Details for: CXXC1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 120.4794
Cell Significance Index: -18.7400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 73.4890
Cell Significance Index: -18.6400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.5991
Cell Significance Index: -20.1500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 45.6273
Cell Significance Index: -23.4700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 35.7961
Cell Significance Index: -24.0200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.2623
Cell Significance Index: -20.3000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.1921
Cell Significance Index: -22.4300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.7230
Cell Significance Index: -18.0100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.8869
Cell Significance Index: -23.2300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.1995
Cell Significance Index: -15.9700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.7330
Cell Significance Index: -8.1700 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.2065
Cell Significance Index: 35.4000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5933
Cell Significance Index: 259.1400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3391
Cell Significance Index: 1209.1300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9729
Cell Significance Index: 105.8200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8857
Cell Significance Index: 46.0100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5531
Cell Significance Index: 54.7100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5239
Cell Significance Index: 14.6400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4484
Cell Significance Index: 12.9200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4359
Cell Significance Index: 19.7600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4307
Cell Significance Index: 9.3300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4274
Cell Significance Index: 77.0600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4189
Cell Significance Index: 27.0300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3560
Cell Significance Index: 41.9800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3202
Cell Significance Index: 39.3700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3140
Cell Significance Index: 14.6400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3112
Cell Significance Index: 16.2100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3064
Cell Significance Index: 21.1900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3030
Cell Significance Index: 165.4500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2431
Cell Significance Index: 48.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2426
Cell Significance Index: 107.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2341
Cell Significance Index: 32.1500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2279
Cell Significance Index: 29.2200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2026
Cell Significance Index: 140.1500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1863
Cell Significance Index: 5.0700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1724
Cell Significance Index: 32.8000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1617
Cell Significance Index: 32.0800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1542
Cell Significance Index: 5.3600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1514
Cell Significance Index: 3.1700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1202
Cell Significance Index: 5.6500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1150
Cell Significance Index: 41.2400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1123
Cell Significance Index: 3.9500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.0988
Cell Significance Index: 1.5000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0965
Cell Significance Index: 2.5900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0651
Cell Significance Index: 3.4200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0522
Cell Significance Index: 8.9200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0512
Cell Significance Index: 3.6200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0494
Cell Significance Index: 0.7400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0169
Cell Significance Index: 0.5400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0118
Cell Significance Index: 1.5200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0036
Cell Significance Index: 0.2700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0019
Cell Significance Index: 0.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0011
Cell Significance Index: -2.0400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0053
Cell Significance Index: -9.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0108
Cell Significance Index: -16.6300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0146
Cell Significance Index: -0.3100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0152
Cell Significance Index: -11.1300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0162
Cell Significance Index: -22.0300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0171
Cell Significance Index: -12.9300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0197
Cell Significance Index: -12.4900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0296
Cell Significance Index: -3.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0297
Cell Significance Index: -22.0200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0332
Cell Significance Index: -15.0700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0347
Cell Significance Index: -0.5800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0399
Cell Significance Index: -22.5300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0430
Cell Significance Index: -26.8300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0434
Cell Significance Index: -1.1100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0459
Cell Significance Index: -2.8900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0613
Cell Significance Index: -1.6400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0639
Cell Significance Index: -18.4000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0824
Cell Significance Index: -9.6000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0901
Cell Significance Index: -2.3700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0919
Cell Significance Index: -2.7000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1042
Cell Significance Index: -11.9400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1085
Cell Significance Index: -1.1800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1090
Cell Significance Index: -15.8400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1221
Cell Significance Index: -3.5000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1269
Cell Significance Index: -26.7200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1387
Cell Significance Index: -10.6400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1511
Cell Significance Index: -9.2900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1573
Cell Significance Index: -10.5800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2131
Cell Significance Index: -22.1900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2330
Cell Significance Index: -5.8300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2498
Cell Significance Index: -19.7800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2556
Cell Significance Index: -4.3800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2976
Cell Significance Index: -4.0600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3062
Cell Significance Index: -17.1800 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3477
Cell Significance Index: -2.8400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3706
Cell Significance Index: -4.2100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3771
Cell Significance Index: -6.9700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3844
Cell Significance Index: -9.8800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3871
Cell Significance Index: -17.1200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3872
Cell Significance Index: -23.7400 - Cell Name: epidermal cell (CL0000362)
Fold Change: -0.3948
Cell Significance Index: -0.8900 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.4563
Cell Significance Index: -6.4000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4699
Cell Significance Index: -13.8400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4812
Cell Significance Index: -18.2200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4888
Cell Significance Index: -13.9500 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.5090
Cell Significance Index: -7.1400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5185
Cell Significance Index: -10.7600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3253324056
Symbol: CXXC1_HUMAN
Name: CXXC-type zinc finger protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10688657
Title: Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.
PubMed ID: 10688657
PubMed ID: 10799292
Title: PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis.
PubMed ID: 10799292
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16177791
Title: DNA sequence and analysis of human chromosome 18.
PubMed ID: 16177791
DOI: 10.1038/nature03983
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11572867
Title: Identification and characterization of the DNA binding domain of CpG-binding protein.
PubMed ID: 11572867
PubMed ID: 12200428
Title: CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals.
PubMed ID: 12200428
PubMed ID: 16253997
Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.
PubMed ID: 16253997
PubMed ID: 17355966
Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.
PubMed ID: 17355966
PubMed ID: 17998332
Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.
PubMed ID: 17998332
DOI: 10.1128/mcb.01356-07
PubMed ID: 18838538
Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
PubMed ID: 18838538
DOI: 10.1128/mcb.00976-08
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23178126
Title: Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.
PubMed ID: 23178126
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 21407193
Title: The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.
PubMed ID: 21407193
DOI: 10.1038/ncomms1237
Sequence Information:
- Length: 656
- Mass: 75712
- Checksum: 6D2376E449905A18
- Sequence:
MEGDGSDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDGNERDSS EPRDEGGGRK RPVPDPDLQR RAGSGTGVGA MLARGSASPH KSSPQPLVAT PSQHHQQQQQ QIKRSARMCG ECEACRRTED CGHCDFCRDM KKFGGPNKIR QKCRLRQCQL RARESYKYFP SSLSPVTPSE SLPRPRRPLP TQQQPQPSQK LGRIREDEGA VASSTVKEPP EATATPEPLS DEDLPLDPDL YQDFCAGAFD DHGLPWMSDT EESPFLDPAL RKRAVKVKHV KRREKKSEKK KEERYKRHRQ KQKHKDKWKH PERADAKDPA SLPQCLGPGC VRPAQPSSKY CSDDCGMKLA ANRIYEILPQ RIQQWQQSPC IAEEHGKKLL ERIRREQQSA RTRLQEMERR FHELEAIILR AKQQAVREDE ESNEGDSDDT DLQIFCVSCG HPINPRVALR HMERCYAKYE SQTSFGSMYP TRIEGATRLF CDVYNPQSKT YCKRLQVLCP EHSRDPKVPA DEVCGCPLVR DVFELTGDFC RLPKRQCNRH YCWEKLRRAE VDLERVRVWY KLDELFEQER NVRTAMTNRA GLLALMLHQT IQHDPLTTDL RSSADR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.