Details for: HEXB

Gene ID: 3074

Symbol: HEXB

Ensembl ID: ENSG00000049860

Description: hexosaminidase subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.58
    Marker Score: 66101
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.19
    Marker Score: 8623
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.19
    Marker Score: 2506.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.92
    Marker Score: 107528
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.91
    Marker Score: 2309
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.86
    Marker Score: 1025
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.85
    Marker Score: 11249
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.8
    Marker Score: 4707
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.75
    Marker Score: 1819
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.69
    Marker Score: 675
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.68
    Marker Score: 3832
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.66
    Marker Score: 693
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.65
    Marker Score: 4118
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.63
    Marker Score: 4228
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.59
    Marker Score: 6865
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.58
    Marker Score: 785
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.57
    Marker Score: 1600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.49
    Marker Score: 943
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.47
    Marker Score: 3501
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.47
    Marker Score: 2019.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166037
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.42
    Marker Score: 6826
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.39
    Marker Score: 345
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.38
    Marker Score: 46983
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.38
    Marker Score: 644
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.37
    Marker Score: 345
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.37
    Marker Score: 780
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.36
    Marker Score: 498
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.36
    Marker Score: 1361
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.34
    Marker Score: 556
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.33
    Marker Score: 329
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2039
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.32
    Marker Score: 3222
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.32
    Marker Score: 1173.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.31
    Marker Score: 2966
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.3
    Marker Score: 4080
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.3
    Marker Score: 2527
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.28
    Marker Score: 516
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.27
    Marker Score: 44028
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.26
    Marker Score: 11837
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.26
    Marker Score: 289
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.25
    Marker Score: 355
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.24
    Marker Score: 10666
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.24
    Marker Score: 11782
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.24
    Marker Score: 392
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.24
    Marker Score: 75985
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.2
    Marker Score: 13997
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.2
    Marker Score: 504
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2
    Marker Score: 1771
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.19
    Marker Score: 1717
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.18
    Marker Score: 483
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.18
    Marker Score: 8780
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.18
    Marker Score: 369
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2770
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.16
    Marker Score: 4824
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.16
    Marker Score: 335
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.15
    Marker Score: 1344
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.13
    Marker Score: 538
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.13
    Marker Score: 4347
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.12
    Marker Score: 1082
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.11
    Marker Score: 2219
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.09
    Marker Score: 755
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.09
    Marker Score: 260
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.08
    Marker Score: 1206
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.08
    Marker Score: 743
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.08
    Marker Score: 1971
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.07
    Marker Score: 2261
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.07
    Marker Score: 345
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.07
    Marker Score: 1747
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.06
    Marker Score: 253
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.06
    Marker Score: 2703
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.06
    Marker Score: 904
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.06
    Marker Score: 4093
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.05
    Marker Score: 993
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.04
    Marker Score: 10772
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.04
    Marker Score: 607
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Marker Score: 695
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.04
    Marker Score: 1118
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.04
    Marker Score: 1280
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.03
    Marker Score: 251
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.03
    Marker Score: 419
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.03
    Marker Score: 1745
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.03
    Marker Score: 258
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.03
    Marker Score: 38968
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.02
    Marker Score: 1870
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.02
    Marker Score: 15271
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 692
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.01
    Marker Score: 908
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.01
    Marker Score: 7735
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1
    Marker Score: 259
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1
    Marker Score: 662
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71585
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47810
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.99
    Marker Score: 711
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.99
    Marker Score: 223
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.99
    Marker Score: 1318
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.99
    Marker Score: 253
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.98
    Marker Score: 369
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30367
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.98
    Marker Score: 611

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Other Information

**Key characteristics:** - Gene name: HEXB - Ensembl ID: ENSG00000049860 - Protein: HEXB_HUMAN (Beta-N-acetylhexosaminidase subunit beta) - Protein length: 107 amino acids - Protein function: Degradation of glycoproteins and glycolipids in the lysosome **Pathways and functions:** - Chondroitin sulfate/dermatan sulfate metabolism - Cs/ds degradation - Defective hexb causes gm2g2 - Disease, Diseases associated with glycosaminoglycan metabolism - Diseases of glycosylation - Diseases of metabolism - Glycosaminoglycan metabolism - Glycosphingolipid metabolism - Hyaluronan metabolism - Hyaluronan uptake and degradation - Immune system - Innate immune system - Keratan sulfate/keratin metabolism - Keratan sulfate degradation - Metabolism - Metabolism of carbohydrates - Metabolism of lipids **Clinical significance:** - Mutations in the HEXB gene have been linked to several diseases, including galactosemia, which is caused by a deficiency in the HEXB protein. - HexB deficiency can lead to the accumulation of glycoproteins and glycolipids in the lysosome, resulting in tissue damage and disease. - The HEXB gene is also involved in the regulation of inflammation, as it is expressed in immune cells and is involved in the degradation of inflammatory mediators.

