Details for: HGFAC

Gene ID: 3083

Symbol: HGFAC

Ensembl ID: ENSG00000109758

Description: HGF activator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.4297
    Cell Significance Index: -3.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 6.3308
    Cell Significance Index: 106.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.9685
    Cell Significance Index: -3.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.5350
    Cell Significance Index: 155.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2725
    Cell Significance Index: -2.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8222
    Cell Significance Index: 13.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8052
    Cell Significance Index: 17.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5462
    Cell Significance Index: 103.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5157
    Cell Significance Index: 51.0200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.4923
    Cell Significance Index: 6.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4269
    Cell Significance Index: 385.5000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.3450
    Cell Significance Index: 0.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3348
    Cell Significance Index: 5.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3211
    Cell Significance Index: 4.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2701
    Cell Significance Index: 5.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2669
    Cell Significance Index: 95.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2598
    Cell Significance Index: 51.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1423
    Cell Significance Index: 15.4800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1341
    Cell Significance Index: 0.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1114
    Cell Significance Index: 18.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0835
    Cell Significance Index: 5.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0576
    Cell Significance Index: 0.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0517
    Cell Significance Index: 0.6700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0399
    Cell Significance Index: 0.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0379
    Cell Significance Index: 10.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0325
    Cell Significance Index: 1.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0091
    Cell Significance Index: 0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0059
    Cell Significance Index: 3.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0005
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0029
    Cell Significance Index: -0.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0036
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0050
    Cell Significance Index: -3.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -2.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0067
    Cell Significance Index: -0.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0088
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0111
    Cell Significance Index: -1.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0137
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0154
    Cell Significance Index: -3.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0158
    Cell Significance Index: -0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0168
    Cell Significance Index: -3.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0203
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0212
    Cell Significance Index: -2.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0235
    Cell Significance Index: -3.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0246
    Cell Significance Index: -0.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0261
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0267
    Cell Significance Index: -0.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0299
    Cell Significance Index: -0.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0316
    Cell Significance Index: -0.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0331
    Cell Significance Index: -3.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0346
    Cell Significance Index: -3.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0367
    Cell Significance Index: -1.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0400
    Cell Significance Index: -2.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0476
    Cell Significance Index: -3.7700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0495
    Cell Significance Index: -0.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0507
    Cell Significance Index: -1.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0519
    Cell Significance Index: -3.9900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0540
    Cell Significance Index: -1.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0546
    Cell Significance Index: -3.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0573
    Cell Significance Index: -1.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0628
    Cell Significance Index: -4.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0644
    Cell Significance Index: -2.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0679
    Cell Significance Index: -3.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0694
    Cell Significance Index: -1.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0697
    Cell Significance Index: -2.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0743
    Cell Significance Index: -1.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0795
    Cell Significance Index: -3.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0804
    Cell Significance Index: -3.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0827
    Cell Significance Index: -4.3400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0868
    Cell Significance Index: -1.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0879
    Cell Significance Index: -1.8400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0894
    Cell Significance Index: -1.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0918
    Cell Significance Index: -2.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0922
    Cell Significance Index: -3.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0973
    Cell Significance Index: -3.1000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1011
    Cell Significance Index: -1.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1022
    Cell Significance Index: -2.8600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1030
    Cell Significance Index: -0.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1033
    Cell Significance Index: -2.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1071
    Cell Significance Index: -3.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1110
    Cell Significance Index: -2.7700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1122
    Cell Significance Index: -1.8000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1128
    Cell Significance Index: -1.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1150
    Cell Significance Index: -2.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1196
    Cell Significance Index: -4.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1221
    Cell Significance Index: -3.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1221
    Cell Significance Index: -3.2600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1248
    Cell Significance Index: -2.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1265
    Cell Significance Index: -2.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1290
    Cell Significance Index: -3.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1300
    Cell Significance Index: -3.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** HGFAC is expressed in a variety of cell types, including conventional dendritic cells, colon goblet cells, neuroendocrine cells, and hepatocytes, suggesting its involvement in multiple cellular processes. 2. **Signaling Pathways:** The gene is associated with several signaling pathways, including Met receptor activation, signaling by receptor tyrosine kinases, and proteolysis, indicating its potential to regulate cellular responses to various stimuli. 3. **Protein Binding:** HGFAC interacts with other proteins, such as D6RAR4_HUMAN, which may modulate its activity or regulate its expression. 4. **Serine-Type Endopeptidase Activity:** The gene is involved in serine-type endopeptidase activity, which is a critical process for protein degradation and regulation. **Pathways and Functions:** HGFAC is involved in several signaling pathways that regulate cellular responses, including: 1. **Met Receptor Activation:** HGFAC activates the Met receptor, a tyrosine kinase receptor that plays a crucial role in cell proliferation, differentiation, and survival. 2. **Signaling by Receptor Tyrosine Kinases:** The gene is involved in signaling by receptor tyrosine kinases, which regulate various cellular processes, including cell growth, differentiation, and survival. 3. **Proteolysis:** HGFAC is involved in proteolysis, a process that regulates protein degradation and modification, which is essential for cellular homeostasis. 4. **Serine-Type Endopeptidase Activity:** The gene is involved in serine-type endopeptidase activity, which regulates protein degradation and modification. **Clinical Significance:** HGFAC's involvement in various signaling pathways and cellular processes makes it a potential target for therapeutic interventions in several diseases, including: 1. **Cancer:** HGFAC's role in cell proliferation, differentiation, and survival makes it a potential target for cancer therapy. 2. **Inflammatory Diseases:** The gene's involvement in immune responses and tissue homeostasis makes it a potential target for inflammatory diseases, such as atherosclerosis and arthritis. 3. **Neurological Disorders:** HGFAC's role in neuronal survival and differentiation makes it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, HGFAC is a gene that plays a crucial role in regulating cellular signaling pathways and its implications for human health are significant. Further research is needed to fully understand the gene's function and its potential as a therapeutic target for various diseases.

