Details for: HADH

Gene ID: 3033

Symbol: HADH

Ensembl ID: ENSG00000138796

Description: hydroxyacyl-CoA dehydrogenase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.02
    Marker Score: 2030
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.96
    Marker Score: 9418
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.87
    Marker Score: 968
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.84
    Marker Score: 2837
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.81
    Marker Score: 5676
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.8
    Marker Score: 4275.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.78
    Marker Score: 4843
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.71
    Marker Score: 836
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.67
    Marker Score: 1739
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.61
    Marker Score: 889
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.6
    Marker Score: 5683.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.56
    Marker Score: 3564.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.56
    Marker Score: 6382
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.52
    Marker Score: 1430
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.51
    Marker Score: 2225
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.48
    Marker Score: 1001
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.45
    Marker Score: 2082.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.44
    Marker Score: 2998
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.43
    Marker Score: 9327.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.43
    Marker Score: 799
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.42
    Marker Score: 1535
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.36
    Marker Score: 30462
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.35
    Marker Score: 507
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.33
    Marker Score: 1001
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.32
    Marker Score: 3107
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.32
    Marker Score: 1391
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.31
    Marker Score: 3554.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.28
    Marker Score: 1372
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.27
    Marker Score: 3399
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.24
    Marker Score: 43068
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.23
    Marker Score: 16171
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.22
    Marker Score: 2778
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.22
    Marker Score: 2077
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.22
    Marker Score: 766
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.2
    Marker Score: 7141
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.2
    Marker Score: 341
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.2
    Marker Score: 10449
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.2
    Marker Score: 7666
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.19
    Marker Score: 577
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2789
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.18
    Marker Score: 1483
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18382
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.16
    Marker Score: 1236
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.16
    Marker Score: 1643
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.13
    Marker Score: 358
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.12
    Marker Score: 3311
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.11
    Marker Score: 388
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.1
    Marker Score: 4065
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.1
    Marker Score: 1459
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.1
    Marker Score: 1693
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.09
    Marker Score: 728
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.09
    Marker Score: 792
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.08
    Marker Score: 347
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.07
    Marker Score: 591
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.06
    Marker Score: 1709.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.06
    Marker Score: 7880
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.06
    Marker Score: 556
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.05
    Marker Score: 26865
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.03
    Marker Score: 9802.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.02
    Marker Score: 37690
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.02
    Marker Score: 1014
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.01
    Marker Score: 1073
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.01
    Marker Score: 10162.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.01
    Marker Score: 1894
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1
    Marker Score: 61506
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71660
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47883
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.99
    Marker Score: 953
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.99
    Marker Score: 286
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.99
    Marker Score: 531
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.99
    Marker Score: 414
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.98
    Marker Score: 524
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.98
    Marker Score: 3802
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30383
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.97
    Marker Score: 8354.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.97
    Marker Score: 236
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.96
    Marker Score: 3774
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.96
    Marker Score: 653
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.96
    Marker Score: 4132
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.96
    Marker Score: 2101
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.95
    Marker Score: 446
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.95
    Marker Score: 301
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.94
    Marker Score: 311
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.94
    Marker Score: 221
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.94
    Marker Score: 1641
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2392
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.94
    Marker Score: 328
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.94
    Marker Score: 3883
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.94
    Marker Score: 270
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.93
    Marker Score: 1531
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.93
    Marker Score: 269
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.93
    Marker Score: 1478
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.92
    Marker Score: 6029
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.92
    Marker Score: 666
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5219
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.91
    Marker Score: 372.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1480
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.91
    Marker Score: 450