Genular Protein ID: 1545538541

Symbol: HEXB_HUMAN

Name: Beta-N-acetylhexosaminidase subunit beta

UniProtKB Accession Codes:

P07686

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 1 ELM 1 EMBL 20 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 8 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 10 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3013851

Title: Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

PubMed ID: 3013851

DOI: 10.1016/s0021-9258(19)83927-3

PubMed ID: 2977375

Title: Characterization of the human HEXB gene encoding lysosomal beta-hexosaminidase.

PubMed ID: 2977375

DOI: 10.1016/0888-7543(88)90116-4

PubMed ID: 2964638

Title: Gene encoding the human beta-hexosaminidase beta chain: extensive homology of intron placement in the alpha- and beta-chain genes.

PubMed ID: 2964638

DOI: 10.1073/pnas.85.6.1883

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2971039

Title: Synthesis and assembly of a catalytically active lysosomal enzyme, beta-hexosaminidase B, in a cell-free system.

PubMed ID: 2971039

DOI: 10.1016/s0021-9258(18)37728-7

PubMed ID: 2147427

Title: Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase.

PubMed ID: 2147427

DOI: 10.1016/s0021-9258(17)45286-0

PubMed ID: 2966076

Title: Localization of the pro-sequence within the total deduced primary structure of human beta-hexosaminidase B.

PubMed ID: 2966076

DOI: 10.1016/0014-5793(88)80699-9

PubMed ID: 2139028

Title: Characterization of human placental beta-hexosaminidase I2. Proteolytic processing intermediates of hexosaminidase A.

PubMed ID: 2139028

DOI: 10.1016/s0021-9258(19)39219-1

PubMed ID: 2525487

Title: The amino-terminal sequences in the pro-alpha and -beta polypeptides of human lysosomal beta-hexosaminidase A and B are retained in the mature isozymes.

PubMed ID: 2525487

DOI: 10.1016/0014-5793(89)80649-0

PubMed ID: 2965147

Title: Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.

PubMed ID: 2965147

DOI: 10.1016/s0021-9258(18)68826-x

PubMed ID: 2579389

Title: Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase.

PubMed ID: 2579389

DOI: 10.1073/pnas.82.4.1184

PubMed ID: 2971395

Title: Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase.

PubMed ID: 2971395

DOI: 10.1021/bi00414a041

PubMed ID: 8123671

Title: Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.

PubMed ID: 8123671

DOI: 10.1016/0304-4165(94)90118-x

PubMed ID: 8672428

Title: Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A.

PubMed ID: 8672428

DOI: 10.1021/bi9524575

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 11329289

Title: Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B.

PubMed ID: 11329289

DOI: 10.1021/bi002018s

PubMed ID: 11447134

Title: Complete analysis of the glycosylation and disulfide bond pattern of human beta-hexosaminidase B by MALDI-MS.

PubMed ID: 11447134

DOI: 10.1093/glycob/11.7.549

PubMed ID: 11707436

Title: Physiological substrates for human lysosomal beta -hexosaminidase S.

PubMed ID: 11707436

DOI: 10.1074/jbc.m105457200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8673609

Title: Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.

PubMed ID: 8673609

DOI: 10.1038/nsb0796-638

PubMed ID: 12662933

Title: Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.

PubMed ID: 12662933

DOI: 10.1016/s0022-2836(03)00216-x

PubMed ID: 12706724

Title: The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease.

PubMed ID: 12706724

DOI: 10.1016/s0022-2836(03)00311-5

PubMed ID: 1825792

Title: The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis.

PubMed ID: 1825792

DOI: 10.1016/0925-4439(91)90044-a

PubMed ID: 1720305

Title: Molecular basis of an adult form of beta-hexosaminidase B deficiency with motor neuron disease.

PubMed ID: 1720305

DOI: 10.1016/s0006-291x(05)81388-9

PubMed ID: 1531140

Title: A novel exon mutation in the human beta-hexosaminidase beta subunit gene affects 3' splice site selection.

PubMed ID: 1531140

DOI: 10.1016/s0021-9258(18)45894-2

PubMed ID: 8357844

Title: Molecular basis of an adult form of Sandhoff disease: substitution of glutamine for arginine at position 505 of the beta-chain of beta-hexosaminidase results in a labile enzyme.

PubMed ID: 8357844

DOI: 10.1016/0925-4439(93)90134-m

PubMed ID: 7626071

Title: A novel missense mutation (C522Y) is present in the beta-hexosaminidase beta-subunit gene of a Japanese patient with infantile Sandhoff disease.

PubMed ID: 7626071

DOI: 10.1006/bbrc.1995.2007

PubMed ID: 7557963

Title: A common beta hexosaminidase gene mutation in adult Sandhoff disease patients.

PubMed ID: 7557963

DOI: 10.1007/bf00191799

PubMed ID: 7633435

Title: A second, large deletion in the HEXB gene in a patient with infantile Sandhoff disease.

PubMed ID: 7633435

DOI: 10.1093/hmg/4.4.777

PubMed ID: 8950198

Title: Significance of two point mutations present in each HEXB allele of patients with adult GM2 gangliosidosis (Sandhoff disease) homozygosity for the Ile207-->Val substitution is not associated with a clinical or biochemical phenotype.

