Details for: AOC2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 22.0515
Cell Significance Index: -3.4300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 13.5623
Cell Significance Index: -3.4400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.3513
Cell Significance Index: 82.8500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 0.8743
Cell Significance Index: -3.4500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6847
Cell Significance Index: 35.5700 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.5831
Cell Significance Index: 9.2500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4474
Cell Significance Index: 85.1500 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.4110
Cell Significance Index: 3.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2525
Cell Significance Index: 24.9800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2098
Cell Significance Index: 189.4000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2093
Cell Significance Index: 6.0300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2069
Cell Significance Index: 12.4200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2019
Cell Significance Index: 5.4100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1859
Cell Significance Index: 20.2200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1664
Cell Significance Index: 2.2700 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.1553
Cell Significance Index: 2.2600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1507
Cell Significance Index: 3.3000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1435
Cell Significance Index: 23.3400 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.1202
Cell Significance Index: 1.9800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0868
Cell Significance Index: 6.0000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0813
Cell Significance Index: 51.6300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0798
Cell Significance Index: 16.0100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0410
Cell Significance Index: 7.3900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0389
Cell Significance Index: 5.6500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0374
Cell Significance Index: 13.4100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0254
Cell Significance Index: 0.5500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0205
Cell Significance Index: 4.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0201
Cell Significance Index: 2.4700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0164
Cell Significance Index: 0.3400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0161
Cell Significance Index: 2.0700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0148
Cell Significance Index: 0.5200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0135
Cell Significance Index: 0.9100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0103
Cell Significance Index: 1.2000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0071
Cell Significance Index: 0.3200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0051
Cell Significance Index: 2.7700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0047
Cell Significance Index: 2.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0030
Cell Significance Index: 5.7400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0019
Cell Significance Index: 0.1400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0014
Cell Significance Index: -0.0400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0015
Cell Significance Index: -2.7600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0018
Cell Significance Index: -2.8400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0024
Cell Significance Index: -3.2700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0028
Cell Significance Index: -0.0700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0033
Cell Significance Index: -1.5100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0039
Cell Significance Index: -2.8500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0042
Cell Significance Index: -3.1300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0042
Cell Significance Index: -3.1700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0051
Cell Significance Index: -2.8600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0071
Cell Significance Index: -2.0400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0075
Cell Significance Index: -0.2400 - Cell Name: myometrial cell (CL0002366)
Fold Change: -0.0096
Cell Significance Index: -0.1100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0106
Cell Significance Index: -1.0900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0108
Cell Significance Index: -0.2300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0138
Cell Significance Index: -0.8700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0138
Cell Significance Index: -0.6100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0147
Cell Significance Index: -0.6900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0153
Cell Significance Index: -1.7500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0159
Cell Significance Index: -2.7200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0181
Cell Significance Index: -2.4800 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0186
Cell Significance Index: -0.2400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0190
Cell Significance Index: -0.7200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0208
Cell Significance Index: -2.6900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0219
Cell Significance Index: -4.6200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0230
Cell Significance Index: -0.5900 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0258
Cell Significance Index: -0.3700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0271
Cell Significance Index: -0.7600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0273
Cell Significance Index: -3.2200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0291
Cell Significance Index: -1.5200 - Cell Name: mesangial cell (CL0000650)
Fold Change: -0.0300
Cell Significance Index: -0.3800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0309
Cell Significance Index: -0.8400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0312
Cell Significance Index: -0.8900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0313
Cell Significance Index: -3.2600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0338
Cell Significance Index: -0.5100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0339
Cell Significance Index: -0.4900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0380
Cell Significance Index: -1.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0392
Cell Significance Index: -2.9200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0395
Cell Significance Index: -2.5500 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0408
Cell Significance Index: -0.5800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0409
Cell Significance Index: -1.7800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0411
Cell Significance Index: -1.9300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0413
Cell Significance Index: -3.1700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0430
Cell Significance Index: -2.6400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0467
Cell Significance Index: -2.4500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0477
Cell Significance Index: -1.5200 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0493
Cell Significance Index: -0.8300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0494
Cell Significance Index: -1.3200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0531
Cell Significance Index: -1.8600 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0600
Cell Significance Index: -0.7900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0602
Cell Significance Index: -3.3800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0607
Cell Significance Index: -1.2700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0611
Cell Significance Index: -2.0000 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0630
Cell Significance Index: -1.5700 - Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.0630
Cell Significance Index: -0.3300 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0645
Cell Significance Index: -1.6100 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.0654
Cell Significance Index: -0.5200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0659
Cell Significance Index: -1.1100 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0750
Cell Significance Index: -1.0400 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0752
Cell Significance Index: -1.8800 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0760
Cell Significance Index: -1.2200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0763
Cell Significance Index: -1.6200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Key Characteristics:
AOC2 is a copper-containing enzyme, which implies that it relies on the redox properties of copper ions to facilitate its catalytic activity. The enzyme is primarily expressed in cells of the nervous system, including GABAergic interneurons in the cerebral cortex, and in the intestine, where it is found in goblet cells and absorptive cells. AOC2 is also expressed in the colon, where it is localized in tuft cells and intestinal crypt stem cells. The expression of AOC2 in these cell types suggests that it plays a role in regulating metabolic pathways, including those involved in the breakdown of amines and the synthesis of neurotransmitters.
