Details for: AOC2

Gene ID: 314

Symbol: AOC2

Ensembl ID: ENSG00000131480

Description: amine oxidase copper containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.0515
    Cell Significance Index: -3.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.5623
    Cell Significance Index: -3.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3513
    Cell Significance Index: 82.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.8743
    Cell Significance Index: -3.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6847
    Cell Significance Index: 35.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5831
    Cell Significance Index: 9.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4474
    Cell Significance Index: 85.1500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.4110
    Cell Significance Index: 3.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2525
    Cell Significance Index: 24.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2098
    Cell Significance Index: 189.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2093
    Cell Significance Index: 6.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2069
    Cell Significance Index: 12.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2019
    Cell Significance Index: 5.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1859
    Cell Significance Index: 20.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1664
    Cell Significance Index: 2.2700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1553
    Cell Significance Index: 2.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1507
    Cell Significance Index: 3.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1435
    Cell Significance Index: 23.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1202
    Cell Significance Index: 1.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0868
    Cell Significance Index: 6.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0813
    Cell Significance Index: 51.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0798
    Cell Significance Index: 16.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0410
    Cell Significance Index: 7.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0389
    Cell Significance Index: 5.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0374
    Cell Significance Index: 13.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0254
    Cell Significance Index: 0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0205
    Cell Significance Index: 4.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0201
    Cell Significance Index: 2.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0164
    Cell Significance Index: 0.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0161
    Cell Significance Index: 2.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0135
    Cell Significance Index: 0.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0103
    Cell Significance Index: 1.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0071
    Cell Significance Index: 0.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0051
    Cell Significance Index: 2.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0047
    Cell Significance Index: 2.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0019
    Cell Significance Index: 0.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0039
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0051
    Cell Significance Index: -2.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0071
    Cell Significance Index: -2.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0075
    Cell Significance Index: -0.2400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0106
    Cell Significance Index: -1.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0138
    Cell Significance Index: -0.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0138
    Cell Significance Index: -0.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0147
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0153
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0159
    Cell Significance Index: -2.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0181
    Cell Significance Index: -2.4800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0186
    Cell Significance Index: -0.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0190
    Cell Significance Index: -0.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0208
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0219
    Cell Significance Index: -4.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0230
    Cell Significance Index: -0.5900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0258
    Cell Significance Index: -0.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0271
    Cell Significance Index: -0.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0273
    Cell Significance Index: -3.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0291
    Cell Significance Index: -1.5200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0300
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0309
    Cell Significance Index: -0.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0312
    Cell Significance Index: -0.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0313
    Cell Significance Index: -3.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0338
    Cell Significance Index: -0.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0339
    Cell Significance Index: -0.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0380
    Cell Significance Index: -1.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0392
    Cell Significance Index: -2.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0395
    Cell Significance Index: -2.5500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0408
    Cell Significance Index: -0.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0409
    Cell Significance Index: -1.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0411
    Cell Significance Index: -1.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0413
    Cell Significance Index: -3.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0430
    Cell Significance Index: -2.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0467
    Cell Significance Index: -2.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0477
    Cell Significance Index: -1.5200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0493
    Cell Significance Index: -0.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0494
    Cell Significance Index: -1.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0531
    Cell Significance Index: -1.8600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0600
    Cell Significance Index: -0.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0602
    Cell Significance Index: -3.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0607
    Cell Significance Index: -1.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0611
    Cell Significance Index: -2.0000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0630
    Cell Significance Index: -1.5700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0630
    Cell Significance Index: -0.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0645
    Cell Significance Index: -1.6100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0654
    Cell Significance Index: -0.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0659
    Cell Significance Index: -1.1100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0750
    Cell Significance Index: -1.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0752
    Cell Significance Index: -1.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0760
    Cell Significance Index: -1.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0763
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Key Characteristics:

AOC2 is a copper-containing enzyme, which implies that it relies on the redox properties of copper ions to facilitate its catalytic activity. The enzyme is primarily expressed in cells of the nervous system, including GABAergic interneurons in the cerebral cortex, and in the intestine, where it is found in goblet cells and absorptive cells. AOC2 is also expressed in the colon, where it is localized in tuft cells and intestinal crypt stem cells. The expression of AOC2 in these cell types suggests that it plays a role in regulating metabolic pathways, including those involved in the breakdown of amines and the synthesis of neurotransmitters.