PubMed ID: 8950198

DOI: 10.1016/s0925-4439(96)00044-0

PubMed ID: 9401004

Title: Molecular basis of heat labile hexosaminidase B among Jews and Arabs.

PubMed ID: 9401004

DOI: 10.1002/(sici)1098-1004(1997)10:6<424::aid-humu2>3.0.co;2-d

PubMed ID: 9856491

Title: Two mutations remote from an exon/intron junction in the beta-hexosaminidase beta-subunit gene affect 3'-splice site selection and cause Sandhoff disease.

PubMed ID: 9856491

DOI: 10.1007/s004390050851

PubMed ID: 9694901

Title: A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease.

PubMed ID: 9694901

DOI: 10.1074/jbc.273.33.21386

Sequence Information:

  • Length: 556
  • Mass: 63137
  • Checksum: 2267BF1453EA50EF
  • Sequence:
    • MELCGLGLPR PPMLLALLLA TLLAAMLALL TQVALVVQVA EAARAPSVSA KPGPALWPLP 
LLVKMTPNLL HLAPENFYIS HSPNSTAGPS CTLLEEAFRR YHGYIFGFYK WHHEPAEFQA 
KTQVQQLLVS ITLQSECDAF PNISSDESYT LLVKEPVAVL KANRVWGALR GLETFSQLVY 
QDSYGTFTIN ESTIIDSPRF SHRGILIDTS RHYLPVKIIL KTLDAMAFNK FNVLHWHIVD 
DQSFPYQSIT FPELSNKGSY SLSHVYTPND VRMVIEYARL RGIRVLPEFD TPGHTLSWGK 
GQKDLLTPCY SRQNKLDSFG PINPTLNTTY SFLTTFFKEI SEVFPDQFIH LGGDEVEFKC 
WESNPKIQDF MRQKGFGTDF KKLESFYIQK VLDIIATINK GSIVWQEVFD DKAKLAPGTI 
VEVWKDSAYP EELSRVTASG FPVILSAPWY LDLISYGQDW RKYYKVEPLD FGGTQKQKQL 
FIGGEACLWG EYVDATNLTP RLWPRASAVG ERLWSSKDVR DMDDAYDRLT RHRCRMVERG 
IAAQPLYAGY CNHENM

Genular Protein ID: 1225928075

Symbol: A0A024RAJ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RAJ6

Database IDs:

ARBA 13 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 Pfam 4 RefSeq 1 Rhea 10 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 556
  • Mass: 63111
  • Checksum: B3A0A36594F62536
  • Sequence:
    • MELCGLGLPR PPMLLALLLA TLLAAMLALL TQVALVVQVA EAARAPSVSA KPGPALWPLP 
LSVKMTPNLL HLAPENFYIS HSPNSTAGPS CTLLEEAFRR YHGYIFGFYK WHHEPAEFQA 
KTQVQQLLVS ITLQSECDAF PNISSDESYT LLVKEPVAVL KANRVWGALR GLETFSQLVY 
QDSYGTFTIN ESTIIDSPRF SHRGILIDTS RHYLPVKIIL KTLDAMAFNK FNVLHWHIVD 
DQSFPYQSIT FPELSNKGSY SLSHVYTPND VRMVIEYARL RGIRVLPEFD TPGHTLSWGK 
GQKDLLTPCY SRQNKLDSFG PINPTLNTTY SFLTTFFKEI SEVFPDQFIH LGGDEVEFKC 
WESNPKIQDF MRQKGFGTDF KKLESFYIQK VLDIIATINK GSIVWQEVFD DKAKLAPGTI 
VEVWKDSAYP EELSRVTASG FPVILSAPWY LDLISYGQDW RKYYKVEPLD FGGTQKQKQL 
FIGGEACLWG EYVDATNLTP RLWPRASAVG ERLWSSKDVR DMDDAYDRLT RHRCRMVERG 
IAAQPLYAGY CNHENM

Genular Protein ID: 995853522

Symbol: Q5URX0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5URX0

Database IDs:

ARBA 14 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 EC 1 EMBL 9 EPD 1 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 10 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15459180

Title: Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia.

PubMed ID: 15459180

DOI: 10.1093/hmg/ddh315

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 331
  • Mass: 38258
  • Checksum: 53040064142332FD
  • Sequence:
    • MAFNKFNVLH WHIVDDQSFP YQSITFPELS NKGSYSLSHV YTPNDVRMVI EYARLRGIRV 
LPEFDTPGHT LSWGKGQKDL LTPCYSRQNK LDSFGPINPT LNTTYSFLTT FFKEISEVFP 
DQFIHLGGDE VEFKCWESNP KIQDFMRQKG FGTDFKKLES FYIQKVLDII ATINKGSIVW 
QEVFDDKAKL APGTIVEVWK DSAYPEELSR VTASGFPVIL SAPWYLDLIS YGQDWRKYYK 
VEPLDFGGTQ KQKQLFIGGE ACLWGEYVDA TNLTPRLWPR ASAVGERLWS SKDVRDMDDA 
YDRLTRHRCR MVERGIAAQP LYAGYCNHEN M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.