Details for: CXXC1

Gene ID: 30827

Symbol: CXXC1

Ensembl ID: ENSG00000154832

Description: CXXC finger protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.4794
    Cell Significance Index: -18.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.4890
    Cell Significance Index: -18.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.5991
    Cell Significance Index: -20.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.6273
    Cell Significance Index: -23.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.7961
    Cell Significance Index: -24.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.2623
    Cell Significance Index: -20.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1921
    Cell Significance Index: -22.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7230
    Cell Significance Index: -18.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8869
    Cell Significance Index: -23.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1995
    Cell Significance Index: -15.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7330
    Cell Significance Index: -8.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2065
    Cell Significance Index: 35.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5933
    Cell Significance Index: 259.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3391
    Cell Significance Index: 1209.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9729
    Cell Significance Index: 105.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8857
    Cell Significance Index: 46.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5531
    Cell Significance Index: 54.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5239
    Cell Significance Index: 14.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4484
    Cell Significance Index: 12.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4359
    Cell Significance Index: 19.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4307
    Cell Significance Index: 9.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4274
    Cell Significance Index: 77.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4189
    Cell Significance Index: 27.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3560
    Cell Significance Index: 41.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3202
    Cell Significance Index: 39.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3140
    Cell Significance Index: 14.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3112
    Cell Significance Index: 16.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3064
    Cell Significance Index: 21.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3030
    Cell Significance Index: 165.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2431
    Cell Significance Index: 48.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2426
    Cell Significance Index: 107.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2341
    Cell Significance Index: 32.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2279
    Cell Significance Index: 29.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2026
    Cell Significance Index: 140.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1863
    Cell Significance Index: 5.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1724
    Cell Significance Index: 32.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1617
    Cell Significance Index: 32.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1542
    Cell Significance Index: 5.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1514
    Cell Significance Index: 3.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1202
    Cell Significance Index: 5.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1150
    Cell Significance Index: 41.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1123
    Cell Significance Index: 3.9500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0988
    Cell Significance Index: 1.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0965
    Cell Significance Index: 2.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0651
    Cell Significance Index: 3.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0522
    Cell Significance Index: 8.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0512
    Cell Significance Index: 3.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0494
    Cell Significance Index: 0.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0169
    Cell Significance Index: 0.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0118
    Cell Significance Index: 1.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0036
    Cell Significance Index: 0.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0108
    Cell Significance Index: -16.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0146
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0162
    Cell Significance Index: -22.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0171
    Cell Significance Index: -12.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0197
    Cell Significance Index: -12.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0296
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0297
    Cell Significance Index: -22.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0332
    Cell Significance Index: -15.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0347
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0399
    Cell Significance Index: -22.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0430
    Cell Significance Index: -26.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0434
    Cell Significance Index: -1.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0459
    Cell Significance Index: -2.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0613
    Cell Significance Index: -1.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0639
    Cell Significance Index: -18.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0824
    Cell Significance Index: -9.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0901
    Cell Significance Index: -2.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0919
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1042
    Cell Significance Index: -11.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1085
    Cell Significance Index: -1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1090
    Cell Significance Index: -15.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1221
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1269
    Cell Significance Index: -26.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1387
    Cell Significance Index: -10.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1511
    Cell Significance Index: -9.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1573
    Cell Significance Index: -10.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2131
    Cell Significance Index: -22.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2330
    Cell Significance Index: -5.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2498
    Cell Significance Index: -19.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2556
    Cell Significance Index: -4.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2976
    Cell Significance Index: -4.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3062
    Cell Significance Index: -17.1800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3477
    Cell Significance Index: -2.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3706
    Cell Significance Index: -4.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3771
    Cell Significance Index: -6.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3844
    Cell Significance Index: -9.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3871
    Cell Significance Index: -17.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3872
    Cell Significance Index: -23.7400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3948
    Cell Significance Index: -0.8900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4563
    Cell Significance Index: -6.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4699
    Cell Significance Index: -13.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4812
    Cell Significance Index: -18.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4888
    Cell Significance Index: -13.9500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5090
    Cell Significance Index: -7.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5185
    Cell Significance Index: -10.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXXC1 is a member of the CXXC family of proteins, which are characterized by their CXXC finger domain. This domain is responsible for binding to specific DNA sequences and interacting with other proteins. The CXXC1 protein is a zinc finger protein, which means it has a zinc ion at its center, allowing it to bind to DNA and other molecules. The protein is also a histone methyltransferase, which means it can modify histones, the proteins that DNA wraps around to form chromatin. **Pathways and Functions** CXXC1 is involved in several cellular pathways, including: 1. **DNA damage response**: CXXC1 is activated in response to DNA damage and can recruit other proteins to repair the damage. 2. **Epigenetic regulation**: CXXC1 can modify histones, which can lead to changes in gene expression. 3. **Transcriptional control**: CXXC1 can bind to specific DNA sequences and regulate the transcription of genes involved in various cellular processes. 4. **Unfolded protein response**: CXXC1 is involved in the unfolded protein response, which is a cellular response to endoplasmic reticulum stress. 5. **Histone modification**: CXXC1 can modify histones, which can lead to changes in gene expression. **Clinical Significance** CXXC1 has been implicated in several diseases, including: 1. **Cancer**: CXXC1 has been found to be overexpressed in several types of cancer, including breast cancer and lung cancer. 2. **Neurological disorders**: CXXC1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Autoimmune diseases**: CXXC1 has been found to be involved in autoimmune diseases, including rheumatoid arthritis and lupus. 4. **Cardiovascular disease**: CXXC1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. In conclusion, CXXC1 is a gene that plays a critical role in various cellular processes, including DNA damage response, epigenetic regulation, and transcriptional control. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 3253324056