Pathways and Functions:

AOC2 is involved in several metabolic pathways, including:

  1. Amine Metabolic Process: AOC2 catalyzes the oxidative deamination of primary amines, which is essential for regulating the levels of these compounds in the body.
  2. Catecholamine Metabolic Process: AOC2 is also involved in the breakdown of catecholamines, such as dopamine, norepinephrine, and epinephrine, which are neurotransmitters involved in various physiological processes.
  3. Electron Transport Chain: AOC2 is thought to be involved in the electron transport chain, which is a series of protein complexes that generate energy for the cell through the transfer of electrons.
  4. Protein Binding: AOC2 binds to various proteins, including quinones and copper ions, which are essential for its catalytic activity.

Clinical Significance:

AOC2 has been implicated in various diseases and disorders, including:

  1. Neurological Disorders: AOC2 has been linked to neurological disorders, such as Parkinson’s disease and schizophrenia, which are characterized by impaired catecholamine metabolism.
  2. Gastrointestinal Disorders: AOC2 has been implicated in gastrointestinal disorders, such as inflammatory bowel disease and colon cancer, which are characterized by dysregulation of the intestinal microbiome.
  3. Cancer: AOC2 has been found to be overexpressed in certain types of cancer, including colon cancer, which suggests that it may play a role in cancer development and progression.

In conclusion, AOC2 is a copper-containing amine oxidase enzyme that plays a crucial role in regulating metabolic pathways, including those involved in the breakdown of amines and the synthesis of neurotransmitters. Its expression in various cell types suggests that it has a wide range of functions, including those involved in the electron transport chain and protein binding. Further research is needed to fully understand the clinical significance of AOC2 and its role in various diseases and disorders.

Genular Protein ID: 303692917

Symbol: AOC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9119395

Title: Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping.

PubMed ID: 9119395

DOI: 10.1006/geno.1996.4570

PubMed ID: 9722954

Title: Human retina-specific amine oxidase: genomic structure of the gene (AOC2), alternatively spliced variant, and mRNA expression in retina.

PubMed ID: 9722954

DOI: 10.1006/geno.1998.5357

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12755418

Title: High expression of semicarbazide-sensitive amine oxidase genes AOC2 and AOC3, but not the diamine oxidase gene AOC1 in human adipocytes.

PubMed ID: 12755418

DOI: 10.1007/s000110300061

PubMed ID: 17400359

Title: Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes.

PubMed ID: 17400359

DOI: 10.1016/j.biochi.2007.02.013

PubMed ID: 19588076

Title: The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase.

PubMed ID: 19588076

DOI: 10.1007/s00018-009-0076-5

Sequence Information:

  • Length: 756
  • Mass: 83673
  • Checksum: 10263D8D56D3BD25
  • Sequence:
  • MHLKIVLAFL ALSLITIFAL AYVLLTSPGG SSQPPHCPSV SHRAQPWPHP GQSQLFADLS 
    REELTAVMRF LTQRLGPGLV DAAQAQPSDN CIFSVELQLP PKAAALAHLD RGSPPPAREA 
    LAIVLFGGQP QPNVSELVVG PLPHPSYMRD VTVERHGGPL PYHRRPVLRA EFTQMWRHLK 
    EVELPKAPIF LSSTFNYNGS TLAAVHATPR GLRSGDRATW MALYHNISGV GLFLHPVGLE 
    LLLDHRALDP AHWTVQQVFY LGHYYADLGQ LEREFKSGRL EVVRVPLPPP NGASSLRSRN 
    SPGPLPPLQF SPQGSQYSVQ GNLVVSSLWS FTFGHGVFSG LRIFDVRFQG ERIAYEVSVQ 
    ECVSIYGADS PKTMLTRYLD SSFGLGRNSR GLVRGVDCPY QATMVDIHIL VGKGAVQLLP 
    GAVCVFEEAQ GLPLRRHHNY LQNHFYGGLA SSALVVRSVS SVGNYDYIWD FVLYPNGALE 
    GRVHATGYIN TAFLKGGEEG LLFGNRVGER VLGTVHTHAF HFKLDLDVAG LKNWVVAEDV 
    VFKPVAAPWN PEHWLQRPQL TRQVLGKEDL TAFSLGSPLP RYLYLASNQT NAWGHQRGYR 
    IQIHSPLGIH IPLESDMERA LSWGRYQLVV TQRKEEESQS SSIYHQNDIW TPTVTFADFI 
    NNETLLGEDL VAWVTASFLH IPHAEDIPNT VTLGNRVGFL LRPYNFFDED PSIFSPGSVY 
    FEKGQDAGLC SINPVACLPD LAACVPDLPP FSYHGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.