSG00000121716

Description: paired immunoglobin like type 2 receptor beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 144.4596
    Cell Significance Index: -22.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.8723
    Cell Significance Index: -21.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.7964
    Cell Significance Index: -23.5100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.8022
    Cell Significance Index: -23.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7841
    Cell Significance Index: -23.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6824
    Cell Significance Index: -20.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2604
    Cell Significance Index: -22.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8355
    Cell Significance Index: -14.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9566
    Cell Significance Index: -23.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.9381
    Cell Significance Index: 82.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.1572
    Cell Significance Index: 31.8400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.9523
    Cell Significance Index: 5.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3809
    Cell Significance Index: 277.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3324
    Cell Significance Index: 155.2800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.3170
    Cell Significance Index: 8.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9976
    Cell Significance Index: 26.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9515
    Cell Significance Index: 188.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8863
    Cell Significance Index: 144.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8527
    Cell Significance Index: 92.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8095
    Cell Significance Index: 145.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7125
    Cell Significance Index: 54.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6859
    Cell Significance Index: 44.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6814
    Cell Significance Index: 244.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.6744
    Cell Significance Index: 421.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5648
    Cell Significance Index: 31.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5064
    Cell Significance Index: 8.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4829
    Cell Significance Index: 28.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4777
    Cell Significance Index: 22.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4733
    Cell Significance Index: 427.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4417
    Cell Significance Index: 30.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4413
    Cell Significance Index: 241.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4345
    Cell Significance Index: 53.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4212
    Cell Significance Index: 12.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3686
    Cell Significance Index: 10.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3452
    Cell Significance Index: 15.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3358
    Cell Significance Index: 5.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3081
    Cell Significance Index: 20.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2947
    Cell Significance Index: 29.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2883
    Cell Significance Index: 21.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2844
    Cell Significance Index: 39.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2820
    Cell Significance Index: 10.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2463
    Cell Significance Index: 12.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2303
    Cell Significance Index: 4.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2083
    Cell Significance Index: 5.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2073
    Cell Significance Index: 12.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1962
    Cell Significance Index: 86.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1831
    Cell Significance Index: 21.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1674
    Cell Significance Index: 31.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1622
    Cell Significance Index: 7.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1540
    Cell Significance Index: 8.0000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1401
    Cell Significance Index: 0.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1340
    Cell Significance Index: 38.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1302
    Cell Significance Index: 1.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0954
    Cell Significance Index: 12.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0750
    Cell Significance Index: 9.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0608
    Cell Significance Index: 0.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0528
    Cell Significance Index: 0.7200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0413
    Cell Significance Index: 0.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0329
    Cell Significance Index: 2.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0259
    Cell Significance Index: 0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0054
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0123
    Cell Significance Index: -23.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0126
    Cell Significance Index: -23.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0152
    Cell Significance Index: -23.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0201
    Cell Significance Index: -0.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0277
    Cell Significance Index: -0.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0359
    Cell Significance Index: -0.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0361
    Cell Significance Index: -22.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0389
    Cell Significance Index: -8.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0518
    Cell Significance Index: -23.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0520
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0604
    Cell Significance Index: -6.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0771
    Cell Significance Index: -1.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0830
    Cell Significance Index: -3.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1194
    Cell Significance Index: -2.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1483
    Cell Significance Index: -9.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1532
    Cell Significance Index: -3.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1549
    Cell Significance Index: -22.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1841
    Cell Significance Index: -3.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1928
    Cell Significance Index: -4.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2079
    Cell Significance Index: -5.9600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2117
    Cell Significance Index: -3.0400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2131
    Cell Significance Index: -3.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2260
    Cell Significance Index: -7.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2262
    Cell Significance Index: -23.5500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2507
    Cell Significance Index: -3.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2833
    Cell Significance Index: -22.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2850
    Cell Significance Index: -2.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2858
    Cell Significance Index: -4.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2954
    Cell Significance Index: -18.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2973
    Cell Significance Index: -8.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3046
    Cell Significance Index: -8.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PILRB is a type of receptor that belongs to the paired immunoglobulin-like family. It is characterized by its high degree of sequence homology with other members of this family, which are known to play roles in immune regulation. The PILRB protein is a transmembrane receptor that contains a tyrosine kinase domain, which is essential for its signaling function. Its expression is widespread in various tissues, including the immune system, epithelial tissues, and neurons. **Pathways and Functions:** The PILRB gene is involved in several key pathways, including: 1. **Activation of transmembrane receptor protein tyrosine kinase activity**: PILRB is a receptor tyrosine kinase that can activate downstream signaling pathways upon binding to its ligands. 2. **Adaptive immune system**: PILRB plays a role in regulating the adaptive immune response by modulating the activity of immune cells, such as natural killer cells and T cells. 3. **Immunoregulatory interactions between a lymphoid and a non-lymphoid cell**: PILRB is involved in regulating the interactions between immune cells and non-immune cells, such as epithelial cells and neurons. 4. **MHC class I protein binding**: PILRB can bind to MHC class I proteins, which is essential for its function in regulating the adaptive immune response. **Clinical Significance:** The PILRB gene has been implicated in several diseases, including: 1. **Autoimmune disorders**: PILRB has been shown to play a role in regulating the adaptive immune response, and its dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: PILRB has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, and its expression has been associated with poor prognosis. 3. **Neurological disorders**: PILRB has been implicated in several neurological disorders, including Alzheimer's disease and Parkinson's disease, where its expression is altered. In conclusion, the PILRB gene is a complex gene that plays a crucial role in regulating the adaptive immune system and modulating the interactions between immune cells and non-immune cells. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the functions and clinical significance of this gene. **Recommendations:** 1. Further studies are needed to fully understand the mechanisms by which PILRB regulates the adaptive immune response. 2. The development of therapeutic strategies targeting PILRB may provide new avenues for the treatment of autoimmune disorders and cancer. 3. The study of PILRB's role in neurological disorders may provide insights into the underlying mechanisms of these diseases and lead to the development of new treatments. **Limitations:** The current understanding of PILRB is based on a limited number of studies, and further research is needed to fully elucidate its functions and clinical significance. Additionally, the expression of PILRB in different tissues and cell types may be influenced by various factors, including age, sex, and disease status, which should be taken into account when studying its role in disease.

Genular Protein ID: 3723965327

Symbol: PILRB_HUMAN

Name: Paired immunoglobulin-like type 2 receptor beta

UniProtKB Accession Codes:

Q9UKJ0 Q69YF9 Q9HBS0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10660620

Title: PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta.

PubMed ID: 10660620

DOI: 10.1074/jbc.275.6.4467

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 227
  • Mass: 25542
  • Checksum: 7FF960C60AB7EF09
  • Sequence:
    • MGRPLLLPLL LLLQPPAFLQ PGGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE 
LAIVPNVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQESGFL RISNLRKEDQ 
SVYFCRVELD TRRSGRQQLQ SIKGTKLTIT QAVTTTTTWR PSSTTTIAGL RVTESKGHSE 
SWHLSLDTAI RVALAVAVLK TVILGLLCLL LLWWRRRKGS RAPSSDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.