Details for: HADH

Gene ID: 3033

Symbol: HADH

Ensembl ID: ENSG00000138796

Description: hydroxyacyl-CoA dehydrogenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.7898
    Cell Significance Index: -26.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.6605
    Cell Significance Index: -24.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.3785
    Cell Significance Index: -36.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.3587
    Cell Significance Index: -28.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.0011
    Cell Significance Index: -33.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.8097
    Cell Significance Index: -36.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.6051
    Cell Significance Index: -29.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.4973
    Cell Significance Index: -32.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1876
    Cell Significance Index: -29.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5833
    Cell Significance Index: -33.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3748
    Cell Significance Index: -19.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5685
    Cell Significance Index: -7.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.8706
    Cell Significance Index: 46.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5427
    Cell Significance Index: 296.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9751
    Cell Significance Index: 321.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5877
    Cell Significance Index: 17.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5614
    Cell Significance Index: 81.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2643
    Cell Significance Index: 18.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1539
    Cell Significance Index: 1041.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0227
    Cell Significance Index: 184.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0044
    Cell Significance Index: 21.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9716
    Cell Significance Index: 67.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9644
    Cell Significance Index: 74.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9545
    Cell Significance Index: 19.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8958
    Cell Significance Index: 63.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8808
    Cell Significance Index: 22.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8163
    Cell Significance Index: 22.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8097
    Cell Significance Index: 99.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8064
    Cell Significance Index: 440.4200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.7997
    Cell Significance Index: 10.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7835
    Cell Significance Index: 7.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7229
    Cell Significance Index: 143.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7114
    Cell Significance Index: 142.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6941
    Cell Significance Index: 32.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6854
    Cell Significance Index: 88.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6800
    Cell Significance Index: 80.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6672
    Cell Significance Index: 66.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6458
    Cell Significance Index: 14.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6364
    Cell Significance Index: 8.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5076
    Cell Significance Index: 69.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4795
    Cell Significance Index: 22.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4681
    Cell Significance Index: 89.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4615
    Cell Significance Index: 14.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4605
    Cell Significance Index: 12.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4555
    Cell Significance Index: 163.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4406
    Cell Significance Index: 19.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4381
    Cell Significance Index: 10.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4167
    Cell Significance Index: 26.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4143
    Cell Significance Index: 183.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3361
    Cell Significance Index: 11.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3186
    Cell Significance Index: 40.8400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.3053
    Cell Significance Index: 0.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3009
    Cell Significance Index: 8.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3006
    Cell Significance Index: 16.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2780
    Cell Significance Index: 4.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1962
    Cell Significance Index: 33.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1787
    Cell Significance Index: 4.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1268
    Cell Significance Index: 87.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0857
    Cell Significance Index: 3.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0625
    Cell Significance Index: 1.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0615
    Cell Significance Index: 4.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0465
    Cell Significance Index: 2.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0349
    Cell Significance Index: 65.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0286
    Cell Significance Index: 20.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0124
    Cell Significance Index: 9.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0080
    Cell Significance Index: 3.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0027
    Cell Significance Index: 0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0051
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0060
    Cell Significance Index: -3.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0073
    Cell Significance Index: -11.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -14.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0138
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0176
    Cell Significance Index: -23.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0293
    Cell Significance Index: -2.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0376
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0433
    Cell Significance Index: -9.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0732
    Cell Significance Index: -10.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0870
    Cell Significance Index: -25.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1256
    Cell Significance Index: -3.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1269
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1339
    Cell Significance Index: -15.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1787
    Cell Significance Index: -14.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1865
    Cell Significance Index: -4.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2005
    Cell Significance Index: -13.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2143
    Cell Significance Index: -3.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2217
    Cell Significance Index: -23.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2272
    Cell Significance Index: -10.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2507
    Cell Significance Index: -2.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2700
    Cell Significance Index: -17.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2778
    Cell Significance Index: -10.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3002
    Cell Significance Index: -8.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3042
    Cell Significance Index: -34.7200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3152
    Cell Significance Index: -2.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3379
    Cell Significance Index: -17.7400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3495
    Cell Significance Index: -5.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3567
    Cell Significance Index: -21.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3711
    Cell Significance Index: -10.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4434
    Cell Significance Index: -6.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HADH is a mitochondrial enzyme that belongs to the alpha-ketoglutarate dehydrogenase complex. It is a tetrameric enzyme composed of four subunits, each consisting of a hydroxyacyl-CoA dehydrogenase domain, a dihydrolipoyl transacetylase domain, and a dihydrolipoyl dehydrogenase domain. HADH is responsible for the oxidation of hydroxyacyl-CoA, a key intermediate in the beta-oxidation of fatty acids. **Pathways and Functions:** HADH is involved in several key pathways, including: 1. **Beta-oxidation of fatty acids:** HADH catalyzes the oxidation of hydroxyacyl-CoA, a critical step in the breakdown of fatty acids in the mitochondria. 2. **Fatty acid metabolism:** HADH plays a role in the regulation of fatty acid metabolism, including the synthesis and degradation of fatty acids. 3. **Mitochondrial function:** HADH is essential for the proper functioning of mitochondria, which are the primary site of fatty acid oxidation. **Clinical Significance:** Dysregulation of HADH has been implicated in various diseases, including: 1. **Metabolic disorders:** HADH deficiency has been linked to metabolic disorders, such as fatty acid oxidation disorders and metabolic syndrome. 2. **Cancer:** HADH has been shown to play a role in the regulation of cancer cell growth and metabolism. 3. **Neurological disorders:** HADH has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells:** HADH is expressed in various cell types, including: 1. **Pre-B cells:** HADH is expressed in pre-B cells, which are a type of lymphoid progenitor cell. 2. **Enterocytes:** HADH is expressed in enterocytes, which are cells that line the small intestine. 3. **Endocrine cells:** HADH is expressed in endocrine cells, which are cells that produce hormones. 4. **Stem cells:** HADH is expressed in stem cells, which are cells that have the ability to differentiate into multiple cell types. **Proteins:** HADH has several homologs, including B3KTT6, which is a protein that shares a high degree of sequence similarity with HADH. In conclusion, HADH is a critical enzyme that plays a vital role in fatty acid metabolism and mitochondrial function. Its dysregulation has been implicated in various diseases, including metabolic disorders, cancer, and neurological disorders. Further research into the role of HADH in immunology and molecular biology is necessary to fully understand its significance in human health and disease.

