Details for: HGFAC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 14.4297
Cell Significance Index: -3.6600 - Cell Name: hepatoblast (CL0005026)
Fold Change: 6.3308
Cell Significance Index: 106.4800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 2.9685
Cell Significance Index: -3.6600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 2.5350
Cell Significance Index: 155.4200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.2725
Cell Significance Index: -2.7900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.8222
Cell Significance Index: 13.8500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8052
Cell Significance Index: 17.4500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5462
Cell Significance Index: 103.9500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5157
Cell Significance Index: 51.0200 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.4923
Cell Significance Index: 6.2400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4269
Cell Significance Index: 385.5000 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.3450
Cell Significance Index: 0.9100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.3348
Cell Significance Index: 5.0500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.3211
Cell Significance Index: 4.7400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.2701
Cell Significance Index: 5.9200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2669
Cell Significance Index: 95.7300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2598
Cell Significance Index: 51.5700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1423
Cell Significance Index: 15.4800 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.1341
Cell Significance Index: 0.5100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1114
Cell Significance Index: 18.1100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0835
Cell Significance Index: 5.7800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0576
Cell Significance Index: 0.8300 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.0517
Cell Significance Index: 0.6700 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.0399
Cell Significance Index: 0.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0379
Cell Significance Index: 10.9200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0325
Cell Significance Index: 1.6900 - Cell Name: helper T cell (CL0000912)
Fold Change: 0.0091
Cell Significance Index: 0.1300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0059
Cell Significance Index: 3.2100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0005
Cell Significance Index: 0.0300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0007
Cell Significance Index: -0.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0012
Cell Significance Index: -2.3100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0022
Cell Significance Index: -4.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0025
Cell Significance Index: -3.4300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0028
Cell Significance Index: -0.0700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0029
Cell Significance Index: -0.5900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0030
Cell Significance Index: -4.5800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0036
Cell Significance Index: -0.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0040
Cell Significance Index: -2.9600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0045
Cell Significance Index: -2.5700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0048
Cell Significance Index: -3.6400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0050
Cell Significance Index: -3.1900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0051
Cell Significance Index: -3.7600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0066
Cell Significance Index: -2.9800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0067
Cell Significance Index: -0.2400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0088
Cell Significance Index: -0.4000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0111
Cell Significance Index: -1.9000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0137
Cell Significance Index: -1.6800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0154
Cell Significance Index: -3.2400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0158
Cell Significance Index: -0.2200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0168
Cell Significance Index: -3.0200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0203
Cell Significance Index: -2.3600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0212
Cell Significance Index: -2.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0235
Cell Significance Index: -3.4200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0246
Cell Significance Index: -0.5900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0261
Cell Significance Index: -3.5900 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0267
Cell Significance Index: -0.4400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0299
Cell Significance Index: -0.6000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0316
Cell Significance Index: -0.8600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0331
Cell Significance Index: -3.3800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0346
Cell Significance Index: -3.6000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0367
Cell Significance Index: -1.7100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0400
Cell Significance Index: -2.6900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0476
Cell Significance Index: -3.7700 - Cell Name: myometrial cell (CL0002366)
Fold Change: -0.0495
Cell Significance Index: -0.5700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0507
Cell Significance Index: -1.0800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0519
Cell Significance Index: -3.9900 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0540
Cell Significance Index: -1.0600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0546
Cell Significance Index: -3.5200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0573
Cell Significance Index: -1.4300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0628
Cell Significance Index: -4.6800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0644
Cell Significance Index: -2.8500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0679
Cell Significance Index: -3.8100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0694
Cell Significance Index: -1.5000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0697
Cell Significance Index: -2.4400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0743
Cell Significance Index: -1.9900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0795
Cell Significance Index: -3.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0804
Cell Significance Index: -3.7800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0827
Cell Significance Index: -4.3400 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0868
Cell Significance Index: -1.7300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0879
Cell Significance Index: -1.8400 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0894
Cell Significance Index: -1.2400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0918
Cell Significance Index: -2.6200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0922
Cell Significance Index: -3.0200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0973
Cell Significance Index: -3.1000 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.1011
Cell Significance Index: -1.2300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1022
Cell Significance Index: -2.8600 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.1030
Cell Significance Index: -0.8500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1033
Cell Significance Index: -2.6500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1071
Cell Significance Index: -3.7200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1110
Cell Significance Index: -2.7700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.1122
Cell Significance Index: -1.8000 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1128
Cell Significance Index: -1.1700 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1150
Cell Significance Index: -2.9300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1196
Cell Significance Index: -4.3900 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1221
Cell Significance Index: -3.0500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1221
Cell Significance Index: -3.2600 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1248
Cell Significance Index: -2.5400 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1265
Cell Significance Index: -2.6400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1290
Cell Significance Index: -3.4500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1300
Cell Significance Index: -3.8300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1075879558
Symbol: HGFA_HUMAN
Name: Hepatocyte growth factor activator
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7683665
Title: Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII.
PubMed ID: 7683665
PubMed ID: 9874200
Title: Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene -- phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator.
PubMed ID: 9874200
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15340161
Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.
PubMed ID: 15340161
DOI: 10.1110/ps.04682504
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 15713485
Title: Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
PubMed ID: 15713485
PubMed ID: 18077410
Title: Structural insight into distinct mechanisms of protease inhibition by antibodies.
PubMed ID: 18077410
Sequence Information:
- Length: 655
- Mass: 70682
- Checksum: 2CF72F1E1B862ED7
- Sequence:
MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE YCRLEACESL TRVQLSPDLL ATLPEPASPG RQACGRRHKK RTFLRPRIIG GSSSLPGSHP WLAAIYIGDS FCAGSLVHTC WVVSAAHCFS HSPPRDSVSV VLGQHFFNRT TDVTQTFGIE KYIPYTLYSV FNPSDHDLVL IRLKKKGDRC ATRSQFVQPI CLPEPGSTFP AGHKCQIAGW GHLDENVSGY SSSLREALVP LVADHKCSSP EVYGADISPN MLCAGYFDCK SDACQGDSGG PLACEKNGVA YLYGIISWGD GCGRLHKPGV YTRVANYVDW INDRIRPPRR LVAPS
Genular Protein ID: 1504817035
Symbol: D6RAR4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
Sequence Information:
- Length: 662
- Mass: 71483
- Checksum: F2A3D607370547F6
- Sequence:
MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE YCRLEACDLE TEGRESLTRV QLSPDLLATL PEPASPGRQA CGRRHKKRTF LRPRIIGGSS SLPGSHPWLA AIYIGDSFCA GSLVHTCWVV SAAHCFSHSP PRDSVSVVLG QHFFNRTTDV TQTFGIEKYI PYTLYSVFNP SDHDLVLIRL KKKGDRCATR SQFVQPICLP EPGSTFPAGH KCQIAGWGHL DENVSGYSSS LREALVPLVA DHKCSSPEVY GADISPNMLC AGYFDCKSDA CQGDSGGPLA CEKNGVAYLY GIISWGDGCG RLHKPGVYTR VANYVDWIND RIRPPRRLVA PS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.