Genular Protein ID: 1075879558

Symbol: HGFA_HUMAN

Name: Hepatocyte growth factor activator

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7683665

Title: Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII.

PubMed ID: 7683665

DOI: 10.1016/s0021-9258(18)82167-6

PubMed ID: 9874200

Title: Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene -- phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator.

PubMed ID: 9874200

DOI: 10.1046/j.1432-1327.1998.2580355.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 15713485

Title: Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.

PubMed ID: 15713485

DOI: 10.1016/j.jmb.2004.12.048

PubMed ID: 18077410

Title: Structural insight into distinct mechanisms of protease inhibition by antibodies.

PubMed ID: 18077410

DOI: 10.1073/pnas.0708251104

Sequence Information:

  • Length: 655
  • Mass: 70682
  • Checksum: 2CF72F1E1B862ED7
  • Sequence:
  • MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV 
    TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH 
    ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD 
    PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT 
    RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST 
    SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE 
    YCRLEACESL TRVQLSPDLL ATLPEPASPG RQACGRRHKK RTFLRPRIIG GSSSLPGSHP 
    WLAAIYIGDS FCAGSLVHTC WVVSAAHCFS HSPPRDSVSV VLGQHFFNRT TDVTQTFGIE 
    KYIPYTLYSV FNPSDHDLVL IRLKKKGDRC ATRSQFVQPI CLPEPGSTFP AGHKCQIAGW 
    GHLDENVSGY SSSLREALVP LVADHKCSSP EVYGADISPN MLCAGYFDCK SDACQGDSGG 
    PLACEKNGVA YLYGIISWGD GCGRLHKPGV YTRVANYVDW INDRIRPPRR LVAPS

Genular Protein ID: 1504817035

Symbol: D6RAR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 662
  • Mass: 71483
  • Checksum: F2A3D607370547F6
  • Sequence:
  • MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV 
    TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH 
    ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD 
    PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT 
    RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST 
    SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE 
    YCRLEACDLE TEGRESLTRV QLSPDLLATL PEPASPGRQA CGRRHKKRTF LRPRIIGGSS 
    SLPGSHPWLA AIYIGDSFCA GSLVHTCWVV SAAHCFSHSP PRDSVSVVLG QHFFNRTTDV 
    TQTFGIEKYI PYTLYSVFNP SDHDLVLIRL KKKGDRCATR SQFVQPICLP EPGSTFPAGH 
    KCQIAGWGHL DENVSGYSSS LREALVPLVA DHKCSSPEVY GADISPNMLC AGYFDCKSDA 
    CQGDSGGPLA CEKNGVAYLY GIISWGDGCG RLHKPGVYTR VANYVDWIND RIRPPRRLVA 
    PS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.