Pathways and Functions:
AOC2 is involved in several metabolic pathways, including:
- Amine Metabolic Process: AOC2 catalyzes the oxidative deamination of primary amines, which is essential for regulating the levels of these compounds in the body.
- Catecholamine Metabolic Process: AOC2 is also involved in the breakdown of catecholamines, such as dopamine, norepinephrine, and epinephrine, which are neurotransmitters involved in various physiological processes.
- Electron Transport Chain: AOC2 is thought to be involved in the electron transport chain, which is a series of protein complexes that generate energy for the cell through the transfer of electrons.
- Protein Binding: AOC2 binds to various proteins, including quinones and copper ions, which are essential for its catalytic activity.
Clinical Significance:
AOC2 has been implicated in various diseases and disorders, including:
- Neurological Disorders: AOC2 has been linked to neurological disorders, such as Parkinson’s disease and schizophrenia, which are characterized by impaired catecholamine metabolism.
- Gastrointestinal Disorders: AOC2 has been implicated in gastrointestinal disorders, such as inflammatory bowel disease and colon cancer, which are characterized by dysregulation of the intestinal microbiome.
- Cancer: AOC2 has been found to be overexpressed in certain types of cancer, including colon cancer, which suggests that it may play a role in cancer development and progression.
In conclusion, AOC2 is a copper-containing amine oxidase enzyme that plays a crucial role in regulating metabolic pathways, including those involved in the breakdown of amines and the synthesis of neurotransmitters. Its expression in various cell types suggests that it has a wide range of functions, including those involved in the electron transport chain and protein binding. Further research is needed to fully understand the clinical significance of AOC2 and its role in various diseases and disorders.
Genular Protein ID: 303692917
Symbol: AOC2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9119395
Title: Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping.
PubMed ID: 9119395
PubMed ID: 9722954
Title: Human retina-specific amine oxidase: genomic structure of the gene (AOC2), alternatively spliced variant, and mRNA expression in retina.
PubMed ID: 9722954
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12755418
Title: High expression of semicarbazide-sensitive amine oxidase genes AOC2 and AOC3, but not the diamine oxidase gene AOC1 in human adipocytes.
PubMed ID: 12755418
PubMed ID: 17400359
Title: Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes.
PubMed ID: 17400359
PubMed ID: 19588076
Title: The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase.
PubMed ID: 19588076
Sequence Information:
- Length: 756
- Mass: 83673
- Checksum: 10263D8D56D3BD25
- Sequence:
MHLKIVLAFL ALSLITIFAL AYVLLTSPGG SSQPPHCPSV SHRAQPWPHP GQSQLFADLS REELTAVMRF LTQRLGPGLV DAAQAQPSDN CIFSVELQLP PKAAALAHLD RGSPPPAREA LAIVLFGGQP QPNVSELVVG PLPHPSYMRD VTVERHGGPL PYHRRPVLRA EFTQMWRHLK EVELPKAPIF LSSTFNYNGS TLAAVHATPR GLRSGDRATW MALYHNISGV GLFLHPVGLE LLLDHRALDP AHWTVQQVFY LGHYYADLGQ LEREFKSGRL EVVRVPLPPP NGASSLRSRN SPGPLPPLQF SPQGSQYSVQ GNLVVSSLWS FTFGHGVFSG LRIFDVRFQG ERIAYEVSVQ ECVSIYGADS PKTMLTRYLD SSFGLGRNSR GLVRGVDCPY QATMVDIHIL VGKGAVQLLP GAVCVFEEAQ GLPLRRHHNY LQNHFYGGLA SSALVVRSVS SVGNYDYIWD FVLYPNGALE GRVHATGYIN TAFLKGGEEG LLFGNRVGER VLGTVHTHAF HFKLDLDVAG LKNWVVAEDV VFKPVAAPWN PEHWLQRPQL TRQVLGKEDL TAFSLGSPLP RYLYLASNQT NAWGHQRGYR IQIHSPLGIH IPLESDMERA LSWGRYQLVV TQRKEEESQS SSIYHQNDIW TPTVTFADFI NNETLLGEDL VAWVTASFLH IPHAEDIPNT VTLGNRVGFL LRPYNFFDED PSIFSPGSVY FEKGQDAGLC SINPVACLPD LAACVPDLPP FSYHGF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.