Symbol: CXXC1_HUMAN

Name: CXXC-type zinc finger protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10688657

Title: Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.

PubMed ID: 10688657

DOI: 10.1128/mcb.20.6.2108-2121.2000

PubMed ID: 10799292

Title: PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis.

PubMed ID: 10799292

DOI: 10.1006/bbrc.2000.2614

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11572867

Title: Identification and characterization of the DNA binding domain of CpG-binding protein.

PubMed ID: 11572867

DOI: 10.1074/jbc.m107179200

PubMed ID: 12200428

Title: CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals.

PubMed ID: 12200428

DOI: 10.1074/jbc.m205054200

PubMed ID: 16253997

Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.

PubMed ID: 16253997

DOI: 10.1074/jbc.m508312200

PubMed ID: 17355966

Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.

PubMed ID: 17355966

DOI: 10.1074/jbc.m609809200

PubMed ID: 17998332

Title: Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

PubMed ID: 17998332

DOI: 10.1128/mcb.01356-07

PubMed ID: 18838538

Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.

PubMed ID: 18838538

DOI: 10.1128/mcb.00976-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23178126

Title: Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.

PubMed ID: 23178126

DOI: 10.1016/j.cell.2012.10.043

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21407193

Title: The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain.

PubMed ID: 21407193

DOI: 10.1038/ncomms1237

Sequence Information:

  • Length: 656
  • Mass: 75712
  • Checksum: 6D2376E449905A18
  • Sequence:
  • MEGDGSDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF HGDCIRITEK 
    MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDGNERDSS EPRDEGGGRK RPVPDPDLQR 
    RAGSGTGVGA MLARGSASPH KSSPQPLVAT PSQHHQQQQQ QIKRSARMCG ECEACRRTED 
    CGHCDFCRDM KKFGGPNKIR QKCRLRQCQL RARESYKYFP SSLSPVTPSE SLPRPRRPLP 
    TQQQPQPSQK LGRIREDEGA VASSTVKEPP EATATPEPLS DEDLPLDPDL YQDFCAGAFD 
    DHGLPWMSDT EESPFLDPAL RKRAVKVKHV KRREKKSEKK KEERYKRHRQ KQKHKDKWKH 
    PERADAKDPA SLPQCLGPGC VRPAQPSSKY CSDDCGMKLA ANRIYEILPQ RIQQWQQSPC 
    IAEEHGKKLL ERIRREQQSA RTRLQEMERR FHELEAIILR AKQQAVREDE ESNEGDSDDT 
    DLQIFCVSCG HPINPRVALR HMERCYAKYE SQTSFGSMYP TRIEGATRLF CDVYNPQSKT 
    YCKRLQVLCP EHSRDPKVPA DEVCGCPLVR DVFELTGDFC RLPKRQCNRH YCWEKLRRAE 
    VDLERVRVWY KLDELFEQER NVRTAMTNRA GLLALMLHQT IQHDPLTTDL RSSADR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.