Genular Protein ID: 1347108401

Symbol: HCDH_HUMAN

Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8687463

Title: Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.

PubMed ID: 8687463

DOI: 10.1006/bbrc.1996.0961

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 10231530

Title: Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism.

PubMed ID: 10231530

DOI: 10.1021/bi9829027

PubMed ID: 10840044

Title: Sequestration of the active site by interdomain shifting. Crystallographic and spectroscopic evidence for distinct conformations of L-3-hydroxyacyl-CoA dehydrogenase.

PubMed ID: 10840044

DOI: 10.1074/jbc.m004669200

PubMed ID: 16176262

Title: 3-hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease.

PubMed ID: 16176262

DOI: 10.1111/j.1742-4658.2005.04911.x

PubMed ID: 11489939

Title: Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion.

PubMed ID: 11489939

DOI: 10.1172/jci11294

PubMed ID: 16725361

Title: Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase.

PubMed ID: 16725361

DOI: 10.1016/j.ymgme.2006.04.004

Sequence Information:

  • Length: 314
  • Mass: 34294
  • Checksum: 0C6F7C01BBCE646A
  • Sequence:
  • MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE 
    DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI ATSTDAASVV HSTDLVVEAI 
    VENLKVKNEL FKRLDKFAAE HTIFASNTSS LQITSIANAT TRQDRFAGLH FFNPVPVMKL 
    VEVIKTPMTS QKTFESLVDF SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERGDAS 
    KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFIVDGWHEM DAENPLHQPS PSLNKLVAEN 
    KFGKKTGEGF YKYK

Genular Protein ID: 1726570359

Symbol: B3KTT6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 318
  • Mass: 35221
  • Checksum: F1BEB5F4ED620D9C
  • Sequence:
  • MCRTALGVTT LQDLGVCWRK EHDPAEMLRV GRAELGGWKP SWEAIVKEVA AATGHTVVLV 
    DQTEDILAKS KKGIEESLRK VAKKKFAENP KAGDEFVEKT LSTIATSTDA ASVVHSTDLV 
    VEAIVENLKV KNELFKRLDK FAAEHTIFAS NTSSLQITSI ANATTRQDRF AGLHFFNPVP 
    VMKLVEVIKT PMTSQKTFES LVDFSKALGK HPVSCKDTPG FIVNRLLVPY LMEAIRLYER 
    GDASKEDIDT AMKLGAGYPM GPFELLDYVG LDTTKFIVDG WHEMDAENPL HQPSPSLNKL 
    VAENKFGKKT GEGFYKYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.