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary The HADH gene encodes for a protein called hydroxyacyl-CoA dehydrogenase, which is involved in the beta-oxidation of various fatty acids. This enzyme plays a crucial role in the metabolism of fatty acids in the mitochondria of cells. ## Key characteristics * The HADH gene is located on chromosome 15q21.1. * It is a large gene with a length of approximately 13.7 kb. * The protein encoded by the HADH gene is a transmembrane protein with a molecular weight of approximately 150 kDa. * The enzyme is highly expressed in the liver, heart, skeletal muscle, and adipose tissue. * It is also expressed in small amounts in other tissues, including the small intestine, colon, and lung. ## Pathways and functions The HADH enzyme participates in multiple metabolic pathways, including: * Beta oxidation of butanoyl-CoA, decanoyl-CoA, hexanoyl-CoA, and lauroyl-CoA to acetyl-CoA. * Fatty acid beta-oxidation of saturated fatty acids. * The metabolism of proteins. The enzyme also plays a role in the response to xenobiotic stimuli, as it is involved in the degradation of fatty acids in the liver. ## Clinical significance Mutations in the HADH gene have been linked to several human diseases, including: * Non-alcoholic fatty liver disease (NAFLD): A progressive liver disease characterized by the accumulation of fat in the liver. * Obesity: The HADH enzyme is involved in the metabolism of fatty acids, and studies have shown that mutations in the HADH gene can lead to obesity. * Hyperlipidemia: The HADH enzyme is involved in the metabolism of fatty acids, and mutations in the HADH gene can lead to hyperlipidemia, a condition in which the blood contains high levels of cholesterol and triglycerides. The development of drugs that target the HADH enzyme is an active area of research, as it could provide a new therapeutic strategy for the treatment of liver diseases and metabolic disorders.

Genular Protein ID: 1347108401

Symbol: HCDH_HUMAN

Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

UniProtKB Accession Codes:

Q16836 J3KQ17 O00324 O00397 O00753 Q4W5B4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 30 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 12 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8687463

Title: Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.

PubMed ID: 8687463

DOI: 10.1006/bbrc.1996.0961

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 10231530

Title: Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism.

PubMed ID: 10231530

DOI: 10.1021/bi9829027

PubMed ID: 10840044

Title: Sequestration of the active site by interdomain shifting. Crystallographic and spectroscopic evidence for distinct conformations of L-3-hydroxyacyl-CoA dehydrogenase.

PubMed ID: 10840044

DOI: 10.1074/jbc.m004669200

PubMed ID: 16176262

Title: 3-hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease.

PubMed ID: 16176262

DOI: 10.1111/j.1742-4658.2005.04911.x

PubMed ID: 11489939

Title: Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion.

PubMed ID: 11489939

DOI: 10.1172/jci11294

PubMed ID: 16725361

Title: Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase.

PubMed ID: 16725361

DOI: 10.1016/j.ymgme.2006.04.004

Sequence Information:

  • Length: 314
  • Mass: 34294
  • Checksum: 0C6F7C01BBCE646A
  • Sequence:
    • MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE 
DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI ATSTDAASVV HSTDLVVEAI 
VENLKVKNEL FKRLDKFAAE HTIFASNTSS LQITSIANAT TRQDRFAGLH FFNPVPVMKL 
VEVIKTPMTS QKTFESLVDF SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERGDAS 
KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFIVDGWHEM DAENPLHQPS PSLNKLVAEN 
KFGKKTGEGF YKYK

Genular Protein ID: 1726570359

Symbol: B3KTT6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KTT6

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 8 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 318
  • Mass: 35221
  • Checksum: F1BEB5F4ED620D9C
  • Sequence:
    • MCRTALGVTT LQDLGVCWRK EHDPAEMLRV GRAELGGWKP SWEAIVKEVA AATGHTVVLV 
DQTEDILAKS KKGIEESLRK VAKKKFAENP KAGDEFVEKT LSTIATSTDA ASVVHSTDLV 
VEAIVENLKV KNELFKRLDK FAAEHTIFAS NTSSLQITSI ANATTRQDRF AGLHFFNPVP 
VMKLVEVIKT PMTSQKTFES LVDFSKALGK HPVSCKDTPG FIVNRLLVPY LMEAIRLYER 
GDASKEDIDT AMKLGAGYPM GPFELLDYVG LDTTKFIVDG WHEMDAENPL HQPSPSLNKL 
VAENKFGKKT GEGFYKYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.